Prebiotic inulin-type fructans induce specific changes in the human gut microbiota

Gut

Volumn 66, Issue 11, 2017, Pages 1968-1974

  Vandeputte, Doris ^a,b,c   Falony, Gwen ^a,b   Vieira Silva, Sara ^a,b   Wang, Jun ^a,b   Sailer, Manuela ^d   Theis, Stephan ^d   Verbeke, Kristin ^e   Raes, Jeroen ^a,b,c  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^c VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^d BENEO   (Germany)

^e UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

COLONIC MICROFLORA; CONSTIPATION; PREBIOTIC

Indexed keywords

FRUCTAN; INULIN; PREBIOTIC AGENT; RNA 16S; BIOLOGICAL MARKER;

ANAEROSTIPES; ARTICLE; BACTERIUM IDENTIFICATION; BIFIDOBACTERIUM; BILOPHILA; CLINICAL PRACTICE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; EFFECT SIZE; FECAL METABOLISM; FECES; FERMENTATION; HUMAN; INTESTINE FLORA; MASS FRAGMENTOGRAPHY; METABOLOMICS; MICROBIOME; NONHUMAN; POPULATION ABUNDANCE; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; SPECIES COMPOSITION; CHEMISTRY; COLON; CONSTIPATION; DIET THERAPY; FEMALE; MALE; METABOLISM; METABOLOME; MICROBIOLOGY; PHYSIOLOGY; TREATMENT OUTCOME;

BIOMARKERS; COLON; CONSTIPATION; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FECES; FEMALE; GASTROINTESTINAL MICROBIOME; HUMANS; INULIN; MALE; METABOLOME; PREBIOTICS; TREATMENT OUTCOME;

EID: 85029302133     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2016-313271     Document Type: Article

References (48)

1. Gibson GR, Roberfroid MB. Dietary modulation of the human colonic microbiota: Introducing the concept of prebiotics. J Nutr 1995;125:1401-12.
2. Hutkins RW, Krumbeck JA, Bindels LB, et al. Prebiotics: Why definitions matter. Curr Opin Biotechnol 2016;37:1-7.
3. Bindels LB, Delzenne NM, Cani PD, et al. Towards a more comprehensive concept for prebiotics. Nat Rev Gastroenterol Hepatol 2015;12:303-10.
4. Gibson GR, Probert HM, Loo JV, et al. Dietary modulation of the human colonic microbiota: Updating the concept of prebiotics. Nutr Res Rev 2004;17:259-75.
5. Gibson GR, Scott KP, Rastall RA, et al. Dietary prebiotics: Current status and new definition. Food Sci Technol Bull Funct Foods 2010;7:1-19.
6. Roberfroid M, Gibson GR, Hoyles L, et al. Prebiotic effects: Metabolic and health benefits. Br J Nutr 2010;104(Suppl 2):S1-63.
7. Everard A, Lazarevic V, Gaiä N, et al. Microbiome of prebiotic-treated mice reveals novel targets involved in host response during obesity. ISME J 2014;8:2116-30.
8. Everard A, Lazarevic V, Derrien M, et al. Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice. Diabetes 2011;60:2775-86.
9. Flint HJ, Duncan SH, Scott KP, et al. Interactions and competition within the microbial community of the human colon: Links between diet and health. Environ Microbiol 2007;9:1101-11.
10. Macfarlane S, Macfarlane GT, Cummings JH. Review article: Prebiotics in the gastrointestinal tract. Aliment Pharmacol Ther 2006;24:701-14.
11. Vieira-Silva S, Falony G, Darzi Y, et al. Species-function relationships shape ecological properties of the human gut microbiome. Nat Microbiol 2016;1:16088.
12. Micka A, Siepelmeyer A, Holz A, et al. Effect of consumption of chicory inulin on bowel function in healthy subjects with constipation: A randomized, double-blind, placebo-controlled trial. Int J Food Sci Nutr 2017;68:82-9.
13. EFSA Panel on Dietic Products Nutrition and Allergies (NDA). Scientific Opinion on the substantiation of a health claim related to "native chicory inulin" and maintenance of normal defecation by increasing stool frequency pursuant to Article 13.5 of Regulation (EC) No 1924/2006. EFSA J 2015;13:3951.
14. Falony G, Joossens M, Vieira-Silva S, et al. Population-level analysis of gut microbiome variation. Science 2016;352:560-4.
15. Vandeputte D, Falony G, Vieira-Silva S, et al. Stool consistency is strongly associated with gut microbiota richness and composition, enterotypes and bacterial growth rates. Gut 2016;65:57-62.
16. Tigchelaar EF, Bonder MJ, Jankipersadsing SA, et al. Gut microbiota composition associated with stool consistency. Gut 2016;65:540-2.
17. Roager HM, Hansen LB, Bahl MI, et al. Colonic transit time is related to bacterial metabolism and mucosal turnover in the gut. Nat Microbiol 2016;1:16093.
18. Arumugam M, Raes J, Pelletier E, et al. Enterotypes of the human gut microbiome. Nature 2011;473:174-80.
19. Everard A, Belzer C, Geurts L, et al. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc Natl Acad Sci USA 2013;110:9066-71.
20. Ramirez-Farias C, Slezak K, Fuller Z, et al. Effect of inulin on the human gut microbiota: Stimulation of Bifidobacterium adolescentis and Faecalibacterium prausnitzii. Br J Nutr 2009;101:541-50.
21. Scott KP, Martin JC, Duncan SH, et al. Prebiotic stimulation of human colonic butyrate-producing bacteria and bifidobacteria, in vitro. FEMS Microbiol Ecol 2014;87:30-40.
22. Burdock GA. Encyclopedia of food and color additives. Boca Raton, Florida: CRC Press, Inc., 1996.
23. Lairon D. Dietary fibres: Effects on lipid metabolism and mechanisms of action. Eur J Clin Nutr 1996;50:125-33.
24. Falony G, Calmeyn T, Leroy F, et al. Coculture fermentations of Bifidobacterium species and Bacteroides thetaiotaomicron reveal a mechanistic insight into the prebiotic effect of inulin-type fructans. Appl Environ Microbiol 2009;75:2312-19.
25. Schell MA, Karmirantzou M, Snel B, et al. The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract. Proc Natl Acad Sci USA 2002;99:14422-7.
26. Falony G, Vlachou A, Verbrugghe K, et al. Cross-feeding between Bifidobacterium longum BB536 and acetate-converting, butyrate-producing colon bacteria during growth on oligofructose. Appl Environ Microbiol 2006;72:7835-41.
27. Dewulf EM, Cani PD, Claus SP, et al. Insight into the prebiotic concept: Lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women. Gut 2013;62:1112-21.
28. Baron EJ. Bilophila wadsworthia: A unique Gram-negative anaerobic rod. Anaerobe 1997;3:83-6.
29. David LA, Maurice CF, Carmody RN, et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature 2014;505:559-63.
30. Da Silva SM, Venceslau SS, Fernandes CLV, et al. Hydrogen as an energy source for the human pathogen Bilophila wadsworthia. Antonie Van Leeuwenhoek 2008;93:381-90.
31. Trautwein EA, Rieckhoff D, Erbersdobler HF. Dietary inulin lowers plasma cholesterol and triacylglycerol and alters biliary bile acid profile in hamsters. J Nutr 1998;128:1937-43.
32. Petry N, Egli I, Chassard C, et al. Inulin modifies the bifidobacteria population, fecal lactate concentration, and fecal pH but does not influence iron absorption in women with low iron status. Am J Clin Nutr 2012;96:325-31.
33. Baron EJ, Summanen P, Downes J, et al. Bilophila wadsworthia, gen. nov. and sp. nov., a unique gram-negative anaerobic rod recovered from appendicitis specimens and human faeces. J Gen Microbiol 1989;135:3405-11.
34. Druart C, Dewulf EM, Cani PD, et al. Gut microbial metabolites of polyunsaturated fatty acids correlate with specific fecal bacteria and serum markers of metabolic syndrome in obese women. Lipids 2014;49:397-402.
35. Salazar N, Dewulf EM, Neyrinck AM, et al. Inulin-type fructans modulate intestinal Bifidobacterium species populations and decrease fecal short-chain fatty acids in obese women. Clin Nutr 2015;34:501-7.
36. Gerardo SH, Garcia MM, Wexler HM, et al. Adherence of Bilophila wadsworthia to cultured human embryonic intestinal cells. Anaerobe 1998;4:19-27.
37. Devkota S, Wang Y, Musch MW, et al. Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/-mice. Nature 2012;487:104-8.
38. Tsurumaki M, Kotake M, Iwasaki M, et al. The application of omics technologies in the functional evaluation of inulin and inulin-containing prebiotics dietary supplementation. Nutr Diabetes 2015;5:e185.
39. De Preter V, Van Staeyen G, Esser D, et al. Development of a screening method to determine the pattern of fermentation metabolites in faecal samples using on-line purge-and-trap gas chromatographic-mass spectrometric analysis. J Chromatogr A 2009;1216:1476-83.
40. Kozich JJ, Westcott SL, Baxter NT, et al. Development of a dual-index sequencing strategy and curation pipeline for analyzing amplicon sequence data on the MiSeq Illumina sequencing platform. Appl Environ Microbiol 2013;79:5112-20.
41. Sim K, Cox MJ, Wopereis H, et al. Improved detection of bifidobacteria with optimised 16S rRNA-gene based pyrosequencing. PLoS ONE 2012;7:e32543.
42. Mago T, Salzberg SL. FLASH: Fast length adjustment of short reads to improve genome assemblies. Bioinformatics 2011;27:2957-63.
43. Edgar RC, Haas BJ, Clemente JC, et al. UCHIME improves sensitivity and speed of chimera detection. Bioinformatics 2011;27:2194-200.
44. Wang Q, Garrity GM, Tiedje JM, et al. Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. Appl Environ Microbiol 2007;73:5261-7.
45. Mcmurdie PJ, holmes S. phyloseq: An R package for reproducible interactive analysis and graphics of microbiome census data. PLoS ONE 2013;8:e61217.
46. Oksanen J, et al. 629 vegan: Community ecology package. R package V. 2.2-1. 2015;630
47. Wellek S., Blettner M. On the proper use of the crossover design in clinical trials: Part 18 of a series on evaluation of scientific publications. Dtsch Ärzteblatt Int 2012;109:276-81.
48. Benjamini Y, Hochberg Y. Controlling the false discovery rate: A practical and powerful approach to multiple testing. J R Stat Soc Ser B 1995;57:289-300.