-
1
-
-
84865070369
-
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity
-
Jinek, M., Chylinski, K., Fonfara, I., Hauer, M., Doudna, J.A., Charpentier, E., A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science, 337, 2012, 816.
-
(2012)
Science
, vol.337
, pp. 816
-
-
Jinek, M.1
Chylinski, K.2
Fonfara, I.3
Hauer, M.4
Doudna, J.A.5
Charpentier, E.6
-
2
-
-
84908508061
-
Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease
-
Anders, C., Niewoehner, O., Duerst, A., Jinek, M., Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease. Nature, 513, 2014, 569.
-
(2014)
Nature
, vol.513
, pp. 569
-
-
Anders, C.1
Niewoehner, O.2
Duerst, A.3
Jinek, M.4
-
3
-
-
79551685675
-
A TALE nuclease architecture for efficient genome editing
-
Miller, J.C., Tan, S., Qiao, G., Barlow, K.A., Wang, J., Xia, D.F., Meng, X., Paschon, D.E., Leung, E., Hinkley, S.J., et al. A TALE nuclease architecture for efficient genome editing. Nat Biotechnol, 29, 2010, 143.
-
(2010)
Nat Biotechnol
, vol.29
, pp. 143
-
-
Miller, J.C.1
Tan, S.2
Qiao, G.3
Barlow, K.A.4
Wang, J.5
Xia, D.F.6
Meng, X.7
Paschon, D.E.8
Leung, E.9
Hinkley, S.J.10
-
4
-
-
84939482880
-
Genetic compensation induced by deleterious mutations but not gene knockdowns
-
Here, it is shown how genetic compensation creates phenotypic differences between a knockout strategy, targeting the DNA, and a knockdown approach, targeting the RNA.
-
Rossi, A., Kontarakis, Z., Gerri, C., Nolte, H., Hölper, S., Krüger, M., Stainier, D.Y.R., Genetic compensation induced by deleterious mutations but not gene knockdowns. Nature, 524, 2015, 230 Here, it is shown how genetic compensation creates phenotypic differences between a knockout strategy, targeting the DNA, and a knockdown approach, targeting the RNA.
-
(2015)
Nature
, vol.524
, pp. 230
-
-
Rossi, A.1
Kontarakis, Z.2
Gerri, C.3
Nolte, H.4
Hölper, S.5
Krüger, M.6
Stainier, D.Y.R.7
-
5
-
-
85026662935
-
Genetic compensation: a phenomenon in search of mechanisms
-
El-Brolosy, M.A., Stainier, D.Y.R., Genetic compensation: a phenomenon in search of mechanisms. PLoS Genetics, 13, 2017, e1006780.
-
(2017)
PLoS Genetics
, vol.13
, pp. e1006780
-
-
El-Brolosy, M.A.1
Stainier, D.Y.R.2
-
6
-
-
84907527348
-
Transcriptome-wide mapping reveals widespread dynamic-regulated pseudouridylation of ncRNA and mRNA
-
Schwartz, S., Bernstein Douglas, A., Mumbach Maxwell, R., Jovanovic, M., Herbst Rebecca, H., León-Ricardo Brian, X., Engreitz Jesse, M., Guttman, M., Satija, R., Lander Eric, S., et al. Transcriptome-wide mapping reveals widespread dynamic-regulated pseudouridylation of ncRNA and mRNA. Cell 159 (2014), 148–162.
-
(2014)
Cell
, vol.159
, pp. 148-162
-
-
Schwartz, S.1
Bernstein Douglas, A.2
Mumbach Maxwell, R.3
Jovanovic, M.4
Herbst Rebecca, H.5
León-Ricardo Brian, X.6
Engreitz Jesse, M.7
Guttman, M.8
Satija, R.9
Lander Eric, S.10
-
7
-
-
84892372347
-
N6-methyladenosine-dependent regulation of messenger RNA stability
-
Wang, X., Lu, Z., Gomez, A., Hon, G.C., Yue, Y., Han, D., Fu, Y., Parisien, M., Dai, Q., Jia, G., et al. N6-methyladenosine-dependent regulation of messenger RNA stability. Nature 505 (2014), 117–120.
-
(2014)
Nature
, vol.505
, pp. 117-120
-
-
Wang, X.1
Lu, Z.2
Gomez, A.3
Hon, G.C.4
Yue, Y.5
Han, D.6
Fu, Y.7
Parisien, M.8
Dai, Q.9
Jia, G.10
-
8
-
-
0029164692
-
Expression and regulation by interferon of a double-stranded-RNA-specific adenosine deaminase from human cells: evidence for two forms of the deaminase
-
Patterson, J.B., Samuel, C.E., Expression and regulation by interferon of a double-stranded-RNA-specific adenosine deaminase from human cells: evidence for two forms of the deaminase. Mol Cell Biol 15 (1995), 5376–5388.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 5376-5388
-
-
Patterson, J.B.1
Samuel, C.E.2
-
9
-
-
0030051809
-
A mammalian RNA editing enzyme
-
Melcher, T., Maas, S., Herb, A., Sprengel, R., Seeburg, P.H., Higuchi, M., A mammalian RNA editing enzyme. Nature 379 (1996), 460–464.
-
(1996)
Nature
, vol.379
, pp. 460-464
-
-
Melcher, T.1
Maas, S.2
Herb, A.3
Sprengel, R.4
Seeburg, P.H.5
Higuchi, M.6
-
10
-
-
84955695193
-
A-to-I editing of coding and non-coding RNAs by ADARs
-
Nishikura, K., A-to-I editing of coding and non-coding RNAs by ADARs. Nat Rev Mol Cell Biol 17 (2016), 83–96.
-
(2016)
Nat Rev Mol Cell Biol
, vol.17
, pp. 83-96
-
-
Nishikura, K.1
-
11
-
-
85032579510
-
Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs
-
Walkley, C.R., Li, J.B., Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs. Genome Biol, 18, 2017, 205.
-
(2017)
Genome Biol
, vol.18
, pp. 205
-
-
Walkley, C.R.1
Li, J.B.2
-
12
-
-
85045889878
-
A-to-I RNA editing — immune protector and transcriptome diversifier
-
Eisenberg, E., Levanon, E.Y., A-to-I RNA editing — immune protector and transcriptome diversifier. Nat Rev Genet 19 (2018), 473–490.
-
(2018)
Nat Rev Genet
, vol.19
, pp. 473-490
-
-
Eisenberg, E.1
Levanon, E.Y.2
-
13
-
-
84891797364
-
RADAR: a rigorously annotated database of A-to-I RNA editing
-
Ramaswami, G., Li, J.B., RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res 42 (2014), D109–D113.
-
(2014)
Nucleic Acids Res
, vol.42
, pp. D109-D113
-
-
Ramaswami, G.1
Li, J.B.2
-
14
-
-
84895535383
-
A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes
-
Bazak, L., Haviv, A., Barak, M., Jacob-Hirsch, J., Deng, P., Zhang, R., Isaacs, F.J., Rechavi, G., Li, J.B., Eisenberg, E., et al. A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes. Genome Res 24 (2014), 365–376.
-
(2014)
Genome Res
, vol.24
, pp. 365-376
-
-
Bazak, L.1
Haviv, A.2
Barak, M.3
Jacob-Hirsch, J.4
Deng, P.5
Zhang, R.6
Isaacs, F.J.7
Rechavi, G.8
Li, J.B.9
Eisenberg, E.10
-
15
-
-
84943621334
-
Profiling RNA editing in human tissues: towards the inosinome Atlas
-
Picardi, E., Manzari, C., Mastropasqua, F., Aiello, I., D'Erchia, A.M., Pesole, G., Profiling RNA editing in human tissues: towards the inosinome Atlas. Sci Rep, 5, 2015, 14941.
-
(2015)
Sci Rep
, vol.5
, pp. 14941
-
-
Picardi, E.1
Manzari, C.2
Mastropasqua, F.3
Aiello, I.4
D'Erchia, A.M.5
Pesole, G.6
-
16
-
-
85031298074
-
Dynamic landscape and regulation of RNA editing in mammals
-
Tan, M.H., Li, Q., Shanmugam, R., Piskol, R., Kohler, J., Young, A.N., Liu, K.I., Zhang, R., Ramaswami, G., Ariyoshi, K., et al. Dynamic landscape and regulation of RNA editing in mammals. Nature, 550, 2017, 249.
-
(2017)
Nature
, vol.550
, pp. 249
-
-
Tan, M.H.1
Li, Q.2
Shanmugam, R.3
Piskol, R.4
Kohler, J.5
Young, A.N.6
Liu, K.I.7
Zhang, R.8
Ramaswami, G.9
Ariyoshi, K.10
-
17
-
-
85032331429
-
RNA editing with CRISPR-Cas13
-
This is the first report of an RNA editing strategy applying CRISPR/Cas. However, many of the claims appear overstated, for example, the specificity problem seems unsolved.
-
Cox, D.B.T., Gootenberg, J.S., Abudayyeh, O.O., Franklin, B., Kellner, M.J., Joung, J., Zhang, F., RNA editing with CRISPR-Cas13. Science 358 (2017), 1019–1027 This is the first report of an RNA editing strategy applying CRISPR/Cas. However, many of the claims appear overstated, for example, the specificity problem seems unsolved.
-
(2017)
Science
, vol.358
, pp. 1019-1027
-
-
Cox, D.B.T.1
Gootenberg, J.S.2
Abudayyeh, O.O.3
Franklin, B.4
Kellner, M.J.5
Joung, J.6
Zhang, F.7
-
18
-
-
85033727999
-
Abundant off-target edits from site-directed RNA editing can be reduced by nuclear localization of the editing enzyme
-
Here, the problematic global off-target editing of the λN-ADAR approach has been analyzed. Restriction of the editase to the nucleus was shown for the first time to (slightly) improve off-target editing.
-
Vallecillo-Viejo, I.C., Liscovitch-Brauer, N., Montiel-Gonzalez, M.F., Eisenberg, E., Rosenthal, J.J.C., Abundant off-target edits from site-directed RNA editing can be reduced by nuclear localization of the editing enzyme. RNA Biol 15 (2018), 104–114 Here, the problematic global off-target editing of the λN-ADAR approach has been analyzed. Restriction of the editase to the nucleus was shown for the first time to (slightly) improve off-target editing.
-
(2018)
RNA Biol
, vol.15
, pp. 104-114
-
-
Vallecillo-Viejo, I.C.1
Liscovitch-Brauer, N.2
Montiel-Gonzalez, M.F.3
Eisenberg, E.4
Rosenthal, J.J.C.5
-
19
-
-
85049561415
-
Efficient and precise editing of endogenous transcripts with SNAP-tagged ADARs
-
This papers defines a new benchmark for site-directed RNA editing. It is shown that genomic integration of the editing enzyme can dramatically reduce global off-target editing and enables efficient and concurrent editing of endogenous transcripts.
-
Vogel, P., Moschref, M., Li, Q., Merkle, T., Selvasaravanan, K.D., Li, J.B., Stafforst, T., Efficient and precise editing of endogenous transcripts with SNAP-tagged ADARs. Nat Methods 15 (2018), 535–538 This papers defines a new benchmark for site-directed RNA editing. It is shown that genomic integration of the editing enzyme can dramatically reduce global off-target editing and enables efficient and concurrent editing of endogenous transcripts.
-
(2018)
Nat Methods
, vol.15
, pp. 535-538
-
-
Vogel, P.1
Moschref, M.2
Li, Q.3
Merkle, T.4
Selvasaravanan, K.D.5
Li, J.B.6
Stafforst, T.7
-
20
-
-
84870344968
-
Mechanistic insights into editing-site specificity of ADARs
-
Here, the powerful E488Q ADAR mutant, which exemplifies the promise of further ADAR engineering, was described first.
-
Kuttan, A., Bass, B.L., Mechanistic insights into editing-site specificity of ADARs. Proc Natl Acad Sci 109 (2012), E3295–E3304 Here, the powerful E488Q ADAR mutant, which exemplifies the promise of further ADAR engineering, was described first.
-
(2012)
Proc Natl Acad Sci
, vol.109
, pp. E3295-E3304
-
-
Kuttan, A.1
Bass, B.L.2
-
21
-
-
84903209128
-
Optimal guideRNAs for re-directing deaminase activity of hADAR1 and hADAR2 in trans
-
Schneider, M.F., Wettengel, J., Hoffmann, P.C., Stafforst, T., Optimal guideRNAs for re-directing deaminase activity of hADAR1 and hADAR2 in trans. Nucleic Acids Res, 42, 2014, e87.
-
(2014)
Nucleic Acids Res
, vol.42
, pp. e87
-
-
Schneider, M.F.1
Wettengel, J.2
Hoffmann, P.C.3
Stafforst, T.4
-
22
-
-
84867835332
-
An RNA-deaminase conjugate selectively repairs point mutations
-
This is the pioneering, first description of an engineered ADAR fusion protein for RNA-guided, site-directed RNA editing.
-
Stafforst, T., Schneider, M.F., An RNA-deaminase conjugate selectively repairs point mutations. Angew Chem Int Ed 51 (2012), 11166–11169 This is the pioneering, first description of an engineered ADAR fusion protein for RNA-guided, site-directed RNA editing.
-
(2012)
Angew Chem Int Ed
, vol.51
, pp. 11166-11169
-
-
Stafforst, T.1
Schneider, M.F.2
-
23
-
-
0037225952
-
A general method for the covalent labeling of fusion proteins with small molecules in vivo
-
This is a comprehensive description of the SNAP-tag technology.
-
Keppler, A., Gendreizig, S., Gronemeyer, T., Pick, H., Vogel, H., Johnsson, K., A general method for the covalent labeling of fusion proteins with small molecules in vivo. Nat Biotech 21 (2003), 86–89 This is a comprehensive description of the SNAP-tag technology.
-
(2003)
Nat Biotech
, vol.21
, pp. 86-89
-
-
Keppler, A.1
Gendreizig, S.2
Gronemeyer, T.3
Pick, H.4
Vogel, H.5
Johnsson, K.6
-
24
-
-
33745712857
-
Directed evolution of O6-alkylguanine-DNA alkyltransferase for applications in protein labeling
-
Gronemeyer, T., Chidley, C., Juillerat, A., Heinis, C., Johnsson, K., Directed evolution of O6-alkylguanine-DNA alkyltransferase for applications in protein labeling. Protein Eng Des Sel 19 (2006), 309–316.
-
(2006)
Protein Eng Des Sel
, vol.19
, pp. 309-316
-
-
Gronemeyer, T.1
Chidley, C.2
Juillerat, A.3
Heinis, C.4
Johnsson, K.5
-
25
-
-
84902201236
-
Improving site-directed RNA editing in vitro and in cell culture by chemical modification of the GuideRNA
-
This is the first description that ADAR enzymes accept densely chemically modified gRNAs without losing editing activity.
-
Vogel, P., Schneider, M.F., Wettengel, J., Stafforst, T., Improving site-directed RNA editing in vitro and in cell culture by chemical modification of the GuideRNA. Angew Chem Int Ed 53 (2014), 6267–6271 This is the first description that ADAR enzymes accept densely chemically modified gRNAs without losing editing activity.
-
(2014)
Angew Chem Int Ed
, vol.53
, pp. 6267-6271
-
-
Vogel, P.1
Schneider, M.F.2
Wettengel, J.3
Stafforst, T.4
-
26
-
-
84952837160
-
Site-directed RNA editing in vivo can be triggered by the light-driven assembly of an artificial riboprotein
-
This describes the firstin vivo-implementation of site-directed RNA editing. It also describes the photocaging approach to the SNAP–ADAR strategy.
-
Hanswillemenke, A., Kuzdere, T., Vogel, P., Jékely, G., Stafforst, T., Site-directed RNA editing in vivo can be triggered by the light-driven assembly of an artificial riboprotein. J Am Chem Soci 137 (2015), 15875–15881 This describes the firstin vivo-implementation of site-directed RNA editing. It also describes the photocaging approach to the SNAP–ADAR strategy.
-
(2015)
J Am Chem Soci
, vol.137
, pp. 15875-15881
-
-
Hanswillemenke, A.1
Kuzdere, T.2
Vogel, P.3
Jékely, G.4
Stafforst, T.5
-
27
-
-
13844281898
-
Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy
-
Kim, D.-H., Behlke, M.A., Rose, S.D., Chang, M.-S., Choi, S., Rossi, J.J., Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy. Nat Biotechnol, 23, 2004, 222.
-
(2004)
Nat Biotechnol
, vol.23
, pp. 222
-
-
Kim, D.-H.1
Behlke, M.A.2
Rose, S.D.3
Chang, M.-S.4
Choi, S.5
Rossi, J.J.6
-
28
-
-
28444469246
-
Silencing of microRNAs in vivo with `antagomirs’
-
Krützfeldt, J., Rajewsky, N., Braich, R., Rajeev, K.G., Tuschl, T., Manoharan, M., Stoffel, M., Silencing of microRNAs in vivo with `antagomirs’. Nature 438 (2005), 685–689.
-
(2005)
Nature
, vol.438
, pp. 685-689
-
-
Krützfeldt, J.1
Rajewsky, N.2
Braich, R.3
Rajeev, K.G.4
Tuschl, T.5
Manoharan, M.6
Stoffel, M.7
-
29
-
-
85009064500
-
Pharmacology of antisense drugs
-
Bennett, C.F., Baker, B.F., Pham, N., Swayze, E., Geary, R.S., Pharmacology of antisense drugs. Annu Rev Pharmacol Toxicol 57 (2017), 81–105.
-
(2017)
Annu Rev Pharmacol Toxicol
, vol.57
, pp. 81-105
-
-
Bennett, C.F.1
Baker, B.F.2
Pham, N.3
Swayze, E.4
Geary, R.S.5
-
30
-
-
84982283717
-
The notorious R.N.A. in the spotlight — drug or target for the treatment of disease
-
Reautschnig, P., Vogel, P., Stafforst, T., The notorious R.N.A. in the spotlight — drug or target for the treatment of disease. RNA Biol 14 (2017), 651–668.
-
(2017)
RNA Biol
, vol.14
, pp. 651-668
-
-
Reautschnig, P.1
Vogel, P.2
Stafforst, T.3
-
31
-
-
85029480886
-
Switching protein localization by site-directed RNA editing under control of light
-
This is the first description of directed editing-induced inclusion of start and stop codons to artificially switch protein composition.
-
Vogel, P., Hanswillemenke, A., Stafforst, T., Switching protein localization by site-directed RNA editing under control of light. ACS Synth Biol 6 (2017), 1642–1649 This is the first description of directed editing-induced inclusion of start and stop codons to artificially switch protein composition.
-
(2017)
ACS Synth Biol
, vol.6
, pp. 1642-1649
-
-
Vogel, P.1
Hanswillemenke, A.2
Stafforst, T.3
-
32
-
-
0032540286
-
NMR structure of the bacteriophage lambda N peptide/boxB RNA complex: recognition of a GNRA fold by an arginine-rich motif
-
Legault, P., Li, J., Mogridge, J., Kay, L.E., Greenblatt, J., NMR structure of the bacteriophage lambda N peptide/boxB RNA complex: recognition of a GNRA fold by an arginine-rich motif. Cell 93 (1998), 289–299.
-
(1998)
Cell
, vol.93
, pp. 289-299
-
-
Legault, P.1
Li, J.2
Mogridge, J.3
Kay, L.E.4
Greenblatt, J.5
-
33
-
-
84887300101
-
Correction of mutations within the cystic fibrosis transmembrane conductance regulator by site-directed RNA editing
-
This is the pioneering first description of the λN-ADAR trans-tethering approach. It also shows the first restoration of a diseased phenotype with an RNA editing approach.
-
Montiel-Gonzalez, M.F., Vallecillo-Viejo, I., Yudowski, G.A., Rosenthal, J.J.C., Correction of mutations within the cystic fibrosis transmembrane conductance regulator by site-directed RNA editing. Proc Natl Acad Sci 110 (2013), 18285–18290 This is the pioneering first description of the λN-ADAR trans-tethering approach. It also shows the first restoration of a diseased phenotype with an RNA editing approach.
-
(2013)
Proc Natl Acad Sci
, vol.110
, pp. 18285-18290
-
-
Montiel-Gonzalez, M.F.1
Vallecillo-Viejo, I.2
Yudowski, G.A.3
Rosenthal, J.J.C.4
-
34
-
-
85016148680
-
An efficient system for selectively altering genetic information within mRNAs
-
e157-e157 Here, it is shown that the editing efficiency of the tethering approach benefits from recruiting several hyperactive ADAR deaminases to the target. The hyperactive mutant has been used here first, its propensity for strong off-target editing, however, also became apparent.
-
Montiel-González, M.F., Vallecillo-Viejo, I.C., Rosenthal Joshua, J.C., An efficient system for selectively altering genetic information within mRNAs. Nucleic Acids Res, 44, 2016 e157-e157 Here, it is shown that the editing efficiency of the tethering approach benefits from recruiting several hyperactive ADAR deaminases to the target. The hyperactive mutant has been used here first, its propensity for strong off-target editing, however, also became apparent.
-
(2016)
Nucleic Acids Res
, vol.44
-
-
Montiel-González, M.F.1
Vallecillo-Viejo, I.C.2
Rosenthal Joshua, J.C.3
-
35
-
-
85032748097
-
Site-directed RNA repair of endogenous Mecp2 RNA in neurons
-
This is the first description of an entirely virus-encoded RNA editing system. It was applied to correct a point mutation on an endogenous transcriptex vivo in mouse neurons.
-
Sinnamon, J.R., Kim, S.Y., Corson, G.M., Song, Z., Nakai, H., Adelman, J.P., Mandel, G., Site-directed RNA repair of endogenous Mecp2 RNA in neurons. Proc Natl Acad Sci 114 (2017), E9395–E9402 This is the first description of an entirely virus-encoded RNA editing system. It was applied to correct a point mutation on an endogenous transcriptex vivo in mouse neurons.
-
(2017)
Proc Natl Acad Sci
, vol.114
, pp. E9395-E9402
-
-
Sinnamon, J.R.1
Kim, S.Y.2
Corson, G.M.3
Song, Z.4
Nakai, H.5
Adelman, J.P.6
Mandel, G.7
-
36
-
-
84974606818
-
C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector
-
Abudayyeh, O.O., Gootenberg, J.S., Konermann, S., Joung, J., Slaymaker, I.M., Cox, D.B., Shmakov, S., Makarova, K.S., Semenova, E., Minakhin, L., et al. C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector. Science, 353, 2016, aaf5573.
-
(2016)
Science
, vol.353
, pp. aaf5573
-
-
Abudayyeh, O.O.1
Gootenberg, J.S.2
Konermann, S.3
Joung, J.4
Slaymaker, I.M.5
Cox, D.B.6
Shmakov, S.7
Makarova, K.S.8
Semenova, E.9
Minakhin, L.10
-
37
-
-
84965028802
-
RNA modifications: what have we learned and where are we headed?
-
Frye, M., Jaffrey, S.R., Pan, T., Rechavi, G., Suzuki, T., RNA modifications: what have we learned and where are we headed?. Nat Rev Genet 17 (2016), 365–372.
-
(2016)
Nat Rev Genet
, vol.17
, pp. 365-372
-
-
Frye, M.1
Jaffrey, S.R.2
Pan, T.3
Rechavi, G.4
Suzuki, T.5
-
38
-
-
0025943830
-
Substrate specificity of the dsRNA unwinding/modifying activity
-
Nishikura, K., Yoo, C., Kim, U., Murray, J.M., Estes, P.A., Cash, F.E., Liebhaber, S.A., Substrate specificity of the dsRNA unwinding/modifying activity. Embo J 10 (1991), 3523–3532.
-
(1991)
Embo J
, vol.10
, pp. 3523-3532
-
-
Nishikura, K.1
Yoo, C.2
Kim, U.3
Murray, J.M.4
Estes, P.A.5
Cash, F.E.6
Liebhaber, S.A.7
-
39
-
-
84945178024
-
Recognition of duplex RNA by the deaminase domain of the RNA editing enzyme ADAR2
-
Phelps, K.J., Tran, K., Eifler, T., Erickson, A.I., Fisher, A.J., Beal, P.A., Recognition of duplex RNA by the deaminase domain of the RNA editing enzyme ADAR2. Nucleic Acids Res 43 (2015), 1123–1132.
-
(2015)
Nucleic Acids Res
, vol.43
, pp. 1123-1132
-
-
Phelps, K.J.1
Tran, K.2
Eifler, T.3
Erickson, A.I.4
Fisher, A.J.5
Beal, P.A.6
-
40
-
-
85052877430
-
Implementation of the CRISPR–Cas13a system in fission yeast and its repurposing for precise RNA editing
-
Jing, X., Xie, B., Chen, L., Zhang, N., Jiang, Y., Qin, H., Wang, H., Hao, P., Yang, S., Li, X., Implementation of the CRISPR–Cas13a system in fission yeast and its repurposing for precise RNA editing. Nucleic Acids Res, 2018, 10.1093/nar/gky433.
-
(2018)
Nucleic Acids Res
-
-
Jing, X.1
Xie, B.2
Chen, L.3
Zhang, N.4
Jiang, Y.5
Qin, H.6
Wang, H.7
Hao, P.8
Yang, S.9
Li, X.10
-
41
-
-
0029090176
-
Toward the therapeutic editing of mutated RNA sequences
-
Woolf, T.M., Chase, J.M., Stinchcomb, D.T., Toward the therapeutic editing of mutated RNA sequences. Proc Natl Acad Sci 92 (1995), 8298–8302.
-
(1995)
Proc Natl Acad Sci
, vol.92
, pp. 8298-8302
-
-
Woolf, T.M.1
Chase, J.M.2
Stinchcomb, D.T.3
-
42
-
-
85018319578
-
Harnessing human ADAR2 for RNA repair — recoding a PINK1 mutation rescues mitophagy
-
This is the first description of an RNA editing approach that recruits the natural human ADARs with a gRNA, and circumvents ADAR engineering. Restoration of a disease phenotype was shown.
-
Wettengel, J., Reautschnig, P., Geisler, S., Kahle, P.J., Stafforst, T., Harnessing human ADAR2 for RNA repair — recoding a PINK1 mutation rescues mitophagy. Nucleic Acids Res 45 (2017), 2797–2808 This is the first description of an RNA editing approach that recruits the natural human ADARs with a gRNA, and circumvents ADAR engineering. Restoration of a disease phenotype was shown.
-
(2017)
Nucleic Acids Res
, vol.45
, pp. 2797-2808
-
-
Wettengel, J.1
Reautschnig, P.2
Geisler, S.3
Kahle, P.J.4
Stafforst, T.5
-
43
-
-
85009754998
-
Applying human ADAR1p110 and ADAR1p150 for site-directed RNA editing — G/C substitution stabilizes GuideRNAs against editing
-
Heep, M., Mach, P., Reautschnig, P., Wettengel, J., Stafforst, T., Applying human ADAR1p110 and ADAR1p150 for site-directed RNA editing — G/C substitution stabilizes GuideRNAs against editing. Genes, 8, 2017, 34.
-
(2017)
Genes
, vol.8
, pp. 34
-
-
Heep, M.1
Mach, P.2
Reautschnig, P.3
Wettengel, J.4
Stafforst, T.5
-
44
-
-
85011392399
-
Construction of a guide-RNA for site-directed RNA mutagenesis utilising intracellular A-to-I RNA editing
-
Here, an alternative gRNA for the recruitment of natural ADARs is shown, however, with less comprehensive characterization.
-
Fukuda, M., Umeno, H., Nose, K., Nishitarumizu, A., Noguchi, R., Nakagawa, H., Construction of a guide-RNA for site-directed RNA mutagenesis utilising intracellular A-to-I RNA editing. Scientific Rep, 7, 2017, 41478 Here, an alternative gRNA for the recruitment of natural ADARs is shown, however, with less comprehensive characterization.
-
(2017)
Scientific Rep
, vol.7
, pp. 41478
-
-
Fukuda, M.1
Umeno, H.2
Nose, K.3
Nishitarumizu, A.4
Noguchi, R.5
Nakagawa, H.6
-
45
-
-
84963603761
-
Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity
-
This is the only available structural information on the ADAR deaminase/RNA substrate complex, useful for guide RNA and ADAR engineering.
-
Matthews, M.M., Thomas, J.M., Zheng, Y., Tran, K., Phelps, K.J., Scott, A.I., Havel, J., Fisher, A.J., Beal, P.A., Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity. Nat Struct Mol Biol 23 (2016), 426–433 This is the only available structural information on the ADAR deaminase/RNA substrate complex, useful for guide RNA and ADAR engineering.
-
(2016)
Nat Struct Mol Biol
, vol.23
, pp. 426-433
-
-
Matthews, M.M.1
Thomas, J.M.2
Zheng, Y.3
Tran, K.4
Phelps, K.J.5
Scott, A.I.6
Havel, J.7
Fisher, A.J.8
Beal, P.A.9
-
46
-
-
84868106296
-
A distant cis acting intronic element induces site-selective RNA editing
-
Daniel, C., Venø, M.T., Ekdahl, Y., Kjems, J., Öhman, M., A distant cis acting intronic element induces site-selective RNA editing. Nucleic Acids Res 40 (2012), 9876–9886.
-
(2012)
Nucleic Acids Res
, vol.40
, pp. 9876-9886
-
-
Daniel, C.1
Venø, M.T.2
Ekdahl, Y.3
Kjems, J.4
Öhman, M.5
-
47
-
-
84881332124
-
Tertiary structural elements determine the extent and specificity of messenger RNA editing
-
Rieder, L.E., Staber, C.J., Hoopengardner, B., Reenan, R.A., Tertiary structural elements determine the extent and specificity of messenger RNA editing. Nat Commun, 4, 2013, 2232.
-
(2013)
Nat Commun
, vol.4
, pp. 2232
-
-
Rieder, L.E.1
Staber, C.J.2
Hoopengardner, B.3
Reenan, R.A.4
-
48
-
-
84896707317
-
Alu elements shape the primate transcriptome by cis-regulation of RNA editing
-
Daniel, C., Silberberg, G., Behm, M., Ohman, M., Alu elements shape the primate transcriptome by cis-regulation of RNA editing. Genome Biol, 15, 2014, R28.
-
(2014)
Genome Biol
, vol.15
, pp. R28
-
-
Daniel, C.1
Silberberg, G.2
Behm, M.3
Ohman, M.4
-
49
-
-
85031932588
-
Editing inducer elements increases A-to-I editing efficiency in the mammalian transcriptome
-
Here, editing inducer elements are defined that may help improving the guide RNA design.
-
Daniel, C., Widmark, A., Rigardt, D., Öhman, M., Editing inducer elements increases A-to-I editing efficiency in the mammalian transcriptome. Genome Biol, 18, 2017, 195 Here, editing inducer elements are defined that may help improving the guide RNA design.
-
(2017)
Genome Biol
, vol.18
, pp. 195
-
-
Daniel, C.1
Widmark, A.2
Rigardt, D.3
Öhman, M.4
-
50
-
-
85027937587
-
Site-directed RNA editing with antagomir deaminases — a tool to study protein and RNA function
-
Vogel, P., Stafforst, T., Site-directed RNA editing with antagomir deaminases — a tool to study protein and RNA function. ChemMedChem 9 (2014), 2021–2025.
-
(2014)
ChemMedChem
, vol.9
, pp. 2021-2025
-
-
Vogel, P.1
Stafforst, T.2
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