Astrocyte pathology in Alexander disease causes a marked inflammatory environment

Acta Neuropathologica

Volumn 130, Issue 4, 2015, Pages 469-486

  Olabarria, Markel ^a,b   Putilina, Maria ^a   Riemer, Ellen C ^c   Goldman, James E ^a  

^a Department of Medicine   (United States)

^b BASQUE FOUNDATION FOR SCIENCE   (Spain)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Alexander disease; Astrocytes; CCL2; Chemokines; CXCL10; Gliosis; Microglia; RNA seq

Indexed keywords

CARBON TETRACHLORIDE; CD11B ANTIGEN; CD68 ANTIGEN; COLONY STIMULATING FACTOR 1; CXCL1 CHEMOKINE; CXCL2 CHEMOKINE; EOTAXIN; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 16; INTERLEUKIN 17; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 23; INTERLEUKIN 27; INTERLEUKIN 3; INTERLEUKIN 4; INTERLEUKIN 7; KI 67 ANTIGEN; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 5; MYELIN; RANTES; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; CYTOKINE; GLIAL FIBRILLARY ACIDIC PROTEIN;

ALEXANDER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; B LYMPHOCYTE; CELL ACTIVATION; CELL DENSITY; CELL PROLIFERATION; CELL STRESS; CEREBROVASCULAR ACCIDENT; CHILD; CONTROLLED STUDY; CORPUS STRIATUM; DENTATE GYRUS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FEMALE; GENE MUTATION; GENE ONTOLOGY; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; INFANT; LYMPHOCYTIC INFILTRATION; MALE; MICROGLIA; MOLECULAR PATHOLOGY; MONOCYTE; MOUSE; MYELITIS; NEOCORTEX; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; OLIGODENDROCYTE PRECURSOR CELL; OLIGODENDROGLIA; PRESCHOOL CHILD; PRIORITY JOURNAL; RNA SEQUENCE; STRATUM LACUNOSUM MOLECULARE; STRATUM RADIATUM; T LYMPHOCYTE; THALAMUS; UPREGULATION; ANIMAL; DISEASE COURSE; DISEASE MODEL; GENETICS; IMMUNOLOGY; IMMUNOMODULATION; METABOLISM; PATHOLOGY; PHYSIOLOGY; SPINAL CORD; TRANSGENIC MOUSE;

ALEXANDER DISEASE; ANIMALS; ASTROCYTES; CHILD, PRESCHOOL; CYTOKINES; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FEMALE; GLIAL FIBRILLARY ACIDIC PROTEIN; HIPPOCAMPUS; HUMANS; INFANT; MALE; MICE, TRANSGENIC; MICROGLIA; NEUROIMMUNOMODULATION; SPINAL CORD;

EID: 84942372572     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-015-1469-1     Document Type: Article

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