IL-33 drives influenza-induced asthma exacerbations by halting innate and adaptive antiviral immunity

Journal of Allergy and Clinical Immunology

Volumn 143, Issue 4, 2019, Pages 1355-1370.e16

  Ravanetti, Lara ^a   Dijkhuis, Annemiek ^a   Dekker, Tamara ^a   Sabogal Pineros, Yanaika S ^a   Ravi, Abilash ^a   Dierdorp, Barbara S ^a   Erjefält, Jonas S ^b   Mori, Michiko ^b   Pavlidis, Stelios ^c   Adcock, Ian M ^c   Rao, Navin L ^d   Lutter, René ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b LUND UNIVERSITY   (Sweden)

^c NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^d JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

airway hyperresponsiveness; airways epithelial cells; Asthma; dendritic cells; exacerbation; IL 33; immune response; influenza; NETosis

Indexed keywords

BETA INTERFERON; HOUSE DUST MITE ALLERGEN EXTRACT; INTERLEUKIN 33; THYMIC STROMAL LYMPHOPOIETIN; CYTOKINE;

ADAPTIVE IMMUNITY; ALLERGIC ASTHMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; ASTHMA; BRONCHIAL CELL LINE; CYTOLYSIS; DENDRITIC CELL; DISEASE EXACERBATION; EPITHELIUM CELL; HUMAN; HUMAN CELL; INFLUENZA; INNATE IMMUNITY; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY TRACT ALLERGY; RESPIRATORY TRACT INFLAMMATION; RHINOVIRUS; ANIMAL; C57BL MOUSE; COMPLICATION; IMMUNOLOGY; INFLUENZA A VIRUS (H3N2); ORTHOMYXOVIRUS INFECTION; PNEUMONIA; RECURRENT DISEASE; VIROLOGY;

ADAPTIVE IMMUNITY; ANIMALS; ASTHMA; CYTOKINES; HUMANS; IMMUNITY, INNATE; INFLUENZA A VIRUS, H3N2 SUBTYPE; INFLUENZA, HUMAN; INTERLEUKIN-33; MICE; MICE, INBRED C57BL; ORTHOMYXOVIRIDAE INFECTIONS; PNEUMONIA; SYMPTOM FLARE UP;

EID: 85056702331     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2018.08.051     Document Type: Article

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