Effect of antipsychotic medication alone vs combined with psychosocial intervention on outcomes of early-stage schizophrenia: A randomized, 1-year study

Archives of General Psychiatry

Volumn 67, Issue 9, 2010, Pages 895-904

  Guo, Xiaofeng ^a   Zhai, Jinguo ^a,b   Liu, Zhening ^a   Fang, Maosheng ^a   Wang, Bo ^c   Wang, Chuanyue ^d   Hu, Bin ^e   Sun, Xueli ^f   Lv, Luxian ^g   Lu, Zheng ^h   Ma, Cui ⁱ   He, Xiaolin ⁱ   Guo, Tiansheng ^j   Xie, Shiping ^k   Wu, Renrong ^a   Xue, Zhimin ^a   Chen, Jindong ^a   Twamley, Elizabeth W ^l   Jin, Hua ^l   Zhao, Jingping ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b JINING MEDICAL UNIVERSITY   (China)

^c Chongqing Mental Hospital   (China)

^d CAPITAL MEDICAL UNIVERSITY   (China)

^e Psychiatric Hospital of Jiangxi Province   (China)

^f SICHUAN UNIVERSITY   (China)

^g Mental Hospital of Henan Province   (China)

^h SHANGHAI MENTAL HEALTH CENTER   (China)

ⁱ Guangzhou Brain Hospital   (China)

^j Hunan Brain Hospital   (China)

^k THE AFFILIATED BRAIN HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^l UNIVERSITY OF CALIFORNIA   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; ARIPIPRAZOLE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CHLORPROMAZINE; CHOLINERGIC RECEPTOR BLOCKING AGENT; CLOZAPINE; LITHIUM CARBONATE; NEUROLEPTIC AGENT; OLANZAPINE; QUETIAPINE; RISPERIDONE; SULPIRIDE;

ADOLESCENT; ADULT; ARTICLE; CLINICAL TRIAL; COGNITIVE THERAPY; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DAILY LIFE ACTIVITY; DIZZINESS; DRUG EFFICACY; DRUG WITHDRAWAL; EDUCATION; EMPLOYMENT; EXTRAPYRAMIDAL SYMPTOM; FAMILY THERAPY; FEMALE; HUMAN; HYPERSOMNIA; INSOMNIA; MAJOR CLINICAL STUDY; MALE; MENSTRUAL IRREGULARITY; MULTICENTER STUDY; OUTCOME ASSESSMENT; PATIENT COMPLIANCE; POSITIVE AND NEGATIVE SYNDROME SCALE; PSYCHOEDUCATION; PSYCHOSOCIAL CARE; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; REMISSION; SCHIZOPHRENIA; SHORT FORM 36; SIDE EFFECT; SOCIAL ADAPTATION; SOCIAL STATUS; SOMNOLENCE; URINARY HESITANCY; WEIGHT GAIN; XEROSTOMIA;

ACTIVITIES OF DAILY LIVING; ADULT; ANTIPSYCHOTIC AGENTS; ATTITUDE TO HEALTH; AWARENESS; CHINA; COGNITIVE THERAPY; COMBINED MODALITY THERAPY; FEMALE; HEALTH STATUS; HUMANS; LONGITUDINAL STUDIES; MALE; PATIENT EDUCATION AS TOPIC; QUALITY OF LIFE; RECURRENCE; SCHIZOPHRENIA; SOCIAL ADJUSTMENT; TREATMENT OUTCOME;

EID: 77956384933     PISSN: 0003990X     EISSN: 15383636     Source Type: Journal    
DOI: 10.1001/archgenpsychiatry.2010.105     Document Type: Article

References (52)

1. Freedman R. Schizophrenia. N Engl J Med. 2003;349(18):1738-1749.
2. Lieberman JA, Stroup TS, McEvoy JP, Swartz MS, Rosenheck RA, Perkins DO, Keefe RS, Davis SM, Davis CE, Lebowitz BD, Severe J, Hsiao JK; Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Investigators. Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med. 2005;353(12):1209-1223.
3. Mojtabai R, Lavelle J, Gibson PJ, Bromet EJ. Atypical antipsychotics in first admission schizophrenia: medication continuation and outcomes. Schizophr Bull. 2003;29(3):519-530. (Pubitemid 37339386)
4. Weiden PJ, Kozma C, Grogg A, Locklear J. Partial compliance and risk of rehospitalization among California Medicaid patients with schizophrenia. Psychiatr Serv. 2004;55(8):886-891. (Pubitemid 39025215)
5. Penn DL, Waldheter EJ, Perkins DO, Mueser KT, Lieberman JA. Psychosocial treatment for first-episode psychosis: a research update. Am J Psychiatry. 2005;162(12):2220-2232. (Pubitemid 41740199)
6. Rosenbaum B, Valbak K, Harder S, Knudsen P, Køster A, Lajer M, Lindhardt A, Winther G, Petersen L, Jørgensen P, Nordentoft M, Andreasen AH. The Danish National Schizophrenia Project: prospective, comparative longitudinal treatment study of first-episode psychosis. Br J Psychiatry. 2005;186(9):394-399. (Pubitemid 40663421)
7. Marder SR, Wirshing WC, Mintz J, McKenzie J, Johnston K, Eckman TA, Lebell M, Zimmerman K, Liberman RP. Two-year outcome of social skills training and group psychotherapy for outpatients with schizophrenia. Am J Psychiatry. 1996;153(12):1585-1592. (Pubitemid 26406169)
8. Turkington D, Kingdon D, Weiden PJ. Cognitive behavior therapy for schizophrenia. Am J Psychiatry. 2006;163(3):365-373.
9. Granholm E, McQuaid JR, McClure FS, Link PC, Perivoliotis D, Gottlieb JD, Patterson TL, Jeste DV. Randomized controlled trial of cognitive behavioral social skills training for older people with schizophrenia: 12-month follow-up. J Clin Psychiatry. 2007;68(5):730-737. (Pubitemid 46841856)
10. Lehman AF, Lieberman JA, Dixon LB, McGlashan TH, Miller AL, Perkins DO, Kreyenbuhl J; American Psychiatric Association; Steering Committee on Practice Guidelines. Practice guideline for the treatment of patients with schizophrenia, second edition. Am J Psychiatry. 2004;161(suppl 2):s1-s56.
11. Birchwood M, Todd P, Jackson C. Early intervention in psychosis: the critical period hypothesis. Br J Psychiatry Suppl. 1998;172(33):53-59. (Pubitemid 28258899)
12. Bertelsen M, Jeppesen P, Petersen L, Thorup A, Øhlenschlaeger J, le Quach P, Christensen TØ, Krarup G, Jørgensen P, Nordentoft M. Five-year follow-up of a randomized multicenter trial of intensive early intervention vs standard treatment for patients with a first episode of psychotic illness: the OPUS trial. Arch Gen Psychiatry. 2008;65(7):762-771.
13. Jeppesen P, Petersen L, Thorup A, Abel MB, Oehlenschlaeger J, Christensen TØ, Krarup G, Hemmingsen R, Jørgensen P, Nordentoft M. Integrated treatment of first-episode psychosis: effect of treatment on family burden: OPUS trial. Br J Psychiatry Suppl. 2005;187(48):s85-s90. (Pubitemid 41139671)
14. Grawe RW, Falloon IR, Widen JH, Skogvoll E. Two years of continued early treatment for recent-onset schizophrenia: a randomised controlled study. Acta Psychiatr Scand. 2006;114(5):328-336. (Pubitemid 44521300)
15. Craig TK, Garety P, Power P, Rahaman N, Colbert S, Fornells-Ambrojo M, Dunn G. The Lambeth Early Onset (LEO) Team: randomised controlled trial of the effectiveness of specialised care for early psychosis. BMJ. 2004;329(7474):1067. doi:10.1136/bmj.38246.594873.7C.
16. Garety PA, Craig TK, Dunn G, Fornells-Ambrojo M, Colbert S, Rahaman N, Read J, Power P. Specialised care for early psychosis: symptoms, social functioning, and patient satisfaction [published correction appears in Br J Psychiatry. 2006;188:295]. Br J Psychiatry. 2006;188(1):37-45. (Pubitemid 43021925)
17. Guo XF, Zhao JP, Liu ZN, Zhai JG, Xue ZM, Chen JD. Antipsychotic Combination With Psychosocial Intervention on Outcome of Schizophrenia (ACPIOS): rationale and design of the clinical trial. Clin Schizophr Relat Psychoses. 2007;1(2):185-192.
18. First MB, Spitzer RL, Gibbon M, Williams JBW, Benjamin LS. Structured Clinical Interview for DSM-IV Axis I Disorders-Clinician Version (SCID-CV). Washington, DC: American Psychiatry Press; 1997.
19. Kay SR, Fiszbein A, Opler LA. The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophr Bull. 1987;13(2):261-276. (Pubitemid 18039085)
20. Si TM, Shu L, Yu X, Ma C, Wang GH, Bai PS, Liu XH, Ji LP, Shi JG, Chen XS, Mei QY, Su KQ, Zhang HY, Ma H. Antipsychotic drug patterns of schizophrenia in China: a cross-sectioned study [in Chinese]. Chin J Psychiatry. 2004;37(3):152-155.
21. Lehman AF, Kreyenbuhl J, Buchanan RW, Dickerson FB, Dixon LB, Goldberg R, Green-Paden LD, Tenhula WN, Boerescu D, Tek C, Sandson N, Steinwachs DM. The Schizophrenia Patient Outcomes Research Team (PORT): updated treatment recommendations 2003. Schizophr Bull. 2004;30(2):193-217. (Pubitemid 38828528)
22. Gleeson J, Jackson H, Stavely H, Burnett P. Family interventions in early psychosis. In: McGorry PD, Henry HJ, eds. The Recognition and Management of Early Psychosis: A Preventive Approach. Cambridge, England: Cambridge University Press; 1999:306-406.
23. Zhang M, He Y, Gittelman M, Wong Z, Yan H. Group psychoeducation of relatives of schizophrenic patients: two-year experiences. Psychiatry Clin Neurosci. 1998;52(suppl):S344-S347. (Pubitemid 128676359)
24. Bäuml J, Froböse T, Kraemer S, Rentrop M, Pitschel-Walz G. Psychoeducation: a basic psychotherapeutic intervention for patients with schizophrenia and their families. Schizophr Bull. 2006;32(suppl 1):S1-S9.
25. Askey R, Gamble C, Gray R. Family work in first-onset psychosis: a literature review. J Psychiatr Ment Health Nurs. 2007;14(4):356-365.
26. Addington J, Burnett P. Working with families in the early stages of psychosis. In: McGorry PD, Gleeson JF, eds. Psychological Interventions in Early Psychosis: A Practical Treatment Handbook. Chichester, England: John Wiley & Sons Ltd; 2004:99-116.
27. Liberman RP, Eckman TA, Marder SR. Rehab rounds: Training in social problem solving among persons with schizophrenia. Psychiatr Serv. 2001;52(1):31-33.
28. Liberman RP, Wallace CJ, Blackwell G, Eckman TA, Vaccaro JV, Kuehnel TG. Innovations in skills training for the seriously mentally ill: the UCLA Social and Independent Living Skills Modules. Innovations Res. 1993;2(2):43-60.
29. Bellack AS, Mueser KT, Gingerich S, Agresta J. Social Skills Training for Schizophrenia: A Step-by-Step Guide. 2nd ed. New York, NY: Guilford Press; 2004.
30. Fowler D, Garety PA, Kuipers L. Cognitive Behaviour Therapy for Psychosis: Theory and Practice. Chichester, England: John Wiley & Sons Ltd; 1999.
31. Turkington D, Sensky T, Scott J, Barnes TR, Nur U, Siddle R, Hammond K, Samarasekara N, Kingdon D. A randomized controlled trial of cognitive-behavior therapy for persistent symptoms in schizophrenia: a five-year follow-up. Schizophr Res. 2008;98(1-3):1-7. (Pubitemid 350245592)
32. Csernansky JG, Mahmoud R, Brenner R; Risperidone-USA-79 Study Group. A comparison of risperidone and haloperidol for the prevention of relapse in patients with schizophrenia. N Engl J Med. 2002;346(1):16-22. (Pubitemid 34438915)
33. Guy W. ECDEU Assessment Manual for Psychopharmacology. Rev ed. Rockville, MD: Dept of Health, Education, and Welfare; 1976.
34. McEvoy JP, Apperson LJ, Appelbaum PS, Ortlip P, Brecosky J, Hammill K, Geller JL, Roth L. Insight in schizophrenia: its relationship to acute psychopathology. J Nerv Ment Dis. 1989;177(1):43-47. (Pubitemid 19043858)
35. Ware JE Jr, Sherbourne CD. The MOS 36-Item Short-Form Health Survey (SF-36), I: conceptual framework and item selection. Med Care. 1992;30(6):473-483.
36. Ware JE, Snow KK, Kosisnki M, Gandek B. SF-36 Health Survey Manual and Interpretation Guide. Boston, MA: Health Institute, New England Medical Center; 1993.
37. Endicott J, Spitzer RL, Fleiss JL, Cohen J. The Global Assessment Scale: a procedure for measuring overall severity of psychiatric disturbance. Arch Gen Psychiatry. 1976;33(6):766-771.
38. Katz S, Ford AB, Moskowitz RW, Jackson BA, Jaffe MW. Studies of illness in the aged: the index of ADL: a standardized measure of biological and psychosocial function. JAMA. 1963;185(12):914-919.
39. Lawton MP, Brody EM. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist. 1969;9(3):179-186.
40. Zhang MY. Chinese version of ADL [in Chinese]. Shanghai Arch Psychiatry. 1989;1(2):68-71.
41. Zhang MY, Katzman R, Salmon D, Jin H, Cai GJ, Wang ZY, Qu GY, Grant I, Yu E, Levy P, Klauber MR, Liu WT. The prevalence of dementia and Alzheimer's disease in Shanghai, China: impact of age, gender, and education. Ann Neurol. 1990;27(4):428-437. (Pubitemid 20132059)
42. Cox D, Oakes D. Analysis of Survival Data. London, England: Chapman & Hall; 1984.
43. Everitt BS. Analysis of longitudinal data: beyond MANOVA. Br J Psychiatry. 1998;172(1):7-10. (Pubitemid 28122519)
44. Kahn RS, Fleischhacker WW, Boter H, Davidson M, Vergouwe Y, Keet IP, Gheorghe MD, Rybakowski JK, Galderisi S, Libiger J, Hummer M, Dollfus S, López-Ibor JJ, Hranov LG, Gaebel W, Peuskens J, Lindefors N, Riecher-Rössler A, Grobbee DE; EUFEST study group. Effectiveness of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: an open randomised clinical trial. Lancet. 2008;371(9618):1085-1097. (Pubitemid 351418005)
45. Ascher-Svanum H, Faries DE, Zhu B, Ernst FR, Swartz MS, Swanson JW. Medication adherence and long-term functional outcomes in the treatment of schizophrenia in usual care. J Clin Psychiatry. 2006;67(3):453-460.
46. Osterberg L, Blaschke T. Adherence to medication. N Engl J Med. 2005;353(5):487-497.
47. Tunis SL, Croghan TW, Heilman DK, Johnstone BM, Obenchain RL. Reliability, validity, and application of the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) in schizophrenic patients treated with olanzapine versus haloperidol. Med Care. 1999;37(7):678-691.
48. Nasrallah HA, Duchesne I, Mehnert A, Janagap C, Eerdekens M. Health-related quality of life in patients with schizophrenia during treatment with long-acting, injectable risperidone. J Clin Psychiatry. 2004;65(4):531-536.
49. Lewis S, Tarrier N, Haddock G, Bentall R, Kinderman P, Kingdon D, Siddle R, Drake R, Everitt J, Leadley K, Benn A, Grazebrook K, Haley C, Akhtar S, Davies L, Palmer S, Faragher B, Dunn G. Randomized controlled trial of cognitive-behavioural therapy in early schizophrenia: acute-phase outcomes. Br J Psychiatry Suppl. 2002;181(43):s91-s97. (Pubitemid 34983519)
50. Petersen L, Jeppesen P, Thorup A, Abel MB, Øhlenschlaeger J, Christensen TØ, Krarup G, Jørgensen P, Nordentoft M. A randomised multicentre trial of integrated versus standard treatment for patients with a first episode of psychotic illness [published correction appears in BMJ. 2005;331(7524):1065]. BMJ. 2005;331(7517):602. doi:10.1136/bmj.38565.415000.E01.
51. Petersen L, Nordentoft M, Jeppesen P, Ohlenschaeger J, Thorup A, Christensen TØ, Krarup G, Dahlstrøm J, Haastrup B, Jørgensen P. Improving 1-year outcome in first-episode psychosis: OPUS trial. Br J Psychiatry Suppl. 2005;48(48):s98-s103. (Pubitemid 41139673)
52. Tarrier N, Lewis S, Haddock G, Bentall R, Drake R, Kinderman P, Kingdon D, Siddle R, Everitt J, Leadley K, Benn A, Grazebrook K, Haley C, Akhtar S, Davies L, Palmer S, Dunn G. Cognitive-behavioural therapy in first-episode and early schizophrenia: 18-month follow-up of a randomised controlled trial. Br J Psychiatry. 2004;184(3):231-239. (Pubitemid 38333762)