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Volumn 17, Issue 2, 2018, Pages 149-160

What is the risk-benefit ratio of long-term antipsychotic treatment in people with schizophrenia?

Author keywords

benefit to risk ratio; dopaminergic hypersensitivity; effectiveness; efficacy; Long term antipsychotic treatment; metabolic disturbance; mortality; non adherence; physical morbidity; psychosocial interventions; schizophrenia; tardive dyskinesia

Indexed keywords

CLOZAPINE; DEUTETRABENAZINE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NEUROLEPTIC AGENT; OLANZAPINE; PLACEBO; VALBENAZINE;

EID: 85047797436     PISSN: 17238617     EISSN: 20515545     Source Type: Journal    
DOI: 10.1002/wps.20516     Document Type: Article
Times cited : (220)

References (156)
  • 2
    • 1642283731 scopus 로고    scopus 로고
    • Practice guideline for the treatment of patients with schizophrenia, 2nd ed
    • Lehman AF, Lieberman JA, Dixon LB et al. Practice guideline for the treatment of patients with schizophrenia, 2nd ed. Am J Psychiatry 2004;161(Suppl. 2):1-56.
    • (2004) Am J Psychiatry , vol.161 , pp. 1-56
    • Lehman, A.F.1    Lieberman, J.A.2    Dixon, L.B.3
  • 3
    • 73949137552 scopus 로고    scopus 로고
    • The 2009 schizophrenia PORT psychopharmacological treatment recommendations and summary statements
    • Buchanan RW, Kreyenbuhl J, Kelly DL et al. The 2009 schizophrenia PORT psychopharmacological treatment recommendations and summary statements. Schizophr Bull 2010;36:71-93.
    • (2010) Schizophr Bull , vol.36 , pp. 71-93
    • Buchanan, R.W.1    Kreyenbuhl, J.2    Kelly, D.L.3
  • 4
    • 85029088286 scopus 로고    scopus 로고
    • Canadian schizophrenia guidelines: schizophrenia and other psychotic disorders with coexisting substance use disorders
    • Crockford D, Addington D. Canadian schizophrenia guidelines: schizophrenia and other psychotic disorders with coexisting substance use disorders. Can J Psychiatry 2017;62:624-34.
    • (2017) Can J Psychiatry , vol.62 , pp. 624-634
    • Crockford, D.1    Addington, D.2
  • 5
    • 84964241000 scopus 로고    scopus 로고
    • Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for the management of schizophrenia and related disorders
    • Galletly C, Castle D, Dark F et al. Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for the management of schizophrenia and related disorders. Aust N Z J Psychiatry 2016;50:410-72.
    • (2016) Aust N Z J Psychiatry , vol.50 , pp. 410-472
    • Galletly, C.1    Castle, D.2    Dark, F.3
  • 6
    • 0028336845 scopus 로고
    • Depot antipsychotic drugs. Place in therapy
    • Davis JM, Matalon L, Watanabe MD et al. Depot antipsychotic drugs. Place in therapy. Drugs 1994;47:741-73.
    • (1994) Drugs , vol.47 , pp. 741-773
    • Davis, J.M.1    Matalon, L.2    Watanabe, M.D.3
  • 7
    • 0026049403 scopus 로고
    • The current unsatisfactory state of relapse prevention in schizophrenic psychoses – suggestions for improvement
    • Kissling W. The current unsatisfactory state of relapse prevention in schizophrenic psychoses – suggestions for improvement. Clin Neuropharmacol 1991;14(Suppl. 2):S33-44.
    • (1991) Clin Neuropharmacol , vol.14 , pp. S33-44
    • Kissling, W.1
  • 8
    • 0042978712 scopus 로고    scopus 로고
    • Relapse prevention in schizophrenia with new-generation antipsychotics: a systematic review and exploratory meta-analysis of randomized, controlled trials
    • Leucht S, Barnes TRE, Kissling W et al. Relapse prevention in schizophrenia with new-generation antipsychotics: a systematic review and exploratory meta-analysis of randomized, controlled trials. Am J Psychiatry 2003;160:1209-22.
    • (2003) Am J Psychiatry , vol.160 , pp. 1209-1222
    • Leucht, S.1    Barnes, T.R.E.2    Kissling, W.3
  • 9
    • 84861585734 scopus 로고    scopus 로고
    • Antipsychotic drugs versus placebo for relapse prevention in schizophrenia: a systematic review and meta-analysis
    • Leucht S, Tardy M, Komossa K et al. Antipsychotic drugs versus placebo for relapse prevention in schizophrenia: a systematic review and meta-analysis. Lancet 2012;379:2063-71.
    • (2012) Lancet , vol.379 , pp. 2063-2071
    • Leucht, S.1    Tardy, M.2    Komossa, K.3
  • 10
    • 84884161208 scopus 로고    scopus 로고
    • Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis
    • Leucht S, Cipriani A, Spineli L et al. Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. Lancet 2013;382:951-62.
    • (2013) Lancet , vol.382 , pp. 951-962
    • Leucht, S.1    Cipriani, A.2    Spineli, L.3
  • 11
    • 84856243720 scopus 로고    scopus 로고
    • Antipsychotic treatment for schizophrenia in the maintenance phase: a systematic review of the guidelines and algorithms
    • Takeuchi H, Suzuki T, Uchida H et al. Antipsychotic treatment for schizophrenia in the maintenance phase: a systematic review of the guidelines and algorithms. Schizophr Res 2012;134:219-25.
    • (2012) Schizophr Res , vol.134 , pp. 219-225
    • Takeuchi, H.1    Suzuki, T.2    Uchida, H.3
  • 12
    • 84996564309 scopus 로고    scopus 로고
    • Should psychiatrists be more cautious about the long-term prophylactic use of antipsychotics?
    • Murray RM, Quattrone D, Natesan S et al. Should psychiatrists be more cautious about the long-term prophylactic use of antipsychotics? Br J Psychiatry 2016;209:361-5.
    • (2016) Br J Psychiatry , vol.209 , pp. 361-365
    • Murray, R.M.1    Quattrone, D.2    Natesan, S.3
  • 13
    • 84883542097 scopus 로고    scopus 로고
    • Recovery in remitted first-episode psychosis at 7 years of follow-up of an early dose reduction/discontinuation or maintenance treatment strategy: long-term follow-up of a 2-year randomized clinical trial
    • Wunderink L, Nieboer RM, Wiersma D et al. Recovery in remitted first-episode psychosis at 7 years of follow-up of an early dose reduction/discontinuation or maintenance treatment strategy: long-term follow-up of a 2-year randomized clinical trial. JAMA Psychiatry 2013;70:913-20.
    • (2013) JAMA Psychiatry , vol.70 , pp. 913-920
    • Wunderink, L.1    Nieboer, R.M.2    Wiersma, D.3
  • 14
    • 85027958492 scopus 로고    scopus 로고
    • Does treatment of schizophrenia with antipsychotic medications eliminate or reduce psychosis? A 20-year multi-follow-up study
    • Harrow M, Jobe TH, Faull RN. Does treatment of schizophrenia with antipsychotic medications eliminate or reduce psychosis? A 20-year multi-follow-up study. Psychol Med 2014;44:3007-16.
    • (2014) Psychol Med , vol.44 , pp. 3007-3016
    • Harrow, M.1    Jobe, T.H.2    Faull, R.N.3
  • 15
    • 85021190128 scopus 로고    scopus 로고
    • A 20-year multi-followup longitudinal study assessing whether antipsychotic medications contribute to work functioning in schizophrenia
    • Harrow M, Jobe TH, Faull RN et al. A 20-year multi-followup longitudinal study assessing whether antipsychotic medications contribute to work functioning in schizophrenia. Psychiatry Res 2017;256:267-74.
    • (2017) Psychiatry Res , vol.256 , pp. 267-274
    • Harrow, M.1    Jobe, T.H.2    Faull, R.N.3
  • 16
    • 33947303207 scopus 로고    scopus 로고
    • Breakthrough” dopamine supersensitivity during ongoing antipsychotic treatment leads to treatment failure over time
    • “, -
    • Samaha A-N, Seeman P, Stewart J et al. “Breakthrough” dopamine supersensitivity during ongoing antipsychotic treatment leads to treatment failure over time. J Neurosci 2007;27:2979-86.
    • (2007) J Neurosci , vol.27 , pp. 2979-2986
    • Samaha, A.-N.1    Seeman, P.2    Stewart, J.3
  • 17
    • 84940749622 scopus 로고    scopus 로고
    • Antipsychotic maintenance treatment: time to rethink?
    • Moncrieff J. Antipsychotic maintenance treatment: time to rethink? PLoS Med 2015;12:e1001861.
    • (2015) PLoS Med , vol.12
    • Moncrieff, J.1
  • 18
    • 85021782269 scopus 로고    scopus 로고
    • The long-term effects of antipsychotic medication on clinical course in schizophrenia
    • Goff DC, Falkai P, Fleischhacker WW et al. The long-term effects of antipsychotic medication on clinical course in schizophrenia. Am J Psychiatry 2017;174:840-9.
    • (2017) Am J Psychiatry , vol.174 , pp. 840-849
    • Goff, D.C.1    Falkai, P.2    Fleischhacker, W.W.3
  • 19
    • 84930677623 scopus 로고    scopus 로고
    • Does long term use of psychiatric drugs cause more harm than good?
    • Gøtzsche PC, Young AH, Crace J. Does long term use of psychiatric drugs cause more harm than good? BMJ 2015;350:h2435.
    • (2015) BMJ , vol.350 , pp. h2435
    • Gøtzsche, P.C.1    Young, A.H.2    Crace, J.3
  • 20
    • 83455219307 scopus 로고    scopus 로고
    • Quantifying clinical relevance in the treatment of schizophrenia
    • Correll CU, Kishimoto T, Nielsen J et al. Quantifying clinical relevance in the treatment of schizophrenia. Clin Ther 2011;33:B16-39.
    • (2011) Clin Ther , vol.33 , pp. B16-39
    • Correll, C.U.1    Kishimoto, T.2    Nielsen, J.3
  • 21
    • 84880193278 scopus 로고    scopus 로고
    • Assessing the comparative effectiveness of long-acting injectable vs. oral antipsychotic medications in the prevention of relapse provides a case study in comparative effectiveness research in psychiatry
    • Kane JM, Kishimoto T, Correll CU. Assessing the comparative effectiveness of long-acting injectable vs. oral antipsychotic medications in the prevention of relapse provides a case study in comparative effectiveness research in psychiatry. J Clin Epidemiol 2013;66(Suppl. 8):S37-41.
    • (2013) J Clin Epidemiol , vol.66 , pp. S37-41
    • Kane, J.M.1    Kishimoto, T.2    Correll, C.U.3
  • 22
    • 80052149754 scopus 로고    scopus 로고
    • Randomized controlled trials in schizophrenia: opportunities, limitations, and trial design alternatives
    • Correll CU, Kishimoto T, Kane JM. Randomized controlled trials in schizophrenia: opportunities, limitations, and trial design alternatives. Dialogues Clin Neurosci 2011;13:155-72.
    • (2011) Dialogues Clin Neurosci , vol.13 , pp. 155-172
    • Correll, C.U.1    Kishimoto, T.2    Kane, J.M.3
  • 23
    • 84885170937 scopus 로고    scopus 로고
    • Non-adherence to medication in patients with psychotic disorders: epidemiology, contributing factors and management strategies
    • Kane JM, Kishimoto T, Correll CU. Non-adherence to medication in patients with psychotic disorders: epidemiology, contributing factors and management strategies. World Psychiatry 2013;12:216-26.
    • (2013) World Psychiatry , vol.12 , pp. 216-226
    • Kane, J.M.1    Kishimoto, T.2    Correll, C.U.3
  • 24
    • 33751223525 scopus 로고    scopus 로고
    • Antipsychotic adherence over time among patients receiving treatment for schizophrenia: a retrospective review
    • Valenstein M, Ganoczy D, McCarthy JF et al. Antipsychotic adherence over time among patients receiving treatment for schizophrenia: a retrospective review. J Clin Psychiatry 2006;67:1542-50.
    • (2006) J Clin Psychiatry , vol.67 , pp. 1542-1550
    • Valenstein, M.1    Ganoczy, D.2    McCarthy, J.F.3
  • 25
    • 85011672047 scopus 로고    scopus 로고
    • Real-world adherence assessment of lurasidone and other oral atypical antipsychotics among patients with schizophrenia: an administrative claims analysis
    • Rajagopalan K, Wade S, Meyer N et al. Real-world adherence assessment of lurasidone and other oral atypical antipsychotics among patients with schizophrenia: an administrative claims analysis. Curr Med Res Opin 2017;33:813-20.
    • (2017) Curr Med Res Opin , vol.33 , pp. 813-820
    • Rajagopalan, K.1    Wade, S.2    Meyer, N.3
  • 26
    • 85016435363 scopus 로고    scopus 로고
    • Accuracy of clinician assessments of medication status in the emergency setting: a comparison of clinician assessment of antipsychotic usage and plasma level determination
    • Lopez LV, Shaikh A, Merson J et al. Accuracy of clinician assessments of medication status in the emergency setting: a comparison of clinician assessment of antipsychotic usage and plasma level determination. J Clin Psychopharmacol 2017;37:310-4.
    • (2017) J Clin Psychopharmacol , vol.37 , pp. 310-314
    • Lopez, L.V.1    Shaikh, A.2    Merson, J.3
  • 27
    • 84863776224 scopus 로고    scopus 로고
    • Risk factors for relapse following treatment for first episode psychosis: a systematic review and meta-analysis of longitudinal studies
    • Alvarez-Jimenez M, Priede A, Hetrick SE et al. Risk factors for relapse following treatment for first episode psychosis: a systematic review and meta-analysis of longitudinal studies. Schizophr Res 2012;139:116-28.
    • (2012) Schizophr Res , vol.139 , pp. 116-128
    • Alvarez-Jimenez, M.1    Priede, A.2    Hetrick, S.E.3
  • 28
    • 84994429457 scopus 로고    scopus 로고
    • Five-fold increased risk of relapse following breaks in antipsychotic treatment of first episode psychosis
    • Winton-Brown TT, Elanjithara T, Power P et al. Five-fold increased risk of relapse following breaks in antipsychotic treatment of first episode psychosis. Schizophr Res 2017;179:50-6.
    • (2017) Schizophr Res , vol.179 , pp. 50-56
    • Winton-Brown, T.T.1    Elanjithara, T.2    Power, P.3
  • 29
    • 85022031155 scopus 로고    scopus 로고
    • Poor medication adherence and risk of relapse associated with continued cannabis use in patients with first-episode psychosis: a prospective analysis
    • Schoeler T, Petros N, Di Forti M et al. Poor medication adherence and risk of relapse associated with continued cannabis use in patients with first-episode psychosis: a prospective analysis. Lancet Psychiatry 2017;4:627-33.
    • (2017) Lancet Psychiatry , vol.4 , pp. 627-633
    • Schoeler, T.1    Petros, N.2    Di Forti, M.3
  • 30
    • 77949772157 scopus 로고    scopus 로고
    • Predictors and clinical consequences of non-adherence with antipsychotic medication in the outpatient treatment of schizophrenia
    • Novick D, Haro JM, Suarez D et al. Predictors and clinical consequences of non-adherence with antipsychotic medication in the outpatient treatment of schizophrenia. Psychiatry Res 2010;176:109-13.
    • (2010) Psychiatry Res , vol.176 , pp. 109-113
    • Novick, D.1    Haro, J.M.2    Suarez, D.3
  • 31
    • 84892639627 scopus 로고    scopus 로고
    • Long-acting injectable vs oral antipsychotics for relapse prevention in schizophrenia: a meta-analysis of randomized trials
    • Kishimoto T, Robenzadeh A, Leucht C et al. Long-acting injectable vs oral antipsychotics for relapse prevention in schizophrenia: a meta-analysis of randomized trials. Schizophr Bull 2014;40:192-213.
    • (2014) Schizophr Bull , vol.40 , pp. 192-213
    • Kishimoto, T.1    Robenzadeh, A.2    Leucht, C.3
  • 32
    • 84887080795 scopus 로고    scopus 로고
    • Long-acting injectable versus oral antipsychotics in schizophrenia: a systematic review and meta-analysis of mirror-image studies
    • Kishimoto T, Nitta M, Borenstein M et al. Long-acting injectable versus oral antipsychotics in schizophrenia: a systematic review and meta-analysis of mirror-image studies. J Clin Psychiatry 2013;74:957-65.
    • (2013) J Clin Psychiatry , vol.74 , pp. 957-965
    • Kishimoto, T.1    Nitta, M.2    Borenstein, M.3
  • 33
    • 84883482534 scopus 로고    scopus 로고
    • Effect of prior treatment with antipsychotic long-acting injection on randomised clinical trial treatment outcomes
    • Barnes TRE, Drake RJ, Dunn G et al. Effect of prior treatment with antipsychotic long-acting injection on randomised clinical trial treatment outcomes. Br J Psychiatry 2013;203:215-20.
    • (2013) Br J Psychiatry , vol.203 , pp. 215-220
    • Barnes, T.R.E.1    Drake, R.J.2    Dunn, G.3
  • 34
    • 84927125015 scopus 로고    scopus 로고
    • Switching from risperidone long-acting injectable to paliperidone long-acting injectable or oral antipsychotics: analysis of a Medicaid claims database
    • Voss EA, Ryan PB, Stang PE et al. Switching from risperidone long-acting injectable to paliperidone long-acting injectable or oral antipsychotics: analysis of a Medicaid claims database. Int Clin Psychopharmacol 2015;30:151-7.
    • (2015) Int Clin Psychopharmacol , vol.30 , pp. 151-157
    • Voss, E.A.1    Ryan, P.B.2    Stang, P.E.3
  • 35
    • 85047798151 scopus 로고    scopus 로고
    • Effectiveness of long-acting injectable vs oral antipsychotics in patients with schizophrenia: a meta-analysis of prospective and retrospective cohort studies
    • (in press)
    • Kishimoto T, Hagi K, Nitta M et al. Effectiveness of long-acting injectable vs oral antipsychotics in patients with schizophrenia: a meta-analysis of prospective and retrospective cohort studies. Schizophr Bull (in press).
    • Schizophr Bull
    • Kishimoto, T.1    Hagi, K.2    Nitta, M.3
  • 36
    • 79958233416 scopus 로고    scopus 로고
    • A nationwide cohort study of oral and depot antipsychotics after first hospitalization for schizophrenia
    • Tiihonen J, Haukka J, Taylor M et al. A nationwide cohort study of oral and depot antipsychotics after first hospitalization for schizophrenia. Am J Psychiatry 2011;168:603-9.
    • (2011) Am J Psychiatry , vol.168 , pp. 603-609
    • Tiihonen, J.1    Haukka, J.2    Taylor, M.3
  • 37
    • 85020619657 scopus 로고    scopus 로고
    • Real-world effectiveness of antipsychotic treatments in a nationwide cohort of 29823 patients with schizophrenia
    • Tiihonen J, Mittendorfer-Rutz E, Majak M et al. Real-world effectiveness of antipsychotic treatments in a nationwide cohort of 29823 patients with schizophrenia. JAMA Psychiatry 2017;74:686-93.
    • (2017) JAMA Psychiatry , vol.74 , pp. 686-693
    • Tiihonen, J.1    Mittendorfer-Rutz, E.2    Majak, M.3
  • 38
    • 84995630387 scopus 로고    scopus 로고
    • Safety and tolerability of long-acting injectable versus oral antipsychotics: a meta-analysis of randomized controlled studies comparing the same antipsychotics
    • Misawa F, Kishimoto T, Hagi K et al. Safety and tolerability of long-acting injectable versus oral antipsychotics: a meta-analysis of randomized controlled studies comparing the same antipsychotics. Schizophr Res 2016;176:220-30.
    • (2016) Schizophr Res , vol.176 , pp. 220-230
    • Misawa, F.1    Kishimoto, T.2    Hagi, K.3
  • 39
    • 84925304433 scopus 로고    scopus 로고
    • Clinical predictors of therapeutic response to antipsychotics in schizophrenia
    • Carbon M, Correll CU. Clinical predictors of therapeutic response to antipsychotics in schizophrenia. Dialogues Clin Neurosci 2014;16:505-24.
    • (2014) Dialogues Clin Neurosci , vol.16 , pp. 505-524
    • Carbon, M.1    Correll, C.U.2
  • 40
    • 85032972126 scopus 로고    scopus 로고
    • Declining clinical course of psychotic disorders over the two decades following first hospitalization: evidence from the Suffolk County Mental Health Project
    • Kotov R, Fochtmann L, Li K et al. Declining clinical course of psychotic disorders over the two decades following first hospitalization: evidence from the Suffolk County Mental Health Project. Am J Psychiatry 2017;174:1064-74.
    • (2017) Am J Psychiatry , vol.174 , pp. 1064-1074
    • Kotov, R.1    Fochtmann, L.2    Li, K.3
  • 41
    • 84906940362 scopus 로고    scopus 로고
    • Lifetime use of antipsychotic medication and its relation to change of verbal learning and memory in midlife schizophrenia – an observational 9-year follow-up study
    • Husa AP, Rannikko I, Moilanen J et al. Lifetime use of antipsychotic medication and its relation to change of verbal learning and memory in midlife schizophrenia – an observational 9-year follow-up study. Schizophr Res 2014;158:134-41.
    • (2014) Schizophr Res , vol.158 , pp. 134-141
    • Husa, A.P.1    Rannikko, I.2    Moilanen, J.3
  • 42
    • 84872395809 scopus 로고    scopus 로고
    • Characteristics of subjects with schizophrenia spectrum disorder with and without antipsychotic medication – A 10-year follow-up of the Northern Finland 1966 Birth Cohort study
    • Moilanen J, Haapea M, Miettunen J et al. Characteristics of subjects with schizophrenia spectrum disorder with and without antipsychotic medication – A 10-year follow-up of the Northern Finland 1966 Birth Cohort study. Eur Psychiatry 2013;28:53-8.
    • (2013) Eur Psychiatry , vol.28 , pp. 53-58
    • Moilanen, J.1    Haapea, M.2    Miettunen, J.3
  • 43
    • 85017168783 scopus 로고    scopus 로고
    • Stability and development of psychotic symptoms and the use of antipsychotic medication – long-term follow-up
    • Gotfredsen DR, Wils RS, Hjorthøj C et al. Stability and development of psychotic symptoms and the use of antipsychotic medication – long-term follow-up. Psychol Med 2017;47:2118-29.
    • (2017) Psychol Med , vol.47 , pp. 2118-2129
    • Gotfredsen, D.R.1    Wils, R.S.2    Hjorthøj, C.3
  • 44
    • 85006013279 scopus 로고    scopus 로고
    • Antipsychotic medication and remission of psychotic symptoms 10 years after a first-episode psychosis
    • Wils RS, Gotfredsen DR, Hjorthøj C et al. Antipsychotic medication and remission of psychotic symptoms 10 years after a first-episode psychosis. Schizophr Res 2017;182:42-8.
    • (2017) Schizophr Res , vol.182 , pp. 42-48
    • Wils, R.S.1    Gotfredsen, D.R.2    Hjorthøj, C.3
  • 45
    • 84949845557 scopus 로고    scopus 로고
    • Different outcomes of never-treated and treated patients with schizophrenia: 14-year follow-up study in rural China
    • Ran M-S, Weng X, Chan CL-W et al. Different outcomes of never-treated and treated patients with schizophrenia: 14-year follow-up study in rural China. Br J Psychiatry 2015;207:495-500.
    • (2015) Br J Psychiatry , vol.207 , pp. 495-500
    • Ran, M.-S.1    Weng, X.2    Chan, C.L.-W.3
  • 46
    • 84973305090 scopus 로고    scopus 로고
    • Mortality and cumulative exposure to antipsychotics, antidepressants, and benzodiazepines in patients with schizophrenia: an observational follow-up study
    • Tiihonen J, Mittendorfer-Rutz E, Torniainen M et al. Mortality and cumulative exposure to antipsychotics, antidepressants, and benzodiazepines in patients with schizophrenia: an observational follow-up study. Am J Psychiatry 2016;173:600-6.
    • (2016) Am J Psychiatry , vol.173 , pp. 600-606
    • Tiihonen, J.1    Mittendorfer-Rutz, E.2    Torniainen, M.3
  • 47
    • 68949172254 scopus 로고    scopus 로고
    • 11-year follow-up of mortality in patients with schizophrenia: a population-based cohort study (FIN11 study)
    • Tiihonen J, Lönnqvist J, Wahlbeck K et al. 11-year follow-up of mortality in patients with schizophrenia: a population-based cohort study (FIN11 study). Lancet 2009;374:620-7.
    • (2009) Lancet , vol.374 , pp. 620-627
    • Tiihonen, J.1    Lönnqvist, J.2    Wahlbeck, K.3
  • 48
    • 34249715417 scopus 로고    scopus 로고
    • Guided discontinuation versus maintenance treatment in remitted first-episode psychosis: relapse rates and functional outcome
    • Wunderink L, Nienhuis FJ, Sytema S et al. Guided discontinuation versus maintenance treatment in remitted first-episode psychosis: relapse rates and functional outcome. J Clin Psychiatry 2007;68:654-61.
    • (2007) J Clin Psychiatry , vol.68 , pp. 654-661
    • Wunderink, L.1    Nienhuis, F.J.2    Sytema, S.3
  • 49
    • 79959747688 scopus 로고    scopus 로고
    • Low dose vs standard dose of antipsychotics for relapse prevention in schizophrenia: meta-analysis
    • Uchida H, Suzuki T, Takeuchi H et al. Low dose vs standard dose of antipsychotics for relapse prevention in schizophrenia: meta-analysis. Schizophr Bull 2011;37:788-99.
    • (2011) Schizophr Bull , vol.37 , pp. 788-799
    • Uchida, H.1    Suzuki, T.2    Takeuchi, H.3
  • 50
    • 85047792094 scopus 로고    scopus 로고
    • Collaborating Centre for Drug Statistics Methodology. ATC/DDD Index
    • World Health Organization. Collaborating Centre for Drug Statistics Methodology. ATC/DDD Index 2017. http://www.whocc.no/atcddd/.
    • (2017)
  • 51
    • 84883476426 scopus 로고    scopus 로고
    • Effects of risperidone and olanzapine dose reduction on cognitive function in stable patients with schizophrenia: an open-label, randomized, controlled, pilot study. Schizophr
    • Takeuchi H, Suzuki T, Remington G et al. Effects of risperidone and olanzapine dose reduction on cognitive function in stable patients with schizophrenia: an open-label, randomized, controlled, pilot study. Schizophr Bull 2013;39:993-8.
    • (2013) Bull , vol.39 , pp. 993-998
    • Takeuchi, H.1    Suzuki, T.2    Remington, G.3
  • 52
    • 84966461423 scopus 로고    scopus 로고
    • Clinical outcome after antipsychotic treatment discontinuation in functionally recovered first-episode nonaffective psychosis individuals: a 3-year naturalistic follow-up study
    • Mayoral-van Son J, de la Foz VO, Martinez-Garcia O et al. Clinical outcome after antipsychotic treatment discontinuation in functionally recovered first-episode nonaffective psychosis individuals: a 3-year naturalistic follow-up study. J Clin Psychiatry 2016;77:492-500.
    • (2016) J Clin Psychiatry , vol.77 , pp. 492-500
    • Mayoral-van Son, J.1    de la Foz, V.O.2    Martinez-Garcia, O.3
  • 53
    • 84856466929 scopus 로고    scopus 로고
    • Metabolic and cardiovascular adverse effects associated with antipsychotic drugs
    • De Hert M, Detraux J, van Winkel R et al. Metabolic and cardiovascular adverse effects associated with antipsychotic drugs. Nat Rev Endocrinol 2011;8:114-26.
    • (2011) Nat Rev Endocrinol , vol.8 , pp. 114-126
    • De Hert, M.1    Detraux, J.2    van Winkel, R.3
  • 54
    • 79952395209 scopus 로고    scopus 로고
    • Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care
    • De Hert M, Correll CU, Bobes J et al. Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care. World Psychiatry 2011;10:52-77.
    • (2011) World Psychiatry , vol.10 , pp. 52-77
    • De Hert, M.1    Correll, C.U.2    Bobes, J.3
  • 55
    • 85019175108 scopus 로고    scopus 로고
    • Prevalence, incidence and mortality from cardiovascular disease in patients with pooled and specific severe mental illness: a large-scale meta-analysis of 3,211,768 patients and 113,383,368 controls
    • Correll CU, Solmi M, Veronese N et al. Prevalence, incidence and mortality from cardiovascular disease in patients with pooled and specific severe mental illness: a large-scale meta-analysis of 3,211,768 patients and 113,383,368 controls. World Psychiatry 2017;16:163-80.
    • (2017) World Psychiatry , vol.16 , pp. 163-180
    • Correll, C.U.1    Solmi, M.2    Veronese, N.3
  • 56
    • 84997514469 scopus 로고    scopus 로고
    • Physical multimorbidity and psychosis: comprehensive cross sectional analysis including 242,952 people across 48 low- and middle-income countries
    • Stubbs B, Koyanagi A, Veronese N et al. Physical multimorbidity and psychosis: comprehensive cross sectional analysis including 242,952 people across 48 low- and middle-income countries. BMC Med 2016;14:189.
    • (2016) BMC Med , vol.14 , pp. 189
    • Stubbs, B.1    Koyanagi, A.2    Veronese, N.3
  • 57
    • 84973137860 scopus 로고    scopus 로고
    • Diabetes mellitus in people with schizophrenia, bipolar disorder and major depressive disorder: a systematic review and large scale meta-analysis
    • Vancampfort D, Correll CU, Galling B et al. Diabetes mellitus in people with schizophrenia, bipolar disorder and major depressive disorder: a systematic review and large scale meta-analysis. World Psychiatry 2016;15:166-74.
    • (2016) World Psychiatry , vol.15 , pp. 166-174
    • Vancampfort, D.1    Correll, C.U.2    Galling, B.3
  • 58
    • 84942512953 scopus 로고    scopus 로고
    • Risk of metabolic syndrome and its components in people with schizophrenia and related psychotic disorders, bipolar disorder and major depressive disorder: a systematic review and meta-analysis
    • Vancampfort D, Stubbs B, Mitchell AJ et al. Risk of metabolic syndrome and its components in people with schizophrenia and related psychotic disorders, bipolar disorder and major depressive disorder: a systematic review and meta-analysis. World Psychiatry 2015;14:339-47.
    • (2015) World Psychiatry , vol.14 , pp. 339-347
    • Vancampfort, D.1    Stubbs, B.2    Mitchell, A.J.3
  • 59
    • 84930444696 scopus 로고    scopus 로고
    • Effects of antipsychotics, antidepressants and mood stabilizers on risk for physical diseases in people with schizophrenia, depression and bipolar disorder
    • Correll CU, Detraux J, De Lepeleire J et al. Effects of antipsychotics, antidepressants and mood stabilizers on risk for physical diseases in people with schizophrenia, depression and bipolar disorder. World Psychiatry 2015;14:119-36.
    • (2015) World Psychiatry , vol.14 , pp. 119-136
    • Correll, C.U.1    Detraux, J.2    De Lepeleire, J.3
  • 60
    • 84885097121 scopus 로고    scopus 로고
    • A meta-analysis of cardio-metabolic abnormalities in drug naïve, first-episode and multi-episode patients with schizophrenia versus general population controls
    • Vancampfort D, Wampers M, Mitchell AJ et al. A meta-analysis of cardio-metabolic abnormalities in drug naïve, first-episode and multi-episode patients with schizophrenia versus general population controls. World Psychiatry 2013;12:240-50.
    • (2013) World Psychiatry , vol.12 , pp. 240-250
    • Vancampfort, D.1    Wampers, M.2    Mitchell, A.J.3
  • 61
    • 85029697640 scopus 로고    scopus 로고
    • Sedentary behavior and physical activity levels in people with schizophrenia, bipolar disorder and major depressive disorder: a global systematic review and meta-analysis
    • Vancampfort D, Firth J, Schuch FB et al. Sedentary behavior and physical activity levels in people with schizophrenia, bipolar disorder and major depressive disorder: a global systematic review and meta-analysis. World Psychiatry 2017;16:308-15.
    • (2017) World Psychiatry , vol.16 , pp. 308-315
    • Vancampfort, D.1    Firth, J.2    Schuch, F.B.3
  • 62
    • 35148893170 scopus 로고    scopus 로고
    • Physical illness and schizophrenia: a review of the literature
    • Leucht S, Burkard T, Henderson J et al. Physical illness and schizophrenia: a review of the literature. Acta Psychiatr Scand 2007;116:317-33.
    • (2007) Acta Psychiatr Scand , vol.116 , pp. 317-333
    • Leucht, S.1    Burkard, T.2    Henderson, J.3
  • 63
    • 85010703254 scopus 로고    scopus 로고
    • Excess mortality in persons with severe mental disorders: a multilevel intervention framework and priorities for clinical practice, policy and research agendas
    • Liu NH, Daumit GL, Dua T et al. Excess mortality in persons with severe mental disorders: a multilevel intervention framework and priorities for clinical practice, policy and research agendas. World Psychiatry 2017;16:30-40.
    • (2017) World Psychiatry , vol.16 , pp. 30-40
    • Liu, N.H.1    Daumit, G.L.2    Dua, T.3
  • 64
    • 85013367800 scopus 로고    scopus 로고
    • Years of potential life lost and life expectancy in schizophrenia: a systematic review and meta-analysis
    • Hjorthøj C, Stürup AE, McGrath JJ. Years of potential life lost and life expectancy in schizophrenia: a systematic review and meta-analysis. Lancet Psychiatry 2017;4:295-301.
    • (2017) Lancet Psychiatry , vol.4 , pp. 295-301
    • Hjorthøj, C.1    Stürup, A.E.2    McGrath, J.J.3
  • 65
    • 34948840329 scopus 로고    scopus 로고
    • A systematic review of mortality in schizophrenia: is the differential mortality gap worsening over time?
    • Saha S, Chant D, McGrath J. A systematic review of mortality in schizophrenia: is the differential mortality gap worsening over time? Arch Gen Psychiatry 2007;64:1123-31.
    • (2007) Arch Gen Psychiatry , vol.64 , pp. 1123-1131
    • Saha, S.1    Chant, D.2    McGrath, J.3
  • 66
    • 84949024396 scopus 로고    scopus 로고
    • Premature mortality among adults with schizophrenia in the United States
    • Olfson M, Gerhard T, Huang C et al. Premature mortality among adults with schizophrenia in the United States. JAMA Psychiatry 2015;72:1172-81.
    • (2015) JAMA Psychiatry , vol.72 , pp. 1172-1181
    • Olfson, M.1    Gerhard, T.2    Huang, C.3
  • 67
    • 85016937098 scopus 로고    scopus 로고
    • Duration and relevance of untreated psychiatric disorders, 1: Psychotic disorders
    • Rubio JM, Correll CU. Duration and relevance of untreated psychiatric disorders, 1: Psychotic disorders. J Clin Psychiatry 2017;78:358-9.
    • (2017) J Clin Psychiatry , vol.78 , pp. 358-359
    • Rubio, J.M.1    Correll, C.U.2
  • 68
    • 84928014375 scopus 로고    scopus 로고
    • Excess mortality in severe mental illness: 10-year population-based cohort study in rural Ethiopia
    • Fekadu A, Medhin G, Kebede D et al. Excess mortality in severe mental illness: 10-year population-based cohort study in rural Ethiopia. Br J Psychiatry 2015;206:289-96.
    • (2015) Br J Psychiatry , vol.206 , pp. 289-296
    • Fekadu, A.1    Medhin, G.2    Kebede, D.3
  • 69
    • 68549107765 scopus 로고    scopus 로고
    • Differences in mortality and suicidal behaviour between treated and never-treated people with schizophrenia in rural China
    • Ran MS, Chan CL, Chen EY et al. Differences in mortality and suicidal behaviour between treated and never-treated people with schizophrenia in rural China. Br J Psychiatry 2009;195:126-31.
    • (2009) Br J Psychiatry , vol.195 , pp. 126-131
    • Ran, M.S.1    Chan, C.L.2    Chen, E.Y.3
  • 70
    • 85011387541 scopus 로고    scopus 로고
    • Excess mortality from mental, neurological, and substance use disorders in the Global Burden of Disease Study 2010
    • In, Patel V, Chisholm D, Dua T, (eds)., 3rd ed, Washington, International Bank for Reconstruction and Development/World Bank
    • Charlson FJ, Baxter AJ, Dua T et al. Excess mortality from mental, neurological, and substance use disorders in the Global Burden of Disease Study 2010. In: Patel V, Chisholm D, Dua T et al (eds). Mental, neurological, and substance use disorders: disease control priorities, 3rd ed. Washington: International Bank for Reconstruction and Development/World Bank, 2016.
    • (2016) Mental, neurological, and substance use disorders: disease control priorities
    • Charlson, F.J.1    Baxter, A.J.2    Dua, T.3
  • 71
    • 78650606809 scopus 로고    scopus 로고
    • Assessment of mortality and marital status of schizophrenic patients over a period of 13 years
    • Ponnudurai R, Jayakar J, Sathiya Sekaran B. Assessment of mortality and marital status of schizophrenic patients over a period of 13 years. Indian J Psychiatry 2006;48:84-7.
    • (2006) Indian J Psychiatry , vol.48 , pp. 84-87
    • Ponnudurai, R.1    Jayakar, J.2    Sathiya Sekaran, B.3
  • 72
    • 2942741092 scopus 로고    scopus 로고
    • Antipsychotic-induced weight gain and metabolic abnormalities: implications for increased mortality in patients with schizophrenia
    • Casey DE, Haupt DW, Newcomer JW et al. Antipsychotic-induced weight gain and metabolic abnormalities: implications for increased mortality in patients with schizophrenia. J Clin Psychiatry 2004;65(Suppl. 7):4-18.
    • (2004) J Clin Psychiatry , vol.65 , pp. 4-18
    • Casey, D.E.1    Haupt, D.W.2    Newcomer, J.W.3
  • 73
    • 84874784904 scopus 로고    scopus 로고
    • Comorbidities and mortality in persons with schizophrenia: a Swedish national cohort study
    • Crump C, Winkleby MA, Sundquist K et al. Comorbidities and mortality in persons with schizophrenia: a Swedish national cohort study. Am J Psychiatry 2013;170:324-33.
    • (2013) Am J Psychiatry , vol.170 , pp. 324-333
    • Crump, C.1    Winkleby, M.A.2    Sundquist, K.3
  • 74
    • 84870050297 scopus 로고    scopus 로고
    • Cardiovascular morbidity, mortality and pharmacotherapy in patients with schizophrenia
    • Lahti M, Tiihonen J, Wildgust H et al. Cardiovascular morbidity, mortality and pharmacotherapy in patients with schizophrenia. Psychol Med 2012;42:2275-85.
    • (2012) Psychol Med , vol.42 , pp. 2275-2285
    • Lahti, M.1    Tiihonen, J.2    Wildgust, H.3
  • 75
    • 85017476098 scopus 로고    scopus 로고
    • Antipsychotic medication and long-term mortality risk in patients with schizophrenia; a systematic review and meta-analysis
    • Vermeulen J, van Rooijen G, Doedens P et al. Antipsychotic medication and long-term mortality risk in patients with schizophrenia; a systematic review and meta-analysis. Psychol Med 2017;47:2217-28.
    • (2017) Psychol Med , vol.47 , pp. 2217-2228
    • Vermeulen, J.1    van Rooijen, G.2    Doedens, P.3
  • 78
    • 85010669573 scopus 로고    scopus 로고
    • Reduced all-cause mortality with antipsychotics and antidepressants compared to increased all-cause mortality with benzodiazepines in patients with schizophrenia observed in naturalistic treatment settings
    • Rubio JM, Correll CU. Reduced all-cause mortality with antipsychotics and antidepressants compared to increased all-cause mortality with benzodiazepines in patients with schizophrenia observed in naturalistic treatment settings. Evid Based Ment Health 2017;20:e6.
    • (2017) Evid Based Ment Health , vol.20
    • Rubio, J.M.1    Correll, C.U.2
  • 79
    • 84921009118 scopus 로고
    • Cerebral ventricular size and cognitive impairment in chronic schizophrenia
    • Johnstone EC, Crow TJ, Frith CD et al. Cerebral ventricular size and cognitive impairment in chronic schizophrenia. Lancet 1976;2:924-6.
    • (1976) Lancet , pp. 2:924-6
    • Johnstone, E.C.1    Crow, T.J.2    Frith, C.D.3
  • 80
    • 84936889499 scopus 로고    scopus 로고
    • The neuropathology of schizophrenia: a selective review of past studies and emerging themes in brain structure and cytoarchitecture
    • Bakhshi K, Chance SA. The neuropathology of schizophrenia: a selective review of past studies and emerging themes in brain structure and cytoarchitecture. Neuroscience 2015;303:82-102.
    • (2015) Neuroscience , vol.303 , pp. 82-102
    • Bakhshi, K.1    Chance, S.A.2
  • 81
    • 28444491442 scopus 로고    scopus 로고
    • Regional deficits in brain volume in schizophrenia: a meta-analysis of voxel-based morphometry studies
    • Honea R, Crow TJ, Passingham D et al. Regional deficits in brain volume in schizophrenia: a meta-analysis of voxel-based morphometry studies. Am J Psychiatry 2005;162:2233-45.
    • (2005) Am J Psychiatry , vol.162 , pp. 2233-2245
    • Honea, R.1    Crow, T.J.2    Passingham, D.3
  • 82
    • 84888300131 scopus 로고    scopus 로고
    • Laterality interacts with sex across the schizophrenia/bipolarity continuum: an interpretation of meta-analyses of structural MRI
    • Crow TJ, Chance SA, Priddle TH et al. Laterality interacts with sex across the schizophrenia/bipolarity continuum: an interpretation of meta-analyses of structural MRI. Psychiatry Res 2013;210:1232-44.
    • (2013) Psychiatry Res , vol.210 , pp. 1232-1244
    • Crow, T.J.1    Chance, S.A.2    Priddle, T.H.3
  • 83
    • 84942863168 scopus 로고    scopus 로고
    • Brain structural abnormalities in a group of never-medicated patients with long-term schizophrenia
    • Zhang W, Deng W, Yao L et al. Brain structural abnormalities in a group of never-medicated patients with long-term schizophrenia. Am J Psychiatry 2015;172:995-1003.
    • (2015) Am J Psychiatry , vol.172 , pp. 995-1003
    • Zhang, W.1    Deng, W.2    Yao, L.3
  • 84
    • 85017395357 scopus 로고    scopus 로고
    • Alterations in the hippocampus and thalamus in individuals at high risk for psychosis
    • Harrisberger F, Buechler R, Smieskova R et al. Alterations in the hippocampus and thalamus in individuals at high risk for psychosis. NPJ Schizophr 2016;2:16033.
    • (2016) NPJ Schizophr , vol.2 , pp. 16033
    • Harrisberger, F.1    Buechler, R.2    Smieskova, R.3
  • 85
    • 79955479434 scopus 로고    scopus 로고
    • Longitudinal volume reductions in people at high genetic risk of schizophrenia as they develop psychosis
    • McIntosh AM, Owens DC, Moorhead WJ et al. Longitudinal volume reductions in people at high genetic risk of schizophrenia as they develop psychosis. Biol Psychiatry 2011;69:953-8.
    • (2011) Biol Psychiatry , vol.69 , pp. 953-958
    • McIntosh, A.M.1    Owens, D.C.2    Moorhead, W.J.3
  • 86
    • 85021826838 scopus 로고    scopus 로고
    • Reduced thickness of the anterior cingulate cortex in individuals with an at-risk mental state who later develop psychosis
    • Takayanagi Y, Kulason S, Sasabayashi D et al. Reduced thickness of the anterior cingulate cortex in individuals with an at-risk mental state who later develop psychosis. Schizophr Bull 2017;43:907-13.
    • (2017) Schizophr Bull , vol.43 , pp. 907-913
    • Takayanagi, Y.1    Kulason, S.2    Sasabayashi, D.3
  • 87
    • 0036277310 scopus 로고    scopus 로고
    • Neurotoxicity, neuroplasticity, and magnetic resonance imaging morphometry: what is happening in the schizophrenic brain?
    • Weinberger DR, McClure RK. Neurotoxicity, neuroplasticity, and magnetic resonance imaging morphometry: what is happening in the schizophrenic brain? Arch Gen Psychiatry 2002;59:553-8.
    • (2002) Arch Gen Psychiatry , vol.59 , pp. 553-558
    • Weinberger, D.R.1    McClure, R.K.2
  • 88
    • 0042655425 scopus 로고    scopus 로고
    • Neurotoxicity, neuroplasticity, and magnetic resonance imaging morphometry
    • Mathalon DH, Rapoport JL, Davis KL et al. Neurotoxicity, neuroplasticity, and magnetic resonance imaging morphometry. Arch Gen Psychiatry 2003;60:846-8.
    • (2003) Arch Gen Psychiatry , vol.60 , pp. 846-848
    • Mathalon, D.H.1    Rapoport, J.L.2    Davis, K.L.3
  • 89
    • 0027434132 scopus 로고
    • Total nerve cell number in neocortex in chronic schizophrenics and controls estimated using optical disectors
    • Pakkenberg B. Total nerve cell number in neocortex in chronic schizophrenics and controls estimated using optical disectors. Biol Psychiatry 1993;34:768-72.
    • (1993) Biol Psychiatry , vol.34 , pp. 768-772
    • Pakkenberg, B.1
  • 90
    • 0000049816 scopus 로고    scopus 로고
    • Elevated neuronal density in prefrontal area 46 in brains from schizophrenic patients: application of a three-dimensional, stereologic counting method
    • Selemon LD, Rajkowska G, Goldman-Rakic PS. Elevated neuronal density in prefrontal area 46 in brains from schizophrenic patients: application of a three-dimensional, stereologic counting method. J Comp Neurol 1998;392:402-12.
    • (1998) J Comp Neurol , vol.392 , pp. 402-412
    • Selemon, L.D.1    Rajkowska, G.2    Goldman-Rakic, P.S.3
  • 91
    • 0032924127 scopus 로고    scopus 로고
    • The neuropathology of schizophrenia. A critical review of the data and their interpretation
    • Harrison PJ. The neuropathology of schizophrenia. A critical review of the data and their interpretation. Brain J Neurol 1999;122(Pt. 4):593-624.
    • (1999) Brain J Neurol , vol.122 , pp. 593-624
    • Harrison, P.J.1
  • 92
    • 84883484772 scopus 로고    scopus 로고
    • Brain volumes in schizophrenia: a meta-analysis in over 18 000 subjects
    • Haijma SV, Van Haren N, Cahn W et al. Brain volumes in schizophrenia: a meta-analysis in over 18 000 subjects. Schizophr Bull 2013;39:1129-38.
    • (2013) Schizophr Bull , vol.39 , pp. 1129-1138
    • Haijma, S.V.1    Van Haren, N.2    Cahn, W.3
  • 93
    • 0029991226 scopus 로고    scopus 로고
    • Reversibility of brain tissue loss in anorexia nervosa assessed with a computerized Talairach 3-D proportional grid
    • Swayze VW, Andersen A, Arndt S et al. Reversibility of brain tissue loss in anorexia nervosa assessed with a computerized Talairach 3-D proportional grid. Psychol Med 1996;26:381-90.
    • (1996) Psychol Med , vol.26 , pp. 381-390
    • Swayze, V.W.1    Andersen, A.2    Arndt, S.3
  • 94
    • 0028805110 scopus 로고
    • Longitudinal changes in magnetic resonance imaging brain volumes in abstinent and relapsed alcoholics
    • Pfefferbaum A, Sullivan EV, Mathalon DH et al. Longitudinal changes in magnetic resonance imaging brain volumes in abstinent and relapsed alcoholics. Alcohol Clin Exp Res 1995;19:1177-91.
    • (1995) Alcohol Clin Exp Res , vol.19 , pp. 1177-1191
    • Pfefferbaum, A.1    Sullivan, E.V.2    Mathalon, D.H.3
  • 95
    • 0023757328 scopus 로고
    • Reversible brain shrinkage in abstinent alcoholics, measured by MRI
    • Schroth G, Naegele T, Klose U et al. Reversible brain shrinkage in abstinent alcoholics, measured by MRI. Neuroradiology 1988;30:385-9.
    • (1988) Neuroradiology , vol.30 , pp. 385-389
    • Schroth, G.1    Naegele, T.2    Klose, U.3
  • 96
    • 0018935399 scopus 로고
    • Apparent cerebral atrophy in patients on treatment with steroids
    • Gordon N. Apparent cerebral atrophy in patients on treatment with steroids. Dev Med Child Neurol 1980;22:502-6.
    • (1980) Dev Med Child Neurol , vol.22 , pp. 502-506
    • Gordon, N.1
  • 97
    • 84929495092 scopus 로고    scopus 로고
    • The effect of antipsychotic treatment on cortical gray matter changes in schizophrenia: does the class matter? A meta-analysis and meta-regression of longitudinal magnetic resonance imaging studies
    • Vita A, De Peri L, Deste G et al. The effect of antipsychotic treatment on cortical gray matter changes in schizophrenia: does the class matter? A meta-analysis and meta-regression of longitudinal magnetic resonance imaging studies. Biol Psychiatry 2015;78:403-12.
    • (2015) Biol Psychiatry , vol.78 , pp. 403-412
    • Vita, A.1    De Peri, L.2    Deste, G.3
  • 98
    • 85033580875 scopus 로고    scopus 로고
    • Heterogeneity and homogeneity of regional brain structure in schizophrenia
    • Brugger S, Howes OD. Heterogeneity and homogeneity of regional brain structure in schizophrenia. JAMA Psychiatry 2017;74:1104-11.
    • (2017) JAMA Psychiatry , vol.74 , pp. 1104-1111
    • Brugger, S.1    Howes, O.D.2
  • 99
    • 84880417244 scopus 로고    scopus 로고
    • Progressive brain changes in schizophrenia related to antipsychotic treatment? A meta-analysis of longitudinal MRI studies
    • Fusar-Poli P, Smieskova R, Kempton MJ et al. Progressive brain changes in schizophrenia related to antipsychotic treatment? A meta-analysis of longitudinal MRI studies. Neurosci Biobehav Rev 2013;37:1680-91.
    • (2013) Neurosci Biobehav Rev , vol.37 , pp. 1680-1691
    • Fusar-Poli, P.1    Smieskova, R.2    Kempton, M.J.3
  • 100
    • 84930324327 scopus 로고    scopus 로고
    • Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium
    • van Erp TGM, Hibar DP, Rasmussen JM et al. Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium. Mol Psychiatry 2016;21:547-53.
    • (2016) Mol Psychiatry , vol.21 , pp. 547-553
    • van Erp, T.G.M.1    Hibar, D.P.2    Rasmussen, J.M.3
  • 101
    • 78651338152 scopus 로고    scopus 로고
    • Gray matter in first-episode schizophrenia before and after antipsychotic drug treatment. Anatomical likelihood estimation meta-analyses with sample size weighting
    • Leung M, Cheung C, Yu K et al. Gray matter in first-episode schizophrenia before and after antipsychotic drug treatment. Anatomical likelihood estimation meta-analyses with sample size weighting. Schizophr Bull 2011;37:199-211.
    • (2011) Schizophr Bull , vol.37 , pp. 199-211
    • Leung, M.1    Cheung, C.2    Yu, K.3
  • 102
    • 79952441953 scopus 로고    scopus 로고
    • Brain volume changes after withdrawal of atypical antipsychotics in patients with first-episode schizophrenia
    • Boonstra G, van Haren NEM, Schnack HG et al. Brain volume changes after withdrawal of atypical antipsychotics in patients with first-episode schizophrenia. J Clin Psychopharmacol 2011;31:146-53.
    • (2011) J Clin Psychopharmacol , vol.31 , pp. 146-153
    • Boonstra, G.1    van Haren, N.E.M.2    Schnack, H.G.3
  • 103
    • 79951503453 scopus 로고    scopus 로고
    • Long-term antipsychotic treatment and brain volumes: a longitudinal study of first-episode schizophrenia
    • Ho BC, Andreasen NC, Ziebell S et al. Long-term antipsychotic treatment and brain volumes: a longitudinal study of first-episode schizophrenia. Arch Gen Psychiatry 2011;68:128-37.
    • (2011) Arch Gen Psychiatry , vol.68 , pp. 128-137
    • Ho, B.C.1    Andreasen, N.C.2    Ziebell, S.3
  • 104
    • 84881023245 scopus 로고    scopus 로고
    • Relapse duration, treatment intensity, and brain tissue loss in schizophrenia: a prospective longitudinal MRI study
    • Andreasen NC, Liu D, Ziebell S et al. Relapse duration, treatment intensity, and brain tissue loss in schizophrenia: a prospective longitudinal MRI study. Am J Psychiatry 2013;170:609-15.
    • (2013) Am J Psychiatry , vol.170 , pp. 609-615
    • Andreasen, N.C.1    Liu, D.2    Ziebell, S.3
  • 105
    • 84939252487 scopus 로고    scopus 로고
    • Progressive brain atrophy and cortical thinning in schizophrenia after commencing clozapine treatment
    • Ahmed M, Cannon DM, Scanlon C et al. Progressive brain atrophy and cortical thinning in schizophrenia after commencing clozapine treatment. Neuropsychopharmacology 2015;40:2409-17.
    • (2015) Neuropsychopharmacology , vol.40 , pp. 2409-2417
    • Ahmed, M.1    Cannon, D.M.2    Scanlon, C.3
  • 106
    • 0035869532 scopus 로고    scopus 로고
    • Longitudinal study of brain morphology in first episode schizophrenia
    • Lieberman J, Chakos M, Wu H et al. Longitudinal study of brain morphology in first episode schizophrenia. Biol Psychiatry 2001;49:487-99.
    • (2001) Biol Psychiatry , vol.49 , pp. 487-499
    • Lieberman, J.1    Chakos, M.2    Wu, H.3
  • 107
    • 84925351972 scopus 로고    scopus 로고
    • A multimodal analysis of antipsychotic effects on brain structure and function in first-episode schizophrenia
    • Lesh TA, Tanase C, Geib BR et al. A multimodal analysis of antipsychotic effects on brain structure and function in first-episode schizophrenia. JAMA Psychiatry 2015;72:226-34.
    • (2015) JAMA Psychiatry , vol.72 , pp. 226-234
    • Lesh, T.A.1    Tanase, C.2    Geib, B.R.3
  • 108
    • 0017599705 scopus 로고
    • Antischizophrenic drugs: chronic treatment elevates dopamine receptor binding in brain
    • Burt DR, Creese I, Snyder SH. Antischizophrenic drugs: chronic treatment elevates dopamine receptor binding in brain. Science 1977;196:326-8.
    • (1977) Science , vol.196 , pp. 326-328
    • Burt, D.R.1    Creese, I.2    Snyder, S.H.3
  • 109
    • 0033626576 scopus 로고    scopus 로고
    • Increased dopamine D2 receptor binding after long-term treatment with antipsychotics in humans: a clinical PET study
    • Silvestri S, Seeman MV, Negrete JC et al. Increased dopamine D2 receptor binding after long-term treatment with antipsychotics in humans: a clinical PET study. Psychopharmacology 2000;152:174-80.
    • (2000) Psychopharmacology , vol.152 , pp. 174-180
    • Silvestri, S.1    Seeman, M.V.2    Negrete, J.C.3
  • 111
    • 0037223482 scopus 로고    scopus 로고
    • Oxidative mechanisms and tardive dyskinesia
    • Lohr JB, Kuczenski R, Niculescu AB. Oxidative mechanisms and tardive dyskinesia. CNS Drugs 2003;17:47-62.
    • (2003) CNS Drugs , vol.17 , pp. 47-62
    • Lohr, J.B.1    Kuczenski, R.2    Niculescu, A.B.3
  • 112
    • 42349094914 scopus 로고    scopus 로고
    • Antipsychotic-induced tardive dyskinesia and polymorphic variations in COMT, DRD2, CYP1A2 and MnSOD genes: a meta-analysis of pharmacogenetic interactions
    • Bakker PR, van Harten PN, van Os J. Antipsychotic-induced tardive dyskinesia and polymorphic variations in COMT, DRD2, CYP1A2 and MnSOD genes: a meta-analysis of pharmacogenetic interactions. Mol Psychiatry 2008;13:544-56.
    • (2008) Mol Psychiatry , vol.13 , pp. 544-556
    • Bakker, P.R.1    van Harten, P.N.2    van Os, J.3
  • 113
    • 0020442427 scopus 로고
    • A prospective study of tardive dyskinesia development: preliminary results
    • Kane JM, Woerner M, Weinhold P et al. A prospective study of tardive dyskinesia development: preliminary results. J Clin Psychopharmacol 1982;2:345-9.
    • (1982) J Clin Psychopharmacol , vol.2 , pp. 345-349
    • Kane, J.M.1    Woerner, M.2    Weinhold, P.3
  • 114
    • 1542373740 scopus 로고    scopus 로고
    • Lower risk for tardive dyskinesia associated with second-generation antipsychotics: a systematic review of 1-year studies
    • Correll CU, Leucht S, Kane JM. Lower risk for tardive dyskinesia associated with second-generation antipsychotics: a systematic review of 1-year studies. Am J Psychiatry 2004;161:414-25.
    • (2004) Am J Psychiatry , vol.161 , pp. 414-425
    • Correll, C.U.1    Leucht, S.2    Kane, J.M.3
  • 115
    • 85016946440 scopus 로고    scopus 로고
    • Tardive dyskinesia prevalence in the period of second-generation antipsychotic use: a meta-analysis
    • Carbon M, Hsieh C-H, Kane JM et al. Tardive dyskinesia prevalence in the period of second-generation antipsychotic use: a meta-analysis. J Clin Psychiatry 2017;78:e264-78.
    • (2017) J Clin Psychiatry , vol.78 , pp. e264-e278
    • Carbon, M.1    Hsieh, C.-H.2    Kane, J.M.3
  • 116
    • 0028148794 scopus 로고
    • Methylphenidate response, psychopathology and tardive dyskinesia as predictors of relapse in schizophrenia
    • Lieberman JA, Alvir J, Geisler S et al. Methylphenidate response, psychopathology and tardive dyskinesia as predictors of relapse in schizophrenia. Neuropsychopharmacology 1994;11:107-18.
    • (1994) Neuropsychopharmacology , vol.11 , pp. 107-118
    • Lieberman, J.A.1    Alvir, J.2    Geisler, S.3
  • 117
    • 84958975714 scopus 로고    scopus 로고
    • Impact of dopamine supersensitivity psychosis in treatment-resistant schizophrenia: an analysis of multi-factors predicting long-term prognosis
    • Yamanaka H, Kanahara N, Suzuki T et al. Impact of dopamine supersensitivity psychosis in treatment-resistant schizophrenia: an analysis of multi-factors predicting long-term prognosis. Schizophr Res 2016;170:252-8.
    • (2016) Schizophr Res , vol.170 , pp. 252-258
    • Yamanaka, H.1    Kanahara, N.2    Suzuki, T.3
  • 118
    • 0023143647 scopus 로고
    • Morbidity and mortality in tardive dyskinesia: associations in chronic schizophrenia
    • Youssef HA, Waddington JL. Morbidity and mortality in tardive dyskinesia: associations in chronic schizophrenia. Acta Psychiatr Scand 1987;75:74-7.
    • (1987) Acta Psychiatr Scand , vol.75 , pp. 74-77
    • Youssef, H.A.1    Waddington, J.L.2
  • 119
    • 0041706321 scopus 로고    scopus 로고
    • Neuroleptic withdrawal in treatment-resistant patients with schizophrenia: tardive dyskinesia is not associated with supersensitive psychosis
    • Apud JA, Egan MF, Wyatt RJ. Neuroleptic withdrawal in treatment-resistant patients with schizophrenia: tardive dyskinesia is not associated with supersensitive psychosis. Schizophr Res 2003;63:151-60.
    • (2003) Schizophr Res , vol.63 , pp. 151-160
    • Apud, J.A.1    Egan, M.F.2    Wyatt, R.J.3
  • 120
    • 33748336475 scopus 로고    scopus 로고
    • Tardive dyskinesia circa 2006
    • Kane JM. Tardive dyskinesia circa 2006. Am J Psychiatry 2006;163:1316-8.
    • (2006) Am J Psychiatry , vol.163 , pp. 1316-1318
    • Kane, J.M.1
  • 121
    • 85028358568 scopus 로고    scopus 로고
    • Efficacy of valbenazine (nbi-98854) in treating subjects with tardive dyskinesia and schizophrenia or schizoaffective disorder
    • Kane JM, Correll CU, Liang GS et al. Efficacy of valbenazine (nbi-98854) in treating subjects with tardive dyskinesia and schizophrenia or schizoaffective disorder. Psychopharmacol Bull 2017;47:69-76.
    • (2017) Psychopharmacol Bull , vol.47 , pp. 69-76
    • Kane, J.M.1    Correll, C.U.2    Liang, G.S.3
  • 122
    • 85019850856 scopus 로고    scopus 로고
    • Randomized controlled trial of deutetrabenazine for tardive dyskinesia: the ARM-TD study
    • Fernandez HH, Factor SA, Hauser RA et al. Randomized controlled trial of deutetrabenazine for tardive dyskinesia: the ARM-TD study. Neurology 2017;88:2003-10.
    • (2017) Neurology , vol.88 , pp. 2003-2010
    • Fernandez, H.H.1    Factor, S.A.2    Hauser, R.A.3
  • 123
    • 84899491639 scopus 로고    scopus 로고
    • A prospective comparative study of risperidone long-acting injectable for treatment-resistant schizophrenia with dopamine supersensitivity psychosis
    • Kimura H, Kanahara N, Komatsu N et al. A prospective comparative study of risperidone long-acting injectable for treatment-resistant schizophrenia with dopamine supersensitivity psychosis. Schizophr Res 2014;155:52-8.
    • (2014) Schizophr Res , vol.155 , pp. 52-58
    • Kimura, H.1    Kanahara, N.2    Komatsu, N.3
  • 124
    • 0018835477 scopus 로고
    • Neuroleptic-induced supersensitivity psychosis: clinical and pharmacologic characteristics
    • Chouinard G, Jones BD. Neuroleptic-induced supersensitivity psychosis: clinical and pharmacologic characteristics. Am J Psychiatry 1980;137:16-21.
    • (1980) Am J Psychiatry , vol.137 , pp. 16-21
    • Chouinard, G.1    Jones, B.D.2
  • 125
    • 33745108559 scopus 로고    scopus 로고
    • Does antipsychotic withdrawal provoke psychosis? Review of the literature on rapid onset psychosis (supersensitivity psychosis) and withdrawal-related relapse
    • Moncrieff J. Does antipsychotic withdrawal provoke psychosis? Review of the literature on rapid onset psychosis (supersensitivity psychosis) and withdrawal-related relapse. Acta Psychiatr Scand 2006;114:3-13.
    • (2006) Acta Psychiatr Scand , vol.114 , pp. 3-13
    • Moncrieff, J.1
  • 126
    • 85034034138 scopus 로고    scopus 로고
    • Dopamine supersensitivity psychosis in schizophrenia: concepts and implications in clinical practice
    • Nakata Y, Kanahara N, Iyo M. Dopamine supersensitivity psychosis in schizophrenia: concepts and implications in clinical practice. J Psychopharmacol 2017;31:1511-8.
    • (2017) J Psychopharmacol , vol.31 , pp. 1511-1518
    • Nakata, Y.1    Kanahara, N.2    Iyo, M.3
  • 127
    • 85011728929 scopus 로고    scopus 로고
    • Antipsychotic induced dopamine supersensitivity psychosis: a comprehensive review
    • Yin J, Barr AM, Ramos-Miguel A et al. Antipsychotic induced dopamine supersensitivity psychosis: a comprehensive review. Curr Neuropharmacol 2017;15:174-83.
    • (2017) Curr Neuropharmacol , vol.15 , pp. 174-183
    • Yin, J.1    Barr, A.M.2    Ramos-Miguel, A.3
  • 128
    • 78751622092 scopus 로고    scopus 로고
    • Pharmacological blockade of dopamine D2 receptors by aripiprazole is not associated with striatal sensitization
    • Koener B, Goursaud S, Van De Stadt M et al. Pharmacological blockade of dopamine D2 receptors by aripiprazole is not associated with striatal sensitization. Naunyn-Schmiedeberg's Arch Pharmacol 2011;383:65-77.
    • (2011) Naunyn-Schmiedeberg's Arch Pharmacol , vol.383 , pp. 65-77
    • Koener, B.1    Goursaud, S.2    Van De Stadt, M.3
  • 129
    • 65449123582 scopus 로고    scopus 로고
    • A 28-week, randomized, double-blind study of olanzapine versus aripiprazole in the treatment of schizophrenia
    • Kane JM, Osuntokun O, Kryzhanovskaya LA et al. A 28-week, randomized, double-blind study of olanzapine versus aripiprazole in the treatment of schizophrenia. J Clin Psychiatry 2009;70:572-81.
    • (2009) J Clin Psychiatry , vol.70 , pp. 572-581
    • Kane, J.M.1    Osuntokun, O.2    Kryzhanovskaya, L.A.3
  • 130
    • 65449188660 scopus 로고    scopus 로고
    • Maintenance of response with atypical antipsychotics in the treatment of schizophrenia: a post-hoc analysis of 5 double-blind, randomized clinical trials
    • Stauffer V, Ascher-Svanum H, Liu L et al. Maintenance of response with atypical antipsychotics in the treatment of schizophrenia: a post-hoc analysis of 5 double-blind, randomized clinical trials. BMC Psychiatry 2009;9:13.
    • (2009) BMC Psychiatry , vol.9 , pp. 13
    • Stauffer, V.1    Ascher-Svanum, H.2    Liu, L.3
  • 131
    • 84881465015 scopus 로고    scopus 로고
    • A systematic review and meta-analysis of recovery in schizophrenia
    • Jääskeläinen E, Juola P, Hirvonen N et al. A systematic review and meta-analysis of recovery in schizophrenia. Schizophr Bull 2013;39:1296-306.
    • (2013) Schizophr Bull , vol.39 , pp. 1296-1306
    • Jääskeläinen, E.1    Juola, P.2    Hirvonen, N.3
  • 132
    • 85047808820 scopus 로고    scopus 로고
    • The relationship between clinical and personal recovery in patients with schizophrenia spectrum disorders: a systematic review and meta-analysis
    • (in press)
    • Van Eck RM, Burger TJ, Vellinga A et al. The relationship between clinical and personal recovery in patients with schizophrenia spectrum disorders: a systematic review and meta-analysis. Schizophr Bull (in press).
    • Schizophr Bull
    • Van Eck, R.M.1    Burger, T.J.2    Vellinga, A.3
  • 133
    • 84962361579 scopus 로고    scopus 로고
    • Comprehensive versus usual community care for first-episode psychosis: 2-year outcomes from the NIMH RAISE Early Treatment Program
    • Kane JM, Robinson DG, Schooler NR et al. Comprehensive versus usual community care for first-episode psychosis: 2-year outcomes from the NIMH RAISE Early Treatment Program. Am J Psychiatry 2016;173:362-72.
    • (2016) Am J Psychiatry , vol.173 , pp. 362-372
    • Kane, J.M.1    Robinson, D.G.2    Schooler, N.R.3
  • 134
    • 73949110936 scopus 로고    scopus 로고
    • The 2009 schizophrenia PORT psychosocial treatment recommendations and summary statements
    • Dixon LB, Dickerson F, Bellack AS et al. The 2009 schizophrenia PORT psychosocial treatment recommendations and summary statements. Schizophr Bull 2010;36:48-70.
    • (2010) Schizophr Bull , vol.36 , pp. 48-70
    • Dixon, L.B.1    Dickerson, F.2    Bellack, A.S.3
  • 135
    • 44949167544 scopus 로고    scopus 로고
    • Cognitive behavior therapy for schizophrenia: effect sizes, clinical models, and methodological rigor
    • Wykes T, Steel C, Everitt B et al. Cognitive behavior therapy for schizophrenia: effect sizes, clinical models, and methodological rigor. Schizophr Bull 2008;34:523-37.
    • (2008) Schizophr Bull , vol.34 , pp. 523-537
    • Wykes, T.1    Steel, C.2    Everitt, B.3
  • 137
    • 84898822349 scopus 로고    scopus 로고
    • Cognitive therapy for people with schizophrenia spectrum disorders not taking antipsychotic drugs: a single-blind randomised controlled trial
    • Morrison AP, Turkington D, Pyle M et al. Cognitive therapy for people with schizophrenia spectrum disorders not taking antipsychotic drugs: a single-blind randomised controlled trial. Lancet 2014;383:1395-403.
    • (2014) Lancet , vol.383 , pp. 1395-1403
    • Morrison, A.P.1    Turkington, D.2    Pyle, M.3
  • 138
    • 0033969038 scopus 로고    scopus 로고
    • A randomized controlled trial of cognitive-behavioral therapy for persistent symptoms in schizophrenia resistant to medication
    • Sensky T, Turkington D, Kingdon D et al. A randomized controlled trial of cognitive-behavioral therapy for persistent symptoms in schizophrenia resistant to medication. Arch Gen Psychiatry 2000;57:165-72.
    • (2000) Arch Gen Psychiatry , vol.57 , pp. 165-172
    • Sensky, T.1    Turkington, D.2    Kingdon, D.3
  • 139
    • 84903789394 scopus 로고    scopus 로고
    • Cognitive-behavioral therapy for medication-resistant psychosis: a meta-analytic review
    • Burns AMN, Erickson DH, Brenner CA. Cognitive-behavioral therapy for medication-resistant psychosis: a meta-analytic review. Psychiatr Serv 2014;65:874-80.
    • (2014) Psychiatr Serv , vol.65 , pp. 874-880
    • Burns, A.M.N.1    Erickson, D.H.2    Brenner, C.A.3
  • 140
    • 77956384933 scopus 로고    scopus 로고
    • Effect of antipsychotic medication alone vs combined with psychosocial intervention on outcomes of early-stage schizophrenia: a randomized, 1-year study
    • Guo X, Zhai J, Liu Z et al. Effect of antipsychotic medication alone vs combined with psychosocial intervention on outcomes of early-stage schizophrenia: a randomized, 1-year study. Arch Gen Psychiatry 2010;67:895-904.
    • (2010) Arch Gen Psychiatry , vol.67 , pp. 895-904
    • Guo, X.1    Zhai, J.2    Liu, Z.3
  • 141
    • 0036020712 scopus 로고    scopus 로고
    • Psychological treatments in schizophrenia: I. Meta-analysis of family intervention and cognitive behaviour therapy
    • Pilling S, Bebbington P, Kuipers E et al. Psychological treatments in schizophrenia: I. Meta-analysis of family intervention and cognitive behaviour therapy. Psychol Med 2002;32:763-82.
    • (2002) Psychol Med , vol.32 , pp. 763-782
    • Pilling, S.1    Bebbington, P.2    Kuipers, E.3
  • 142
    • 0030914609 scopus 로고    scopus 로고
    • Relapse and rehospitalization during maintenance treatment of schizophrenia. The effects of dose reduction and family treatment
    • Schooler NR, Keith SJ, Severe JB et al. Relapse and rehospitalization during maintenance treatment of schizophrenia. The effects of dose reduction and family treatment. Arch Gen Psychiatry 1997;54:453-63.
    • (1997) Arch Gen Psychiatry , vol.54 , pp. 453-463
    • Schooler, N.R.1    Keith, S.J.2    Severe, J.B.3
  • 143
    • 85041674783 scopus 로고    scopus 로고
    • Psychopharmacological treatment in the RAISE-ETP study: outcomes of a manual and computer decision support system based intervention
    • Robinson DG, Schooler NR, Correll CU et al. Psychopharmacological treatment in the RAISE-ETP study: outcomes of a manual and computer decision support system based intervention. Am J Psychiatry 2018;175:169-79.
    • (2018) Am J Psychiatry , vol.175 , pp. 169-179
    • Robinson, D.G.1    Schooler, N.R.2    Correll, C.U.3
  • 144
    • 84865335577 scopus 로고    scopus 로고
    • Acute and maintenance effects of non-pharmacologic interventions for antipsychotic associated weight gain and metabolic abnormalities: a meta-analytic comparison of randomized controlled trials
    • Caemmerer J, Correll CU, Maayan L. Acute and maintenance effects of non-pharmacologic interventions for antipsychotic associated weight gain and metabolic abnormalities: a meta-analytic comparison of randomized controlled trials. Schizophr Res 2012;140:159-68.
    • (2012) Schizophr Res , vol.140 , pp. 159-168
    • Caemmerer, J.1    Correll, C.U.2    Maayan, L.3
  • 145
    • 84973131560 scopus 로고    scopus 로고
    • The CHANGE trial: no superiority of lifestyle coaching plus care coordination plus treatment as usual compared to treatment as usual alone in reducing risk of cardiovascular disease in adults with schizophrenia spectrum disorders and abdominal obesity
    • Speyer H, Nørgaard HCB, Birk M et al. The CHANGE trial: no superiority of lifestyle coaching plus care coordination plus treatment as usual compared to treatment as usual alone in reducing risk of cardiovascular disease in adults with schizophrenia spectrum disorders and abdominal obesity. World Psychiatry 2016;15:155-65.
    • (2016) World Psychiatry , vol.15 , pp. 155-165
    • Speyer, H.1    Nørgaard, H.C.B.2    Birk, M.3
  • 146
    • 85030671179 scopus 로고    scopus 로고
    • Effect of lifestyle coaching versus care coordination versus treatment as usual in people with severe mental illness and overweight: two-years follow-up of the randomized CHANGE trial
    • Jakobsen AS, Speyer H, Nørgaard HCB et al. Effect of lifestyle coaching versus care coordination versus treatment as usual in people with severe mental illness and overweight: two-years follow-up of the randomized CHANGE trial. PLoS One 2017;12:e0185881.
    • (2017) PLoS One , vol.12
    • Jakobsen, A.S.1    Speyer, H.2    Nørgaard, H.C.B.3
  • 147
    • 85021968418 scopus 로고    scopus 로고
    • The slow death of the concept of schizophrenia and the painful birth of the psychosis spectrum
    • Guloksuz S, van Os J. The slow death of the concept of schizophrenia and the painful birth of the psychosis spectrum. Psychol Med 2018;48:229-44.
    • (2018) Psychol Med , vol.48 , pp. 229-244
    • Guloksuz, S.1    van Os, J.2
  • 148
    • 85019184218 scopus 로고    scopus 로고
    • A critique of the “ultra-high risk” and “transition” paradigm
    • van Os J, Guloksuz S. A critique of the “ultra-high risk” and “transition” paradigm. World Psychiatry 2017;16:200-6.
    • (2017) World Psychiatry , vol.16 , pp. 200-206
    • van Os, J.1    Guloksuz, S.2
  • 149
    • 34249655132 scopus 로고    scopus 로고
    • Neuroleptic withdrawal with remitted schizophrenics: a naturalistic follow-up study
    • Nishikawa T, Hayashi T, Koga I et al. Neuroleptic withdrawal with remitted schizophrenics: a naturalistic follow-up study. Psychiatry 2007;70:68-79.
    • (2007) Psychiatry , vol.70 , pp. 68-79
    • Nishikawa, T.1    Hayashi, T.2    Koga, I.3
  • 150
    • 0035154103 scopus 로고    scopus 로고
    • Clinical outcome following neuroleptic discontinuation in patients with remitted recent-onset schizophrenia
    • Gitlin M, Nuechterlein K, Subotnik KL et al. Clinical outcome following neuroleptic discontinuation in patients with remitted recent-onset schizophrenia. Am J Psychiatry 2001;158:1835-42.
    • (2001) Am J Psychiatry , vol.158 , pp. 1835-1842
    • Gitlin, M.1    Nuechterlein, K.2    Subotnik, K.L.3
  • 151
    • 77954224633 scopus 로고    scopus 로고
    • D2 receptor genetic variation and clinical response to antipsychotic drug treatment: a meta-analysis
    • Zhang J-P, Lencz T, Malhotra AK. D2 receptor genetic variation and clinical response to antipsychotic drug treatment: a meta-analysis. Am J Psychiatry 2010;167:763-72.
    • (2010) Am J Psychiatry , vol.167 , pp. 763-772
    • Zhang, J.-P.1    Lencz, T.2    Malhotra, A.K.3
  • 152
    • 84920848264 scopus 로고    scopus 로고
    • Antipsychotic treatment and functional connectivity of the striatum in first-episode schizophrenia
    • Sarpal DK, Robinson DG, Lencz T et al. Antipsychotic treatment and functional connectivity of the striatum in first-episode schizophrenia. JAMA Psychiatry 2015;72:5.
    • (2015) JAMA Psychiatry , vol.72 , pp. 5
    • Sarpal, D.K.1    Robinson, D.G.2    Lencz, T.3
  • 153
    • 84954306689 scopus 로고    scopus 로고
    • Baseline striatal functional connectivity as a predictor of response to antipsychotic drug treatment
    • Sarpal DK, Argyelan M, Robinson DG et al. Baseline striatal functional connectivity as a predictor of response to antipsychotic drug treatment. Am J Psychiatry 2016;173:69-77.
    • (2016) Am J Psychiatry , vol.173 , pp. 69-77
    • Sarpal, D.K.1    Argyelan, M.2    Robinson, D.G.3
  • 154
    • 84894061068 scopus 로고    scopus 로고
    • Ventral tegmental area/midbrain functional connectivity and response to antipsychotic medication in schizophrenia
    • Hadley JA, Nenert R, Kraguljac NV et al. Ventral tegmental area/midbrain functional connectivity and response to antipsychotic medication in schizophrenia. Neuropsychopharmacology 2014;39:1020-30.
    • (2014) Neuropsychopharmacology , vol.39 , pp. 1020-1030
    • Hadley, J.A.1    Nenert, R.2    Kraguljac, N.V.3
  • 155
    • 84988842527 scopus 로고    scopus 로고
    • Personalized prediction of psychosis: external validation of the NAPLS-2 psychosis risk calculator with the EDIPPP project
    • Carrión RE, Cornblatt BA, Burton CZ et al. Personalized prediction of psychosis: external validation of the NAPLS-2 psychosis risk calculator with the EDIPPP project. Am J Psychiatry 2016;173:989-96.
    • (2016) Am J Psychiatry , vol.173 , pp. 989-996
    • Carrión, R.E.1    Cornblatt, B.A.2    Burton, C.Z.3
  • 156
    • 84902295643 scopus 로고    scopus 로고
    • Clinically meaningful biomarkers for psychosis: a systematic and quantitative review
    • Prata D, Mechelli A, Kapur S. Clinically meaningful biomarkers for psychosis: a systematic and quantitative review. Neurosci Biobehav Rev 2014;45:134-141.
    • (2014) Neurosci Biobehav Rev , vol.45 , pp. 134-141
    • Prata, D.1    Mechelli, A.2    Kapur, S.3


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