The hemagglutinin of bat-associated influenza viruses is activated by TMPRSS2 for pH-dependent entry into bat but not human cells

PLoS ONE

Volumn 11, Issue 3, 2016, Pages

  Hoffmann, Markus ^a   Krüger, Nadine ^b   Zmora, Pawel ^a   Wrensch, Florian ^a   Herrler, Georg ^b   Pöhlmann, Stefan ^a  

^a GERMAN PRIMATE CENTER   (Germany)

^b UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

HEMAGGLUTININ LIKE PROTEIN; MEMBRANE PROTEIN; NEURAMINIDASE LIKE PROTEIN; PROTEIN TMPRSS2; RHABDOVIRAL VECTOR; SERINE PROTEINASE; SIALIC ACID; UNCLASSIFIED DRUG; VIRUS VECTOR; INFLUENZA VIRUS HEMAGGLUTININ; TMPRSS2 PROTEIN, HUMAN;

ARTICLE; BAT; CONTROLLED STUDY; ENDOSOME; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HUMAN TISSUE; INFLUENZA VIRUS; MAMMAL; NONHUMAN; PH; PROTEIN DEGRADATION; PROTEIN FUNCTION; PSEUDOTYPE; VIRUS CELL INTERACTION; VIRUS ENTRY; ANIMAL; CHLOROCEBUS AETHIOPS; DOG; GENETIC TRANSDUCTION; HAMSTER; HEK293 CELL LINE; INFLUENZA A VIRUS; MDCK CELL LINE; METABOLISM; PHYSIOLOGY; VERO CELL LINE; VIRAL TROPISM;

ANIMALS; CERCOPITHECUS AETHIOPS; CHIROPTERA; CRICETINAE; DOGS; HEK293 CELLS; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HUMANS; HYDROGEN-ION CONCENTRATION; INFLUENZA A VIRUS; MADIN DARBY CANINE KIDNEY CELLS; SERINE ENDOPEPTIDASES; TRANSDUCTION, GENETIC; VERO CELLS; VIRAL TROPISM; VIRUS INTERNALIZATION;

EID: 84962685782     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0152134     Document Type: Article

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