mTOR/STAT-3 pathway mediates mesenchymal stem cell–secreted hepatocyte growth factor protective effects against lipopolysaccharide-induced vascular endothelial barrier dysfunction and apoptosis

Journal of Cellular Biochemistry

Volumn 120, Issue 3, 2019, Pages 3637-3650

  Meng, Shan Shan ^a   Guo, Feng Mei ^a   Zhang, Xi Wen ^a   Chang, Wei ^a   Peng, Fei ^a   Qiu, Hai Bo ^a   Yang, Yi ^a  

^a MEDICAL SCHOOL OF SOUTHEAST UNIVERSITY   (China)

Author keywords

acute respiratory distress syndrome (ARDS); endothelial barrier; hepatocyte growth factor (HGF); mammalian TOR (mTOR) signal transducer and activator of transcription 3 (STAT 3) pathway; mesenchymal stem cell (MSC); permeability

Indexed keywords

4 [[(4 METHYLPHENYL)SULFONYLOXY]ACETAMIDO]SALICYLIC ACID; LIPOPOLYSACCHARIDE; MAMMALIAN TARGET OF RAPAMYCIN; OCCLUDIN; RAPAMYCIN; SCATTER FACTOR; STAT3 PROTEIN; TIGHT JUNCTION PROTEIN; HGF PROTEIN, MOUSE; MTOR PROTEIN, MOUSE; STAT3 PROTEIN, MOUSE; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL MEMBRANE PERMEABILITY; CELL PROLIFERATION; CELL PROTECTION; CELLULAR SECRETION; COCULTURE; ENDOTHELIAL DYSFUNCTION; GENE OVEREXPRESSION; IMMUNOFLUORESCENCE; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SURVIVAL; VASCULAR ENDOTHELIUM; ANIMAL; BIOSYNTHESIS; CAPILLARY PERMEABILITY; DRUG EFFECT; ENDOTHELIUM CELL; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CAPILLARY PERMEABILITY; ENDOTHELIAL CELLS; HEPATOCYTE GROWTH FACTOR; LIPOPOLYSACCHARIDES; MESENCHYMAL STEM CELLS; MICE; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TOR SERINE-THREONINE KINASES;

EID: 85053711927     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.27642     Document Type: Article

References (36)

1. Bellani G, Laffey JG, Pham T, et al. Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA. 2016;315:788-800
2. Sweeney RM, Mcauley DF. Acute respiratory distress syndrome. Lancet. 2016;388:2416-2430
3. Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med. 2000;342:1334-1349
4. Yang Y, Chen Q, Liu A, Xu X, Han J, Qiu H. Synergism of MSC-secreted HGF and VEGF in stabilising endothelial barrier function upon lipopolysaccharide stimulation via the Rac1 pathway. Stem Cell Res Ther. 2015;6:250
5. Hu S, Li J, Xu X, et al. The hepatocyte growth factor-expressing character is required for mesenchymal stem cells to protect the lung injured by lipopolysaccharide in vivo. Stem Cell Res Ther. 2016;7:66
6. Sheth K, Bankey P. The liver as an immune organ. Curr Opin Crit Care. 2001;7:99-104
7. Phung TL, Ziv K, Dabydeen D, et al. Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin. Cancer Cell. 2006;10:159-170
8. Stoeltzing O, Meric-Bernstam F, Ellis LM. Intracellular signaling in tumor and endothelial cells: the expected and, yet again, the unexpected. Cancer Cell. 2006;10:89-91
9. Nakao T, Shiota M, Tatemoto Y, Izumi Y, Iwao H. Pravastatin induces rat aortic endothelial cell proliferation and migration via activation of PI3K/Akt/mTOR/p70 S6 kinase signaling. J Pharmacol Sci. 2007;105:334-341
10. Yang C, Lee H, Pal S, et al. B cells promote tumor progression via STAT3 regulated-angiogenesis. PLoS One. 2013;8:e64159
11. Nakamura R, Sene A, Santeford A, et al. IL10-driven STAT3 signalling in senescent macrophages promotes pathological eye angiogenesis. Nat Commun. 2015;6:7847
12. Armstrong SM, Khajoee V, Wang C, et al. Coregulation of transcellular and paracellular leak across microvascular endothelium by dynamin and Rac. Am J Pathol. 2012;180:1308-1323
13. Ware LB, Matthay MA. Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair. Am J Physiol Lung Cell Mol Physiol. 2002;282:L924-L940
14. Geiser T. Mechanisms of alveolar epithelial repair in acute lung injury--a translational approach. Swiss Med Wkly. 2003;133:586-590
15. Naota M, Shimada A, Morita T, Inoue K, Takano H. Translocation pathway of the intratracheally instilled C60 fullerene from the lung into the blood circulation in the mouse: possible association of diffusion and caveolae-mediated pinocytosis. Toxicol Pathol. 2009;37:456-462
16. Mehta D, Malik AB. Signaling mechanisms regulating endothelial permeability. Physiol Rev. 2006;86:279-367
17. Furuse M, Hirase T, Itoh M, et al. Occludin: a novel integral membrane protein localizing at tight junctions. J Cell Biol. 1993;123:1777-1788
18. Saitou M, Furuse M, Sasaki H, et al. Complex phenotype of mice lacking occludin, a component of tight junction strands. Mol Biol Cell. 2000;11:4131-4142
19. Janosevic D, Axis J, Bacallao RL, Amsler K. Occludin content modulates hydrogen peroxide-induced increase in renal epithelial paracellular permeability. J Cell Biochem. 2016;117:769-779
20. Cummins PM. Occludin: one protein, many forms. Mol Cell Biol. 2012;32:242-250
21. Feldman G, Mullin J, Ryan M. Occludin: structure, function and regulation. Adv Drug Deliv Rev. 2005;57:883-917
22. Rao R. Occludin phosphorylation in regulation of epithelial tight junctions. Ann N Y Acad Sci. 2009;1165:62-68
23. Nakano Y, Tasaka S, Saito F, et al. Endothelin-1 level in epithelial lining fluid of patients with acute respiratory distress syndrome. Respirology. 2007;12:740-743
24. Boscoe M, Goodwin A, Amrani M, Yacoub M. Endothelins and the lung. Int J Biochem Cell Biol. 2000;32:41-62
25. Sanai L, Haynes WG, Mackenzie A, Grant IS, Webb DJ. Endothelin production in sepsis and the adult respiratory distress syndrome. Intensive Care Med. 1996;22:52-56
26. Van Der Heijden M, Van Nieuw Amerongen GP, Koolwijk P, Van Hinsbergh VWM, Groeneveld ABJ. Angiopoietin-2, permeability oedema, occurrence, and severity of ALI/ARDS in septic and nonseptic critically ill patients. Thorax. 2008;63:903-909
27. Ware LB, Conner ER, Matthay MA. von Willebrand factor antigen is an independent marker of poor outcome in patients with early acute lung injury. Crit Care Med. 2001;29:2325-2331
28. Ware LB, Eisner MD, Thompson BT, Parsons PE, Matthay MA. Significance of von Willebrand factor in septic and nonseptic patients with acute lung injury. Am J Respir Crit Care Med. 2004;170:766-772
29. Hara K, Maruki Y, Long X, et al. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell. 2002;110:177-189
30. Jacinto E, Loewith R, Schmidt A, et al. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol. 2004;6:1122-1128
31. Kim DH, Sarbassov DD, Ali SM, et al. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell. 2002;110:163-175
32. Kim DH, Sarbassov DD, Ali SM, et al. GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol Cell. 2003;11:895-904
33. Loewith R, Jacinto E, Wullschleger S, et al. Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell. 2002;10:457-468
34. Dos D. Sarbassov S, Ali SM, Kim DH, et al. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol. 2004;14:1296-1302
35. Lee D, Sykes SM, Kalaitzidis D, et al. Transmembrane inhibitor of RICTOR/mTORC2 in hematopoietic progenitors. Stem Cell Reports. 2014;3:832-840
36. Sarbassov DD, Ali SM, Sengupta S, et al. Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol Cell. 2006;22:159-168