Accuracy of clinician assessments of medication status in the emergency setting: A comparison of clinician assessment of antipsychotic usage and plasma level determination

Journal of Clinical Psychopharmacology

Volumn 37, Issue 3, 2017, Pages 310-314

  Lopez, Leonardo V ^a,b   Shaikh, Atef ^a   Merson, Jonathan ^a,b   Greenberg, Jessica ^a   Suckow, Raymond F ^c   Kane, John M ^a,b,d  

^a ZUCKER HILLSIDE HOSPITAL   (United States)

^b DONALD AND BARBARA ZUCKER SCHOOL OF MEDICINE AT HOFSTRA NORTHWELL   (United States)

^c NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^d FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

Author keywords

Adherence; Antipsychotics; Psychosis; Schizophrenia; Therapeutic drug monitoring

Indexed keywords

ARIPIPRAZOLE; NEUROLEPTIC AGENT; OLANZAPINE; PALIPERIDONE; QUETIAPINE; RISPERIDONE;

ADULT; AGED; ARTICLE; BIPOLAR I DISORDER; CLINICAL TRIAL; DISEASE EXACERBATION; DRUG BLOOD LEVEL; DRUG MONITORING; EMERGENCY CARE; EMERGENCY PHYSICIAN; EMERGENCY WARD; FEMALE; HUMAN; LIQUID CHROMATOGRAPHY; MAJOR CLINICAL STUDY; MALE; PRESCRIPTION; PRIORITY JOURNAL; PSYCHIATRIC DEPARTMENT; PSYCHOSIS; SCHIZOAFFECTIVE PSYCHOSIS; SCHIZOPHRENIA; ADOLESCENT; BIPOLAR DISORDER; BLOOD; COMPARATIVE STUDY; HOSPITAL ADMISSION; HOSPITAL EMERGENCY SERVICE; MEDICATION COMPLIANCE; MIDDLE AGED; PSYCHOTIC DISORDERS; STANDARDS; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ANTIPSYCHOTIC AGENTS; BIPOLAR DISORDER; DRUG MONITORING; EMERGENCY SERVICE, HOSPITAL; FEMALE; HUMANS; MALE; MEDICATION ADHERENCE; MIDDLE AGED; PATIENT ADMISSION; PSYCHIATRIC DEPARTMENT, HOSPITAL; PSYCHOTIC DISORDERS; SCHIZOPHRENIA; YOUNG ADULT;

EID: 85016435363     PISSN: 02710749     EISSN: 1533712X     Source Type: Journal    
DOI: 10.1097/JCP.0000000000000697     Document Type: Article

References (25)

1. Kessler RC, Demler O, Frank RG, et al. Prevalence and treatment ofmental disorders, 1990 to 2003. N Engl JMed. 2005;352:2515-2523.
2. Wu EQ, BirnbaumHG, Shi L, et al. The economic burden of schizophrenia in the United States in 2002. J Clin Psychiatry. 2005;66:1122-1129.
3. Gilmer TP, Dolder CR, Lacro JP, et al. Adherence to treatment with antipsychotic medication and health care costs among Medicaid beneficiaries with schizophrenia. Am J Psychiatry. 2004;161:692-699.
4. Lang K, Meyers JL, Korn JR, et al. Medication adherence and hospitalization among patients with schizophrenia treated with antipsychotics. Psychiatr Serv. 2010;61:1239-1247.
5. Cooper D, Moisan J, Gregoire JP. Adherence to atypical antipsychotic treatment among newly treated patients: A population-based study in schizophrenia. J Clin Psychiatry. 2007;68:818-825.
6. Masand PS, Roca M, Turner MS, et al. Partial adherence to antipsychotic medication impacts the course of illness in patients with schizophrenia: A review. Prim Care Companion J Clin Psychiatry. 2009;11:147-154.
7. Weiden PJ, Kozma C, Grogg A, et al. Partial compliance and risk of rehospitalization among California Medicaid patients with schizophrenia. Psychiatr Serv. 2004;55:886-891.
8. Clayton CD, Veach J, Macfadden W, et al. Assessment of clinician awareness of nonadherence using a new structured rating scale. J Psychiatr Pract. 2010;16:164-169.
9. Velligan DI, Wang M, Diamond P, et al. Relationships among subjective and objective measures of adherence to oral antipsychotic medications. Psychiatr Serv. 2007;58:1187-1192.
10. Asberg M, Cronholm B, Sjöqvist F, et al. Correlation of subjective side effects with plasma concentrations of nortriptyline. Br Med J. 1970;4:18-21.
11. Bell R, McLaren A, Galanos J, et al. The clinical use of plasma clozapine levels. Aust N Z J Psychiatry. 1998;32:567-574.
12. Cooper TB. Clozapine plasma level monitoring: current status. Psychiatr Q. 1996;67:297-311.
13. Gelenberg AJ, Carroll JA, Baudhuin MG, et al. The meaning of serum lithium levels in maintenance therapy of mood disorders: A review of the literature. J Clin Psychiatry. 1989;50(suppl):17-22.
14. Lopez LV, Kane JM. Plasma levels of second-generation antipsychotics and clinical response in acute psychosis: A review of the literature. Schizophr Res. 2013;147:368-374.
15. Hiemke C, Baumann P, Bergemann N, et al. AGNP consensus guidelines for therapeutic drug monitoring in psychiatry: update 2011. Pharmacopsychiatry. 2011;44:195-235.
16. Catlow JT, Barton RD, Clemens M, et al. Analysis of olanzapine in human plasma utilizing reversed-phase high-performance liquid chromatography with electrochemical detection. J Chromatogr B Biomed Appl. 1995;668:85-90.
17. Eaddy M, Grogg A, Locklear J. Assessment of compliance with antipsychotic treatment and resource utilization in a Medicaid population. Clin Ther. 2005;27:263-272.
18. Hogarty GE, Ulrich RF. The limitations of antipsychotic medication on schizophrenia relapse and adjustment and the contributions of psychosocial treatment. J Psychiatr Res. 1998;32:243-250.
19. Olivares JM, Rodriguez-Morales A, Diels J, et al. Long-term outcomes in patients with schizophrenia treated with risperidone long-acting injection or oral antipsychotics in Spain: results from the Electronic Schizophrenia Treatment Adherence Registry (e-STAR). Eur Psychiatry. 2009;24: 287-296.
20. Kishimoto T, Nitta M, Borenstein M, et al. Long-acting injectable versus oral antipsychotics in schizophrenia: A systematic review and meta-analysis of mirror-image studies. J Clin Psychiatry. 2013;74:957-965.
21. Kopelowicz A, Liberman RP, Zarate R. Recent advances in social skills training for schizophrenia. Schizophr Bull. 2006;32(suppl 1):S12-S23.
22. McCutcheon R, Beck K, Bloomfield MA, et al. Treatment resistant or resistant to treatment? Antipsychotic plasma levels in patients with poorly controlled psychotic symptoms. J Psychopharmacol. 2015;29: 892-897.
23. Howes OD, Vergunst F, Gee S, et al. Adherence to treatment guidelines in clinical practice: study of antipsychotic treatment prior to clozapine initiation. Br J Psychiatry. 2012;201:481-485.
24. Llorca PM. Partial compliance in schizophrenia and the impact on patient outcomes. Psychiatry Res. 2008;161:235-247.
25. Keith SJ, Kane JM. Partial compliance and patient consequences in schizophrenia: our patients can do better. J Clin Psychiatry. 2003;64: 1308-1315.