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Volumn 11, Issue 3, 2018, Pages 820-834

The cytosolic sensor STING is required for intestinal homeostasis and control of inflammation

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; DEXTRAN SULFATE; IMMUNOGLOBULIN A; TRANSCRIPTION FACTOR FOXP3; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; MEMBRANE PROTEIN; MPYS PROTEIN, MOUSE; SECRETORY IMMUNOGLOBULIN;

EID: 85047967039     PISSN: 19330219     EISSN: 19353456     Source Type: Journal    
DOI: 10.1038/mi.2017.88     Document Type: Article
Times cited : (97)

References (78)
  • 1
    • 23344454388 scopus 로고    scopus 로고
    • Mucosal immunity
    • Mayer, L. Mucosal immunity. Immunol. Rev. 206, 5 (2005).
    • (2005) Immunol. Rev. , vol.206 , pp. 5
    • Mayer, L.1
  • 3
    • 84859808080 scopus 로고    scopus 로고
    • Oral tolerance to food protein
    • Pabst, O. &Mowat, A.M. Oral tolerance to food protein. Mucosal Immunol. 5, 232-239 (2012).
    • (2012) Mucosal Immunol. , vol.5 , pp. 232-239
    • Pabst, O.1    Mowat, A.M.2
  • 4
    • 84859389254 scopus 로고    scopus 로고
    • The microbiome in infectious disease and inflammation
    • Honda, K. &Littman, D.R. The microbiome in infectious disease and inflammation. Annu. Rev. Immunol. 30, 759-795 (2012).
    • (2012) Annu. Rev. Immunol. , vol.30 , pp. 759-795
    • Honda, K.1    Littman, D.R.2
  • 5
    • 77952318832 scopus 로고    scopus 로고
    • Intestinal bacteria and the regulation of immune cell homeostasis
    • Hill, D.A. &Artis, D. Intestinal bacteria and the regulation of immune cell homeostasis. Annu. Rev. Immunol. 28, 623-667 (2010).
    • (2010) Annu. Rev. Immunol. , vol.28 , pp. 623-667
    • Hill, D.A.1    Artis, D.2
  • 6
    • 33646182727 scopus 로고    scopus 로고
    • Organizing cell renewal in the intestine: Stem cells, signals and combinatorial control
    • Crosnier, C., Stamataki, D. &Lewis, J. Organizing cell renewal in the intestine: stem cells, signals and combinatorial control. Nat. Rev. Genet. 7, 349-359 (2006).
    • (2006) Nat. Rev. Genet. , vol.7 , pp. 349-359
    • Crosnier, C.1    Stamataki, D.2    Lewis, J.3
  • 7
    • 84947447820 scopus 로고    scopus 로고
    • The DNA sensor AIM2 maintains intestinal homeostasis via regulation of epithelial antimicrobial host defense
    • Hu, S. et al. The DNA sensor AIM2 maintains intestinal homeostasis via regulation of epithelial antimicrobial host defense. Cell Rep. 13, 1922-1936 (2015).
    • (2015) Cell Rep. , vol.13 , pp. 1922-1936
    • Hu, S.1
  • 8
    • 84876348441 scopus 로고    scopus 로고
    • The role of pattern recognition receptors in intestinal inflammation
    • Fukata, M. &Arditi, M. The role of pattern recognition receptors in intestinal inflammation. Mucosal Immunol. 6, 451-463 (2013).
    • (2013) Mucosal Immunol. , vol.6 , pp. 451-463
    • Fukata, M.1    Arditi, M.2
  • 9
    • 3242664636 scopus 로고    scopus 로고
    • Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis
    • Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S. &Medzhitov, R. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 118, 229-241 (2004).
    • (2004) Cell , vol.118 , pp. 229-241
    • Rakoff-Nahoum, S.1    Paglino, J.2    Eslami-Varzaneh, F.3    Edberg, S.4    Medzhitov, R.5
  • 10
    • 84982244545 scopus 로고    scopus 로고
    • AIM2 contributes to the maintenance of intestinal integrity via Akt and protects against Salmonella mucosal infection
    • Hu, G.Q. et al. AIM2 contributes to the maintenance of intestinal integrity via Akt and protects against Salmonella mucosal infection. Mucosal Immunol. 9, 1330-1339 (2016).
    • (2016) Mucosal Immunol. , vol.9 , pp. 1330-1339
    • Hu, G.Q.1
  • 11
    • 53349178089 scopus 로고    scopus 로고
    • STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
    • Ishikawa, H. &Barber, G.N. STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature 455, 674-678 (2008).
    • (2008) Nature , vol.455 , pp. 674-678
    • Ishikawa, H.1    Barber, G.N.2
  • 12
    • 80054966913 scopus 로고    scopus 로고
    • STING is a direct innate immune sensor of cyclic di-GMP
    • Burdette, D.L. et al. STING is a direct innate immune sensor of cyclic di-GMP. Nature 478, 515-518 (2011).
    • (2011) Nature , vol.478 , pp. 515-518
    • Burdette, D.L.1
  • 13
    • 84873711885 scopus 로고    scopus 로고
    • Cyclic GMP-AMP synthase is a cytosolicDNAsensor that activates the type i interferon pathway
    • Sun, L., Wu, J., Du, F., Chen, X. &Chen, Z.J. Cyclic GMP-AMP synthase is a cytosolicDNAsensor that activates the type I interferon pathway. Science 339, 786-791 (2013).
    • (2013) Science , vol.339 , pp. 786-791
    • Sun, L.1    Wu, J.2    Du, F.3    Chen, X.4    Chen, Z.J.5
  • 14
    • 84871218439 scopus 로고    scopus 로고
    • STING and the innate immune response to nucleic acids in the cytosol
    • Burdette, D.L. &Vance, R.E. STING and the innate immune response to nucleic acids in the cytosol. Nat. Immunol. 14, 19-26 (2013).
    • (2013) Nat. Immunol. , vol.14 , pp. 19-26
    • Burdette, D.L.1    Vance, R.E.2
  • 15
    • 53349168904 scopus 로고    scopus 로고
    • The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation
    • Zhong, B. et al. The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity 29, 538-550 (2008).
    • (2008) Immunity , vol.29 , pp. 538-550
    • Zhong, B.1
  • 16
    • 66649109939 scopus 로고    scopus 로고
    • ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization
    • Sun, W. et al. ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization. Proc. Natl. Acad. Sci. USA 106, 8653-8658 (2009).
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 8653-8658
    • Sun, W.1
  • 17
    • 49449115516 scopus 로고    scopus 로고
    • MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals
    • Jin, L., Waterman, P.M., Jonscher, K.R., Short, C.M., Reisdorph, N.A. &Cambier, J.C. MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals. Mol. Cell Biol. 28, 5014-5026 (2008).
    • (2008) Mol. Cell Biol. , vol.28 , pp. 5014-5026
    • Jin, L.1    Waterman, P.M.2    Jonscher, K.R.3    Short, C.M.4    Reisdorph, N.A.5    Cambier, J.C.6
  • 18
    • 84902584152 scopus 로고    scopus 로고
    • The role of type i interferons in intestinal infection, homeostasis, and inflammation
    • Cho, H. &Kelsall, B.L. The role of type I interferons in intestinal infection, homeostasis, and inflammation. Immunol. Rev. 260, 145-167 (2014).
    • (2014) Immunol. Rev. , vol.260 , pp. 145-167
    • Cho, H.1    Kelsall, B.L.2
  • 20
    • 84883417081 scopus 로고    scopus 로고
    • Type i IFNs regulate effector and regulatory T cell accumulation and anti-inflammatory cytokine production during T cellmediated colitis
    • Kole, A. et al. Type I IFNs regulate effector and regulatory T cell accumulation and anti-inflammatory cytokine production during T cellmediated colitis. J. Immunol. 191, 2771-2779 (2013).
    • (2013) J. Immunol. , vol.191 , pp. 2771-2779
    • Kole, A.1
  • 21
    • 79251506939 scopus 로고    scopus 로고
    • The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides
    • Sauer, J.D. et al. The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides. Infect. Immun. 79, 688-694 (2011).
    • (2011) Infect. Immun. , vol.79 , pp. 688-694
    • Sauer, J.D.1
  • 22
    • 84959353023 scopus 로고    scopus 로고
    • STING activation by translocation from the ER is associated with infection and autoinflammatory disease
    • Dobbs, N., Burnaevskiy, N., Chen, D., Gonugunta, V.K., Alto, N.M. &Yan, N. STING activation by translocation from the ER is associated with infection and autoinflammatory disease. Cell Host Microbe 18, 157-168 (2015).
    • (2015) Cell Host Microbe , vol.18 , pp. 157-168
    • Dobbs, N.1    Burnaevskiy, N.2    Chen, D.3    Gonugunta, V.K.4    Alto, N.M.5    Yan, N.6
  • 23
    • 84910131670 scopus 로고    scopus 로고
    • Cutting edge: STING mediates protection against colorectal tumorigenesis by governing the magnitude of intestinal inflammation
    • Zhu, Q. et al. Cutting edge: STING mediates protection against colorectal tumorigenesis by governing the magnitude of intestinal inflammation. J. Immunol. 193, 4779-4782 (2014).
    • (2014) J. Immunol. , vol.193 , pp. 4779-4782
    • Zhu, Q.1
  • 24
    • 84943663898 scopus 로고    scopus 로고
    • Diverse roles of STINGdependent signaling on the development of cancer
    • Ahn, J., Konno, H. &Barber, G.N. Diverse roles of STINGdependent signaling on the development of cancer. Oncogene 34, 5302-5308 (2015).
    • (2015) Oncogene , vol.34 , pp. 5302-5308
    • Ahn, J.1    Konno, H.2    Barber, G.N.3
  • 25
    • 85048024337 scopus 로고    scopus 로고
    • What is the role of cyclic di-GMP signaling within the human gutmicrobiome?
    • Rudlaff, R.M. &Waters, C.M. What is the role of cyclic di-GMP signaling within the human gutmicrobiome?. Microbiome Sci. Med. 1, 39-44 (2014).
    • (2014) Microbiome Sci. Med. , vol.1 , pp. 39-44
    • Rudlaff, R.M.1    Waters, C.M.2
  • 26
    • 84883425402 scopus 로고    scopus 로고
    • Cyclic dinucleotides and the innate immune response
    • Danilchanka, O. &Mekalanos, J.J. Cyclic dinucleotides and the innate immune response. Cell 154, 962-970 (2013).
    • (2013) Cell , vol.154 , pp. 962-970
    • Danilchanka, O.1    Mekalanos, J.J.2
  • 27
    • 84861980130 scopus 로고    scopus 로고
    • Interactions between the microbiota and the immune system
    • Hooper, L.V., Littman, D.R. &Macpherson, A.J. Interactions between the microbiota and the immune system. Science 336, 1268-1273 (2012).
    • (2012) Science , vol.336 , pp. 1268-1273
    • Hooper, L.V.1    Littman, D.R.2    Macpherson, A.J.3
  • 28
    • 0027358220 scopus 로고
    • Cell proliferation in colonic crypts of germ-free and conventional mice-preliminary report
    • Nowacki, M.R. Cell proliferation in colonic crypts of germ-free and conventional mice-preliminary report. Folia Histochem. Cytobiol. 31, 77-81 (1993).
    • (1993) Folia Histochem. Cytobiol. , vol.31 , pp. 77-81
    • Nowacki, M.R.1
  • 29
    • 73649204145 scopus 로고
    • Influence of the normal flora on mucosal morphology and cellular renewal in the ileum A comparison of germ-free and conventional mice
    • Abrams, G.D., Bauer, H. &Sprinz, H. Influence of the normal flora on mucosal morphology and cellular renewal in the ileum. A comparison of germ-free and conventional mice. Lab. Invest. 12, 355-364 (1963).
    • (1963) Lab. Invest. , vol.12 , pp. 355-364
    • Abrams, G.D.1    Bauer, H.2    Sprinz, H.3
  • 30
    • 79251581856 scopus 로고    scopus 로고
    • Importance and regulation of the colonic mucus barrier in a mouse model of colitis
    • Petersson, J. et al. Importance and regulation of the colonic mucus barrier in a mouse model of colitis. Am. J. Physiol. Gastrointest. Liver Physiol. 300, G327-G333 (2011).
    • (2011) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.300 , pp. G327-G333
    • Petersson, J.1
  • 31
    • 67349250428 scopus 로고    scopus 로고
    • The gut microbiota shapes intestinal immune responses during health and disease
    • Round, J.L. &Mazmanian, S.K. The gut microbiota shapes intestinal immune responses during health and disease. Nat. Rev. Immunol. 9, 313-323 (2009).
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 313-323
    • Round, J.L.1    Mazmanian, S.K.2
  • 32
    • 77954051526 scopus 로고    scopus 로고
    • Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses
    • Hapfelmeier, S. et al. Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses. Science 328, 1705-1709 (2010).
    • (2010) Science , vol.328 , pp. 1705-1709
    • Hapfelmeier, S.1
  • 33
    • 0015173745 scopus 로고
    • Serum and secretory IgA in axenic and holoxenic mice
    • Benveniste, J., Lespinats, G. &Salomon, J. Serum and secretory IgA in axenic and holoxenic mice. J. Immunol. 107, 1656-1662 (1971).
    • (1971) J. Immunol. , vol.107 , pp. 1656-1662
    • Benveniste, J.1    Lespinats, G.2    Salomon, J.3
  • 34
    • 1242296822 scopus 로고    scopus 로고
    • Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut
    • Suzuki, K. et al. Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut. Proc. Natl. Acad. Sci. USA 101, 1981-1986 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 1981-1986
    • Suzuki, K.1
  • 35
    • 84941647683 scopus 로고    scopus 로고
    • BALB/c and C57BL/6 mice differ in polyreactive IgA abundance, which impacts the generation of antigen-specific IgA and microbiota diversity
    • Fransen, F. et al. BALB/c and C57BL/6 mice differ in polyreactive IgA abundance, which impacts the generation of antigen-specific IgA and microbiota diversity. Immunity 43, 527-540 (2015).
    • (2015) Immunity , vol.43 , pp. 527-540
    • Fransen, F.1
  • 37
    • 84881068658 scopus 로고    scopus 로고
    • The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis
    • Smith, P.M. et al. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science 341, 569-573 (2013).
    • (2013) Science , vol.341 , pp. 569-573
    • Smith, P.M.1
  • 38
    • 84984851216 scopus 로고    scopus 로고
    • Interferon Tau affects mouse intestinal microbiota and expression of IL-17
    • Ren, W. et al. Interferon Tau affects mouse intestinal microbiota and expression of IL-17. Mediat. Inflamm. 2016, 2839232 (2016).
    • (2016) Mediat. Inflamm. , vol.2016 , pp. 2839232
    • Ren, W.1
  • 39
    • 0027215978 scopus 로고
    • Expansion of alpha beta T-cell receptor-bearing intestinal intraepithelial lymphocytes after microbial colonization in germ-free mice and its independence from thymus
    • Umesaki, Y., Setoyama, H.,Matsumoto, S. &Okada, Y. Expansion of alpha beta T-cell receptor-bearing intestinal intraepithelial lymphocytes after microbial colonization in germ-free mice and its independence from thymus. Immunology 79, 32-37 (1993).
    • (1993) Immunology , vol.79 , pp. 32-37
    • Umesaki, Y.1    Setoyama, H.2    Matsumoto, S.3    Okada, Y.4
  • 40
    • 79959664629 scopus 로고    scopus 로고
    • The light anddark sidesof intestinal intraepithelial lymphocytes
    • Cheroutre, H., Lambolez, F. &Mucida, D. The light anddark sidesof intestinal intraepithelial lymphocytes. Nat. Rev. Immunol. 11, 445-456 (2011).
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 445-456
    • Cheroutre, H.1    Lambolez, F.2    Mucida, D.3
  • 41
    • 84976336408 scopus 로고    scopus 로고
    • Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis
    • Klose, C.S. &Artis, D. Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis. Nat. Immunol. 17, 765-774 (2016).
    • (2016) Nat. Immunol. , vol.17 , pp. 765-774
    • Klose, C.S.1    Artis, D.2
  • 42
    • 84907968021 scopus 로고    scopus 로고
    • Development, differentiation, and diversity of innate lymphoid cells
    • Diefenbach, A., Colonna, M. &Koyasu, S. Development, differentiation, and diversity of innate lymphoid cells. Immunity 41, 354-365 (2014).
    • (2014) Immunity , vol.41 , pp. 354-365
    • Diefenbach, A.1    Colonna, M.2    Koyasu, S.3
  • 43
    • 47249119632 scopus 로고    scopus 로고
    • Latencyassociated peptide identifies a novel CD4CD25 regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis
    • Chen, M.L., Yan, B.S., Bando, Y., Kuchroo, V.K. &Weiner, H.L. Latencyassociated peptide identifies a novel CD4CD25 regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis. J. Immunol. 180, 7327-7337 (2008).
    • (2008) J. Immunol. , vol.180 , pp. 7327-7337
    • Chen, M.L.1    Yan, B.S.2    Bando, Y.3    Kuchroo, V.K.4    Weiner, H.L.5
  • 44
    • 84859390119 scopus 로고    scopus 로고
    • Induced CD4Foxp3 regulatory T cells in immune tolerance
    • Bilate, A.M. &Lafaille, J.J. Induced CD4Foxp3 regulatory T cells in immune tolerance. Annu. Rev. Immunol. 30, 733-758 (2012).
    • (2012) Annu. Rev. Immunol. , vol.30 , pp. 733-758
    • Bilate, A.M.1    Lafaille, J.J.2
  • 45
    • 84928484992 scopus 로고    scopus 로고
    • IFN-alpha/beta receptor signaling promotes regulatory T cell development and function under stress conditions
    • Metidji, A., Rieder, S.A., Glass, D.D., Cremer, I., Punkosdy, G.A. &Shevach, E.M. IFN-alpha/beta receptor signaling promotes regulatory T cell development and function under stress conditions. J. Immunol. 194, 4265-4276 (2015).
    • (2015) J. Immunol. , vol.194 , pp. 4265-4276
    • Metidji, A.1    Rieder, S.A.2    Glass, D.D.3    Cremer, I.4    Punkosdy, G.A.5    Shevach, E.M.6
  • 46
    • 84862740015 scopus 로고    scopus 로고
    • Type i interferons maintain Foxp3 expression and T-regulatory cell functions under inflammatory conditions in mice
    • Lee, S.E. et al. Type I interferons maintain Foxp3 expression and T-regulatory cell functions under inflammatory conditions in mice. Gastroenterology 143, 145-154 (2012).
    • (2012) Gastroenterology , vol.143 , pp. 145-154
    • Lee, S.E.1
  • 48
    • 0029866240 scopus 로고    scopus 로고
    • Inflammatory bowel disease in C.B-17 scid mice reconstituted with the CD45RBhigh subset of CD4 T cells
    • Leach, M.W., Bean, A.G., Mauze, S., Coffman, R.L. &Powrie, F. Inflammatory bowel disease in C.B-17 scid mice reconstituted with the CD45RBhigh subset of CD4 T cells. Am. J. Pathol. 148, 1503-1515 (1996).
    • (1996) Am. J. Pathol. , vol.148 , pp. 1503-1515
    • Leach, M.W.1    Bean, A.G.2    Mauze, S.3    Coffman, R.L.4    Powrie, F.5
  • 49
    • 14644403009 scopus 로고    scopus 로고
    • Tolllike receptor 9-induced type i IFN protects mice from experimental colitis
    • Katakura, K., Lee, J., Rachmilewitz, D., Li, G., Eckmann, L. &Raz, E. Tolllike receptor 9-induced type I IFN protects mice from experimental colitis. J. Clin. Invest. 115, 695-702 (2005).
    • (2005) J. Clin. Invest. , vol.115 , pp. 695-702
    • Katakura, K.1    Lee, J.2    Rachmilewitz, D.3    Li, G.4    Eckmann, L.5    Raz, E.6
  • 50
    • 0036241068 scopus 로고    scopus 로고
    • Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis
    • Rachmilewitz, D. et al. Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis. Gastroenterology 122, 1428-1441 (2002).
    • (2002) Gastroenterology , vol.122 , pp. 1428-1441
    • Rachmilewitz, D.1
  • 51
    • 84894066731 scopus 로고    scopus 로고
    • Type i interferon signalling in the intestinal epithelium affects Paneth cells, microbial ecology and epithelial regeneration
    • Tschurtschenthaler, M. et al. Type I interferon signalling in the intestinal epithelium affects Paneth cells, microbial ecology and epithelial regeneration. Gut 63, 1921-1931 (2014).
    • (2014) Gut , vol.63 , pp. 1921-1931
    • Tschurtschenthaler, M.1
  • 52
    • 0023950659 scopus 로고    scopus 로고
    • The influence of exogenous antigenic stimulation on the specificity repertoire of background immunoglobulin-secreting cells of different isotypes
    • Bos,N.A., Meeuwsen, C.G., Wostmann,B.S., Pleasants, J.R. &Benner, R. The influence of exogenous antigenic stimulation on the specificity repertoire of background immunoglobulin-secreting cells of different isotypes. Cell. Immunol. 112, 371-380.
    • Cell. Immunol. , vol.112 , pp. 371-380
    • Bos, N.A.1    Meeuwsen, C.G.2    Wostmann, B.S.3    Pleasants, J.R.4    Benner, R.5
  • 53
    • 84962433328 scopus 로고    scopus 로고
    • Secretory IgA in the coordination of establishment and maintenance of the microbiota
    • Pabst, O., Cerovic, V. &Hornef, M. Secretory IgA in the coordination of establishment and maintenance of the microbiota. Trends Immunol. 37, 287-296 (2016).
    • (2016) Trends Immunol. , vol.37 , pp. 287-296
    • Pabst, O.1    Cerovic, V.2    Hornef, M.3
  • 54
    • 84879075084 scopus 로고    scopus 로고
    • Intestinal microbiota: A source of novel biomarkers in inflammatory bowel diseases?
    • Berry, D. &Reinisch,W. Intestinal microbiota: a source of novel biomarkers in inflammatory bowel diseases?. Best Pract. Res. Clin. Gastroenterol. 27, 47-58 (2013).
    • (2013) Best Pract. Res. Clin. Gastroenterol. , vol.27 , pp. 47-58
    • Berry, D.1    Reinisch, W.2
  • 55
    • 77649180268 scopus 로고    scopus 로고
    • The role of intestinal bifidobacteria onimmune system development in young rats
    • Dong,P.,Yang,Y.&Wang,W.P. The role of intestinal bifidobacteria onimmune system development in young rats. Early Hum. Dev. 86, 51-58 (2010).
    • (2010) Early Hum. Dev. , vol.86 , pp. 51-58
    • Dong, P.1    Yang, Y.2    Wang, W.P.3
  • 57
    • 85007529996 scopus 로고    scopus 로고
    • Functional and phenotypic heterogeneity of group 3 innate lymphoid cells
    • Melo-Gonzalez, F. &Hepworth, M.R. Functional and phenotypic heterogeneity of group 3 innate lymphoid cells. Immunology 150, 265-275 (2017).
    • (2017) Immunology , vol.150 , pp. 265-275
    • Melo-Gonzalez, F.1    Hepworth, M.R.2
  • 58
    • 84940527399 scopus 로고    scopus 로고
    • IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin-EGFR interactions
    • Monticelli, L.A., Osborne, L.C., Noti, M., Tran, S.V., Zaiss, D.M. &Artis, D. IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin-EGFR interactions. Proc.Natl. Acad. Sci. USA 112, 10762-10767 (2015).
    • (2015) Proc.Natl. Acad. Sci. USA , vol.112 , pp. 10762-10767
    • Monticelli, L.A.1    Osborne, L.C.2    Noti, M.3    Tran, S.V.4    Zaiss, D.M.5    Artis, D.6
  • 59
    • 84871369338 scopus 로고    scopus 로고
    • Essential contribution of IRF3 to intestinal homeostasis and microbiota-mediated Tslp gene induction
    • Negishi, H. et al. Essential contribution of IRF3 to intestinal homeostasis and microbiota-mediated Tslp gene induction. Proc. Natl. Acad. Sci. USA 109, 21016-21021 (2012).
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 21016-21021
    • Negishi, H.1
  • 60
    • 84952869199 scopus 로고    scopus 로고
    • Unique and redundant functions of NKp46 ILC3s in models of intestinal inflammation
    • Song, C. et al. Unique and redundant functions of NKp46 ILC3s in models of intestinal inflammation. J. Exp. Med. 212, 1869-1882 (2015).
    • (2015) J. Exp. Med. , vol.212 , pp. 1869-1882
    • Song, C.1
  • 61
    • 77951878587 scopus 로고    scopus 로고
    • Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology
    • Buonocore, S. et al. Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature 464, 1371-1375 (2010).
    • (2010) Nature , vol.464 , pp. 1371-1375
    • Buonocore, S.1
  • 62
    • 85027945857 scopus 로고    scopus 로고
    • Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues
    • Bernink, J.H. et al. Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues. Nat. Immunol. 14, 221-229 (2013).
    • (2013) Nat. Immunol. , vol.14 , pp. 221-229
    • Bernink, J.H.1
  • 63
    • 33746377279 scopus 로고    scopus 로고
    • Regulatory Tcells suppress systemic and mucosal immune activation to control intestinal inflammation
    • Izcue, A., Coombes, J.L. &Powrie, F. Regulatory Tcells suppress systemic and mucosal immune activation to control intestinal inflammation. Immunol. Rev. 212, 256-271 (2006).
    • (2006) Immunol. Rev. , vol.212 , pp. 256-271
    • Izcue, A.1    Coombes, J.L.2    Powrie, F.3
  • 64
    • 84939478859 scopus 로고    scopus 로고
    • Regulatory immune cells in regulation of intestinal inflammatory response to microbiota
    • Sun, M., He, C., Cong, Y. &Liu, Z. Regulatory immune cells in regulation of intestinal inflammatory response to microbiota. Mucosal Immunol. 8, 969-978 (2015).
    • (2015) Mucosal Immunol. , vol.8 , pp. 969-978
    • Sun, M.1    He, C.2    Cong, Y.3    Liu, Z.4
  • 65
    • 85021353353 scopus 로고    scopus 로고
    • Tissue adaptation: Implications for gut immunity and tolerance
    • Faria, A.M.C., Reis, B.S. &Mucida, D. Tissue adaptation: Implications for gut immunity and tolerance. J. Exp. Med. 214, 1211-1226 (2017).
    • (2017) J. Exp. Med. , vol.214 , pp. 1211-1226
    • Faria, A.M.C.1    Reis, B.S.2    Mucida, D.3
  • 66
    • 84921786777 scopus 로고    scopus 로고
    • Regional specialization within the intestinal immune system
    • Mowat, A.M. &Agace, W.W. Regional specialization within the intestinal immune system. Nat. Rev. Immunol. 14, 667-685 (2014).
    • (2014) Nat. Rev. Immunol. , vol.14 , pp. 667-685
    • Mowat, A.M.1    Agace, W.W.2
  • 67
    • 11444256541 scopus 로고    scopus 로고
    • Pranlukast inhibits NF-kappaB activation and MUC2 gene expression in cultured human epithelial cells
    • Ishinaga, H., Takeuchi, K., Kishioka, C., Suzuki, S.,Basbaum, C. &Majima, Y. Pranlukast inhibits NF-kappaB activation and MUC2 gene expression in cultured human epithelial cells. Pharmacology 73, 89-96 (2005).
    • (2005) Pharmacology , vol.73 , pp. 89-96
    • Ishinaga, H.1    Takeuchi, K.2    Kishioka, C.3    Suzuki, S.4    Basbaum, C.5    Majima, Y.6
  • 68
    • 12444252936 scopus 로고    scopus 로고
    • TNF-alpha activates MUC2 transcription via NFkappaB but inhibits via JNK activation
    • Ahn, D.H. et al. TNF-alpha activates MUC2 transcription via NFkappaB but inhibits via JNK activation. Cell. Physiol. Biochem. 15, 29-40 (2005).
    • (2005) Cell. Physiol. Biochem. , vol.15 , pp. 29-40
    • Ahn, D.H.1
  • 69
    • 0037160093 scopus 로고    scopus 로고
    • Transforming growth factor-beta-Smad signaling pathway cooperates with NF-kappa B to mediate nontypeable Haemophilus influenzae-induced MUC2 mucin transcription
    • Jono, H. et al. Transforming growth factor-beta-Smad signaling pathway cooperates with NF-kappa B to mediate nontypeable Haemophilus influenzae-induced MUC2 mucin transcription. J. Biol. Chem. 277, 45547-45557 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 45547-45557
    • Jono, H.1
  • 70
    • 84886280379 scopus 로고    scopus 로고
    • Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals
    • Shan, M. et al. Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals. Science 342, 447-453 (2013).
    • (2013) Science , vol.342 , pp. 447-453
    • Shan, M.1
  • 71
    • 0036500996 scopus 로고    scopus 로고
    • Colorectal cancer in mice genetically deficient in the mucin Muc2
    • Velcich, A. et al. Colorectal cancer in mice genetically deficient in the mucin Muc2. Science 295, 1726-1729 (2002).
    • (2002) Science , vol.295 , pp. 1726-1729
    • Velcich, A.1
  • 72
    • 84941804631 scopus 로고    scopus 로고
    • Ancient origin of cGAS-STING reveals mechanism of universal 2',3' cGAMP signaling
    • Kranzusch, P.J., Wilson, S.C., Lee, A.S., Berger, J.M., Doudna, J.A. &Vance, R.E. Ancient origin of cGAS-STING reveals mechanism of universal 2',3' cGAMP signaling. Mol. Cell 59, 891-903 (2015).
    • (2015) Mol. Cell , vol.59 , pp. 891-903
    • Kranzusch, P.J.1    Wilson, S.C.2    Lee, A.S.3    Berger, J.M.4    Doudna, J.A.5    Vance, R.E.6
  • 73
    • 55749083885 scopus 로고    scopus 로고
    • Great times for small molecules: C-di-AMP, a second messenger candidate in Bacteria and Archaea
    • Romling, U. Great times for small molecules: c-di-AMP, a second messenger candidate in Bacteria and Archaea. Sci. Signal. 1, pe39 (2008).
    • (2008) Sci. Signal. , vol.1 , pp. pe39
    • Romling, U.1
  • 74
    • 84880508067 scopus 로고    scopus 로고
    • Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING
    • Zhang, X. et al. Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol. Cell 51, 226-235 (2013).
    • (2013) Mol. Cell , vol.51 , pp. 226-235
    • Zhang, X.1
  • 75
    • 79961003564 scopus 로고    scopus 로고
    • MyD88 and STING signaling pathways are required for IRF3-mediated IFN-beta induction in response to Brucella abortus infection
    • de Almeida, L.A. et al. MyD88 and STING signaling pathways are required for IRF3-mediated IFN-beta induction in response to Brucella abortus infection. PLoS ONE 6, e23135 (2011).
    • (2011) PLoS ONE , vol.6 , pp. e23135
    • De Almeida, L.A.1
  • 76
    • 0028519015 scopus 로고
    • Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4 T cells
    • Powrie, F., Leach, M.W., Mauze, S., Menon, S., Caddle, L.B. &Coffman, R.L. Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4 T cells. Immunity 1, 553-562 (1994).
    • (1994) Immunity , vol.1 , pp. 553-562
    • Powrie, F.1    Leach, M.W.2    Mauze, S.3    Menon, S.4    Caddle, L.B.5    Coffman, R.L.6
  • 77
    • 85016122461 scopus 로고    scopus 로고
    • Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes
    • Marino, E. et al. Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes. Nat. Immunol. 18, 552-562 (2017).
    • (2017) Nat. Immunol. , vol.18 , pp. 552-562
    • Marino, E.1
  • 78
    • 0037346154 scopus 로고    scopus 로고
    • Oral tolerance induced by continuous feeding: Enhanced up-regulation of transforming growth factor-beta/interleukin-10 and suppression of experimental autoimmune encephalomyelitis
    • Faria, A.M., Maron, R., Ficker, S.M., Slavin, A.J., Spahn, T. &Weiner, H.L. Oral tolerance induced by continuous feeding: enhanced up-regulation of transforming growth factor-beta/interleukin-10 and suppression of experimental autoimmune encephalomyelitis. J. Autoimmun. 20, 135-145 (2003).
    • (2003) J. Autoimmun. , vol.20 , pp. 135-145
    • Faria, A.M.1    Maron, R.2    Ficker, S.M.3    Slavin, A.J.4    Spahn, T.5    Weiner, H.L.6


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