Electrospun nanofibrous polymeric scaffold with targeted drug release profiles for potential application as wound dressing

International Journal of Pharmaceutics

Volumn 364, Issue 1, 2008, Pages 87-93

  Thakur, R A ^a   Florek, C A ^b   Kohn, J ^b   Michniak, B B ^a  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

Anesthetic; Antibiotic; Electrospinning; Lidocaine; Muciprocin; PLLA; Wound

Indexed keywords

LIDOCAINE; NANOFIBER; POLYLACTIC ACID; PSEUDOMONIC ACID;

ANTIBACTERIAL ACTIVITY; ARTICLE; DRUG DELIVERY SYSTEM; DRUG DETERMINATION; DRUG FORMULATION; DRUG RELEASE; PRIORITY JOURNAL; WOUND DRESSING;

ANESTHETICS, LOCAL; ANTI-BACTERIAL AGENTS; BACTERIA; BANDAGES; CALORIMETRY, DIFFERENTIAL SCANNING; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; DRUG DELIVERY SYSTEMS; ELECTROCHEMISTRY; FIBROBLASTS; HUMANS; LIDOCAINE; MICROBIAL SENSITIVITY TESTS; MICROSCOPY, ELECTRON, SCANNING; MUPIROCIN; NANOTUBES; POLYMERS;

EID: 53949085112     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2008.07.033     Document Type: Article

References (34)

1. Aydin O.N., Eyigor M., and Aydin N. Antimicrobial activity of ropivacaine and other local anaesthetics. Eur. J. Anaesthesiol. 18 (2001) 687-694
2. "Bactroban® ointment (2% ointment) product monograph." Glaxosmithkline Inc., Ontario. http://www.gsk.ca/english/docs-pdf/bactroban_oint_pm_07052001.pdf.
3. Badami A.S., Kreke M.R., Thompson M.S., Riffle J.S., and Goldstein A.S. Effect of fiber diameter on spreading, proliferation, and differentiation of osteoblastic cells on electrospun poly(lactic acid) substrates. Biomaterials 27 (2006) 596-606
4. Boyle V.J., Fancher M.E., and Ross Jr. R.W. Rapid, modified Kirby-Bauer susceptibility test with single, high-concentration antimicrobial disks. Antimicrob. Agents Chemother. 3 (1973) 418-424
5. Brewster M.E., Verreck G., Chun I., Rosenblatt J., Mensch J., Van Dijck A., Noppe M., Arien A., Bruining M., and Peeters J. The use of polymer-based electrospun nanofibers containing amorphous drug dispersions for the delivery of poorly water-soluble pharmaceuticals. Pharmazie 59 (2004) 387-391
6. Chew S.Y., Wen J., Yim E.K., and Leong K.W. Sustained release of proteins from electrospun biodegradable fibers. Biomacromolecules 6 (2005) 2017-2024
7. Cui W., Li X., Zhu X., Yu G., Zhou S., and Weng J. Investigation of drug release and matrix degradation of electrospun poly(dl-lactide) fibers with paracetanol inoculation. Biomacromolecules 7 (2006) 1623-1629
8. Drucker M., Cardenas E., Arizti P., Valenzuela A., and Gamboa A. Experimental studies on the effect of lidocaine on wound healing. World J Surg 22 (1998) 394-397 (discussion 397-8)
9. Echevarria L., Blanco-Prieto M.J., Campanero M.A., Santoyo S., and Ygartua P. Development and validation of a liquid chromatographic method for in vitro mupirocin quantification in both skin layers and percutaneous penetration studies. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 796 (2003) 233-241
10. Finlay J.E., Miller L.A., and Poupard J.A. Interpretive criteria for testing susceptibility of staphylococci to mupirocin. Antimicrob. Agents Chemother. 41 (1997) 1137-1139
11. Fong H., Chun I., and Reneker D.H. Beaded nanofibers formed during electrospinning. Polymer 40 (1999) 4585-4592
12. Hooper K., Cox J.D., and Kohn J. Comparison of the effect of ethylene oxide and gamma-irradiation on selected tyrosine-derived polycarbonates and poly(l-lactic acid). J. Appl. Polym. Sci. 63 (1997) 1499-1510
13. Huang L., Nagapudi K., Apkarian R.P., and Chaikof E.L. Engineered collagen-PEO nanofibers and fabrics. J. Biomater. Sci. Polym. Ed. 12 (2001) 979-993
14. Jiang H., Fang D., Hsiao B., Chu B., and Chen W. Preparation and characterization of ibuprofen-loaded poly(lactide-co-glycolide)/poly(ethylene glycol)-g-chitosan electrospun membranes. J. Biomater. Sci. Polym. Ed. 15 (2004) 279-296
15. Jiang H., Hu Y., Li Y., Zhao P., Zhu K., and Chen W. A facile technique to prepare biodegradable coaxial electrospun nanofibers for controlled release of bioactive agents. J. Control Release 108 (2005) 237-243
16. Kang L., Jun H.W., and McCall J.W. HPLC assay of Lidocaine in plasma with solid phase extraction and UV detection. J. Pharm. Biomed. Anal. 19 (1999) 737-745
17. Kenawy R., Bowlin G.L., Mansfield K., Layman J., Simpson D.G., Sanders E.H., and Wnek G.E. Release of tetracycline hydrochloride from electrospun poly(ethylene-co-vinylacetate), poly(lactic acid), and a blend. J. Control Release 81 (2002) 57-64
18. Kenawy R., Layman J.M., Watkins J.R., Bowlin G.L., Matthews J.A., Simpson D.G., and Wnek G.E. Electrospinning of poly(ethylene-co-vinyl alcohol) fibers. Biomaterials 24 (2003) 907-913
19. Khil M.S., Cha D.I., Kim H.Y., Kim I.S., and Bhattarai N. Electrospun nanofibrous polyurethane membrane as wound dressing. J. Biomed. Mater. Res. B Appl. Biomater. 67 (2003) 675-679
20. Kim K., Luu Y.K., Chang C., Fang D., Hsiao B.S., Chu B., and Hadjiargyrou M. Incorporation and controlled release of a hydrophilic antibiotic using poly(lactide-co-glycolide)-based electrospun nanofibrous scaffolds. J. Control Release 98 (2004) 47-56
21. Luong-Van E., Grondahl L., Chua K.N., Leong K.W., Nurcombe V., and Cool S.M. Controlled release of heparin from poly(epsilon-caprolactone) electrospun fibers. Biomaterials 27 (2006) 2042-2050
22. Martinsson T., Haegerstrand A., and Dalsgaard C.J. Ropivacaine and lidocaine inhibit proliferation of non-transformed cultured adult human fibroblasts, endothelial cells and keratinocytes. Agents Actions 40 (1993) 78-85
23. Meidan V.M., Al-Khalili M., and Michniak B.B. Enhanced iontophoretic delivery of buspirone hydrochloride across human skin using chemical enhancers. Int. J. Pharm. 264 (2003) 73-83
24. Popescu A., and Salcido R.S. Wound pain: a challenge for the patient and the wound care specialist. Adv. Skin Wound Care 17 (2004) 14-20 (quiz 21-2)
25. Rho K.S., Jeong L., Lee G., Seo B.M., Park Y.J., Hong S.D., Roh S., Cho J.J., Park W.H., and Min B.M. Electrospinning of collagen nanofibers: effects on the behavior of normal human keratinocytes and early-stage wound healing. Biomaterials 27 (2006) 1452-1461
26. Siepmann J., and Peppas N.A. Hydrophilic matrices for controlled drug delivery: an improved mathematical model to predict the resulting drug release kinetics (the "sequential layer" model). Pharm. Res. 17 (2000) 1290-1298
27. Siepmann J., Kranz H., Bodmeier R., and Peppas N.A. HPMC-matrices for controlled drug delivery: a new model combining diffusion, swelling, and dissolution mechanisms and predicting the release kinetics. Pharm. Res. 16 (1999) 1748-1756
28. Sutherland R., Boon R.J., Griffin K.E., Masters P.J., Slocombe B., and White A.R. Antibacterial activity of mupirocin (pseudomonic acid), a new antibiotic for topical use. Antimicrob. Agents Chemother. 27 (1985) 495-498
29. Verreck G., Chun I., Rosenblatt J., Peeters J., Dijck A.V., Mensch J., Noppe M., and Brewster M.E. Incorporation of drugs in an amorphous state into electrospun nanofibers composed of a water-insoluble, nonbiodegradable polymer. J. Control Release 92 (2003) 349-360
30. Xu X., Yang L., Wang X., Chen X., Liang Q., Zeng J., and Jing X. Ultrafine medicated fibers electrospun from W/O emulsions. J. Control Release 108 (2005) 33-42
31. Yang F., Murugan R., Wang S., and Ramakrishna S. Electrospinning of nano/micro scale poly(l-lactic acid) aligned fibers and their potential in neural tissue engineering. Biomaterials 26 (2005) 2603-2610
32. Zeng J., Xu X., Chen X., Liang Q., Bian X., Yang L., and Jing X. Biodegradable electrospun fibers for drug delivery. J. Control Release 92 (2003) 227-231
33. Zeng J., Yang L., Liang Q., Zhang X., Guan H., Xu X., Chen X., and Jing X. Influence of the drug compatibility with polymer solution on the release kinetics of electrospun fiber formulation. J. Control Release 105 (2005) 43-51
34. Zong X., Bien H., Chung C.Y., Yin L., Fang D., Hsiao B.S., Chu B., and Entcheva E. Electrospun fine-textured scaffolds for heart tissue constructs. Biomaterials 26 (2005) 5330-5338