Physical multimorbidity and psychosis: Comprehensive cross sectional analysis including 242,952 people across 48 low- and middle-income countries

BMC Medicine

Volumn 14, Issue 1, 2016, Pages

  Stubbs, Brendon ^a,b   Koyanagi, Ai ^c,d   Veronese, Nicola ^e,f   Vancampfort, Davy ^g,h   Solmi, Marco ^e,f,i   Gaughran, Fiona ^b   Carvalho, André F ^j   Lally, John ^b,k   Mitchell, Alex J ^l   Mugisha, James ^m,n   Correll, Christoph U ^o,p  

^a SOUTH LONDON AND MAUDSLEY NHS FOUNDATION TRUST   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF BARCELONA   (Spain)

^d CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE SALUD MENTAL CIBERSAM   (Spain)

^e UNIVERSITY OF PADOVA   (Italy)

^f Institute of Clinical Research and Education in Medicine (IREM)   (Italy)

^g KU LEUVEN DEPARTMENT OF REHABILITATION SCIENCES   (Belgium)

^h UNIVERSITY HOSPITALS LEUVEN   (Belgium)

ⁱ Local Health Unit ULSS 17   (Italy)

^j FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^k ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^l UNIVERSITY OF LEICESTER   (United Kingdom)

^m KYAMBOGO UNIVERSITY   (Uganda)

ⁿ Butabika National Referral and Teaching Mental Hospital   (Uganda)

^o ZUCKER HILLSIDE HOSPITAL   (United States)

^p DONALD AND BARBARA ZUCKER SCHOOL OF MEDICINE AT HOFSTRA NORTHWELL   (United States)

more..

Author keywords

Metabolism; Multimorbidity; Physical health; Psychosis; Psychotic experiences

Indexed keywords

ADULT; AGED; ANGINA PECTORIS; ARTHRITIS; ARTICLE; ASTHMA; BACKACHE; COMORBIDITY; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIABETES MELLITUS; DISEASE ASSESSMENT; DISEASE ASSOCIATION; FEMALE; HEALTH BEHAVIOR; HEARING DISORDER; HIGH RISK POPULATION; HUMAN; LOW INCOME COUNTRY; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MIDDLE INCOME COUNTRY; MORBIDITY; MULTIMORBIDITY; PATIENT ASSESSMENT; PERIODONTAL DISEASE; PREVALENCE; PSYCHOSIS; SOCIAL STATUS; TUBERCULOSIS; VISUAL IMPAIRMENT; ADOLESCENT; CARDIOVASCULAR DISEASES; CHRONIC DISEASE; ECONOMICS; GLOBAL HEALTH; HEALTH SURVEY; INTERNATIONAL COOPERATION; METABOLIC DISEASES; POVERTY; PRINCIPAL COMPONENT ANALYSIS; PROCEDURES; PSYCHOTIC DISORDERS; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; CARDIOVASCULAR DISEASES; CHRONIC DISEASE; COMORBIDITY; CROSS-SECTIONAL STUDIES; FEMALE; GLOBAL HEALTH; HEALTH SURVEYS; HUMANS; INTERNATIONALITY; MALE; METABOLIC DISEASES; MIDDLE AGED; POVERTY; PREVALENCE; PRINCIPAL COMPONENT ANALYSIS; PSYCHOTIC DISORDERS; YOUNG ADULT;

EID: 84997514469     PISSN: None     EISSN: 17417015     Source Type: Journal    
DOI: 10.1186/s12916-016-0734-z     Document Type: Article

References (64)

1. Lawrence D, Hancock KJ, Kisely S. The gap in life expectancy from preventable physical illness in psychiatric patients in Western Australia: retrospective analysis of population based registers. BMJ. 2013;346:f2539.
2. Walker ER, McGee RE, Druss BG. Mortality in Mental Disorders and Global Disease Burden Implications: A Systematic Review and Meta-analysis. JAMA Psychiatry. 2015;72(4):334-41.
3. Chang CK, Hayes RD, Broadbent M, Fernandes AC, Lee W, Hotopf M, et al. All-cause mortality among people with serious mental illness (SMI), substance use disorders, and depressive disorders in southeast London: a cohort study. BMC Psychiatry. 2010;10:77.
4. Gardner-Sood P, Lally J, Smith S, Atakan Z, Ismail K, Greenwood KE, et al. Cardiovascular risk factors and metabolic syndrome in people with established psychotic illnesses: baseline data from the IMPaCT randomized controlled trial. Psychol Med. 2015;45(12):2619-29.
5. Vancampfort D, Stubbs B, Mitchell AJ, De Hert M, Wampers M, Ward PB, et al. Risk of metabolic syndrome and its components in people with schizophrenia and related psychotic disorders, bipolar disorder and major depressive disorder: a systematic review and meta-analysis. World Psychiatry. 2015;14(3):339-47.
6. Vancampfort D, Correll CU, Galling B, Probst M, De Hert M, Ward PB, et al. Diabetes mellitus in people with schizophrenia, bipolar disorder and major depressive disorder: a systematic review and large scale meta-analysis. World Psychiatry. 2016;15(2):166-74.
7. Correll CU, Detraux J, De Lepeleire J, De Hert M. Effects of antipsychotics, antidepressants and mood stabilizers on risk for physical diseases in people with schizophrenia, depression and bipolar disorder. World Psychiatry. 2015;14(2):119-36.
8. Foley DL, Mackinnon A, Watts GF, Shaw JE, Magliano DJ, Castle DJ, et al. Cardiometabolic risk indicators that distinguish adults with psychosis from the general population, by age and gender. PLoS One. 2013;8(12), e82606.
9. Foley DL, Mackinnon A, Morgan VA, Watts GF, McGrath JJ, Castle DJ, et al. Predictors of type 2 diabetes in a nationally representative sample of adults with psychosis. World Psychiatry. 2014;13(2):176-83.
10. Stubbs B, Mitchell AJ, De Hert M, Correll CU, Soundy A, Stroobants M, et al. The prevalence and moderators of clinical pain in people with schizophrenia: a systematic review and large scale meta-analysis. Schizophr Res. 2014;160(1-3):1-8.
11. Stubbs B, Gardner-Sood P, Smith S, Ismail K, Greenwood K, Patel A, et al. Pain is independently associated with reduced health related quality of life in people with psychosis. Psychiatry Res. 2015;230(2):585-91.
12. Ryan A, Wallace E, O'Hara P, Smith SM. Multimorbidity and functional decline in community-dwelling adults: a systematic review. Health Qual Life Outcomes. 2015;13:168.
13. Fortin M, Lapointe L, Hudon C, Vanasse A, Ntetu AL, Maltais D. Multimorbidity and quality of life in primary care: a systematic review. Health Qual Life Outcomes. 2004;2:51.
14. Gallo JJ, Hwang S, Joo JH, Bogner HR, Morales KH, Bruce ML, et al. Multimorbidity, depression, and mortality in primary care: randomized clinical trial of an evidence-based depression care management program on mortality risk. J Gen Intern Med. 2016;31(4):380-6.
15. Di Angelantonio E, Kaptoge S, Wormser D, Willeit P, Butterworth AS, Bansal N, et al. Association of cardiometabolic multimorbidity with mortality. JAMA. 2015;314(1):52-60.
16. Lehnert T, Heider D, Leicht H, Heinrich S, Corrieri S, Luppa M, et al. Review: health care utilization and costs of elderly persons with multiple chronic conditions. Med Care Res Rev. 2011;68(4):387-420.
17. Smith DJ, Langan J, McLean G, Guthrie B, Mercer SW. Schizophrenia is associated with excess multiple physical-health comorbidities but low levels of recorded cardiovascular disease in primary care: cross-sectional study. BMJ Open. 2013;3(4): pii: e002808.
18. Moreno C, Nuevo R, Chatterji S, Verdes E, Arango C, Ayuso-Mateos JL. Psychotic symptoms are associated with physical health problems independently of a mental disorder diagnosis: results from the WHO World Health Survey. World Psychiatry. 2013;12(3):251-7.
19. Saha S, Scott J, Varghese D, McGrath J. The association between physical health and delusional-like experiences: a general population study. PLoS One. 2011;6(4), e18566.
20. Koyanagi A, Stickley A, Haro JM. Subclinical psychosis and pain in an English national sample: The role of common mental disorders. Schizophr Res. 2016;175(1-3):209-15.
21. Sharifi V, Eaton WW, Wu LT, Roth KB, Burchett BM, Mojtabai R. Psychotic experiences and risk of death in the general population: 24-27 year follow-up of the Epidemiologic Catchment Area study. Br J Psychiatry. 2015;207(1):30-6.
22. Docherty M, Stubbs B, Gaughran F. Strategies to deal with comorbid physical illness in psychosis. Epidemiol Psychiatr Sci. 2016;25(3):197-204.
23. Moore S, Shiers D, Daly B, Mitchell AJ, Gaughran F. Promoting physical health for people with schizophrenia by reducing disparities in medical and dental care. Acta Psychiatr Scand. 2015;132(2):109-21.
24. Garin N, Koyanagi A, Chatterji S, Tyrovolas S, Olaya B, Leonardi M, et al. Global multimorbidity patterns: a cross-sectional, population-based, multi-country study. J Gerontol A Biol Sci Med Sci. 2016;71(2):205-14.
25. Rukat A, Musisi S, Strohle A, Mundt AP. Prescription patterns of psychotropic medications for the treatment of psychotic disorders in the largest mental health institutions of Uganda. J Clin Psychopharmacol. 2014;34(5):571-6.
26. Leucht S, Cipriani A, Spineli L, Mavridis D, Orey D, Richter F, et al. Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. Lancet. 2013;382(9896):951-62.
27. Nielsen J, Skadhede S, Correll CU. Antipsychotics associated with the development of type 2 diabetes in antipsychotic-naive schizophrenia patients. Neuropsychopharmacology. 2010;35(9):1997-2004.
28. De Hert M, Detraux J, van Winkel R, Yu W, Correll CU. Metabolic and cardiovascular adverse effects associated with antipsychotic drugs. Nat Rev Endocrinol. 2012;8(2):114-26.
29. Koyanagi A, Stickley A, Haro JM. Psychotic symptoms and smoking in 44 countries. Acta Psychiatr Scand. 2016;133(6):497-505.
30. Moussavi S, Chatterji S, Verdes E, Tandon A, Patel V, Ustun B. Depression, chronic diseases, and decrements in health: results from the World Health Surveys. Lancet. 2007;370(9590):851-8.
31. Ustun TB, Chatterji S, Mechbal A, Murray CJL, WHS Collaborating Groups. The World Health Surveys. In: Murray CJL, Evans DB, editors. Health systems performance assessment: debates, methods and empiricism. Geneva: World Health Organization; 2003. p. 797-808.
32. Nuevo R, Chatterji S, Verdes E, Naidoo N, Arango C, Ayuso-Mateos JL. The continuum of psychotic symptoms in the general population: a cross-national study. Schizophr Bull. 2012;38(3):475-85.
33. Rose GA. The diagnosis of ischaemic heart pain and intermittent claudication in field surveys. Bull World Health Organ. 1962;27:645-58.
34. Freeman EE, Roy-Gagnon MH, Samson E, Haddad S, Aubin MJ, Vela C, et al. The global burden of visual difficulty in low, middle, and high income countries. PLoS One. 2013;8(5), e63315.
35. Goldhaber-Fiebert JD, Jeon CY, Cohen T, Murray MB. Diabetes mellitus and tuberculosis in countries with high tuberculosis burdens: individual risks and social determinants. Int J Epidemiol. 2011;40(2):417-28.
36. Kessler RC, Ustun TB. The World Mental Health (WMH) Survey Initiative Version of the World Health Organization (WHO) Composite International Diagnostic Interview (CIDI). Int J Methods Psychiatr Res. 2004;13(2):93-121.
37. Cooper L, Peters L, Andrews G. Validity of the Composite International Diagnostic Interview (CIDI) psychosis module in a psychiatric setting. J Psychiatr Res. 1998;32(6):361-8.
38. Akinyemiju TF. Socio-economic and health access determinants of breast and cervical cancer screening in low-income countries: analysis of the World Health Survey. PLoS One. 2012;7(11), e48834.
39. Koyanagi A, Oh H, Stickley A, Haro JM, DeVylder J. Risk and functional significance of psychotic experiences among individuals with depression in 44 low- and middle-income countries. Psychol Med. 2016;46(12):2655-65.
40. De Hert M, Correll CU, Bobes J, Cetkovich-Bakmas M, Cohen D, Asai I, et al. Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care. World Psychiatry. 2011;10(1):52-77.
41. De Hert M, Cohen D, Bobes J, Cetkovich-Bakmas M, Leucht S, Ndetei DM, et al. Physical illness in patients with severe mental disorders. II. Barriers to care, monitoring and treatment guidelines, plus recommendations at the system and individual level. World Psychiatry. 2011;10(2):138-51.
42. Correll CU, Hauser M, Auther AM, Cornblatt BA. Research in people with psychosis risk syndrome: a review of the current evidence and future directions. J Child Psychol Psychiatry. 2010;51(4):390-431.
43. Vancampfort D, Mitchell AJ, Hert M, Sienaert P, Probst M, Buys R, et al. Type 2 diabetes in patients with major depressive disorder: a metaanalysis of prevalence estimates and predictors. Depress Anxiety. 2015;32(10):763-73.
44. Stubbs B, Vancampfort D, Bobes J, De Hert M, Mitchell AJ. How can we promote smoking cessation in people with schizophrenia in practice? A clinical overview. Acta Psychiatr Scand. 2015;132(2):122-30.
45. Kouidrat Y, Amad A, Lalau JD, Loas G. Eating disorders in schizophrenia: implications for research and management. Schizophr Res Treatment. 2014;2014:791573.
46. Dipasquale S, Pariante CM, Dazzan P, Aguglia E, McGuire P, Mondelli V. The dietary pattern of patients with schizophrenia: A systematic review. J Psychiatr Res. 2013;47(2):197-207.
47. Koyanagi A, Stickley A, Haro JM. Psychotic-like experiences and disordered eating in the English general population. Psychiatry Res. 2016;241:26-34.
48. Felton DA. Edentulism and comorbid factors. J Prosthodont. 2009;18(2):88-96.
49. Hassmiller KM. The association between smoking and tuberculosis. Salud Publica Mex. 2006;48 Suppl 1:S201-16.
50. Silvestri M, Franchi S, Pistorio A, Petecchia L, Rusconi F. Smoke exposure, wheezing, and asthma development: a systematic review and meta-analysis in unselected birth cohorts. Pediatr Pulmonol. 2015;50(4):353-62.
51. Saha S, Scott JG, Varghese D, McGrath JJ. The association between general psychological distress and delusional-like experiences: a large population-based study. Schizophr Res. 2011;127(1-3):246-51.
52. Samaras K, Correll CU, Curtis J. Premature mortality and schizophrenia - the need to heal right from the start. JAMA Psychiat. 2016;73(5):535-6.
53. Barnett K, Mercer SW, Norbury M, Watt G, Wyke S, Guthrie B. Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study. Lancet. 2012;380(9836):37-43.
54. Asante A, Price J, Hayen A, Jan S, Wiseman V. Equity in health care financing in low- and middle-income countries: a systematic review of evidence from studies using benefit and financing incidence analyses. PLoS One. 2016;11(4), e0152866.
55. Kadam U. Redesigning the general practice consultation to improve care for patients with multimorbidity. BMJ. 2012;345, e6202.
56. Oni T, McGrath N, BeLue R, Roderick P, Colagiuri S, May CR, et al. Chronic diseases and multi-morbidity--a conceptual modification to the WHO ICCC model for countries in health transition. BMC Public Health. 2014;14:575.
57. Mugisha J, Ssebunnya J, Kigozi FN. Towards understanding governance issues in integration of mental health into primary health care in Uganda. Int J Ment Health Syst. 2016;10:25.
58. Mitchell AJ, De Hert M. Promotion of physical health in persons with schizophrenia: can we prevent cardiometabolic problems before they begin? Acta Psychiatr Scand. 2015;132(2):83-5.
59. Mitchell AJ, Malone D, Doebbeling CC. Quality of medical care for people with and without comorbid mental illness and substance misuse: systematic review of comparative studies. Br J Psychiatry. 2009;194(6):491-9.
60. Mitchell AJ, Lord O. Do deficits in cardiac care influence high mortality rates in schizophrenia? A systematic review and pooled analysis. J Psychopharmacol. 2010;24(4 Suppl):69-80.
61. Mitchell AJ, Lawrence D. Revascularisation and mortality rates following acute coronary syndromes in people with severe mental illness: comparative meta-analysis. Br J Psychiatry. 2011;198(6):434-41.
62. Mitchell AJ, Lord O, Malone D. Differences in the prescribing of medication for physical disorders in individuals with v. without mental illness: meta-analysis. Br J Psychiatry. 2012;201(6):435-43.
63. Mitchell AJ, Pereira IES, Yadegarfar M, Pepereke S, Mugadza V, Stubbs B. Breast cancer screening in women with mental illness: comparative meta-analysis of mammography uptake. Br J Psychiatry. 2014;205(6):428-35.
64. Alonso J, Buron A, Bruffaerts R, He Y, Posada-Villa J, Lepine JP, et al. Association of perceived stigma and mood and anxiety disorders: results from the World Mental Health Surveys. Acta Psychiatr Scand. 2008;118(4):305-14.