메뉴 건너뛰기




Volumn 30, Issue 6, 2018, Pages

Cardiovascular safety of prokinetic agents: A focus on drug-induced arrhythmias

Author keywords

5 HT4; adverse drug reactions; cytochrome P450; drug induced long QT syndrome; gastrointestinal motility; torsades de pointes

Indexed keywords

ANTIARRHYTHMIC AGENT; ANTIBIOTIC AGENT; ANTIDEPRESSANT AGENT; ANTIEMETIC AGENT; ANTIFUNGAL AGENT; ANTIHISTAMINIC AGENT; ANTINEOPLASTIC AGENT; CHOLINESTERASE INHIBITOR; CISAPRIDE; DOMPERIDONE; DOPAMINE RECEPTOR BLOCKING AGENT; ERYTHROMYCIN; GHRELIN RECEPTOR; MOTILIN RECEPTOR AGONIST; NEUROLEPTIC AGENT; OPIATE AGONIST; PROKINETIC AGENT; SEROTONIN AGONIST; TEGASEROD; ANTIINFECTIVE AGENT; CARDIOVASCULAR AGENT; GASTROINTESTINAL AGENT;

EID: 85047856104     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/nmo.13302     Document Type: Review
Times cited : (53)

References (136)
  • 1
    • 38849092560 scopus 로고    scopus 로고
    • Development of drugs for gastrointestinal motor disorders: translating science to clinical need
    • Sanger GJ, Alpers DH. Development of drugs for gastrointestinal motor disorders: translating science to clinical need. Neurogastroenterol Motil. 2008;20:177-184.
    • (2008) Neurogastroenterol Motil , vol.20 , pp. 177-184
    • Sanger, G.J.1    Alpers, D.H.2
  • 2
    • 84885080634 scopus 로고    scopus 로고
    • Pharmacological agents currently in clinical trials for disorders in neurogastroenterology
    • Camilleri M. Pharmacological agents currently in clinical trials for disorders in neurogastroenterology. J Clin Invest. 2013;123:4111-4120.
    • (2013) J Clin Invest , vol.123 , pp. 4111-4120
    • Camilleri, M.1
  • 3
    • 0000354570 scopus 로고
    • Prolonged Q-T interval – what does it mean
    • Schwartz PJ, Moss AJ. Prolonged Q-T interval – what does it mean. J Cardiovasc Med. 1982;7:1317-1330.
    • (1982) J Cardiovasc Med , vol.7 , pp. 1317-1330
    • Schwartz, P.J.1    Moss, A.J.2
  • 4
    • 0021615201 scopus 로고
    • Recurrent ventricular-tachycardia associated with Qt prolongation after mitral-valve replacement and its association with intravenous administration of erythromycin
    • Mccomb JM, Campbell NPS, Cleland J. Recurrent ventricular-tachycardia associated with Qt prolongation after mitral-valve replacement and its association with intravenous administration of erythromycin. Am J Cardiol. 1984;54:922-923.
    • (1984) Am J Cardiol , vol.54 , pp. 922-923
    • Mccomb, J.M.1    Campbell, N.P.S.2    Cleland, J.3
  • 6
    • 0141648403 scopus 로고    scopus 로고
    • QTc interval prolongation associated with intravenous methadone
    • Kornick CA, Kilborn MJ, Santiago-Palma J, et al. QTc interval prolongation associated with intravenous methadone. Pain. 2003;105:499-506.
    • (2003) Pain , vol.105 , pp. 499-506
    • Kornick, C.A.1    Kilborn, M.J.2    Santiago-Palma, J.3
  • 7
    • 0035212983 scopus 로고    scopus 로고
    • Rates of torsades de pointes associated with ciprofloxacin, ofloxacin, levofloxacin, gatifloxacin, and moxifloxacin
    • Frothingham R. Rates of torsades de pointes associated with ciprofloxacin, ofloxacin, levofloxacin, gatifloxacin, and moxifloxacin. Pharmacotherapy. 2001;21:1468-1472.
    • (2001) Pharmacotherapy , vol.21 , pp. 1468-1472
    • Frothingham, R.1
  • 9
    • 84951573634 scopus 로고    scopus 로고
    • Drug-induced proarrhythmia: risk factors and electrophysiological mechanisms
    • Frommeyer G, Eckardt L. Drug-induced proarrhythmia: risk factors and electrophysiological mechanisms. Nat Rev Cardiol. 2016;13:36-47.
    • (2016) Nat Rev Cardiol , vol.13 , pp. 36-47
    • Frommeyer, G.1    Eckardt, L.2
  • 10
    • 85008670859 scopus 로고    scopus 로고
    • Predicting the unpredictable: drug-induced QT prolongation and torsades de pointes
    • Schwartz PJ, Woosley RL. Predicting the unpredictable: drug-induced QT prolongation and torsades de pointes. J Am Coll Cardiol. 2016;67:1639-1650.
    • (2016) J Am Coll Cardiol , vol.67 , pp. 1639-1650
    • Schwartz, P.J.1    Woosley, R.L.2
  • 11
    • 84861481127 scopus 로고    scopus 로고
    • Potassium-channel mutations and cardiac arrhythmias–diagnosis and therapy
    • Giudicessi JR, Ackerman MJ. Potassium-channel mutations and cardiac arrhythmias–diagnosis and therapy. Nat Rev Cardiol. 2012;9:319-332.
    • (2012) Nat Rev Cardiol , vol.9 , pp. 319-332
    • Giudicessi, J.R.1    Ackerman, M.J.2
  • 12
    • 64549103023 scopus 로고    scopus 로고
    • AHA/ACCF/HRS Recommendations for the Standardization and Interpretation of the Electrocardiogram Part IV: the ST Segment, T and U Waves, and the QT Interval A Scientific Statement From the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society
    • Rautaharju PM, Surawicz B, Gettes LS. AHA/ACCF/HRS Recommendations for the Standardization and Interpretation of the Electrocardiogram Part IV: the ST Segment, T and U Waves, and the QT Interval A Scientific Statement From the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society. Circulation. 2009;119:E241-E250.
    • (2009) Circulation , vol.119 , pp. E241-E250
    • Rautaharju, P.M.1    Surawicz, B.2    Gettes, L.S.3
  • 14
    • 85061167148 scopus 로고    scopus 로고
    • Prevention of torsade de pointes in hospital settings: a scientific statement From the American Heart Association and the American College of Cardiology Foundation (vol 121, pg 1047, 2010)
    • Drew BJ. Prevention of torsade de pointes in hospital settings: a scientific statement From the American Heart Association and the American College of Cardiology Foundation (vol 121, pg 1047, 2010). Circulation. 2010;122:E440-E440.
    • (2010) Circulation , vol.122 , pp. E440
    • Drew, B.J.1
  • 16
    • 0002304545 scopus 로고
    • Quinidine syncope. Paroxysmal ventricular fibrillation occurring during treatment of chronic atrial arrhythmias
    • Selzer A, Wray HW. Quinidine syncope. Paroxysmal ventricular fibrillation occurring during treatment of chronic atrial arrhythmias. Circulation. 1964;30:17-26.
    • (1964) Circulation , vol.30 , pp. 17-26
    • Selzer, A.1    Wray, H.W.2
  • 17
    • 0027468346 scopus 로고
    • Terfenadine-ketoconazole interaction. Pharmacokinetic and electrocardiographic consequences
    • Honig PK, Wortham DC, Zamani K, Conner DP, Mullin JC, Cantilena LR. Terfenadine-ketoconazole interaction. Pharmacokinetic and electrocardiographic consequences. JAMA. 1993;269:1513-1518.
    • (1993) JAMA , vol.269 , pp. 1513-1518
    • Honig, P.K.1    Wortham, D.C.2    Zamani, K.3    Conner, D.P.4    Mullin, J.C.5    Cantilena, L.R.6
  • 18
    • 0027474601 scopus 로고
    • Mechanism of the cardiotoxic actions of terfenadine
    • Woosley RL, Chen Y, Freiman JP, Gillis RA. Mechanism of the cardiotoxic actions of terfenadine. JAMA. 1993;269:1532-1536.
    • (1993) JAMA , vol.269 , pp. 1532-1536
    • Woosley, R.L.1    Chen, Y.2    Freiman, J.P.3    Gillis, R.A.4
  • 20
    • 0034967764 scopus 로고    scopus 로고
    • Postmarketing reports of QT prolongation and ventricular arrhythmia in association with cisapride and food and drug administration regulatory actions
    • Wysowski DK, Corken A, Gallo-Torres H, Talarico L, Rodriguez EM. Postmarketing reports of QT prolongation and ventricular arrhythmia in association with cisapride and food and drug administration regulatory actions. Am J Gastroenterol. 2001;96:1698-1703.
    • (2001) Am J Gastroenterol , vol.96 , pp. 1698-1703
    • Wysowski, D.K.1    Corken, A.2    Gallo-Torres, H.3    Talarico, L.4    Rodriguez, E.M.5
  • 21
    • 0029761822 scopus 로고    scopus 로고
    • HERG, a primary human ventricular target of the nonsedating antihistamine terfenadine
    • Roy M, Dumaine R, Brown AM. HERG, a primary human ventricular target of the nonsedating antihistamine terfenadine. Circulation. 1996;94:817-823.
    • (1996) Circulation , vol.94 , pp. 817-823
    • Roy, M.1    Dumaine, R.2    Brown, A.M.3
  • 22
    • 0031893970 scopus 로고    scopus 로고
    • Block of the rapid component of the delayed rectifier potassium current by the prokinetic agent cisapride underlies drug-related lengthening of the QT interval
    • Drolet B, Khalifa M, Daleau P, Hamelin BA, Turgeon J. Block of the rapid component of the delayed rectifier potassium current by the prokinetic agent cisapride underlies drug-related lengthening of the QT interval. Circulation. 1998;97:204-210.
    • (1998) Circulation , vol.97 , pp. 204-210
    • Drolet, B.1    Khalifa, M.2    Daleau, P.3    Hamelin, B.A.4    Turgeon, J.5
  • 23
    • 0033818157 scopus 로고    scopus 로고
    • Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate
    • Mitcheson JS, Chen J, Sanguinetti MC. Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate. J Gen Physiol. 2000;115:229-240.
    • (2000) J Gen Physiol , vol.115 , pp. 229-240
    • Mitcheson, J.S.1    Chen, J.2    Sanguinetti, M.C.3
  • 24
    • 33750480200 scopus 로고    scopus 로고
    • Drug-induced long QT syndrome: hERG K+ channel block and disruption of protein trafficking by fluoxetine and norfluoxetine
    • Rajamani S, Eckhardt LL, Valdivia CR, et al. Drug-induced long QT syndrome: hERG K+ channel block and disruption of protein trafficking by fluoxetine and norfluoxetine. Br J Pharmacol. 2006;149:481-489.
    • (2006) Br J Pharmacol , vol.149 , pp. 481-489
    • Rajamani, S.1    Eckhardt, L.L.2    Valdivia, C.R.3
  • 25
    • 19944429871 scopus 로고    scopus 로고
    • Pentamidine-induced long QT syndrome and block of hERG trafficking
    • Kuryshev YA, Ficker E, Wang L, et al. Pentamidine-induced long QT syndrome and block of hERG trafficking. J Pharmacol Exp Ther. 2005;312:316-323.
    • (2005) J Pharmacol Exp Ther , vol.312 , pp. 316-323
    • Kuryshev, Y.A.1    Ficker, E.2    Wang, L.3
  • 26
    • 18744395493 scopus 로고    scopus 로고
    • Protein trafficking abnormalities: a new mechanism in drug-induced long QT syndrome
    • Eckhardt LL, Rajamani S, January CT. Protein trafficking abnormalities: a new mechanism in drug-induced long QT syndrome. Br J Pharmacol. 2005;145:3-4.
    • (2005) Br J Pharmacol , vol.145 , pp. 3-4
    • Eckhardt, L.L.1    Rajamani, S.2    January, C.T.3
  • 27
    • 84860376625 scopus 로고    scopus 로고
    • Suppression of phosphoinositide 3-kinase signaling and alteration of multiple ion currents in drug-induced long QT syndrome
    • Lu Z, Wu CY, Jiang YP, et al. Suppression of phosphoinositide 3-kinase signaling and alteration of multiple ion currents in drug-induced long QT syndrome. Sci Transl Med. 2012;4:131ra50.
    • (2012) Sci Transl Med , vol.4 , pp. 131ra50
    • Lu, Z.1    Wu, C.Y.2    Jiang, Y.P.3
  • 28
    • 84904573224 scopus 로고    scopus 로고
    • Screening for acute IKr block is insufficient to detect torsades de pointes liability: role of late sodium current
    • Yang T, Chun YW, Stroud DM, et al. Screening for acute IKr block is insufficient to detect torsades de pointes liability: role of late sodium current. Circulation. 2014;130:224-234.
    • (2014) Circulation , vol.130 , pp. 224-234
    • Yang, T.1    Chun, Y.W.2    Stroud, D.M.3
  • 29
    • 85046683600 scopus 로고    scopus 로고
    • CredibleMeds. https://crediblemeds.org/. 2017.
    • (2017) CredibleMeds
  • 31
    • 0014076676 scopus 로고
    • Gastrointestinal actions of metoclopramide. An experimental study
    • Jacoby HI, Brodie DA. Gastrointestinal actions of metoclopramide. An experimental study. Gastroenterology. 1967;52:676-684.
    • (1967) Gastroenterology , vol.52 , pp. 676-684
    • Jacoby, H.I.1    Brodie, D.A.2
  • 32
    • 34548139349 scopus 로고    scopus 로고
    • Domperidone: review of pharmacology and clinical applications in gastroenterology
    • Reddymasu SC, Soykan I, McCallum RW. Domperidone: review of pharmacology and clinical applications in gastroenterology. Am J Gastroenterol. 2007;102:2036-2045.
    • (2007) Am J Gastroenterol , vol.102 , pp. 2036-2045
    • Reddymasu, S.C.1    Soykan, I.2    McCallum, R.W.3
  • 33
    • 1542359492 scopus 로고    scopus 로고
    • Review article: clinical implications of enteric and central D2 receptor blockade by antidopaminergic gastrointestinal prokinetics
    • Tonini M, Cipollina L, Poluzzi E, Crema F, Corazza GR, De Ponti F. Review article: clinical implications of enteric and central D2 receptor blockade by antidopaminergic gastrointestinal prokinetics. Aliment Pharmacol Ther. 2004;19:379-390.
    • (2004) Aliment Pharmacol Ther , vol.19 , pp. 379-390
    • Tonini, M.1    Cipollina, L.2    Poluzzi, E.3    Crema, F.4    Corazza, G.R.5    De Ponti, F.6
  • 35
    • 71449126721 scopus 로고    scopus 로고
    • Review article: metoclopramide and tardive dyskinesia
    • Rao AS, Camilleri M. Review article: metoclopramide and tardive dyskinesia. Aliment Pharmacol Ther. 2010;31:11-19.
    • (2010) Aliment Pharmacol Ther , vol.31 , pp. 11-19
    • Rao, A.S.1    Camilleri, M.2
  • 36
    • 84878931697 scopus 로고    scopus 로고
    • The metoclopramide black box warning for tardive dyskinesia: effect on clinical practice, adverse event reporting, and prescription drug lawsuits
    • Ehrenpreis ED, Deepak P, Sifuentes H, Devi R, Du H, Leikin JB. The metoclopramide black box warning for tardive dyskinesia: effect on clinical practice, adverse event reporting, and prescription drug lawsuits. Am J Gastroenterol. 2013;108:866-872.
    • (2013) Am J Gastroenterol , vol.108 , pp. 866-872
    • Ehrenpreis, E.D.1    Deepak, P.2    Sifuentes, H.3    Devi, R.4    Du, H.5    Leikin, J.B.6
  • 37
    • 34250831122 scopus 로고    scopus 로고
    • Evidence of lowest brain penetration of an antiemetic drug, metopimazine, compared to domperidone, metoclopramide and chlorpromazine, using an in vitro model of the blood-brain barrier
    • Jolliet P, Nion S, Allain-Veyrac G, et al. Evidence of lowest brain penetration of an antiemetic drug, metopimazine, compared to domperidone, metoclopramide and chlorpromazine, using an in vitro model of the blood-brain barrier. Pharmacol Res. 2007;56:11-17.
    • (2007) Pharmacol Res , vol.56 , pp. 11-17
    • Jolliet, P.1    Nion, S.2    Allain-Veyrac, G.3
  • 38
    • 17844373845 scopus 로고    scopus 로고
    • Comparison of the effects of metoclopramide and domperidone on HERG channels
    • Claassen S, Zunkler BJ. Comparison of the effects of metoclopramide and domperidone on HERG channels. Pharmacology. 2005;74:31-36.
    • (2005) Pharmacology , vol.74 , pp. 31-36
    • Claassen, S.1    Zunkler, B.J.2
  • 39
    • 84875232401 scopus 로고    scopus 로고
    • Domperidone: limited benefits with significant risk for sudden cardiac death
    • Hondeghem LM. Domperidone: limited benefits with significant risk for sudden cardiac death. J Cardiovasc Pharmacol. 2013;61:218-225.
    • (2013) J Cardiovasc Pharmacol , vol.61 , pp. 218-225
    • Hondeghem, L.M.1
  • 40
    • 0019491264 scopus 로고
    • On the pharmacokinetics of domperidone in animals and man. IV. The pharmacokinetics of intravenous domperidone and its bioavailability in man following intramuscular, oral and rectal administration
    • Heykants J, Hendriks R, Meuldermans W, Michiels M, Scheygrond H, Reyntjens H. On the pharmacokinetics of domperidone in animals and man. IV. The pharmacokinetics of intravenous domperidone and its bioavailability in man following intramuscular, oral and rectal administration. Eur J Drug Metab Pharmacokinet. 1981;6:61-70.
    • (1981) Eur J Drug Metab Pharmacokinet , vol.6 , pp. 61-70
    • Heykants, J.1    Hendriks, R.2    Meuldermans, W.3    Michiels, M.4    Scheygrond, H.5    Reyntjens, H.6
  • 41
    • 0036185735 scopus 로고    scopus 로고
    • Determination of domperidone in human plasma by LC-MS and its pharmacokinetics in healthy Chinese volunteers
    • Wu MS, Gao L, Cai XH, Wang GJ. Determination of domperidone in human plasma by LC-MS and its pharmacokinetics in healthy Chinese volunteers. Acta Pharmacol Sin. 2002;23:285-288.
    • (2002) Acta Pharmacol Sin , vol.23 , pp. 285-288
    • Wu, M.S.1    Gao, L.2    Cai, X.H.3    Wang, G.J.4
  • 42
    • 11244267290 scopus 로고    scopus 로고
    • Identification of the cytochrome P450 enzymes involved in the metabolism of domperidone
    • Simard C, Michaud V, Gibbs B, Masse R, Lessard E, Turgeon J. Identification of the cytochrome P450 enzymes involved in the metabolism of domperidone. Xenobiotica. 2004;34:1013-1023.
    • (2004) Xenobiotica , vol.34 , pp. 1013-1023
    • Simard, C.1    Michaud, V.2    Gibbs, B.3    Masse, R.4    Lessard, E.5    Turgeon, J.6
  • 43
    • 33646741238 scopus 로고    scopus 로고
    • The ATP-binding cassette transporters and their implication in drug disposition: a special look at the heart
    • Couture L, Nash JA, Turgeon J. The ATP-binding cassette transporters and their implication in drug disposition: a special look at the heart. Pharmacol Rev. 2006;58:244-258.
    • (2006) Pharmacol Rev , vol.58 , pp. 244-258
    • Couture, L.1    Nash, J.A.2    Turgeon, J.3
  • 44
    • 78650798184 scopus 로고    scopus 로고
    • Metabolic activity and mRNA levels of human cardiac CYP450s involved in drug metabolism
    • Michaud V, Frappier M, Dumas MC, Turgeon J. Metabolic activity and mRNA levels of human cardiac CYP450s involved in drug metabolism. PLoS ONE. 2010;5:e15666.
    • (2010) PLoS ONE , vol.5
    • Michaud, V.1    Frappier, M.2    Dumas, M.C.3    Turgeon, J.4
  • 45
    • 26444560585 scopus 로고    scopus 로고
    • Non-cardiac QTc-prolonging drugs and the risk of sudden cardiac death
    • Straus SM, Sturkenboom MC, Bleumink GS, et al. Non-cardiac QTc-prolonging drugs and the risk of sudden cardiac death. Eur Heart J. 2005;26:2007-2012.
    • (2005) Eur Heart J , vol.26 , pp. 2007-2012
    • Straus, S.M.1    Sturkenboom, M.C.2    Bleumink, G.S.3
  • 46
    • 77957763739 scopus 로고    scopus 로고
    • Domperidone and ventricular arrhythmia or sudden cardiac death: a population-based case-control study in the Netherlands
    • van Noord C, Dieleman JP, van Herpen G, Verhamme K, Sturkenboom MC. Domperidone and ventricular arrhythmia or sudden cardiac death: a population-based case-control study in the Netherlands. Drug Saf. 2010;33:1003-1014.
    • (2010) Drug Saf , vol.33 , pp. 1003-1014
    • van Noord, C.1    Dieleman, J.P.2    van Herpen, G.3    Verhamme, K.4    Sturkenboom, M.C.5
  • 47
    • 77957371802 scopus 로고    scopus 로고
    • Risk of serious ventricular arrhythmia and sudden cardiac death in a cohort of users of domperidone: a nested case-control study
    • Johannes CB, Varas-Lorenzo C, McQuay LJ, Midkiff KD, Fife D. Risk of serious ventricular arrhythmia and sudden cardiac death in a cohort of users of domperidone: a nested case-control study. Pharmacoepidemiol Drug Saf. 2010;19:881-888.
    • (2010) Pharmacoepidemiol Drug Saf , vol.19 , pp. 881-888
    • Johannes, C.B.1    Varas-Lorenzo, C.2    McQuay, L.J.3    Midkiff, K.D.4    Fife, D.5
  • 48
    • 45849134924 scopus 로고    scopus 로고
    • A systematic review of the efficacy of domperidone for the treatment of diabetic gastroparesis
    • Sugumar A, Singh A, Pasricha PJ. A systematic review of the efficacy of domperidone for the treatment of diabetic gastroparesis. Clin Gastroenterol Hepatol. 2008;6:726-733.
    • (2008) Clin Gastroenterol Hepatol , vol.6 , pp. 726-733
    • Sugumar, A.1    Singh, A.2    Pasricha, P.J.3
  • 49
    • 66049094274 scopus 로고    scopus 로고
    • Current pharmacological management of gastro-esophageal reflux in children: an evidence-based systematic review
    • Tighe MP, Afzal NA, Bevan A, Beattie RM. Current pharmacological management of gastro-esophageal reflux in children: an evidence-based systematic review. Paediatr Drugs. 2009;11:185-202.
    • (2009) Paediatr Drugs , vol.11 , pp. 185-202
    • Tighe, M.P.1    Afzal, N.A.2    Bevan, A.3    Beattie, R.M.4
  • 50
    • 84906416462 scopus 로고
    • Importance of the jejunal hormone motilin
    • Christofides ND. Importance of the jejunal hormone motilin. J Clin Pathol. 1978;8:51-57.
    • (1978) J Clin Pathol , vol.8 , pp. 51-57
    • Christofides, N.D.1
  • 51
    • 0030725634 scopus 로고    scopus 로고
    • Concentration-dependent stimulation of cholinergic motor nerves or smooth muscle by [Nle13]motilin in the isolated rabbit gastric antrum
    • Van Assche G, Depoortere I, Thijs T, Janssens JJ, Peeters TL. Concentration-dependent stimulation of cholinergic motor nerves or smooth muscle by [Nle13]motilin in the isolated rabbit gastric antrum. Eur J Pharmacol. 1997;337:267-274.
    • (1997) Eur J Pharmacol , vol.337 , pp. 267-274
    • Van Assche, G.1    Depoortere, I.2    Thijs, T.3    Janssens, J.J.4    Peeters, T.L.5
  • 52
    • 84866972210 scopus 로고    scopus 로고
    • Regional- and agonist-dependent facilitation of human neurogastrointestinal functions by motilin receptor agonists
    • Broad J, Mukherjee S, Samadi M, Martin JE, Dukes GE, Sanger GJ. Regional- and agonist-dependent facilitation of human neurogastrointestinal functions by motilin receptor agonists. Br J Pharmacol. 2012;167:763-774.
    • (2012) Br J Pharmacol , vol.167 , pp. 763-774
    • Broad, J.1    Mukherjee, S.2    Samadi, M.3    Martin, J.E.4    Dukes, G.E.5    Sanger, G.J.6
  • 53
    • 40049097822 scopus 로고    scopus 로고
    • Hormones of the gut-brain axis as targets for the treatment of upper gastrointestinal disorders
    • Sanger GJ, Lee K. Hormones of the gut-brain axis as targets for the treatment of upper gastrointestinal disorders. Nat Rev Drug Discov. 2008;7:241-254.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 241-254
    • Sanger, G.J.1    Lee, K.2
  • 54
    • 84885470949 scopus 로고    scopus 로고
    • Motilin: towards a new understanding of the gastrointestinal neuropharmacology and therapeutic use of motilin receptor agonists
    • Sanger GJ, Wang Y, Hobson A, Broad J. Motilin: towards a new understanding of the gastrointestinal neuropharmacology and therapeutic use of motilin receptor agonists. Br J Pharmacol. 2013;170:1323-1332.
    • (2013) Br J Pharmacol , vol.170 , pp. 1323-1332
    • Sanger, G.J.1    Wang, Y.2    Hobson, A.3    Broad, J.4
  • 56
    • 0028260442 scopus 로고
    • Comparison of the effects of midecamycin acetate and azithromycin on gastrointestinal motility in man
    • Sifrim D, Matsuo H, Janssens J, Vantrappen G. Comparison of the effects of midecamycin acetate and azithromycin on gastrointestinal motility in man. Drugs Exp Clin Res. 1994;20:121-126.
    • (1994) Drugs Exp Clin Res , vol.20 , pp. 121-126
    • Sifrim, D.1    Matsuo, H.2    Janssens, J.3    Vantrappen, G.4
  • 57
    • 84875465813 scopus 로고    scopus 로고
    • The antibiotic azithromycin is a motilin receptor agonist in human stomach: comparison with erythromycin
    • Broad J, Sanger GJ. The antibiotic azithromycin is a motilin receptor agonist in human stomach: comparison with erythromycin. Br J Pharmacol. 2013;168:1859-1867.
    • (2013) Br J Pharmacol , vol.168 , pp. 1859-1867
    • Broad, J.1    Sanger, G.J.2
  • 58
    • 34247370872 scopus 로고    scopus 로고
    • The use of erythromycin as a gastrointestinal prokinetic agent in adult critical care: benefits versus risks
    • Hawkyard CV, Koerner RJ. The use of erythromycin as a gastrointestinal prokinetic agent in adult critical care: benefits versus risks. J Antimicrob Chemother. 2007;59:347-358.
    • (2007) J Antimicrob Chemother , vol.59 , pp. 347-358
    • Hawkyard, C.V.1    Koerner, R.J.2
  • 59
    • 0344034363 scopus 로고    scopus 로고
    • Characterization of the inhibitory effects of erythromycin and clarithromycin on the HERG potassium channel
    • Stanat SJ, Carlton CG, Crumb WJ Jr, Agrawal KC, Clarkson CW. Characterization of the inhibitory effects of erythromycin and clarithromycin on the HERG potassium channel. Mol Cell Biochem. 2003;254:1-7.
    • (2003) Mol Cell Biochem , vol.254 , pp. 1-7
    • Stanat, S.J.1    Carlton, C.G.2    Crumb, W.J.3    Agrawal, K.C.4    Clarkson, C.W.5
  • 60
    • 0029661890 scopus 로고    scopus 로고
    • QTc-interval prolongation associated with slow intravenous erythromycin lactobionate infusions in critically ill patients: a prospective evaluation and review of the literature
    • Tschida SJ, Guay DR, Straka RJ, Hoey LL, Johanning R, Vance-Bryan K. QTc-interval prolongation associated with slow intravenous erythromycin lactobionate infusions in critically ill patients: a prospective evaluation and review of the literature. Pharmacotherapy. 1996;16:663-674.
    • (1996) Pharmacotherapy , vol.16 , pp. 663-674
    • Tschida, S.J.1    Guay, D.R.2    Straka, R.J.3    Hoey, L.L.4    Johanning, R.5    Vance-Bryan, K.6
  • 61
    • 0036881096 scopus 로고    scopus 로고
    • Cytochrome P450 3A4 and P-glycoprotein mediate the interaction between an oral erythromycin breath test and rifampin
    • Paine MF, Wagner DA, Hoffmaster KA, Watkins PB. Cytochrome P450 3A4 and P-glycoprotein mediate the interaction between an oral erythromycin breath test and rifampin. Clin Pharmacol Ther. 2002;72:524-535.
    • (2002) Clin Pharmacol Ther , vol.72 , pp. 524-535
    • Paine, M.F.1    Wagner, D.A.2    Hoffmaster, K.A.3    Watkins, P.B.4
  • 63
    • 33845605104 scopus 로고    scopus 로고
    • No proarrhythmic properties of the antibiotics Moxifloxacin or Azithromycin in anaesthetized dogs with chronic-AV block
    • Thomsen MB, Beekman JD, Attevelt NJ, et al. No proarrhythmic properties of the antibiotics Moxifloxacin or Azithromycin in anaesthetized dogs with chronic-AV block. Br J Pharmacol. 2006;149:1039-1048.
    • (2006) Br J Pharmacol , vol.149 , pp. 1039-1048
    • Thomsen, M.B.1    Beekman, J.D.2    Attevelt, N.J.3
  • 65
    • 84877254751 scopus 로고    scopus 로고
    • Use of azithromycin and death from cardiovascular causes
    • Svanstrom H, Pasternak B, Hviid A. Use of azithromycin and death from cardiovascular causes. N Engl J Med. 2013;368:1704-1712.
    • (2013) N Engl J Med , vol.368 , pp. 1704-1712
    • Svanstrom, H.1    Pasternak, B.2    Hviid, A.3
  • 66
    • 84946730330 scopus 로고    scopus 로고
    • The role of macrolide antibiotics in increasing cardiovascular risk
    • Cheng YJ, Nie XY, Chen XM, et al. The role of macrolide antibiotics in increasing cardiovascular risk. J Am Coll Cardiol. 2015;66:2173-2184.
    • (2015) J Am Coll Cardiol , vol.66 , pp. 2173-2184
    • Cheng, Y.J.1    Nie, X.Y.2    Chen, X.M.3
  • 68
    • 84887363636 scopus 로고    scopus 로고
    • Azithromycin and risk of sudden cardiac death: guilty as charged or falsely accused?
    • Giudicessi JR, Ackerman MJ. Azithromycin and risk of sudden cardiac death: guilty as charged or falsely accused? Clevel Clin J Med. 2013;80:539-544.
    • (2013) Clevel Clin J Med , vol.80 , pp. 539-544
    • Giudicessi, J.R.1    Ackerman, M.J.2
  • 70
    • 0032772797 scopus 로고    scopus 로고
    • Pharmacological characterization of 5-HT4 receptors mediating relaxation of canine isolated rectum circular smooth muscle
    • Prins NH, Van Haselen JF, Lefebvre RA, Briejer MR, Akkermans LM, Schuurkes JA. Pharmacological characterization of 5-HT4 receptors mediating relaxation of canine isolated rectum circular smooth muscle. Br J Pharmacol. 1999;127:1431-1437.
    • (1999) Br J Pharmacol , vol.127 , pp. 1431-1437
    • Prins, N.H.1    Van Haselen, J.F.2    Lefebvre, R.A.3    Briejer, M.R.4    Akkermans, L.M.5    Schuurkes, J.A.6
  • 71
    • 0033998810 scopus 로고    scopus 로고
    • An improved in vitro bioassay for the study of 5-HT(4) receptors in the human isolated large intestinal circular muscle
    • Prins NH, Shankley NP, Welsh NJ, et al. An improved in vitro bioassay for the study of 5-HT(4) receptors in the human isolated large intestinal circular muscle. Br J Pharmacol. 2000;129:1601-1608.
    • (2000) Br J Pharmacol , vol.129 , pp. 1601-1608
    • Prins, N.H.1    Shankley, N.P.2    Welsh, N.J.3
  • 72
    • 0036152825 scopus 로고    scopus 로고
    • Presynaptic modulation of cholinergic neurotransmission in the human proximal stomach
    • Leclere PG, Lefebvre RA. Presynaptic modulation of cholinergic neurotransmission in the human proximal stomach. Br J Pharmacol. 2002;135:135-142.
    • (2002) Br J Pharmacol , vol.135 , pp. 135-142
    • Leclere, P.G.1    Lefebvre, R.A.2
  • 74
    • 0037472231 scopus 로고    scopus 로고
    • 5-HT4 receptor ligands: applications and new prospects
    • Langlois M, Fischmeister R. 5-HT4 receptor ligands: applications and new prospects. J Med Chem. 2003;46:319-344.
    • (2003) J Med Chem , vol.46 , pp. 319-344
    • Langlois, M.1    Fischmeister, R.2
  • 75
    • 0024239598 scopus 로고
    • Cisapride. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use as a prokinetic agent in gastrointestinal motility disorders
    • McCallum RW, Prakash C, Campoli-Richards DM, Goa KL. Cisapride. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use as a prokinetic agent in gastrointestinal motility disorders. Drugs. 1988;36:652-681.
    • (1988) Drugs , vol.36 , pp. 652-681
    • McCallum, R.W.1    Prakash, C.2    Campoli-Richards, D.M.3    Goa, K.L.4
  • 76
    • 0030920299 scopus 로고    scopus 로고
    • A comparison of two cohort studies evaluating the safety of cisapride: prescription-event monitoring and a large phase IV study
    • Wager E, Tooley PJ, Pearce GL, Wilton LV, Mann RD. A comparison of two cohort studies evaluating the safety of cisapride: prescription-event monitoring and a large phase IV study. Eur J Clin Pharmacol. 1997;52:87-94.
    • (1997) Eur J Clin Pharmacol , vol.52 , pp. 87-94
    • Wager, E.1    Tooley, P.J.2    Pearce, G.L.3    Wilton, L.V.4    Mann, R.D.5
  • 77
    • 0032854375 scopus 로고    scopus 로고
    • The risk of serious cardiac arrhythmias among cisapride users in the United Kingdom and Canada
    • Walker AM, Szneke P, Weatherby LB, et al. The risk of serious cardiac arrhythmias among cisapride users in the United Kingdom and Canada. Am J Med. 1999;107:356-362.
    • (1999) Am J Med , vol.107 , pp. 356-362
    • Walker, A.M.1    Szneke, P.2    Weatherby, L.B.3
  • 78
    • 0035000688 scopus 로고    scopus 로고
    • Does cisapride influence cardiac rhythm? Results of a United States multicenter, double-blind, placebo-controlled pediatric study
    • Levy J, Hayes C, Kern J, et al. Does cisapride influence cardiac rhythm? Results of a United States multicenter, double-blind, placebo-controlled pediatric study. J Pediatr Gastroenterol Nutr. 2001;32:458-463.
    • (2001) J Pediatr Gastroenterol Nutr , vol.32 , pp. 458-463
    • Levy, J.1    Hayes, C.2    Kern, J.3
  • 79
    • 0037298891 scopus 로고    scopus 로고
    • Meta-analysis of randomized controlled trials on the benefits and risks of using cisapride for the treatment of gastroesophageal reflux in children
    • Dalby-Payne JR, Morris AM, Craig JC. Meta-analysis of randomized controlled trials on the benefits and risks of using cisapride for the treatment of gastroesophageal reflux in children. J Gastroenterol Hepatol. 2003;18:196-202.
    • (2003) J Gastroenterol Hepatol , vol.18 , pp. 196-202
    • Dalby-Payne, J.R.1    Morris, A.M.2    Craig, J.C.3
  • 80
    • 0026758450 scopus 로고
    • Tachycardia during cisapride treatment
    • Olsson S, Edwards IR. Tachycardia during cisapride treatment. BMJ. 1992;305:748-749.
    • (1992) BMJ , vol.305 , pp. 748-749
    • Olsson, S.1    Edwards, I.R.2
  • 83
    • 0029997359 scopus 로고    scopus 로고
    • Cisapride-induced prolongation of cardiac action potential and early afterdepolarizations in rabbit Purkinje fibres
    • Puisieux FL, Adamantidis MM, Dumotier BM, Dupuis BA. Cisapride-induced prolongation of cardiac action potential and early afterdepolarizations in rabbit Purkinje fibres. Br J Pharmacol. 1996;117:1377-1379.
    • (1996) Br J Pharmacol , vol.117 , pp. 1377-1379
    • Puisieux, F.L.1    Adamantidis, M.M.2    Dumotier, B.M.3    Dupuis, B.A.4
  • 84
    • 0030704669 scopus 로고    scopus 로고
    • A mechanism for the proarrhythmic effects of cisapride (Propulsid): high affinity blockade of the human cardiac potassium channel HERG
    • Rampe D, Roy ML, Dennis A, Brown AM. A mechanism for the proarrhythmic effects of cisapride (Propulsid): high affinity blockade of the human cardiac potassium channel HERG. FEBS Lett. 1997;417:28-32.
    • (1997) FEBS Lett , vol.417 , pp. 28-32
    • Rampe, D.1    Roy, M.L.2    Dennis, A.3    Brown, A.M.4
  • 85
    • 0030693690 scopus 로고    scopus 로고
    • Blockage of the HERG human cardiac K+ channel by the gastrointestinal prokinetic agent cisapride
    • Mohammad S, Zhou Z, Gong Q, January CT. Blockage of the HERG human cardiac K+ channel by the gastrointestinal prokinetic agent cisapride. Am J Physiol. 1997;273:H2534-H2538.
    • (1997) Am J Physiol , vol.273 , pp. H2534-H2538
    • Mohammad, S.1    Zhou, Z.2    Gong, Q.3    January, C.T.4
  • 88
    • 0034694849 scopus 로고    scopus 로고
    • Contraindicated use of cisapride: impact of food and drug administration regulatory action
    • Smalley W, Shatin D, Wysowski DK, et al. Contraindicated use of cisapride: impact of food and drug administration regulatory action. JAMA. 2000;284:3036-3039.
    • (2000) JAMA , vol.284 , pp. 3036-3039
    • Smalley, W.1    Shatin, D.2    Wysowski, D.K.3
  • 89
    • 0035802316 scopus 로고    scopus 로고
    • Coprescribing and codispensing of cisapride and contraindicated drugs
    • Jones JK, Fife D, Curkendall S, Goehring E Jr, Guo JJ, Shannon M. Coprescribing and codispensing of cisapride and contraindicated drugs. JAMA. 2001;286:1607-1609.
    • (2001) JAMA , vol.286 , pp. 1607-1609
    • Jones, J.K.1    Fife, D.2    Curkendall, S.3    Goehring, E.4    Guo, J.J.5    Shannon, M.6
  • 90
    • 0035123099 scopus 로고    scopus 로고
    • Review article: tegaserod
    • Camilleri M. Review article: tegaserod. Aliment Pharmacol Ther. 2001;15:277-289.
    • (2001) Aliment Pharmacol Ther , vol.15 , pp. 277-289
    • Camilleri, M.1
  • 91
    • 84858287886 scopus 로고    scopus 로고
    • Systematic review: cardiovascular safety profile of 5-HT(4) agonists developed for gastrointestinal disorders
    • Tack J, Camilleri M, Chang L, et al. Systematic review: cardiovascular safety profile of 5-HT(4) agonists developed for gastrointestinal disorders. Aliment Pharmacol Ther. 2012;35:745-767.
    • (2012) Aliment Pharmacol Ther , vol.35 , pp. 745-767
    • Tack, J.1    Camilleri, M.2    Chang, L.3
  • 92
    • 84871714544 scopus 로고    scopus 로고
    • An in vitro investigation of the cardiovascular effects of the 5-HT(4) receptor selective agonists, velusetrag and TD-8954
    • Beattie DT, Higgins DL, Ero MP, et al. An in vitro investigation of the cardiovascular effects of the 5-HT(4) receptor selective agonists, velusetrag and TD-8954. Vascul Pharmacol. 2013;58:150-156.
    • (2013) Vascul Pharmacol , vol.58 , pp. 150-156
    • Beattie, D.T.1    Higgins, D.L.2    Ero, M.P.3
  • 93
    • 0034821488 scopus 로고    scopus 로고
    • In vitro metabolism of tegaserod in human liver and intestine: assessment of drug interactions
    • Vickers AE, Zollinger M, Dannecker R, Tynes R, Heitz F, Fischer V. In vitro metabolism of tegaserod in human liver and intestine: assessment of drug interactions. Drug Metab Dispos. 2001;29:1269-1276.
    • (2001) Drug Metab Dispos , vol.29 , pp. 1269-1276
    • Vickers, A.E.1    Zollinger, M.2    Dannecker, R.3    Tynes, R.4    Heitz, F.5    Fischer, V.6
  • 94
    • 0030893442 scopus 로고    scopus 로고
    • First pharmacokinetic-pharmacodynamic study in humans with a selective 5-hydroxytryptamine4 receptor agonist
    • Appel S, Kumle A, Hubert M, Duvauchelle T. First pharmacokinetic-pharmacodynamic study in humans with a selective 5-hydroxytryptamine4 receptor agonist. J Clin Pharmacol. 1997;37:229-237.
    • (1997) J Clin Pharmacol , vol.37 , pp. 229-237
    • Appel, S.1    Kumle, A.2    Hubert, M.3    Duvauchelle, T.4
  • 96
    • 36949024233 scopus 로고    scopus 로고
    • The cardiovascular safety profile of renzapride, a novel treatment for irritable bowel syndrome
    • Meyers NL, Hickling RI. The cardiovascular safety profile of renzapride, a novel treatment for irritable bowel syndrome. J Int Med Res. 2007;35:848-866.
    • (2007) J Int Med Res , vol.35 , pp. 848-866
    • Meyers, N.L.1    Hickling, R.I.2
  • 97
    • 0030801806 scopus 로고    scopus 로고
    • Electrophysiological characterization of the prokinetic agents cisapride and mosapride in vivo and in vitro: implications for proarrhythmic potential?
    • Carlsson L, Amos GJ, Andersson B, Drews L, Duker G, Wadstedt G. Electrophysiological characterization of the prokinetic agents cisapride and mosapride in vivo and in vitro: implications for proarrhythmic potential? J Pharmacol Exp Ther. 1997;282:220-227.
    • (1997) J Pharmacol Exp Ther , vol.282 , pp. 220-227
    • Carlsson, L.1    Amos, G.J.2    Andersson, B.3    Drews, L.4    Duker, G.5    Wadstedt, G.6
  • 98
    • 0035197735 scopus 로고    scopus 로고
    • Gastrointestinal prokinetic drugs have different affinity for the human cardiac human ether-a-gogo K(+) channel
    • Potet F, Bouyssou T, Escande D, Baro I. Gastrointestinal prokinetic drugs have different affinity for the human cardiac human ether-a-gogo K(+) channel. J Pharmacol Exp Ther. 2001;299:1007-1012.
    • (2001) J Pharmacol Exp Ther , vol.299 , pp. 1007-1012
    • Potet, F.1    Bouyssou, T.2    Escande, D.3    Baro, I.4
  • 100
    • 0033679897 scopus 로고    scopus 로고
    • Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans
    • Date Y, Kojima M, Hosoda H, et al. Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology. 2000;141:4255-4261.
    • (2000) Endocrinology , vol.141 , pp. 4255-4261
    • Date, Y.1    Kojima, M.2    Hosoda, H.3
  • 101
    • 33144482883 scopus 로고    scopus 로고
    • Influence of ghrelin on interdigestive gastrointestinal motility in humans
    • Tack J, Depoortere I, Bisschops R, et al. Influence of ghrelin on interdigestive gastrointestinal motility in humans. Gut. 2006;55:327-333.
    • (2006) Gut , vol.55 , pp. 327-333
    • Tack, J.1    Depoortere, I.2    Bisschops, R.3
  • 102
    • 77956316577 scopus 로고    scopus 로고
    • Safety and efficacy of ghrelin agonist TZP-101 in relieving symptoms in patients with diabetic gastroparesis: a randomized, placebo-controlled study
    • Ejskjaer N, Dimcevski G, Wo J, et al. Safety and efficacy of ghrelin agonist TZP-101 in relieving symptoms in patients with diabetic gastroparesis: a randomized, placebo-controlled study. Neurogastroenterol Motil. 2010;22:1069-e281.
    • (2010) Neurogastroenterol Motil , vol.22 , pp. e281-1069
    • Ejskjaer, N.1    Dimcevski, G.2    Wo, J.3
  • 103
    • 84879164825 scopus 로고    scopus 로고
    • Safety and efficacy of ulimorelin administered postoperatively to accelerate recovery of gastrointestinal motility following partial bowel resection: results of two randomized, placebo-controlled phase 3 trials
    • Shaw M, Pediconi C, McVey D, et al. Safety and efficacy of ulimorelin administered postoperatively to accelerate recovery of gastrointestinal motility following partial bowel resection: results of two randomized, placebo-controlled phase 3 trials. Dis Colon Rectum. 2013;56:888-897.
    • (2013) Dis Colon Rectum , vol.56 , pp. 888-897
    • Shaw, M.1    Pediconi, C.2    McVey, D.3
  • 104
    • 85029322792 scopus 로고    scopus 로고
    • Efficacy and safety of relamorelin in diabetics with symptoms of gastroparesis: a randomized, placebo-controlled study
    • Camilleri M, McCallum RW, Tack J, Spence SC, Gottesdiener K, Fiedorek FT. Efficacy and safety of relamorelin in diabetics with symptoms of gastroparesis: a randomized, placebo-controlled study. Gastroenterology. 2017;153:1240-1250.e2.
    • (2017) Gastroenterology , vol.153 , pp. 1240-1250.e2
    • Camilleri, M.1    McCallum, R.W.2    Tack, J.3    Spence, S.C.4    Gottesdiener, K.5    Fiedorek, F.T.6
  • 105
    • 85047884159 scopus 로고    scopus 로고
    • Gastroparesis: pharmacotherapy and cardiac risk
    • [published November 20 2017]., -
    • Hellstrom PM, Al-Saffar A. Gastroparesis: pharmacotherapy and cardiac risk [published November 20 2017]. Scand J Gastroenterol. 2017;1-6. http://doi.org/10.1080/00365521.2017.1401117
    • (2017) Scand J Gastroenterol , pp. 1-6
    • Hellstrom, P.M.1    Al-Saffar, A.2
  • 106
    • 84884492481 scopus 로고    scopus 로고
    • Development and validation of a risk score to predict QT interval prolongation in hospitalized patients
    • Tisdale JE, Jaynes HA, Kingery JR, et al. Development and validation of a risk score to predict QT interval prolongation in hospitalized patients. Circ Cardiovasc Qual Outcomes. 2013;6:479-487.
    • (2013) Circ Cardiovasc Qual Outcomes , vol.6 , pp. 479-487
    • Tisdale, J.E.1    Jaynes, H.A.2    Kingery, J.R.3
  • 107
    • 84986888976 scopus 로고    scopus 로고
    • Impact of clinical decision support preventing the use of QT-prolonging medications for patients at risk for torsade de pointes
    • Sorita A, Bos JM, Morlan BW, Tarrell RF, Ackerman MJ, Caraballo PJ. Impact of clinical decision support preventing the use of QT-prolonging medications for patients at risk for torsade de pointes. J Am Med Inform Assoc. 2015;22:e21-e27.
    • (2015) J Am Med Inform Assoc , vol.22 , pp. e21-e27
    • Sorita, A.1    Bos, J.M.2    Morlan, B.W.3    Tarrell, R.F.4    Ackerman, M.J.5    Caraballo, P.J.6
  • 108
    • 84903597825 scopus 로고    scopus 로고
    • Effectiveness of a clinical decision support system for reducing the risk of QT interval prolongation in hospitalized patients
    • Tisdale JE, Jaynes HA, Kingery JR, et al. Effectiveness of a clinical decision support system for reducing the risk of QT interval prolongation in hospitalized patients. Circ Cardiovasc Qual Outcomes. 2014;7:381-390.
    • (2014) Circ Cardiovasc Qual Outcomes , vol.7 , pp. 381-390
    • Tisdale, J.E.1    Jaynes, H.A.2    Kingery, J.R.3
  • 109
    • 85028761707 scopus 로고    scopus 로고
    • Providers' response to clinical decision support for QT prolonging drugs
    • Sharma S, Martijn Bos J, Tarrell RF, et al. Providers' response to clinical decision support for QT prolonging drugs. J Med Syst. 2017;41:161.
    • (2017) J Med Syst , vol.41 , pp. 161
    • Sharma, S.1    Martijn Bos, J.2    Tarrell, R.F.3
  • 110
    • 84905594041 scopus 로고    scopus 로고
    • Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization
    • Arking DE, Pulit SL, Crotti L, et al. Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. Nat Genet. 2014;46:826-36.
    • (2014) Nat Genet , vol.46 , pp. 826-836
    • Arking, D.E.1    Pulit, S.L.2    Crotti, L.3
  • 111
    • 63449136073 scopus 로고    scopus 로고
    • Common variants at ten loci influence QT interval duration in the QTGEN Study
    • Newton-Cheh C, Eijgelsheim M, Rice KM, et al. Common variants at ten loci influence QT interval duration in the QTGEN Study. Nat Genet. 2009;41:399-406.
    • (2009) Nat Genet , vol.41 , pp. 399-406
    • Newton-Cheh, C.1    Eijgelsheim, M.2    Rice, K.M.3
  • 112
    • 63449109595 scopus 로고    scopus 로고
    • Common variants at ten loci modulate the QT interval duration in the QTSCD Study
    • Pfeufer A, Sanna S, Arking DE, et al. Common variants at ten loci modulate the QT interval duration in the QTSCD Study. Nat Genet. 2009;41:407-414.
    • (2009) Nat Genet , vol.41 , pp. 407-414
    • Pfeufer, A.1    Sanna, S.2    Arking, D.E.3
  • 113
    • 84859315750 scopus 로고    scopus 로고
    • A large candidate gene survey identifies the KCNE1 D85N polymorphism as a possible modulator of drug-induced torsades de pointes
    • Kaab S, Crawford DC, Sinner MF, et al. A large candidate gene survey identifies the KCNE1 D85N polymorphism as a possible modulator of drug-induced torsades de pointes. Circ Cardiovasc Genet. 2012;5:91-99.
    • (2012) Circ Cardiovasc Genet , vol.5 , pp. 91-99
    • Kaab, S.1    Crawford, D.C.2    Sinner, M.F.3
  • 114
    • 84897985012 scopus 로고    scopus 로고
    • Exome sequencing implicates an increased burden of rare potassium channel variants in the risk of drug-induced long QT interval syndrome
    • Weeke P, Mosley JD, Hanna D, et al. Exome sequencing implicates an increased burden of rare potassium channel variants in the risk of drug-induced long QT interval syndrome. J Am Coll Cardiol. 2014;63:1430-1437.
    • (2014) J Am Coll Cardiol , vol.63 , pp. 1430-1437
    • Weeke, P.1    Mosley, J.D.2    Hanna, D.3
  • 115
    • 84865283619 scopus 로고    scopus 로고
    • Common variation in the NOS1AP gene is associated with drug-induced QT prolongation and ventricular arrhythmia
    • Jamshidi Y, Nolte IM, Dalageorgou C, et al. Common variation in the NOS1AP gene is associated with drug-induced QT prolongation and ventricular arrhythmia. J Am Coll Cardiol. 2012;60:841-850.
    • (2012) J Am Coll Cardiol , vol.60 , pp. 841-850
    • Jamshidi, Y.1    Nolte, I.M.2    Dalageorgou, C.3
  • 116
    • 85016953516 scopus 로고    scopus 로고
    • Precision cardiovascular medicine: state of genetic testing
    • Giudicessi JR, Kullo IJ, Ackerman MJ. Precision cardiovascular medicine: state of genetic testing. Mayo Clin Proc. 2017;92:642-662.
    • (2017) Mayo Clin Proc , vol.92 , pp. 642-662
    • Giudicessi, J.R.1    Kullo, I.J.2    Ackerman, M.J.3
  • 117
    • 80052694116 scopus 로고    scopus 로고
    • Common genetic variants, QT interval, and sudden cardiac death in a Finnish population-based study
    • Noseworthy PA, Havulinna AS, Porthan K, et al. Common genetic variants, QT interval, and sudden cardiac death in a Finnish population-based study. Circ Cardiovasc Genet. 2011;4:305-311.
    • (2011) Circ Cardiovasc Genet , vol.4 , pp. 305-311
    • Noseworthy, P.A.1    Havulinna, A.S.2    Porthan, K.3
  • 118
    • 85013488718 scopus 로고    scopus 로고
    • Common genetic variant risk score is associated with drug-induced QT prolongation and torsade de pointes risk: a pilot study
    • Strauss DG, Vicente J, Johannesen L, et al. Common genetic variant risk score is associated with drug-induced QT prolongation and torsade de pointes risk: a pilot study. Circulation. 2017;135:1300-1310.
    • (2017) Circulation , vol.135 , pp. 1300-1310
    • Strauss, D.G.1    Vicente, J.2    Johannesen, L.3
  • 119
    • 0029942250 scopus 로고    scopus 로고
    • High affinity open channel block by dofetilide of HERG expressed in a human cell line
    • Snyders DJ, Chaudhary A. High affinity open channel block by dofetilide of HERG expressed in a human cell line. Mol Pharmacol. 1996;49:949-955.
    • (1996) Mol Pharmacol , vol.49 , pp. 949-955
    • Snyders, D.J.1    Chaudhary, A.2
  • 120
    • 84964561192 scopus 로고    scopus 로고
    • Increased late sodium current contributes to the electrophysiological effects of chronic, but not acute, dofetilide administration
    • Qiu XS, Chauveau S, Anyukhovsky EP, et al. Increased late sodium current contributes to the electrophysiological effects of chronic, but not acute, dofetilide administration. Circ Arrhythm Electrophysiol. 2016;9:e003655.
    • (2016) Circ Arrhythm Electrophysiol , vol.9
    • Qiu, X.S.1    Chauveau, S.2    Anyukhovsky, E.P.3
  • 122
    • 0034711465 scopus 로고    scopus 로고
    • Probing the interaction between inactivation gating and Dd-sotalol block of HERG
    • Numaguchi H, Mullins FM, Johnson JP Jr, et al. Probing the interaction between inactivation gating and Dd-sotalol block of HERG. Circ Res. 2000;87:1012-1018.
    • (2000) Circ Res , vol.87 , pp. 1012-1018
    • Numaguchi, H.1    Mullins, F.M.2    Johnson, J.P.3
  • 123
    • 0035170062 scopus 로고    scopus 로고
    • Interactions of a series of fluoroquinolone antibacterial drugs with the human cardiac K+ channel HERG
    • Kang J, Wang L, Chen XL, Triggle DJ, Rampe D. Interactions of a series of fluoroquinolone antibacterial drugs with the human cardiac K+ channel HERG. Mol Pharmacol. 2001;59:122-126.
    • (2001) Mol Pharmacol , vol.59 , pp. 122-126
    • Kang, J.1    Wang, L.2    Chen, X.L.3    Triggle, D.J.4    Rampe, D.5
  • 124
    • 0036089685 scopus 로고    scopus 로고
    • Blockade of human cardiac potassium channel human ether-a-go-go-related gene (HERG) by macrolide antibiotics
    • Volberg WA, Koci BJ, Su W, Lin J, Zhou J. Blockade of human cardiac potassium channel human ether-a-go-go-related gene (HERG) by macrolide antibiotics. J Pharmacol Exp Ther. 2002;302:320-327.
    • (2002) J Pharmacol Exp Ther , vol.302 , pp. 320-327
    • Volberg, W.A.1    Koci, B.J.2    Su, W.3    Lin, J.4    Zhou, J.5
  • 125
    • 0037070199 scopus 로고    scopus 로고
    • Inhibitory actions of the selective serotonin re-uptake inhibitor citalopram on HERG and ventricular L-type calcium currents
    • Witchel HJ, Pabbathi VK, Hofmann G, Paul AA, Hancox JC. Inhibitory actions of the selective serotonin re-uptake inhibitor citalopram on HERG and ventricular L-type calcium currents. FEBS Lett. 2002;512:59-66.
    • (2002) FEBS Lett , vol.512 , pp. 59-66
    • Witchel, H.J.1    Pabbathi, V.K.2    Hofmann, G.3    Paul, A.A.4    Hancox, J.C.5
  • 126
    • 0033772068 scopus 로고    scopus 로고
    • Interactions of the 5-hydroxytryptamine 3 antagonist class of antiemetic drugs with human cardiac ion channels
    • Kuryshev YA, Brown AM, Wang L, Benedict CR, Rampe D. Interactions of the 5-hydroxytryptamine 3 antagonist class of antiemetic drugs with human cardiac ion channels. J Pharmacol Exp Ther. 2000;295:614-620.
    • (2000) J Pharmacol Exp Ther , vol.295 , pp. 614-620
    • Kuryshev, Y.A.1    Brown, A.M.2    Wang, L.3    Benedict, C.R.4    Rampe, D.5
  • 127
    • 78649759788 scopus 로고    scopus 로고
    • Fluconazole inhibits hERG K(+) channel by direct block and disruption of protein trafficking
    • Han S, Zhang Y, Chen Q, et al. Fluconazole inhibits hERG K(+) channel by direct block and disruption of protein trafficking. Eur J Pharmacol. 2011;650:138-144.
    • (2011) Eur J Pharmacol , vol.650 , pp. 138-144
    • Han, S.1    Zhang, Y.2    Chen, Q.3
  • 128
    • 0029994611 scopus 로고    scopus 로고
    • Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizole
    • Suessbrich H, Waldegger S, Lang F, Busch AE. Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizole. FEBS Lett. 1996;385:77-80.
    • (1996) FEBS Lett , vol.385 , pp. 77-80
    • Suessbrich, H.1    Waldegger, S.2    Lang, F.3    Busch, A.E.4
  • 129
    • 0347357886 scopus 로고    scopus 로고
    • Unusual effects of a QT-prolonging drug, arsenic trioxide, on cardiac potassium currents
    • Drolet B, Simard C, Roden DM. Unusual effects of a QT-prolonging drug, arsenic trioxide, on cardiac potassium currents. Circulation. 2004;109:26-29.
    • (2004) Circulation , vol.109 , pp. 26-29
    • Drolet, B.1    Simard, C.2    Roden, D.M.3
  • 130
    • 84884134230 scopus 로고    scopus 로고
    • Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes
    • Doherty KR, Wappel RL, Talbert DR, et al. Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes. Toxicol Appl Pharmacol. 2013;272:245-255.
    • (2013) Toxicol Appl Pharmacol , vol.272 , pp. 245-255
    • Doherty, K.R.1    Wappel, R.L.2    Talbert, D.R.3
  • 131
    • 0030898598 scopus 로고    scopus 로고
    • The inhibitory effect of the antipsychotic drug haloperidol on HERG potassium channels expressed in Xenopus oocytes
    • Suessbrich H, Schonherr R, Heinemann SH, Attali B, Lang F, Busch AE. The inhibitory effect of the antipsychotic drug haloperidol on HERG potassium channels expressed in Xenopus oocytes. Br J Pharmacol. 1997;120:968-974.
    • (1997) Br J Pharmacol , vol.120 , pp. 968-974
    • Suessbrich, H.1    Schonherr, R.2    Heinemann, S.H.3    Attali, B.4    Lang, F.5    Busch, A.E.6
  • 132
    • 0034737431 scopus 로고    scopus 로고
    • High affinity blockade of the HERG cardiac K(+) channel by the neuroleptic pimozide
    • Kang J, Wang L, Cai F, Rampe D. High affinity blockade of the HERG cardiac K(+) channel by the neuroleptic pimozide. Eur J Pharmacol. 2000;392:137-140.
    • (2000) Eur J Pharmacol , vol.392 , pp. 137-140
    • Kang, J.1    Wang, L.2    Cai, F.3    Rampe, D.4
  • 133
    • 0033052403 scopus 로고    scopus 로고
    • Thioridazine lengthens repolarization of cardiac ventricular myocytes by blocking the delayed rectifier potassium current
    • Drolet B, Vincent F, Rail J, et al. Thioridazine lengthens repolarization of cardiac ventricular myocytes by blocking the delayed rectifier potassium current. J Pharmacol Exp Ther. 1999;288:1261-1268.
    • (1999) J Pharmacol Exp Ther , vol.288 , pp. 1261-1268
    • Drolet, B.1    Vincent, F.2    Rail, J.3
  • 134
    • 84923241696 scopus 로고    scopus 로고
    • Effects of donepezil on hERG potassium channels
    • Chae YJ, Lee HJ, Jeon JH, et al. Effects of donepezil on hERG potassium channels. Brain Res. 2015;1597:77-85.
    • (2015) Brain Res , vol.1597 , pp. 77-85
    • Chae, Y.J.1    Lee, H.J.2    Jeon, J.H.3
  • 135
    • 0036828152 scopus 로고    scopus 로고
    • Influence of opioid agonists on cardiac human ether-a-go-go-related gene K(+) currents
    • Katchman AN, McGroary KA, Kilborn MJ, et al. Influence of opioid agonists on cardiac human ether-a-go-go-related gene K(+) currents. J Pharmacol Exp Ther. 2002;303:688-694.
    • (2002) J Pharmacol Exp Ther , vol.303 , pp. 688-694
    • Katchman, A.N.1    McGroary, K.A.2    Kilborn, M.J.3
  • 136
    • 33847647563 scopus 로고    scopus 로고
    • Effect of clebopride, antidopaminergic gastrointestinal prokinetics, on cardiac repolarization
    • Kim KS, Shin WH, Park SJ, Kim EJ. Effect of clebopride, antidopaminergic gastrointestinal prokinetics, on cardiac repolarization. Int J Toxicol. 2007;26:25-31.
    • (2007) Int J Toxicol , vol.26 , pp. 25-31
    • Kim, K.S.1    Shin, W.H.2    Park, S.J.3    Kim, E.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.