5-HT4 receptors located on cholinergic nerves in human colon circular muscle

Neurogastroenterology and Motility

Volumn 17, Issue 3, 2005, Pages 366-375

  Leclere, P G ^a   Prins, N H ^b,c   Schuurkes, J A J ^b   Lefebvre, R A ^a  

^a GHENT UNIVERSITY   (Belgium)

^b JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^c PHARSIGHT CORPORATION   (United States)

Author keywords

5 hydroxytryptamine 4 receptor; Acetylcholine; Cholinergic nerves; Human colon

Indexed keywords

1 METHYL 3 INDOLECARBOXYLIC ACID [1 [2 (METHYLSULFONYLAMINO)ETHYL] 4 PIPERIDINYLMETHYL] ESTER; ACETYLCHOLINE; ATROPINE; PRUCALOPRIDE; SEROTONIN 4 AGONIST; TETRODOTOXIN; BENZOFURAN DERIVATIVE; ENZYME INHIBITOR; N(G) NITROARGININE; NITRIC OXIDE SYNTHASE; SEROTONIN 4 RECEPTOR; SEROTONIN AGONIST; SEROTONIN ANTAGONIST;

ARTICLE; CHOLINERGIC NERVE; COLON MOTILITY; COLON MUCOSA; DRUG EFFECT; ELECTRIC FIELD; EVOKED RESPONSE; HUMAN; HUMAN TISSUE; INTESTINE FUNCTION; INTESTINE TRANSIT TIME; MANOMETRY; NERVE EXCITABILITY; NERVE STIMULATION; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTILITY; CHOLINERGIC SYSTEM; COLON; DRUG ANTAGONISM; ELECTROSTIMULATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; INNERVATION; METABOLISM; MUSCLE CONTRACTION; PHYSIOLOGY; SMOOTH MUSCLE;

ACETYLCHOLINE; BENZOFURANS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COLON; ELECTRIC STIMULATION; ENZYME INHIBITORS; HUMANS; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NITRIC OXIDE SYNTHASE; NITROARGININE; PARASYMPATHETIC NERVOUS SYSTEM; RECEPTORS, SEROTONIN, 5-HT4; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; TETRODOTOXIN;

EID: 20044392508     PISSN: 13501925     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2005.00621.x     Document Type: Article

References (24)

1. 4 receptors. FASEB 1996; 10: 1398-407.
2. Emmanuel AV, Kamm MA, Roy AJ et al. Effect of a novel prokinetic drug, R093877, on gastrointestinal transit in healthy volunteers. Gut 1998; 42: 511-6.
3. 4) agonist, prucalopride, in healthy humans. Gut 1999; 44: 682-6.
4. Sloots CEJ, Poen AC, Kerstens R et al. Effects of prucalopride on colonic transit, anorectal function and bowel habits in patients with chronic constipation. Aliment Pharmacol Ther 2002; 16: 759-67.
5. Emmanuel AV, Roy AJ, Nicholls TJ et al. Prucalopride, a systemic enterokinetic, for the treatment of constipation. Aliment Pharmacol Ther 2002; 16: 1347-56.
6. Briejer MR, Prins NH, Schuurkes JAJ. Effects of the enterokinetic prucalopride (R093877) on colonic motility in fasted dogs. Neurogastroenterol Mot 2001; 13: 465-72.
7. Karaus M, Sarna SK. Giant migrating contractions during defecation in the dog colon. Gastroenterology 1987; 92: 925-33.
8. 4 receptor agonist, prucalopride, on colonic motility in healthy volunteers. Aliment Pharmacol Ther 2002; 16: 603-12.
9. 4 receptors on cholinergic nerves involved in contractility of canine and human large intestine longitudinal muscle. Br J Pharmacol 2000; 131: 927-32.
10. Lepard KJ, Ren J, Galligan JJ. Presynaptic modulation of cholinergic and non-cholinergic fast synaptic transmission in the myenteric plexus of guinea pig ileum. Neurogastroenterol Mot 2004; 16: 355-64.
11. 4 receptors mediating relaxation of canine isolated rectum circular smooth muscle. Br J Pharmacol 1999; 127: 1431-7.
12. 4 receptors in the human isolated large intestinal circular muscle. Br J Pharmacol 2000; 129: 1601-8.
13. 2-agonist UK-14,304 on acetylcholine release in the pig gastric fundus. Neuropharmacology 2001; 40: 270-8.
14. Briejer MR, Bosmans J-P, Van Daele P et al. The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound. Eur J Pharmacol 2001; 423: 71-83.
15. 4 receptor. Br J Pharmacol 1994; 111: 332-8.
16. Burleigh DE, Trout SJ. Evidence against an acetylcholine releasing action of cisapride in the human colon. Br J Clin Pharmacol 1985; 20: 475-8.
17. 4 receptors and cholinergic and tachykininergic neurotransmission in the guinea-pig proximal colon. Eur J Pharmacol 1996; 308: 173-80.
18. 4 receptors. Pflüger'sArch Eur J Physiol 1995; 429: R9.
19. Tam FS, Bunce KT, Hillier K et al. Characterization of the 5-hydroxytryptamine receptor type involved in inhibition of spontaneous activity of human isolated colonic circular muscle. Br J Pharmacol 1994; 113: 143-50.
20. 4-like receptors. Br J Pharmacol 1996; 117: 238-9.
21. McLean PG, Coupar IM. Further investigation into the signal transduction mechanism of the 5-HT4-like receptor in the circular smooth muscle of human colon. Br J Pharmacol 1996; 118: 1058-64.
22. Boeckxstaens GE, Pelckmans PA, Herman AG, Van Maercke YM. Involvement of nitric oxide in the inhibitory innervation of the human isolated colon. Gastroenterology 1993; 104: 690-7.
23. Keef KD, Du C, Ward SM, McGregor B, Sanders KM. Enteric inhibitory neural regulation of human colonic circular muscle: role of nitric oxide. Gastroenterology 1993; 105: 1009-16.
24. 4 receptor in the human and the guineapig colon. Eur J Pharmacol 1999; 383: 281-5.