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One of three contemporaneous studies examining the cytokine and chemokine inflammatory profile of H7N9-infected patients, identifying biomarkers such as IL-1β and IL-18 as poor prognostic markers of disease outcomes.
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One of three contemporaneous studies examining the cytokine and chemokine inflammatory profile of H7N9-infected patients, identifying biomarkers such as IL-1β and IL-18 as poor prognostic markers of disease outcomes.
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This paper, back-to-back, with Thomaset al. demonstrated the protective role of the inflammasome complex during IAV infection and that deficiency in NLRP3, ASC or Caspase-1 rendered mice hypersusceptible to IAV infection. This study also identified a critical role of the inflammasome in the healing process following infection.
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The first identification that aggregated viral proteins activate the NLRP3 inflamamsome, similar to endogenous fibrillar proteins such as Aβ peptide and IAPP. This study identified PB1-F2 as a potential major contributor to the hyperinflammation associated with pandemic and lethal IAV infections.
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Contemporary study to Guardaet al. and identifies IFN as a major regulatory mechanism of inflammasome priming and function.
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