Modeling Alexander disease with patient iPSCs reveals cellular and molecular pathology of astrocytes

Acta Neuropathologica Communications

Volumn 4, Issue 1, 2016, Pages

  Kondo, Takayuki ^a   Funayama, Misato ^a   Miyake, Michiyo ^a   Tsukita, Kayoko ^a   Era, Takumi ^b   Osaka, Hitoshi ^c   Ayaki, Takashi ^d   Takahashi, Ryosuke ^d   Inoue, Haruhisa ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KUMAMOTO UNIVERSITY   (Japan)

^c JICHI MEDICAL UNIVERSITY   (Japan)

^d KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Alexander disease (AxD); Alpha crystallin; Astrocytes; Cytokine; Disease modeling; Glial fibrillary acidic protein (GFAP); Heat shock protein; Induced pluripotent stem cells (iPSCs); Inflammatory response; Inherited astrocytopathy; Rosenthal fibers

Indexed keywords

CYTOKINE; GLIAL FIBRILLARY ACIDIC PROTEIN;

ADULT; AGED; ALEXANDER DISEASE; ASTROCYTE; CELL CULTURE; CELL CULTURE TECHNIQUE; CHILD; ELECTROCHEMICAL ANALYSIS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMAN; IMMUNOBLOTTING; INDUCED PLURIPOTENT STEM CELL; MALE; METABOLISM; MICROARRAY ANALYSIS; MIDDLE AGED; PATHOLOGY; PROTEINOSIS; TRANSMISSION ELECTRON MICROSCOPY;

ADULT; AGED; ALEXANDER DISEASE; ASTROCYTES; CELL CULTURE TECHNIQUES; CELLS, CULTURED; CHILD; CYTOKINES; ELECTROCHEMICAL TECHNIQUES; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; IMMUNOBLOTTING; INDUCED PLURIPOTENT STEM CELLS; MALE; MICROARRAY ANALYSIS; MICROSCOPY, ELECTRON, TRANSMISSION; MIDDLE AGED; PROTEIN AGGREGATION, PATHOLOGICAL;

EID: 85020243880     PISSN: None     EISSN: 20515960     Source Type: Journal    
DOI: 10.1186/s40478-016-0337-0     Document Type: Article

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