Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing

Nature Communications

Volumn 9, Issue 1, 2018, Pages

  Liu, Zhen ^a   Lu, Zongyang ^b   Yang, Guang ^b   Huang, Shisheng ^b   Li, Guanglei ^b   Feng, Songjie ^a   Liu, Yajing ^b   Li, Jianan ^b   Yu, Wenxia ^b   Zhang, Yu ^b   Chen, Jia ^b   Sun, Qiang ^a   Huang, Xingxu ^b,c  

^a Shenzhen Fundamental Research Institutions   (China)

^b SHANGHAITECH UNIVERSITY   (China)

^c INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AR PROTEIN; CELL PROTEIN; GENOMIC DNA; GUIDE RNA; HOXD13 PROTEIN; MESSENGER RNA; SINGLE GUIDE RNA; UNCLASSIFIED DRUG; ADENINE; ANDROGEN RECEPTOR; AR PROTEIN, MOUSE; GREEN FLUORESCENT PROTEIN; HOMEODOMAIN PROTEIN; HOXD13 PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

ADENINE BASE EDITOR SYSTEM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASE EDITOR SYSTEM; BLASTOCYST; EMBRYO; EMBRYO TRANSFER; FEMALE; GENE CONVERSION; GENE EDITING; GERMLINE MUTATION; HIGH THROUGHPUT SEQUENCING; IN VIVO STUDY; INDEL MUTATION; MALE; MICROINJECTION; MOUSE; MOUSE EMBRYO; MOUSE MODEL; MOUSE MUTANT; NEURO-2A CELL LINE; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; SANGER SEQUENCING; SEX TRANSFORMATION; SILENT MUTATION; SINGLE NUCLEOTIDE POLYMORPHISM; SYNDACTYLY; WHOLE GENOME SEQUENCING; ANIMAL; CHEMISTRY; DISEASE MODEL; DNA SEQUENCE; GENETICS; GENOTYPE; HUMAN; HUMAN GENOME; METABOLISM; MUTATION; NEWBORN; PROTEIN DOMAIN; SENSITIVITY AND SPECIFICITY; TUMOR CELL LINE;

ADENINE; ANIMALS; ANIMALS, NEWBORN; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; FEMALE; GENOME, HUMAN; GENOTYPE; GREEN FLUORESCENT PROTEINS; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HOMEODOMAIN PROTEINS; HUMANS; MALE; MICE; MUTATION; PROTEIN DOMAINS; RECEPTORS, ANDROGEN; RNA, GUIDE; RNA, MESSENGER; SENSITIVITY AND SPECIFICITY; SEQUENCE ANALYSIS, DNA; TRANSCRIPTION FACTORS;

EID: 85048705226     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/s41467-018-04768-7     Document Type: Article

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