GFAP Mutations in Astrocytes Impair Oligodendrocyte Progenitor Proliferation and Myelination in an hiPSC Model of Alexander Disease

Cell Stem Cell

Volumn 23, Issue 2, 2018, Pages 239-251.e6

  Li, Li ^a   Tian, E ^a   Chen, Xianwei ^a   Chao, Jianfei ^a   Klein, Jeremy ^a   Qu, Qiuhao ^a   Sun, Guihua ^a   Sun, Guoqiang ^a   Huang, Yanzhou ^a   Warden, Charles D ^a   Ye, Peng ^a   Feng, Lizhao ^a   Li, Xinqiang ^a   Cui, Qi ^a   Sultan, Abdullah ^a   Douvaras, Panagiotis ^b   Fossati, Valentina ^b   Sanjana, Neville E ^c,d,e   Riggs, Arthur D ^a   Shi, Yanhong ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b The New York Stem Cell Foundation Research Institute   (United States)

^c NEW YORK GENOME CENTER   (United States)

^d NEW YORK UNIVERSITY   (United States)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Alexander disease; astrocytes; CHI3L1; disease modeling; iPSCs; leukodystrophy; myelination; neurological disease; oligodendrocyte progenitor cells; oligodendrocytes

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; NANOFIBER; TRANSCRIPTOME; GLIAL FIBRILLARY ASTROCYTIC PROTEIN, MOUSE;

ALEXANDER DISEASE; ARTICLE; ASTROCYTE; CELL PROLIFERATION; COCULTURE; CONTROLLED STUDY; CRISPR-CAS9 SYSTEM; ENZYME ACTIVITY; ENZYME INHIBITION; GENE MUTATION; HUMAN; HUMAN CELL; INDUCED PLURIPOTENT STEM CELL; MYELINATION; OLIGODENDROGLIA; PHENOTYPE; PRIORITY JOURNAL; PROTEIN AGGREGATION; TRANSCRIPTOMICS; ANIMAL; BIOLOGICAL MODEL; CELL CULTURE; GENETICS; KNOCKOUT MOUSE; METABOLISM; MOUSE; MUTATION; OLIGODENDROCYTE PRECURSOR CELL; PATHOLOGY;

ALEXANDER DISEASE; ANIMALS; ASTROCYTES; CELL PROLIFERATION; CELLS, CULTURED; GLIAL FIBRILLARY ACIDIC PROTEIN; INDUCED PLURIPOTENT STEM CELLS; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; MUTATION; OLIGODENDROCYTE PRECURSOR CELLS;

EID: 85050478274     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2018.07.009     Document Type: Article

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