Slc5a8, a Na+-coupled high-affinity transporter for short-chain fatty acids, is a conditional tumour suppressor in colon that protects against colitis and colon cancer under low-fibre dietary conditions

Biochemical Journal

Volumn 469, Issue 2, 2015, Pages 267-278

  Gurav, Ashish ^a   Sivaprakasam, Sathish ^a   Bhutia, Yangzom D ^b   Boettger, Thomas ^c   Singh, Nagendra ^a   Ganapathy, Vadivel ^b  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

^c MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

Author keywords

Bacterial metabolites; Butyrate transporter; Colitis; Colon cancer; Dendritic cell; Dietary fibre; Histone deacetylase; Indoleamine 2,3 dioxygenase 1; Member 8 (Slc5a8) null mouse; Solute carrier gene family 5a

Indexed keywords

AGENTS USED IN INFLAMMATORY BOWEL DISEASE; ALDEHYDE DEHYDROGENASE; DIOXYGENASE; GAMMA INTERFERON; INDOLEAMINE 2,3 DIOXYGENASE 1; SOLUTE CARRIER GENE FAMILY 5A MEMBER 8; STAT3 PROTEIN; TRANSCRIPTION FACTOR FOXP3; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; ALDH1A2 PROTEIN, MOUSE; ANTIHISTAMINIC AGENT; BUTYRIC ACID; CATION TRANSPORT PROTEIN; FATTY ACID; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; IDO1 PROTEIN, MOUSE; INDOLEAMINE 2,3 DIOXYGENASE; SLC5A8 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER PREVENTION; CD4+ T LYMPHOCYTE; CELL CULTURE; CELL ISOLATION; CELL MEMBRANE PERMEABILITY; COLON CANCER; COMPARATIVE STUDY; CONTROLLED STUDY; DENDRITIC CELL; DEXTRAN SODIUM SULFATE-INDUCED COLITIS; DIETARY FIBER; FLOW CYTOMETRY; IMMUNOCOMPETENT CELL; LAMINA PROPRIA; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY T LYMPHOCYTE; RISK FACTOR; RNA ISOLATION; ANIMAL; COLITIS; COLON; COLON TUMOR; DRUG EFFECTS; GENETICS; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; KNOCKOUT MOUSE; MUCOSAL IMMUNITY; PATHOLOGY; PHARMACOLOGY;

BACTERIA (MICROORGANISMS); MAMMALIA;

ALDEHYDE DEHYDROGENASE; ANIMALS; BUTYRIC ACID; CATION TRANSPORT PROTEINS; COLITIS; COLON; COLONIC NEOPLASMS; DENDRITIC CELLS; DIETARY FIBER; FATTY ACIDS; FORKHEAD TRANSCRIPTION FACTORS; HISTAMINE ANTAGONISTS; IMMUNE TOLERANCE; IMMUNITY, MUCOSAL; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; INTERFERON-GAMMA; MICE; MICE, KNOCKOUT; T-LYMPHOCYTES, REGULATORY; TUMOR SUPPRESSOR PROTEINS;

EID: 84937139909     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20150242     Document Type: Article

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