메뉴 건너뛰기




Volumn 19, Issue 7, 2018, Pages

Farnesoid X receptor activation enhances transforming growth factor β-induced epithelial-mesenchymal transition in hepatocellular carcinoma cells

Author keywords

Bile acid; Epithelial; Farnesoid X receptor; Focal adhesion kinase; Guggulsterone; Hepatocellular carcinoma; Mesenchymal transition; N cadherin; Transforming growth factor

Indexed keywords

3 [2 [2 CHLORO 4 [3 (2,6 DICHLOROPHENYL) 5 ISOPROPYL 4 ISOXAZOLYLMETHOXY]PHENYL]VINYL]BENZOIC ACID; CHENODEOXYCHOLIC ACID; FARNESOID X RECEPTOR; FOCAL ADHESION KINASE; GUGGULSTERONE; NERVE CELL ADHESION MOLECULE; OBETICHOLIC ACID; TRANSFORMING GROWTH FACTOR BETA; BILE ACID; CADHERIN; CELL RECEPTOR; FARNESOID X-ACTIVATED RECEPTOR; ISOXAZOLE DERIVATIVE; TRANSFORMING GROWTH FACTOR BETA1;

EID: 85049476805     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms19071898     Document Type: Article
Times cited : (29)

References (33)
  • 1
    • 85044279631 scopus 로고    scopus 로고
    • Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis
    • Jia, W.; Xie, G.; Jia, W. Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis. Nat. Rev. Gastroenterol. Hepatol. 2017, 15, 111–128. [CrossRef] [PubMed]
    • (2017) Nat. Rev. Gastroenterol. Hepatol. , vol.15 , pp. 111-128
    • Jia, W.1    Xie, G.2    Jia, W.3
  • 2
    • 84991736278 scopus 로고    scopus 로고
    • Role of epithelial to mesenchymal transition in hepatocellular carcinoma
    • Giannelli, G.; Koudelkova, P.; Dituri, F.; Mikulits, W. Role of epithelial to mesenchymal transition in hepatocellular carcinoma. J. Hepatol. 2016, 65, 798–808. [CrossRef] [PubMed]
    • (2016) J. Hepatol. , vol.65 , pp. 798-808
    • Giannelli, G.1    Koudelkova, P.2    Dituri, F.3    Mikulits, W.4
  • 5
    • 0033026760 scopus 로고    scopus 로고
    • Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
    • Wang, H.; Chen, J.; Hollister, K.; Sowers, L.C.; Forman, B.M. Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol. Cell 1999, 3, 543–553. [CrossRef]
    • (1999) Mol. Cell , vol.3 , pp. 543-553
    • Wang, H.1    Chen, J.2    Hollister, K.3    Sowers, L.C.4    Forman, B.M.5
  • 6
    • 84905257719 scopus 로고    scopus 로고
    • Bile acid signaling in metabolic disease and drug therapy
    • Li, T.; Chiang, J.Y. Bile acid signaling in metabolic disease and drug therapy. Pharmacol. Rev. 2014, 66, 948–983. [CrossRef] [PubMed]
    • (2014) Pharmacol. Rev. , vol.66 , pp. 948-983
    • Li, T.1    Chiang, J.Y.2
  • 7
    • 85014688842 scopus 로고    scopus 로고
    • Farnesoid X receptor an emerging target to combat obesity
    • De Magalhaes Filho, C.D.; Downes, M.; Evans, R.M. Farnesoid X receptor an emerging target to combat obesity. Dig. Dis. 2017, 35, 185–190. [CrossRef] [PubMed]
    • (2017) Dig. Dis. , vol.35 , pp. 185-190
    • de Magalhaes Filho, C.D.1    Downes, M.2    Evans, R.M.3
  • 8
    • 84929266699 scopus 로고    scopus 로고
    • Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): A multicentre, randomised, placebo-controlled trial
    • Neuschwander-Tetri, B.A.; Loomba, R.; Sanyal, A.J.; Lavine, J.E.; Van Natta, M.L.; Abdelmalek, M.F.; Chalasani, N.; Dasarathy, S.; Diehl, A.M.; Hameed, B.; et al. Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): A multicentre, randomised, placebo-controlled trial. Lancet 2015, 385, 956–965. [CrossRef]
    • (2015) Lancet , vol.385 , pp. 956-965
    • Neuschwander-Tetri, B.A.1    Loomba, R.2    Sanyal, A.J.3    Lavine, J.E.4    van Natta, M.L.5    Abdelmalek, M.F.6    Chalasani, N.7    Dasarathy, S.8    Diehl, A.M.9    Hameed, B.10
  • 10
    • 33645821043 scopus 로고    scopus 로고
    • Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration
    • Huang, W.; Ma, K.; Zhang, J.; Qatanani, M.; Cuvillier, J.; Liu, J.; Dong, B.; Huang, X.; Moore, D.D. Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration. Science 2006, 312, 233–236. [CrossRef] [PubMed]
    • (2006) Science , vol.312 , pp. 233-236
    • Huang, W.1    Ma, K.2    Zhang, J.3    Qatanani, M.4    Cuvillier, J.5    Liu, J.6    Dong, B.7    Huang, X.8    Moore, D.D.9
  • 11
    • 77950616155 scopus 로고    scopus 로고
    • Farnesoid X receptor alleviates age-related proliferation defects in regenerating mouse livers by activating forkhead box m1b transcription
    • Chen, W.D.; Wang, Y.D.; Zhang, L.; Shiah, S.; Wang, M.; Yang, F.; Yu, D.; Forman, B.M.; Huang, W. Farnesoid X receptor alleviates age-related proliferation defects in regenerating mouse livers by activating forkhead box m1b transcription. Hepatology 2010, 51, 953–962. [CrossRef] [PubMed]
    • (2010) Hepatology , vol.51 , pp. 953-962
    • Chen, W.D.1    Wang, Y.D.2    Zhang, L.3    Shiah, S.4    Wang, M.5    Yang, F.6    Yu, D.7    Forman, B.M.8    Huang, W.9
  • 12
    • 84870489524 scopus 로고    scopus 로고
    • Promotion of liver regeneration/repair by farnesoid x receptor in both liver and intestine in mice
    • Zhang, L.; Wang, Y.D.; Chen, W.D.; Wang, X.; Lou, G.; Liu, N.; Lin, M.; Forman, B.M.; Huang, W. Promotion of liver regeneration/repair by farnesoid x receptor in both liver and intestine in mice. Hepatology 2012, 56, 2336–2343. [CrossRef] [PubMed]
    • (2012) Hepatology , vol.56 , pp. 2336-2343
    • Zhang, L.1    Wang, Y.D.2    Chen, W.D.3    Wang, X.4    Lou, G.5    Liu, N.6    Lin, M.7    Forman, B.M.8    Huang, W.9
  • 13
    • 33847044019 scopus 로고    scopus 로고
    • Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor
    • Yang, F.; Huang, X.; Yi, T.; Yen, Y.; Moore, D.D.; Huang, W. Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor. Cancer Res. 2007, 67, 863–867. [CrossRef] [PubMed]
    • (2007) Cancer Res , vol.67 , pp. 863-867
    • Yang, F.1    Huang, X.2    Yi, T.3    Yen, Y.4    Moore, D.D.5    Huang, W.6
  • 14
    • 34447098081 scopus 로고    scopus 로고
    • Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice
    • Kim, I.; Morimura, K.; Shah, Y.; Yang, Q.; Ward, J.M.; Gonzalez, F.J. Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice. Carcinogenesis 2007, 28, 940–946. [CrossRef] [PubMed]
    • (2007) Carcinogenesis , vol.28 , pp. 940-946
    • Kim, I.1    Morimura, K.2    Shah, Y.3    Yang, Q.4    Ward, J.M.5    Gonzalez, F.J.6
  • 15
    • 84920964414 scopus 로고    scopus 로고
    • Prevention of spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice by intestinal-specific farnesoid x receptor reactivation
    • Degirolamo, C.; Modica, S.; Vacca, M.; Di Tullio, G.; Morgano, A.; D’Orazio, A.; Kannisto, K.; Parini, P.; Moschetta, A. Prevention of spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice by intestinal-specific farnesoid x receptor reactivation. Hepatology 2015, 61, 161–170. [CrossRef] [PubMed]
    • (2015) Hepatology , vol.61 , pp. 161-170
    • Degirolamo, C.1    Modica, S.2    Vacca, M.3    Di Tullio, G.4    Morgano, A.5    D’Orazio, A.6    Kannisto, K.7    Parini, P.8    Moschetta, A.9
  • 19
    • 84937204423 scopus 로고    scopus 로고
    • Hepatic stellate cells promote upregulation of epithelial cell adhesion molecule and epithelial-mesenchymal transition in hepatic cancer cells
    • Nagahara, T.; Shiraha, H.; Sawahara, H.; Uchida, D.; Takeuchi, Y.; Iwamuro, M.; Kataoka, J.; Horiguchi, S.; Kuwaki, T.; Onishi, H.; et al. Hepatic stellate cells promote upregulation of epithelial cell adhesion molecule and epithelial-mesenchymal transition in hepatic cancer cells. Oncol. Rep. 2015, 34, 1169–1177. [CrossRef] [PubMed]
    • (2015) Oncol. Rep. , vol.34 , pp. 1169-1177
    • Nagahara, T.1    Shiraha, H.2    Sawahara, H.3    Uchida, D.4    Takeuchi, Y.5    Iwamuro, M.6    Kataoka, J.7    Horiguchi, S.8    Kuwaki, T.9    Onishi, H.10
  • 22
    • 84867305638 scopus 로고    scopus 로고
    • FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model
    • Deuschle, U.; Schüler, J.; Schulz, A.; Schlüter, T.; Kinzel, O.; Abel, U.; Kremoser, C. FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model. PLoS ONE 2012, 7, e43044. [CrossRef] [PubMed]
    • (2012) Plos ONE , vol.7
    • Deuschle, U.1    Schüler, J.2    Schulz, A.3    Schlüter, T.4    Kinzel, O.5    Abel, U.6    Kremoser, C.7
  • 23
    • 85030527615 scopus 로고    scopus 로고
    • The FXR agonist, obeticholic acid, suppresses hcc proliferation & metastasis: Role of IL-6/STAT3 signalling pathway
    • Attia, Y.M.; Tawfiq, R.A.; Ali, A.A.; Elmazar, M.M. The FXR agonist, obeticholic acid, suppresses hcc proliferation & metastasis: Role of IL-6/STAT3 signalling pathway. Sci. Rep. 2017, 7, 12502. [PubMed]
    • (2017) Sci. Rep. , vol.7 , pp. 12502
    • Attia, Y.M.1    Tawfiq, R.A.2    Ali, A.A.3    Elmazar, M.M.4
  • 24
    • 84870481778 scopus 로고    scopus 로고
    • Downregulation of nuclear receptor FXR is associated with multiple malignant clinicopathological characteristics in human hepatocellular carcinoma
    • Su, H.; Ma, C.; Liu, J.; Li, N.; Gao, M.; Huang, A.; Wang, X.; Huang, W.; Huang, X. Downregulation of nuclear receptor FXR is associated with multiple malignant clinicopathological characteristics in human hepatocellular carcinoma. Am. J. Physiol. Gastrointest. Liver Physiol. 2012, 303, G1245–G1253. [CrossRef] [PubMed]
    • (2012) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.303 , pp. G1245-G1253
    • Su, H.1    Ma, C.2    Liu, J.3    Li, N.4    Gao, M.5    Huang, A.6    Wang, X.7    Huang, W.8    Huang, X.9
  • 25
    • 84883501278 scopus 로고    scopus 로고
    • Enhanced expression of farnesoid X receptor in human hepatocellular carcinoma
    • Kumagai, A.; Fukushima, J.; Takikawa, H.; Fukuda, T.; Fukusato, T. Enhanced expression of farnesoid X receptor in human hepatocellular carcinoma. Hepatol. Res. 2013, 43, 959–969. [CrossRef] [PubMed]
    • (2013) Hepatol. Res. , vol.43 , pp. 959-969
    • Kumagai, A.1    Fukushima, J.2    Takikawa, H.3    Fukuda, T.4    Fukusato, T.5
  • 26
    • 84887202124 scopus 로고    scopus 로고
    • Guggulsterone decreases proliferation and metastatic behavior of pancreatic cancer cells by modulating JAK/STAT and Src/FAK signaling
    • Macha, M.A.; Rachagani, S.; Gupta, S.; Pai, P.; Ponnusamy, M.P.; Batra, S.K.; Jain, M. Guggulsterone decreases proliferation and metastatic behavior of pancreatic cancer cells by modulating JAK/STAT and Src/FAK signaling. Cancer Lett. 2013, 341, 166–177. [CrossRef] [PubMed]
    • (2013) Cancer Lett , vol.341 , pp. 166-177
    • Macha, M.A.1    Rachagani, S.2    Gupta, S.3    Pai, P.4    Ponnusamy, M.P.5    Batra, S.K.6    Jain, M.7
  • 27
    • 85010420366 scopus 로고    scopus 로고
    • Overexpression of farnesoid X receptor in small airways contributes to epithelial to mesenchymal transition and COX-2 expression in chronic obstructive pulmonary disease
    • Chen, B.; You, W.J.; Xue, S.; Qin, H.; Zhao, X.J.; Zhang, M.; Liu, X.Q.; Zhu, S.Y.; Jiang, H.D. Overexpression of farnesoid X receptor in small airways contributes to epithelial to mesenchymal transition and COX-2 expression in chronic obstructive pulmonary disease. J. Thorac. Dis. 2016, 8, 3063–3074. [CrossRef] [PubMed]
    • (2016) J. Thorac. Dis. , vol.8 , pp. 3063-3074
    • Chen, B.1    You, W.J.2    Xue, S.3    Qin, H.4    Zhao, X.J.5    Zhang, M.6    Liu, X.Q.7    Zhu, S.Y.8    Jiang, H.D.9
  • 28
    • 84978835125 scopus 로고    scopus 로고
    • Bile acids induce activation of alveolar epithelial cells and lung fibroblasts through farnesoid X receptor-dependent and independent pathways
    • Chen, B.; Cai, H.R.; Xue, S.; You, W.J.; Liu, B.; Jiang, H.D. Bile acids induce activation of alveolar epithelial cells and lung fibroblasts through farnesoid X receptor-dependent and independent pathways. Respirology 2016, 21, 1075–1080. [CrossRef] [PubMed]
    • (2016) Respirology , vol.21 , pp. 1075-1080
    • Chen, B.1    Cai, H.R.2    Xue, S.3    You, W.J.4    Liu, B.5    Jiang, H.D.6
  • 30
    • 85018338007 scopus 로고    scopus 로고
    • The role of bile acids in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
    • Chow, M.D.; Lee, Y.-H.; Guo, G.L. The role of bile acids in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Mol. Aspects Med. 2017, 56, 34–44. [CrossRef] [PubMed]
    • (2017) Mol. Aspects Med. , vol.56 , pp. 34-44
    • Chow, M.D.1    Lee, Y.-H.2    Guo, G.L.3
  • 32
    • 33847780436 scopus 로고    scopus 로고
    • Design, synthesis, and evaluation of non-steroidal farnesoid X receptor (FXR) antagonist
    • Kainuma, M.; Makishima, M.; Hashimoto, Y.; Miyachi, H. Design, synthesis, and evaluation of non-steroidal farnesoid X receptor (FXR) antagonist. Bioorg. Med. Chem. 2007, 15, 2587–2600. [CrossRef] [PubMed]
    • (2007) Bioorg. Med. Chem. , vol.15 , pp. 2587-2600
    • Kainuma, M.1    Makishima, M.2    Hashimoto, Y.3    Miyachi, H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.