Blockade of human cardiac potassium channel Human Ether-a-go-go- Related Gene (HERG) by macrolide antibiotics

Journal of Pharmacology and Experimental Therapeutics

Volumn 302, Issue 1, 2002, Pages 320-327

  Volberg, Walter A ^a   Koci, Bryan J ^a   Su, Weiguo ^a   Lin, Jing ^a   Zhou, Jun ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLARITHROMYCIN; ERYTHROMYCIN; ERYTHROMYCIN DERIVATIVE; ERYTHROMYCYLAMINE; JOSAMYCIN; MACROLIDE; NORERYTHROMYCIN; OLEANDOMYCIN; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; ROXITHROMYCIN; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE DEPOLARIZATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING; DRUG MECHANISM; ELECTRIC POTENTIAL; GENE; HEART; HEART VENTRICLE ARRHYTHMIA; HERG GENE; HUMAN; HUMAN CELL; IC 50; LONG QT SYNDROME; MEMBRANE BINDING; POTASSIUM CURRENT; PRIORITY JOURNAL;

ANTI-BACTERIAL AGENTS; CATION TRANSPORT PROTEINS; CELL LINE; CLARITHROMYCIN; DNA-BINDING PROTEINS; ELECTROPHYSIOLOGY; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; KINETICS; LONG QT SYNDROME; MEMBRANE POTENTIALS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; TRANS-ACTIVATORS;

EID: 0036089685     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.302.1.320     Document Type: Article

References (39)

1. MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia
2. Cellular and ionic mechanisms underlying erythromycin-induced long QT intervals and torsade de pointes
3. "Run-down" of the Ca current during long whole-cell recordings in guinea pig heart cells: Role of phosphorylation and intracellular calcium
4. Drugs that prolong QT interval as an unwanted effect: Assessing their likelihood of inducing hazardous cardiac dysrhythmias
5. QT interval prolongation by non-cardiovascular drugs: Issues and solutions for novel drug development
6. Organising evidence on QT prolongation and occurrence of Torsades de Pointes with non-antiarrhythmic drugs: A call for consensus
7. Cardiac actions of erythromycin: Influence of female sex
8. Modulation of the delayed rectifier potassium current in frog cardiomyocytes by beta-adrenergic agonists and magnesium
9. Improved patch-clamp techniques for high-resolution current recording from cells and cellfree membrane patches
10. Use-dependent "agonist" effect of azimilide on the HERG channel
11. Clarithromycin associated with torsades de pointes
12. A review of erythromycin-induced malignant tachyarrhythmia - Torsade de pointes. A case report
13. Inhibitory effects of vesnarinone on cloned cardiac delayed rectifier K(+) channels expressed in a mammalian cell line
14. QT prolongation and Torsades de Pointes associated with clarithromycin
15. Quantitative structure-activity relationships among macrolide antibacterial agents: In vitro and in vivo potency against Pasteurella multocida
16. A structural basis for drug-induced long QT syndrome
17. Trapping of a methanesulfona-nilide by closure of the HERG potassium channel activation gate
18. Blockage of the HERG human cardiac K+ channel by the gastrointestinal prokinetic agent cisapride
19. Pharmacokinetics of macrolides. Comparison of plasma, tissue and free concentrations with special reference to roxithromycin
20. Oral empiric treatment of community-acquired pneumonia. A multicenter, double-blind, randomized study comparing sparfloxacin with roxithromycin
21. Macrolide drug interactions: An update
22. Clinical pharmacokinetic properties of the macrolide antibiotics. Effects of age and various pathophysiological states (Part I)
23. Pharmacokinetic drug interactions of macrolides
24. Blockade of the human cardiac K+ channel Kv1.5 by the antibiotic erythromycin
25. A mechanism for the proarrhythmic effects of cisapride (Propulsid): High affinity blockade of the human cardiac potassium channel HERG
26. Electrophysiological mechanisms in a canine model of erythromycin-associated long QT syndrome
27. A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel
28. Torsades de pointes in two chronic renal failure patients treated with cisapride and clarithromycin
29. A common polymorphism associated with antibiotic-induced cardiac arrhythmia
30. The inward rectification mechanism of the HERG cardiac potassium channel
31. High affinity open channel block by dofetilide of HERG expressed in a human cell line
32. The influence of cisapride and clarithromycin on QT intervals in healthy volunteers
33. Blockade of human cardiac potassium channel HERG by macrolide antibiotics
34. Macrolide-induced clinically relevant drug interactions with cytochrome P-450A (CYP) 3A4: An update focused on clarithromycin, azithromycin and dirithromycin
35. QT prolongation due to roxithromycin
36. Risk of torsades de pointes with non-cardiac drugs. Doctors need to be aware that many drugs can cause qt prolongation
37. Tissue penetration properties of macrolide antibiotics- comparative tissue distribution of erythromycin-stearate, clarithromycin, roxithromycin and azithromycin in rats
38. Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature