The inhibitory effect of the antipsychotic drug haloperidol on HERG potassium channels expressed in Xenopus oocytes

British Journal of Pharmacology

Volumn 120, Issue 5, 1997, Pages 968-974

  Suessbrich, H ^a   Schonherr R ^a   Heinemann, S H ^b   Attali, B ^b   Lang, F ^c   Busch, A E ^c  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^c WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Arrhythmia; Haloperidol; Human ether a go go related gene (HERG); K+ channel; Torsades de pointes

Indexed keywords

HALOPERIDOL; NEUROLEPTIC AGENT; POTASSIUM CHANNEL; POTASSIUM ION; REDUCED HALOPERIDOL;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG BINDING; ELECTRIC POTENTIAL; FEMALE; HEART VENTRICLE ARRHYTHMIA; MUTANT; NONHUMAN; OOCYTE; PRIORITY JOURNAL; QT INTERVAL; XENOPUS;

ANIMALS; ANTIPSYCHOTIC AGENTS; CATION TRANSPORT PROTEINS; DNA-BINDING PROTEINS; ETHER-A-GO-GO POTASSIUM CHANNELS; HALOPERIDOL; HUMANS; ION CHANNEL GATING; KINETICS; LONG QT SYNDROME; OOCYTES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; RECOMBINANT PROTEINS; RNA, COMPLEMENTARY; TRANS-ACTIVATORS; XENOPUS;

EID: 0030898598     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0700989     Document Type: Article

References (33)

1. + channels in Xenopus oocytes. J. PhysioL, 491, 735-741.
2. BUSCH, A.E., MALLOY, K.J., GROH, W.J., VARNUM, M.D., ADELMAN, J.P. & MAYLIE, J. (1994). The novel class HI antiarrhythmics NE-10064 and NE-10133 inhibit IK, channels expressed in Xenopus oocytes and IKs in guinea pig cardiac myocytes. Biochem. Biophys. Res. Commun., 202, 265-270.
3. CURRAN, M.E., SPLAWSKI, I., TIMOTHY, K.W., VINCENT, G.M., GREEN, E.D. & HEATING, M.T. (1995). A molecular basis for cardiac arrhthrnia: HERG mutations cause long QT syndrome. Cell, 80, 795-803.
4. DiMASCIO, A. (1972). The butyrophenones. In Butyrophenones in Psychiatry, ed. DiMascio, A. & Shader, R.I. p.117. New York: Raven Press.
5. ERESHEFSKY, L., DAVIS, CM., HARRINGTON, C.A., JANN, M.W., BROWNING, J.L., SAKLAD, S.R. & BURCH, N.R. (1984). Haloperidol and reduced haloperidol plasma levels in selected schizophrenic patients. J. Clin. Psychopharmacol., 4, 138-142.
6. + channels are independently regulated by protein kinases and ATP-hydrolysis. Neuron, 13, 1413-1420.
7. PAYER, S.A. (1986). Torsades de pointes vertricular tachyarrhythmia associated with haloperidol, J. Clin. Psychopharmacol., 6, 375-376.
8. + channel current. Circ. Res., 73, 210-216.
9. GALLAGHER, J. (1985). Cardiac arrhythmias. In Textbook of Medicine. 17th edition, ed. Wyngaarden J. & Smith, L. Philadelphia: W.B. Saunders & Co.
10. HENDERSON, R.S., LANE, S. & HENRY, J.A. (1991). Life-threatening ventricular arrhythmia (torsades de pointes) after haloperidol overdose. Hum. Exp. Toxicol., 10, 482-484.
11. HUNT, N. & STERN, T.A. (1995). The association betwen intravenous haloperidol and torsades de pointes. Psychosomatics, 36, 541-549.
12. JACKMAN, W.M., FRIDAY, K.J., ANDERSON, J.L., ALIOT, E.M., CLARK, M. & LAZZARA, R. (1988). The long QT syndromes: a critical review, new clinical observations and a unifying hypothesis. Prog. Cardiovasc. Dis., 31, 115-172.
13. KAMB, A., WEIR, M., RUDY, B., VARMUS, H. & KENYON, C. (1989). Identification of genes from pattern formation, tyrosine kinase, and potassium channel families by DNA amplification. Proc. Natl. Acad. Sei. U.S.A., 86, 4372-4376.
14. MCKINNON, D. (1989). Isolation of a cDNA clone coding for a putative second potassium channel indicates the existence of a gene family. J. Biol. Chem., 264, 8230-8236.
15. METZGER, E. & FRIEDMAN, R. (1993). Prolongation of the corrected QT and torsades de pointes cardiac arrhythmia associated with intravenous haloperidaol in the medically ill. J. Clin. Psychopharmacol., 13, 128-132.
16. MONAHAN, B.P., FERGUSON, C.L., KILLEAVY, E.S., LLOYD, B.K., TROY, J. & CANTILENA, L.R. (1990). Torsade de pointes occurring in association with terfenadine use. J. Am. Med. Assoc., 264, 2788-2790.
17. MURAI, T., KAKIZUKA, A., TAKUMI, T., OHKUBO, H. & NAKA-NISHI, S. (1989). Molecular cloning and sequence analysis of human genomic DNA encoding a novel membrane protein which exhibits a slowly activating potassium channel activity. Biochem. Biophys. Res. Commun., 161, 176-181.
18. PAULMICHL, M., NASMITH, P., HELLMISS, R., REED, K., BOYLE, A., NERBONNE, J.M., PERALATA, E.G. & CLAPHAM, D.E. (1991). Cloning and expression of a rat delayed rectifier potassium channel. Proc. Natl. Acad. Sei. U.S.A., 88, 7892-7895.
19. PO, S.S., ROBERDS, S.L., SNYDERS, D.J., TAMKUN, M.M. & BENNETT, P.B. (1993). Heteromultimeric assembly of human potassium channels. Circ. Res., 72, 1326-1336.
20. SANGUINETTI, M.C., JIANG, C, CURRAN, M.E. & KEATING, M.T. (1995). A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the Iicr potassium channel. Cell, 81,299-307.
21. SANGUINETTI, M.C., JURKIEWICZ, N.C., SCOTT, A. & SIEGL, P.K.S. (1991). Isoproterenol antagonizes prolongation of refractory period by the class III antiarrhythmic agent, E-4031, in guineapig myocytes: mechanism of action. Cire. Res., 68, 77-84.
22. SCHÖNHERR, R. & HEINEMANN, S.H. (1996). Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel. J. Physiol., 493, 635-642.
23. SIMONS, F.E.R., KESSELMAN, M.S., GIDDINS, N.G., PELECH, A.N. & SIMONS, K.J. (1988). Astemizole-induced torsade de pointes. Lancet, 2, 624.
24. SMITH, P., BAUKROWITZ, T. & YELLEN, G. (1996). The inward rectification mechanism of the HERG cardiac potassium channel. Nature, 379, 833-836.
25. STRATMANN, H.G. & KENNEDY, H.L. (1987). Torsades de pointes associated with drugs and toxins: recognition and management. Am. Heart J., 113, 1470-1482.
26. STÜHMER, W., RUPPERSBERG, J.P., SCHROTER, K.H., SAKMANN, B., STOCKER, M., GIESE, K.P., PERSCHKE, A., BAUMANN, A. & PONGS, O. (1989). Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain. EMBO J., 8, 3235-3244.
27. STÜHMER, W., STOCKER, M., SAKMANN, B., SEEBURG, P., BAUMANN, A., GRUPE, A. & PONGS, O. (1988). Potassium channels expressed from rat brain cDNA have delayed rectifier properties. FEBS Lett., 242, 199-206.
28. SUESSBRICH, H., WALDEGGER, S., LANG, F. & BUSCH, A.E. (1996). Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizole. FEBS Le., 385, 77-80.
29. TAMKUN, M.M., BENNET, P.B. & SNYDERS, D.J. (1994). Cloning and expression of human cardiac K"1" channels. In Cardiac Electrophysiology: From Cell to Bedside, ed. Zipes, D. & Jalife, J. pp.21 31. Philadelphia, PA: Saunders.
30. WANG, Z., FERMINI, B. & NATTEL, S. (1994). Rapid and slow components of delayed rectifier current in human and atrial myocytes. Cardiovasc. Res., 28, 1540-1546.
31. WARMKE, J.E. & GANETZKY, B. (1994). A family of potassium channel genes related to eag in Drosophila and mammals. Proc. Natl. Acad. Sei. U.S.A., 91, 3438-3442.
32. YANG, T., PRAKASH, C., RODEN, D.M. & SNYDERS, D.J. (1995). Mechanism of block of a human cardiac potassium channel by terfenadine racemate and enantiomers. Br. J. Pharmacol., 115, 267-274.
33. ZIPES, O.P. (1987). Proarrhythmic effects of antiarrhytmic drugs. Am. J. Cardiol, 59, 26E-31E.