-
1
-
-
0037426726
-
The pathophysiology and treatment of sepsis
-
Hotchkiss, R.S. & Karl, I.E. The pathophysiology and treatment of sepsis. N. Engl. J. Med. 348, 138-150 (2003).
-
(2003)
N. Engl. J. Med.
, vol.348
, pp. 138-150
-
-
Hotchkiss, R.S.1
Karl, I.E.2
-
2
-
-
0038578608
-
Novel strategies for the treatment of sepsis
-
Riedemann, N.C., Guo, R.F. & Ward, P.A. Novel strategies for the treatment of sepsis. Nat. Med. 9, 517-524 (2003).
-
(2003)
Nat. Med.
, vol.9
, pp. 517-524
-
-
Riedemann, N.C.1
Guo, R.F.2
Ward, P.A.3
-
4
-
-
62649121369
-
Regulation of chemokine receptor by Toll-like receptor 2 is critical to neutrophil migration and resistance to polymicrobial sepsis
-
Alves-Filho, J.C. et al. Regulation of chemokine receptor by Toll-like receptor 2 is critical to neutrophil migration and resistance to polymicrobial sepsis. Proc. Natl. Acad. Sci. USA 106, 4018-4023 (2009).
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 4018-4023
-
-
Alves-Filho, J.C.1
-
5
-
-
33845412884
-
GRKs and arrestins: Regulators of migration and infammation
-
Vroon, A., Heijnen, C.J. & Kavelaars, A. GRKs and arrestins: regulators of migration and infammation. J. Leukoc. Biol. 80, 1214-1221 (2006).
-
(2006)
J. Leukoc. Biol.
, vol.80
, pp. 1214-1221
-
-
Vroon, A.1
Heijnen, C.J.2
Kavelaars, A.3
-
6
-
-
0141629679
-
Mechanisms of regulation of the expression and function of G protein-coupled receptor kinases
-
Penela, P., Ribas, C. & Mayor, F. Jr. Mechanisms of regulation of the expression and function of G protein-coupled receptor kinases. Cell. Signal. 15, 973-981 (2003).
-
(2003)
Cell. Signal.
, vol.15
, pp. 973-981
-
-
Penela, P.1
Ribas, C.2
Mayor Jr., F.3
-
7
-
-
27744446058
-
IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
-
Schmitz, J. et al. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 23, 479-490 (2005).
-
(2005)
Immunity
, vol.23
, pp. 479-490
-
-
Schmitz, J.1
-
8
-
-
34848899012
-
IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex
-
Chackerian, A.A. et al. IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex. J. Immunol. 179, 2551-2555 (2007).
-
(2007)
J. Immunol.
, vol.179
, pp. 2551-2555
-
-
Chackerian, A.A.1
-
9
-
-
36749067367
-
IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells
-
Ali, S. et al. IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells. Proc. Natl. Acad. Sci. USA 104, 18660-18665 (2007).
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 18660-18665
-
-
Ali, S.1
-
10
-
-
2642610290
-
Selective expression of a stable cell surface molecule on type 2 but not type 1 helper T cells
-
DOI 10.1084/jem.187.5.787
-
Xu, D. et al. Selective expression of a stable cell surface molecule on type 2 but not type 1 helper T cells. J. Exp. Med. 187, 787-794 (1998). (Pubitemid 28115194)
-
(1998)
Journal of Experimental Medicine
, vol.187
, Issue.5
, pp. 787-794
-
-
Xu, D.1
Chan, W.L.2
Leung, B.P.3
Huang, F.-P.4
Wheeler, R.5
Piedrafita, D.6
Robinson, J.H.7
Liew, F.Y.8
-
11
-
-
0032212250
-
The IL-1 receptor-related T1 antigen is expressed on immature and mature mast cells and on fetal blood mast cell progenitors
-
Moritz, D.R., Rodewald, H.R., Gheyselinck, J. & Klemenz, R. The IL-1 receptor-related T1 antigen is expressed on immature and mature mast cells and on fetal blood mast cell progenitors. J. Immunol. 161, 4866-4874 (1998).
-
(1998)
J. Immunol.
, vol.161
, pp. 4866-4874
-
-
Moritz, D.R.1
Rodewald, H.R.2
Gheyselinck, J.3
Klemenz, R.4
-
12
-
-
0033523665
-
Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses
-
Coyle, A.J. et al. Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses. J. Exp. Med. 190, 895-902 (1999).
-
(1999)
J. Exp. Med.
, vol.190
, pp. 895-902
-
-
Coyle, A.J.1
-
13
-
-
0032499678
-
H2 effector function
-
Löhning, M. et al. T1/ST2 is preferentially expressed on murine TH2 cells, independent of interleukin 4, interleukin 5 and interleukin 10, and important for TH2 effector function. Proc. Natl. Acad. Sci. USA 95, 6930-6935 (1998).
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 6930-6935
-
-
Löhning, M.1
-
14
-
-
20644450804
-
Negative regulation of Toll-like receptor-mediated immune responses
-
Liew, F.Y., Xu, D., Brint, E.K. & O'Neill, L.A. Negative regulation of Toll-like receptor-mediated immune responses. Nat. Rev. Immunol. 5, 446-458 (2005).
-
(2005)
Nat. Rev. Immunol.
, vol.5
, pp. 446-458
-
-
Liew, F.Y.1
Xu, D.2
Brint, E.K.3
O'Neill, L.A.4
-
15
-
-
2942721674
-
ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance
-
Brint, E.K. et al. ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance. Nat. Immunol. 5, 373-379 (2004).
-
(2004)
Nat. Immunol.
, vol.5
, pp. 373-379
-
-
Brint, E.K.1
-
16
-
-
3142724031
-
Toll-like receptor signalling
-
Akira, S. & Takeda, K. Toll-like receptor signalling. Nat. Rev. Immunol. 4, 499-511 (2004).
-
(2004)
Nat. Rev. Immunol.
, vol.4
, pp. 499-511
-
-
Akira, S.1
Takeda, K.2
-
17
-
-
45149129895
-
Toll-like receptor 9 inhibition reduces mortality in polymicrobial sepsis
-
Plitas, G., Burt, B.M., Nguyen, H.M., Bamboat, Z.M. & DeMatteo, R.P. Toll-like receptor 9 inhibition reduces mortality in polymicrobial sepsis. J. Exp. Med. 205, 1277-1283 (2008).
-
(2008)
J. Exp. Med.
, vol.205
, pp. 1277-1283
-
-
Plitas, G.1
Burt, B.M.2
Nguyen, H.M.3
Bamboat, Z.M.4
Dematteo, R.P.5
-
18
-
-
31344481400
-
Toll-like receptor 4 signaling leads to neutrophil migration impairment in polymicrobial sepsis
-
Alves-Filho, J.C., de Freitas, A., Russo, M. & Cunha, F.Q. Toll-like receptor 4 signaling leads to neutrophil migration impairment in polymicrobial sepsis. Crit. Care Med. 34, 461-470 (2006).
-
(2006)
Crit. Care Med.
, vol.34
, pp. 461-470
-
-
Alves-Filho, J.C.1
De Freitas, A.2
Russo, M.3
Cunha, F.Q.4
-
19
-
-
60549101332
-
Protection from lethal Gram-negative bacterial sepsis by targeting Toll-like receptor 4
-
Roger, T. et al. Protection from lethal Gram-negative bacterial sepsis by targeting Toll-like receptor 4. Proc. Natl. Acad. Sci. USA 106, 2348-2352 (2009).
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 2348-2352
-
-
Roger, T.1
-
20
-
-
49249138761
-
TLR4-induced IFN-γ production increases TLR2 sensitivity and drives Gram-negative sepsis in mice
-
Spiller, S. et al. TLR4-induced IFN-γ production increases TLR2 sensitivity and drives Gram-negative sepsis in mice. J. Exp. Med. 205, 1747-1754 (2008).
-
(2008)
J. Exp. Med.
, vol.205
, pp. 1747-1754
-
-
Spiller, S.1
-
21
-
-
0034958947
-
Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome and associated costs of care
-
Angus, D.C. et al. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome and associated costs of care. Crit. Care Med. 29, 1303-1310 (2001).
-
(2001)
Crit. Care Med.
, vol.29
, pp. 1303-1310
-
-
Angus, D.C.1
-
22
-
-
33646759609
-
Cecal ligation and puncture
-
Hubbard, W.J. et al. Cecal ligation and puncture. Shock 24 Suppl 1, 52-57 (2005).
-
(2005)
Shock
, vol.24
, Issue.SUPPL. 1
, pp. 52-57
-
-
Hubbard, W.J.1
-
23
-
-
33344468233
-
Neutrophils and immunity: Challenges and opportunities
-
Nathan, C. Neutrophils and immunity: challenges and opportunities. Nat. Rev. Immunol. 6, 173-182 (2006).
-
(2006)
Nat. Rev. Immunol.
, vol.6
, pp. 173-182
-
-
Nathan, C.1
-
24
-
-
0242383218
-
Cytokine cascade in sepsis
-
Cavaillon, J.M., Adib-Conquy, M., Fitting, C., Adrie, C. & Payen, D. Cytokine cascade in sepsis. Scand. J. Infect. Dis. 35, 535-544 (2003).
-
(2003)
Scand. J. Infect. Dis.
, vol.35
, pp. 535-544
-
-
Cavaillon, J.M.1
Adib-Conquy, M.2
Fitting, C.3
Adrie, C.4
Payen, D.5
-
25
-
-
33745617094
-
Neutrophils in development of multiple organ failure in sepsis
-
Brown, K.A. et al. Neutrophils in development of multiple organ failure in sepsis. Lancet 368, 157-169 (2006).
-
(2006)
Lancet
, vol.368
, pp. 157-169
-
-
Brown, K.A.1
-
26
-
-
0033557688
-
Expression and function of the chemokine receptors CXCR1 and CXCR2 in sepsis
-
Cummings, C.J. et al. Expression and function of the chemokine receptors CXCR1 and CXCR2 in sepsis. J. Immunol. 162, 2341-2346 (1999).
-
(1999)
J. Immunol.
, vol.162
, pp. 2341-2346
-
-
Cummings, C.J.1
-
27
-
-
33847638979
-
Down-regulation of CXCR2 on neutrophils in severe sepsis is mediated by inducible nitric oxide synthase-derived nitric oxide
-
Rios-Santos, F. et al. Down-regulation of CXCR2 on neutrophils in severe sepsis is mediated by inducible nitric oxide synthase-derived nitric oxide. Am. J. Respir. Crit. Care Med. 175, 490-497 (2007).
-
(2007)
Am. J. Respir. Crit. Care Med.
, vol.175
, pp. 490-497
-
-
Rios-Santos, F.1
-
28
-
-
58149257537
-
An IL-1 cytokine member, IL-33, induces human basophil activation via its ST2 receptor
-
Suzukawa, M. et al. An IL-1 cytokine member, IL-33, induces human basophil activation via its ST2 receptor. J. Immunol. 181, 5981-5989 (2008).
-
(2008)
J. Immunol.
, vol.181
, pp. 5981-5989
-
-
Suzukawa, M.1
-
29
-
-
0030935780
-
Ligand-induced desensitization of the human CXC chemokine receptor-2 is modulated by multiple serine residues in the carboxyl-terminal domain of the receptor
-
Mueller, S.G., White, J.R., Schraw, W.P., Lam, V. & Richmond, A. Ligand-induced desensitization of the human CXC chemokine receptor-2 is modulated by multiple serine residues in the carboxyl-terminal domain of the receptor. J. Biol. Chem. 272, 8207-8214 (1997).
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 8207-8214
-
-
Mueller, S.G.1
White, J.R.2
Schraw, W.P.3
Lam, V.4
Richmond, A.5
-
30
-
-
75549085516
-
IL-33 amplifes the polarization of alternatively activated macrophages that contribute to airway infammation
-
Kurowska-Stolarska, M. et al. IL-33 amplifes the polarization of alternatively activated macrophages that contribute to airway infammation. J. Immunol. 183, 6469-6477 (2009).
-
(2009)
J. Immunol.
, vol.183
, pp. 6469-6477
-
-
Kurowska-Stolarska, M.1
-
31
-
-
33751167423
-
Impaired neutrophil chemotaxis in sepsis associates with GRK expression and inhibition of actin assembly and tyrosine phosphorylation
-
Arraes, S.M. et al. Impaired neutrophil chemotaxis in sepsis associates with GRK expression and inhibition of actin assembly and tyrosine phosphorylation. Blood 108, 2906-2913 (2006).
-
(2006)
Blood
, vol.108
, pp. 2906-2913
-
-
Arraes, S.M.1
-
32
-
-
40349098959
-
Toll-like receptors differentially regulate GPCR kinases and arrestins in primary macrophages
-
Loniewski, K., Shi, Y., Pestka, J. & Parameswaran, N. Toll-like receptors differentially regulate GPCR kinases and arrestins in primary macrophages. Mol. Immunol. 45, 2312-2322 (2008).
-
(2008)
Mol. Immunol.
, vol.45
, pp. 2312-2322
-
-
Loniewski, K.1
Shi, Y.2
Pestka, J.3
Parameswaran, N.4
-
33
-
-
44649129170
-
A novel IL-1 family cytokine, IL-33, potently activates human eosinophils
-
Cherry, W.B., Yoon, J., Bartemes, K.R., Iijima, K. & Kita, H. A novel IL-1 family cytokine, IL-33, potently activates human eosinophils. J. Allergy Clin. Immunol. 121, 1484-1490 (2008).
-
(2008)
J. Allergy Clin. Immunol.
, vol.121
, pp. 1484-1490
-
-
Cherry, W.B.1
Yoon, J.2
Bartemes, K.R.3
Iijima, K.4
Kita, H.5
-
34
-
-
49449111630
-
IL-33 exacerbates antigen-induced arthritis by activating mast cells
-
Xu, D. et al. IL-33 exacerbates antigen-induced arthritis by activating mast cells. Proc. Natl. Acad. Sci. USA 105, 10913-10918 (2008).
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 10913-10918
-
-
Xu, D.1
-
35
-
-
67649852593
-
The cytokine interleukin-33 mediates anaphylactic shock
-
Pushparaj, P.N. et al. The cytokine interleukin-33 mediates anaphylactic shock. Proc. Natl. Acad. Sci. USA 106, 9773-9778 (2009).
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 9773-9778
-
-
Pushparaj, P.N.1
-
36
-
-
35348850153
-
H2 cells
-
Komai-Koma, M. et al. IL-33 is a chemoattractant for human TH2 cells. Eur. J. Immunol. 37, 2779-2786 (2007).
-
(2007)
Eur. J. Immunol.
, vol.37
, pp. 2779-2786
-
-
Komai-Koma, M.1
-
37
-
-
0034689033
-
T1/ST2-defcient mice demonstrate the importance of T1/ST2 in developing primary T helper cell type 2 responses
-
Townsend, M.J., Fallon, P.G., Matthews, D.J., Jolin, H.E. & McKenzie, A.N. T1/ST2-defcient mice demonstrate the importance of T1/ST2 in developing primary T helper cell type 2 responses. J. Exp. Med. 191, 1069-1076 (2000).
-
(2000)
J. Exp. Med.
, vol.191
, pp. 1069-1076
-
-
Townsend, M.J.1
Fallon, P.G.2
Matthews, D.J.3
Jolin, H.E.4
McKenzie, A.N.5
-
38
-
-
18744377694
-
Interleukin 10 extends the effectiveness of standard therapy during late sepsis with serum interleukin 6 levels predicting outcome
-
Manley, M.O., O'Riordan, M.A., Levine, A.D. & Latif, S.Q. Interleukin 10 extends the effectiveness of standard therapy during late sepsis with serum interleukin 6 levels predicting outcome. Shock 23, 521-526 (2005).
-
(2005)
Shock
, vol.23
, pp. 521-526
-
-
Manley, M.O.1
O'Riordan, M.A.2
Levine, A.D.3
Latif, S.Q.4
-
39
-
-
0037389094
-
SCCM/ESICM/ACCP/ATS/SIS International Sepsis Defnitions Conference
-
Levy, M.M. et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Defnitions Conference. Crit. Care Med. 31, 1250-1256 (2003).
-
(2001)
Crit. Care Med.
, vol.31
, pp. 1250-1256
-
-
Levy, M.M.1
|