Electrospun Drug-Eluting Fibers for Biomedical Applications

Studies in Mechanobiology, Tissue Engineering and Biomaterials

Volumn 8, Issue , 2011, Pages 57-85

  Natu, Mădălina V ^a   de Sousa, Hermínio C ^a   Gil, Maria H ^a  

^a UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

Drug Release; Drug Solubility; Electrospun Fiber; Fiber Surface; Water Contact Angle

Indexed keywords

EID: 85062762769     PISSN: 18682006     EISSN: 18682014     Source Type: Book Series    
DOI: 10.1007/8415_2010_56     Document Type: Chapter

References (83)

1. Fridrikh, S.V., Yu, J.H., Brenner, M.P., Rutledge, G.C.: Controlling the fiber diameter during electrospinning. Phys. Rev. Lett. doi:10.1103/PhysRevLett.90.144502 (2003)
2. Huang, Z.-M., Zhang, Y.-Z., Kotaki, M., Ramakrishna, S.: A review on polymer nanofibers by electrospinning and their applications in nanocomposites. Comp. Sci. Tech. (2003). doi: 10.1016/S0266-3538(03)00178-7
3. Hohman, M.M., Shin, M., Rutledge, G., Brenner, M.P.: Electrospinning and electrically forced jets. I. Stability theory. Phys. Fluids. (2001). doi:10.1063/1.1383791
4. Rutledge, G.C., Fridrikh, S.V.: Formation of fibers by electrospinning. Adv. Drug Deliv. Rev. (2007). doi:10.1016/j.addr.2007.04.020
5. McClure, M.J., Sell, S.A., Ayres, C.E., Simpson, D.G., Bowlin, G.L.: Electrospinning-aligned and random polydioxanone-polycaprolactone-silk fibroin-blended scaffolds: geometry for a vascular matrix. Biomed. Mater. (2009). doi:10.1088/1748-6041/4/5/055010
6. Lopez-Rubio, A., Sanchez, E., Sanz, Y., Lagaron, J.M.: Encapsulation of living bifidobacteria in ultrathin PVOH electrospun fibers. Biomacromolecules (2009). doi:10.1021/bm900660b
7. Heller, J.: Drug delivery systems. In: Ratner, B.D., Hoffman, A.S., Schoen, F.J., Lemons, J.E. (eds.) Biomaterials Science: An Introduction to Materials in Medicine, 1st edn. Academic Press, London (1996)
8. Cussler, E.L.: Diffusion Mass Transfer in Fluid Systems. Cambridge University Press, New York (1997)
9. Qi, H., Hu, P., Xu, J., Wang, A.: Encapsulation of drug reservoirs in fibers by emulsion electrospinning: morphology characterization and preliminary release assessment. Biomacromolecules (2006). doi:10.1021/bm060264z
10. Liang, D., Luu, Y.K., Kim, K., Hsiao, B.S., Hadjiargyrou, M., Chu B.: In vitro non-viral gene delivery with nanofibrous scaffolds. Nucl Acids Res. (2005). doi:10.1093/nar/gni171
11. Wang, Y., Wang, B., Qiao, W., Yin T.: A novel controlled release drug delivery system for multiple drugs based on electrospun nanofibers containing nanoparticles. J. Pharm. Sci. (2010). doi:10.1002/jps.22189
12. Ayodeji, O., Graham, E., Kniss, D., Lannutti, J., Tomasko, D.: Carbon dioxide impregnation of electrospun polycaprolactone fibers. J Sup Fluids. (2007). doi:10.1016/j.supu.2006.09.011
13. Chronakis, I.S., Milosevic, B., Frenot, A., Ye, L.: Generation of molecular recognition sites in electrospun polymer nanofibers via molecular imprinting. Macromolecules (2006). doi: 10.1021/ma052091w
14. Chronakis, I.S., Jakob, A., Hagstrom, B., Ye, L: Encapsulation and selective recognition of molecularly imprinted theophylline and 17b-estradiol nanoparticles within electrospun polymer nanofibers. Langmuir (2006). doi:10.1021/la0613880
15. Ma, Z., Kotaki, M., Ramakrishna, S.: Surface modified nonwoven polysulphone (PSU) fiber mesh by electrospinning: a novel affinity membrane. J. Membr. Sci. (2006). doi: 10.1016/j.memsci.2005.07.038
16. Casper, C.L., Yang, W., Farach-Carson, M.C., Rabolt, J.F.: Coating electrospun collagen and gelatin fibers with Perlecan domain I for increased growth factor binding. Biomacromolecules (2007). doi:10.1021/bm061003s
17. Casper, C.L., Yamaguchi, N., Kiick, K.L., Rabolt, J.F.: Functionalizing electrospun fibers with biologically relevant macromolecules. Biomacromolecules (2005). doi: 10.1021/bm050007e
18. Skotak, M., Leonov, A.P., Larsen, G., Noriega, S., Subramanian, A.: Biocompatible and biodegradable ultrafine fibrillar scaffold materials for tissue engineering by facile grafting of L-lactide onto chitosan. Biomacromolecules (2008). doi:10.1021/bm800158c
19. Sawicka, K.M., Gouma, P.: Electrospun composite nanofibers for functional applications. J. Nanopart. Res. (2006). doi:10.1007/s11051-005-9026-9
20. Liang, D., Hsiao, B.S., Chu, B.: Functional electrospun nanofibrous scaffolds for biomedical applications. Adv. Drug Deliv.Rev. (2007). doi:10.1016/j.addr.2007.04.021
21. 2 coating on electrospun polymer nanofibers. Adv. Mater. (2009). doi:10.1002/adma.200802458
22. Lee, S.J., Yoo, J.J., Lim, G.J., Atala, A., Stitzel, J.: In vitro evaluation of electrospun nanofiber scaffolds for vascular graft application. J. Biomed. Mater. Res A. (2007). doi: 10.1002/jbm.a.31287
23. Zeng, J., Aigner, A., Czubayko, F., Kissel, T., Wendorff, J.H., Greiner, A: Poly(vinyl alcohol) nanofibers by electrospinning as a protein delivery system and the retardation of enzyme release by additional polymer coatings. Biomacromolecules (2005). doi:10.1021/bm0492576
24. Bogntizki, M., Frese, T., Steinhart, M., Greiner, A., Wendorff, J.H.: Preparation of fibers With nanoscaled morphologies: electrospinning of polymer blends. Polym. Eng. Sci. (2001). doi:10.1002/pen.10799
25. Wei, M., Kang, B., Sung, C., Mead, J.: Core–sheath structure in electrospun nanofibers from polymer blends. Macromol. Mater. Eng. (2006). doi:10.1002/mame.200600284
26. Kalra, V., Kakad, P.A., Mendez, S., Ivannikov, T., Kamperman, M., Joo, Y.L.: Self-assembled structures in electrospun poly(styrene-block-isoprene) fibers. Macromolecules (2006). doi:10.1021/ma052643a
27. Vaz, C.M., van Tuijl, S., Bouten, C.V.C., Baaijens, F.P.T.: Design of scaffolds for blood vessel tissue engineering using a multi-layering electrospinning technique. Acta Biomater. (2005). doi:10.1016/j.actbio.2005.06.006
28. Pham, Q.P., Sharma, U., Mikos, A.G.: Electrospun poly(E-caprolactone) microfiber and multilayer nanofiber/microfiber scaffolds: characterization of scaffolds and measurement of cellular infiltration. Biomacromolecules (2006). doi:10.1021/bm060680j
29. Hong, C.K., Yang, K.S., Oh, S.H., Ahn, J.-H., Cho, B.-H., Nah, C.: Effect of blend composition on the morphology development of electrospun fibres based on PAN/PMMA blends. Polym. Int. (2008). doi:10.1002/pi.2481
30. You, Y., Youk, J.H., Lee, S.W., Min, B.-M., Lee, S.J., Park, W.H.: Preparation of porous ultrafine PGA fibers via selective dissolution of electrospun PGA/PLA blend fibers. Mater. Lett. (2006). doi:10.1016/j.matlet.2005.10.007
31. Sisson, K., Zhang, C., Farach-Carson, M.C., Chase, D.B., Rabolt, J.F.: Evaluation of crosslinking methods for electrospun gelatin on cell growth and viability. Biomacromolecules (2009). doi:10.1021/bm900036s
32. Lee, S.J., Oh, S.H., Liu, J., Soker, S., Atala, A., Yoo, J.J.: The use of thermal treatments to enhance the mechanical properties of electrospun poly(e-caprolactone) scaffolds. Biomaterials (2008). doi:10.1016/j.biomaterials.2007.11.024
33. Wang, X., Zhang, K., Zhu, M., Hsiao, B.S.., Chu, B.: Enhanced mechanical performance of self-bundled electrospun fiber yarns via post-treatments. Macromol. Rapid Commun. (2008). doi:10.1002/marc.200700873
34. Tiwari, S.K., Tzezana, R., Zussman, E., Venkatraman, S.S.: Optimizing partition-controlled drug release from electrospun core–shell bers. Int. J. Pharm. (2010). doi:10.1016/j.ijpharm. 2010.03.021
35. Chew, S.Y., Wen, J., Yim, E.K.F., Leong, K.W.: Sustained release of proteins from electrospun biodegradable fibers. Biomacromolecules (2005). doi: 10.1021/bm0501149
36. Zeng, J., Yang, L., Liang, Q., Zhang, X., Guan, H., Xu, X., Chen, X., Jin, X.: Influence of the drug compatibility with polymer solution on the release kinetics of electrospun fiber formulation. J. Con. Rel. (2005). doi:10.1016/j.jconrel.2005.02.024
37. Xu, X., Yang, L., Xu, X., Wang, X., Chen, X., Liang, Q., Zeng, J., Jing, X.: Ultrafine medicated fibers electrospun from W/O emulsions. J. Con. Rel. (2005). doi:10.1016/j.jconrel.2005.07.021
38. Kim, K., Luu, Y.K., Chang, C., Fang, D., Hsiao, B.S., Chu, B., Hadjiargyro, M.: Incorporation and controlled release of a hydrophilic antibiotic using poly(lactide-co-glycolide)-based electrospun nanofibrous scaffolds. J. Con. Rel. (2004). doi:10.1016/j.jconrel.2004.04.009
39. Okuda, T., Tominaga, K., Kidoaki, S.: Time-programmed dual release formulation by multilayered drug-loaded nanober meshes. J. Con. Rel. (2009). doi:10.1016/j.jconrel.2009. 12.029
40. Ranganath, S.H., Wang, C.-H.: Biodegradable microfiber implants delivering paclitaxel for post-surgical chemotherapy against malignant glioma. Biomaterials (2008). doi:10.1016/j.biomaterials.2008.04.002
41. L-lactide) fibers with paracetanol inoculation. Biomacromolecules (2006). doi:10.1021/bm060057z
42. Buschle-Diller, G., Cooper, J., Xie, Z., Wu, Y., Waldrup, J., Ren, X.: Release of antibiotics from electrospun bicomponent fibers. Cellulose (2007). doi:10.1007/s10570-007-9183-3
43. Nie, H., Soh, B.W., Fu, Y.-.C, Wang, C.-H.: Three-dimensional fibrous PLGA/HAp composite scaffold for BMP-2 Delivery. Biotech. Bioeng. (2007). doi:10.1002/bit.21517
44. Maretschek, S., Greiner, A., Kissel, T.: Electrospun biodegradable nanofiber nonwovens for controlled release of proteins. J. Con. Rel. (2008). doi:10.1016/j.jconrel.2008.01.011
45. Kenawy, E.-R., Bowlin, G.L., Manseld, K., Layman, J., Simpson, D.G., Sanders, E.H., Wnek, G.E.: Release of tetracycline hydrochloride from electrospun poly(ethylene-co-vinylacetate), poly(lactic acid), and a blend. J. Con. Rel. (2002). doi:10.1016/S0168-3659(02)00041-X
46. Xu, X., Chen, X., Xu, X., Lu, T., Wang, X., Yang, L., Jing, X.: BCNU-loaded PEG-PLLA ultrafine fibers and their in vitro antitumor activity against glioma C6 cells. J. Con. Rel. (2006). doi:10.1016/j.jconrel.2006.05.031
47. Xie, Z., Buschle-Diller, G.: Electrospun Poly(D,L-lactide) fibers for drug delivery: the influence of cosolvent and the mechanism of drug release. J. Appl. Polym. Sci. (2009). doi: 10.1002/app.31026
48. Chien Y.W. (1992) Novel Drug Delivery Systems. Marcel Dekker, New York
49. Luong-Van, E., Grndahl, L., Chua, K.N., Leong, K.W., Nurcombe, V., Cool, S.M.: Controlled release of heparin from poly(e-caprolactone) electrospun fibers. Biomaterials (2006). doi:10.1016/j.biomaterials.2005.10.028
50. Zamani, M., Morshed, M., Varshosaz, J., Jannesari, M.: Controlled release of metronidazole benzoate from poly(e-caprolactone) electrospun nanobers for periodontal diseases. Eur. J. Pharm. Biopharm. (2010). doi:10.1016/j.ejpb.2010.02.002
51. Xie, J., Wang, C.-H.: Electrospun micro-and nanofibers for sustained delivery of paclitaxel to treat C6 glioma in vitro. Pharm. Res. (2006). doi:10.1007/s11095-006-9036-z
52. Thakur, R.A., Florek, C.A., Kohn, J., Michniak, B.B.: Electrospun nanobrous polymeric scaffold with targeted drug release proles for potential application as wound dressing. Int. J. Pharm. (2008). doi:10.1016/j.ijpharm.2008.07.033
53. Yu, D.-G., Shen, X.-X., Branford-White, C., White, K., Zhu, L.-M., Annie Blig S.W.: Oral fast-dissolving drug delivery membranes prepared from electrospun polyvinylpyrrolidone ultrafine fibers. Nanotechnology, (2009). doi:10.1088/0957-4484/20/5/055104
54. Taepaiboon, P., Rungsardthong, U., Supaphol, P.: Drug-loaded electrospun mats of poly(vinyl alcohol) fibres and their release characteristics of four model drugs. Nanotechnology (2006). doi:10.1088/0957-4484/17/9/041
55. Verreck, G., Chun, I., Rosenblatt, J., Peeters, J., Van Dijck, A., Mensch, J., Noppe, M., Brewste, M.E.: Incorporation of drugs in an amorphous state into electrospun nanofibers composed of a water-insoluble, nonbiodegradable polymer. J. Con. Rel. (2003). doi:10.1016/S0168-3659(03)00342-0
56. Huang, Z.-M., He, C.-L., Yang, A., Zhang, Y., Han, X.-J., Yin, J., Q.W Encapsulating drugs in biodegradable ultrafine fibers through co-axial electrospinning. J. Biomed. Mater. Res. (2005). A. doi:10.1002/jbm.a.30564
57. Natu, M.V., de Sousa, H.C., Gil, M.H.: Effects of drug solubility, state and loading on controlled release in bicomponent electrospun fibers. Int. J. Pharm. (2010). doi:10.1016/j.ijpharm.2010.06.045
58. Sikareepaisan, P., Suksamrarn, A., Supaphol, P.: Electrospun gelatin fiber mats containing a herbal—Centella asiatica—extract and release characteristic of asiaticoside. Nanotechnology, (2008). doi:10.1088/0957-4484/19/01/015102
59. Tzafriri, A.R.: Mathematical modeling of diffusion-mediated release from bulk degrading matrices. J. Con. Rel. (2000). doi:10.1016/S0168-3659(99)00174-1
60. Kim, T.G., Lee, D.S., Park, T.G.: Controlled protein release from electrospun biodegradable fiber mesh composed of poly(e-caprolactone) and poly(ethylene oxide). Int. J. Pharm. (2007). doi:10.1016/j.ijpharm.2007.01.040
61. Perale, G., Arosio, P., Moscatelli, D., Barri, V., Mller, M., Maccagnan, S., Masi, M.: A new model of resorbable device degradation and drug release: transient 1-dimension diffusional model. J. Con. Rel. (2009). doi:10.1016/j.jconrel.2009.02.014
62. Zong, X., Ran, Sh., Kim, K.-S., Fang, D., Hsiao, B.S., Chu B.: Structure and morphology changes during in vitro degradation of electrospun poly(glycolide-co-lactide) nanofiber membrane. Biomacromolecules (2003). doi:10.1021/bm025717o
63. Peppas, N.A., Brannon-Peppas, L.: Water diffusion and sorption in amorphous macromolecular systems and foods. J. Food Eng. (1994). doi:10.1016/0260-8774(94) 90030-2
64. Zeng, J., Xu, X., Chen, X., Liang, Q., Bian, X., Yang, L., Jin, X.: Biodegradable electrospun fibers for drug delivery. J. Con. Rel. (2003). doi:10.1016/S0168-3659(03)00372-9
65. Qi, M., Li, X., Yang, Y., Zhou, S.: Electrospun fibers of acid-labile biodegradable polymers containing ortho ester groups for controlled release of paracetamol. Eur. J. Pharm. Biopharm. (2008). doi:10.1016/j.ejpb.2008.05.003
66. Taepaiboon, P., Rungsardthong, U., Supaphol, P.: Vitamin-loaded electrospun cellulose acetate nanober mats as transdermal and dermal therapeutic agents of vitamin A acid and vitamin E. Eur. J. Pharm. Biopharm. (2007). doi:10.1016/j.ejpb.2007.03.018
67. Suwantong, O., Opanasopit, P., Ruktanonchai, U., Supaphol, P.: Electrospun cellulose acetate ber mats containing curcumin and release characteristic of the herbal substance. Polymer (2007). doi:10.1016/j.polymer.2007.11.019
68. Verreck, G., Chun, I., Peeters, J., Rosenblatt, J., Brewste, M.E.: Preparation and characterization of nanofibers containing amorphous drug dispersions generated by electrostatic spinning. Pharm. Res. (2003) doi:10.1023/A:1023450006281
69. Kenawy, E.-R., Abdel-Hay, F.I., El-Newehy, M.H., Wnek, G.E.: Processing of polymer nanobers through electrospinning as drug delivery systems. Mater. Chem. Phys. (2009). doi: 10.1016/j.matchemphys.2008.07.081
70. Jiang, H., Hu, Y., Li, Y., Zhao, P., Zhu, K., Che, W.: A facile technique to prepare biodegradable coaxial electrospun nanofibers for controlled release of bioactive agents. J. Con. Rel. (2005). doi:10.1016/j.jconrel.2005.08.006
71. Tammaro, L., Russo, G., Vittoria, V.: Encapsulation of diclofenac molecules into Poly(e-caprolactone) electrospun fibers for delivery protection. J. Nanomater. (2009). doi: 10.1155/2009/238206
72. Abidian, M.R., Kim, D.-H., Martin, D.C.: Conducting-polymer nanotubes for controlled drug release. Adv. Mater. (2006). doi:10.1002/adma.200501726
73. Srikar, R., Yarin, A.L., Megaridis, C.M., Bazilevsky, A.V., Kelley, E.: Desorption-limited mechanism of release from polymer nanofibers. Langmuir. (2008). doi:10.1021/la702449k
74. Panyam, J., Williams, D., Dash, A., Leslie-Pelecky, D., Labhasetwar, V.: Solid-state solubility influences encapsulation and release of hydrophobic drugs from PLGA/PLA nanoparticles. J. Pharm. Sci. (2004). doi:10.1002/jps.20094
75. Drug card for timolol (DB00373), DrugBank database. http://www.drugbank.ca/drugs/DB00373. Cited 27 May 2010
76. Drug card for acetazolamide (DB00819), DrugBank database. http://www.drugbank.ca/drugs/DB00819. Cited 27 May 2010.
77. Marsac, P.J., Li, T., Taylor L.S.: Estimation of drug–polymer miscibility and solubility in amorphous solid dispersions using experimentally determined interaction parameters. Pharm. Res. (2009). doi:10.1007/s11095-008-9721-1
78. Miyajima, M., Koshika, A., Okada, J., Ikeda, M., Nishimura, K.: Effect of polymer crystallinity on papaverine release from poly(L-lactic acid) matrix. J. Con. Rel. (1997). doi: 10.1016/S0168-3659(97)00081-3
79. Jeong, J.-C., Lee, J., Cho, K.: Effects of crystalline microstructure on drug release behavior of poly(e-caprolactone) microspheres. J. Con. Rel. (2003). doi:10.1016/S0168-3659(03)00367-5
80. Cui, W., Li, X., Zhou, S., Weng, J.: Degradation patterns and surface wettability of electrospun brous mats. Polym. Degrad. Stab. (2008). doi:10.1016/j.polymdegradstab.2007.12.002
81. Kang, M., Jung, R., Kim, H.-S., Jin, H.-J.: Preparation of superhydrophobic polystyrene membranes by electrospinning. Colloids Surf. A Physicochem. Eng. Asp. (2008). doi: 10.1016/j.colsurfa.2007.04.122
82. Natu, M.V., Gil, M.H., de Sousa, H.C.: Supercritical solvent impregnation of poly(e-caprolactone)/poly(oxyethylene-b-oxypropylene-b-oxyethylene) and poly(e-caprolactone)/ poly(ethylene-vinyl acetate) blends for controlled release applications. J. Sup. Fluids (2008). doi:10.1016/j.supflu.2008.05.006
83. Hglund, A., Hakkarainen, M., Albertsson, A.-C.: Degradation profile of poly(e-caprolactone)-the influence of macroscopic and macromolecular biomaterial Design. J. Macromol. Sci. A. doi:10.1080/10601320701424487 (2007)