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Volumn 6, Issue 6, 2008, Pages 887-895

Using antimicrobial host defense peptides as anti-infective and immunomodulatory agents

Author keywords

Antibiotic resistance; Antibiotics; Host defense peptide; Immunomodulation; Pattern recognition receptor

Indexed keywords

CHEMOKINE RECEPTOR CCR6; DEFENSIN; HUMAN NEUTROPHIL PEPTIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LACTOFERRIN; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; OFLOXACIN; OMIGANAN; OVALBUMIN; PEXIGANAN; POLYPEPTIDE ANTIBIOTIC AGENT; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIMICROBIAL CATIONIC PEPTIDE; IMMUNOLOGIC FACTOR; PATTERN RECOGNITION RECEPTOR;

EID: 85047685350     PISSN: 14787210     EISSN: 17448336     Source Type: Journal    
DOI: 10.1586/14787210.6.6.887     Document Type: Review
Times cited : (42)

References (84)
  • 1
    • 33746028777 scopus 로고    scopus 로고
    • Intracellular pattern recognition receptors in the host response
    • Meylan E, Tschopp J, Karin M. Intracellular pattern recognition receptors in the host response. Nature 442(7098), 39-44 (2006).
    • (2006) Nature , vol.442 , Issue.7098 , pp. 39-44
    • Meylan, E.1    Tschopp, J.2    Karin, M.3
  • 2
    • 35349016235 scopus 로고    scopus 로고
    • Recognition of microorganisms and activation of the immune response
    • Medzhitov R. Recognition of microorganisms and activation of the immune response. Nature 449(7164), 819-826 (2007).
    • (2007) Nature , vol.449 , Issue.7164 , pp. 819-826
    • Medzhitov, R.1
  • 3
    • 0037165196 scopus 로고    scopus 로고
    • Antimicrobial peptides of multicellular organisms
    • Zasloff M. Antimicrobial peptides of multicellular organisms. Nature 415(6870), 389-395 (2002).
    • (2002) Nature , vol.415 , Issue.6870 , pp. 389-395
    • Zasloff, M.1
  • 4
    • 0032693639 scopus 로고    scopus 로고
    • Why and how are peptide-lipid interactions utilized for self-defense? Magainins and tachyplesins as archetypes
    • Matsuzaki K. Why and how are peptide-lipid interactions utilized for self-defense? Magainins and tachyplesins as archetypes. Biochim. Biophys. Acta 1462(1-2), 1-10 (1999).
    • (1999) Biochim. Biophys. Acta , vol.1462 , Issue.1-2 , pp. 1-10
    • Matsuzaki, K.1
  • 5
    • 0033798839 scopus 로고    scopus 로고
    • Crystallization of antimicrobial pores in membranes: Magainin and protegrin
    • Yang L, Weiss TM, Lehrer RI, Huang HW. Crystallization of antimicrobial pores in membranes: magainin and protegrin. Biophys. J. 79(4), 2002-2009 (2000).
    • (2000) Biophys. J , vol.79 , Issue.4 , pp. 2002-2009
    • Yang, L.1    Weiss, T.M.2    Lehrer, R.I.3    Huang, H.W.4
  • 6
    • 0035853022 scopus 로고    scopus 로고
    • The antibacterial peptide pyrrhocoricin inhibits the ATPase actions of DnaK and prevents chaperone-assisted protein folding
    • Kragol G, Lovas S, Varadi G. Condie BA. Hoffmann R, Otvos L Jr. The antibacterial peptide pyrrhocoricin inhibits the ATPase actions of DnaK and prevents chaperone-assisted protein folding. Biochemistry 40(10), 3016-3026 (2001).
    • (2001) Biochemistry , vol.40 , Issue.10 , pp. 3016-3026
    • Kragol, G.1    Lovas, S.2    Varadi, G.3    Condie, B.A.4    Hoffmann, R.5    Otvos Jr., L.6
  • 7
    • 0035101015 scopus 로고    scopus 로고
    • Construction and characterization of mutations at codon 751 of the Escherichia coli gyrB gene that confer resistance to the antimicrobial peptide microcin B17 and alter the activity of DNA gyrase
    • del Castillo FJ, del Castillo I, Moreno F. Construction and characterization of mutations at codon 751 of the Escherichia coli gyrB gene that confer resistance to the antimicrobial peptide microcin B17 and alter the activity of DNA gyrase. J. Bacteriol. 183(6), 2137-2140 (2001).
    • (2001) J. Bacteriol , vol.183 , Issue.6 , pp. 2137-2140
    • del Castillo, F.J.1    del Castillo, I.2    Moreno, F.3
  • 8
    • 33745217570 scopus 로고    scopus 로고
    • The co-evolution of host cationic antimicrobial peptides and microbial resistance
    • Peschel A, Sahl HG. The co-evolution of host cationic antimicrobial peptides and microbial resistance. Nat. Rev. Microbiol. 4(7), 529-536 (2006).
    • (2006) Nat. Rev. Microbiol , vol.4 , Issue.7 , pp. 529-536
    • Peschel, A.1    Sahl, H.G.2
  • 9
    • 0037057645 scopus 로고    scopus 로고
    • Endogenous antimicrobial peptides and skin infections in atopic dermatitis
    • Ong PY, Ohtake T, Brandt C et al. Endogenous antimicrobial peptides and skin infections in atopic dermatitis, N. Engl. J. Med. 347(15), 1151-1160 (2002).
    • (2002) N. Engl. J. Med , vol.347 , Issue.15 , pp. 1151-1160
    • Ong, P.Y.1    Ohtake, T.2    Brandt, C.3
  • 10
    • 29144483937 scopus 로고    scopus 로고
    • Reduced Paneth cell α-defensins in ileal Crohn's disease
    • Wehkamp J, Salzman NH, Porter E et al. Reduced Paneth cell α-defensins in ileal Crohn's disease. Proc. Natl Acad. Sci. USA 102(50), 18129-18134 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , Issue.50 , pp. 18129-18134
    • Wehkamp, J.1    Salzman, N.H.2    Porter, E.3
  • 11
    • 0142121432 scopus 로고    scopus 로고
    • Trends in development and approval times for new therapeutics in the United States
    • Reichert JM. Trends in development and approval times for new therapeutics in the United States. Nat. Rev. Drug Discov. 2(9), 695-702 (2003).
    • (2003) Nat. Rev. Drug Discov , vol.2 , Issue.9 , pp. 695-702
    • Reichert, J.M.1
  • 12
    • 37749004225 scopus 로고    scopus 로고
    • Protein therapeutics: A summary and pharmacological classification
    • Leader B, Baca QJ, Golan DE. Protein therapeutics: a summary and pharmacological classification. Nat. Rev. Drug Discov. 7(1), 21-39 (2008).
    • (2008) Nat. Rev. Drug Discov , vol.7 , Issue.1 , pp. 21-39
    • Leader, B.1    Baca, Q.J.2    Golan, D.E.3
  • 13
    • 0036598634 scopus 로고    scopus 로고
    • Bioequivalence and the immunogenicity of biopharmaceuticals
    • Schellekens H. Bioequivalence and the immunogenicity of biopharmaceuticals. Nat. Rev. Drug Discov. 1(6), 457-462 (2002).
    • (2002) Nat. Rev. Drug Discov , vol.1 , Issue.6 , pp. 457-462
    • Schellekens, H.1
  • 14
    • 33645803815 scopus 로고    scopus 로고
    • Antimicrobial peptides: Therapeutic potential
    • Zhang L, Falla TJ. Antimicrobial peptides: therapeutic potential. Expert Opin. Pharmacother. 7(6), 653-663 (2006).
    • (2006) Expert Opin. Pharmacother , vol.7 , Issue.6 , pp. 653-663
    • Zhang, L.1    Falla, T.J.2
  • 15
    • 27144504220 scopus 로고    scopus 로고
    • Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus
    • Mygind PH, Fischer RL, Schnorr KM et al. Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus. Nature 437(7061), 975-980 (2005).
    • (2005) Nature , vol.437 , Issue.7061 , pp. 975-980
    • Mygind, P.H.1    Fischer, R.L.2    Schnorr, K.M.3
  • 16
    • 33845699790 scopus 로고    scopus 로고
    • Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies
    • Hancock RE, Sahl HG. Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. Nat. Biotechnol. 24(12), 1551-1557 (2006).
    • (2006) Nat. Biotechnol , vol.24 , Issue.12 , pp. 1551-1557
    • Hancock, R.E.1    Sahl, H.G.2
  • 18
    • 0022402545 scopus 로고
    • Defensins. Natural peptide antibiotics of human neutrophils
    • Ganz T, Selsted ME, Szklarek D et al. Defensins. Natural peptide antibiotics of human neutrophils. J. Clin. Invest. 76(4), 1427-1435 (1985).
    • (1985) J. Clin. Invest , vol.76 , Issue.4 , pp. 1427-1435
    • Ganz, T.1    Selsted, M.E.2    Szklarek, D.3
  • 19
    • 0024370068 scopus 로고
    • Purification and characterization of human neutrophil peptide 4, a novel member of the defensin family
    • Wilde CG, Griffith JE, Marra MN, Snable JL, Scott RW. Purification and characterization of human neutrophil peptide 4, a novel member of the defensin family. J. Biol. Chem. 264(19), 11200-11203 (1989).
    • (1989) J. Biol. Chem , vol.264 , Issue.19 , pp. 11200-11203
    • Wilde, C.G.1    Griffith, J.E.2    Marra, M.N.3    Snable, J.L.4    Scott, R.W.5
  • 20
    • 0026457997 scopus 로고
    • Paneth cells of the human small intestine express an antimicrobial peptide gene
    • Jones DE, Bevins CL. Paneth cells of the human small intestine express an antimicrobial peptide gene. J. Biol. Chem. 267(32), 23216-23225 (1992).
    • (1992) J. Biol. Chem , vol.267 , Issue.32 , pp. 23216-23225
    • Jones, D.E.1    Bevins, C.L.2
  • 21
    • 0027390031 scopus 로고
    • Defensin-6 mRNA in human Paneth cells: Implications for antimicrobial peptides in host defense of the human bowel
    • Jones DE, Bevins CL. Defensin-6 mRNA in human Paneth cells: implications for antimicrobial peptides in host defense of the human bowel. FEBS Lett. 315(2), 187-192 (1993).
    • (1993) FEBS Lett , vol.315 , Issue.2 , pp. 187-192
    • Jones, D.E.1    Bevins, C.L.2
  • 23
    • 0030569343 scopus 로고    scopus 로고
    • Widespread expression of β-defensin hBD-1 in human secretory glands and epithelial cells
    • Zhao C, Wang I, Lehrer RI. Widespread expression of β-defensin hBD-1 in human secretory glands and epithelial cells. FEBS Lett. 396(2-3), 319-322 (1996).
    • (1996) FEBS Lett , vol.396 , Issue.2-3 , pp. 319-322
    • Zhao, C.1    Wang, I.2    Lehrer, R.I.3
  • 25
    • 0036467390 scopus 로고    scopus 로고
    • Defensins of vertebrate animals
    • Lehrer RI, Ganz T. Defensins of vertebrate animals. Curr. Opin. Immunol. 14(1), 96-102 (2002).
    • (2002) Curr. Opin. Immunol , vol.14 , Issue.1 , pp. 96-102
    • Lehrer, R.I.1    Ganz, T.2
  • 27
    • 4444246692 scopus 로고    scopus 로고
    • Primate defensins
    • Lehrer RI. Primate defensins. Nat. Rev. Microbiol. 2(9), 727-738 (2004).
    • (2004) Nat. Rev. Microbiol , vol.2 , Issue.9 , pp. 727-738
    • Lehrer, R.I.1
  • 28
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell 124(4), 783-801 (2006).
    • (2006) Cell , vol.124 , Issue.4 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 29
    • 0030831210 scopus 로고    scopus 로고
    • A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
    • Medzhitov R, Preston-Hurlburt P, Janeway CA Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388(6640), 394-397 (1997).
    • (1997) Nature , vol.388 , Issue.6640 , pp. 394-397
    • Medzhitov, R.1    Preston-Hurlburt, P.2    Janeway Jr, C.A.3
  • 30
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • Akira S, Takeda K. Toll-like receptor signalling. Nat. Rev. Immunol. 4(7), 499-511 (2004).
    • (2004) Nat. Rev. Immunol , vol.4 , Issue.7 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 31
    • 27844487939 scopus 로고    scopus 로고
    • The NF-κB pathway
    • Moynagh PN. The NF-κB pathway. J. Cell Sci. 118(Pt 20), 4589-4592 (2005).
    • (2005) J. Cell Sci , vol.118 , Issue.PART 20 , pp. 4589-4592
    • Moynagh, P.N.1
  • 32
    • 0000215491 scopus 로고    scopus 로고
    • Production of β-defensins by human airway epithelia
    • Singh PK, Jia HP, Wiles K et al. Production of β-defensins by human airway epithelia. Proc. Natl Acad. Sci. USA 95(25), 14961-14966 (1998).
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , Issue.25 , pp. 14961-14966
    • Singh, P.K.1    Jia, H.P.2    Wiles, K.3
  • 34
    • 4444340990 scopus 로고    scopus 로고
    • Direct bacterial protein PAMP recognition by human NK cells involves TLRs and triggers α-defensin production
    • Chalifour A, Jeannin P, Gauchat JF et al. Direct bacterial protein PAMP recognition by human NK cells involves TLRs and triggers α-defensin production. Blood 104(6), 1778-1783 (2004).
    • (2004) Blood , vol.104 , Issue.6 , pp. 1778-1783
    • Chalifour, A.1    Jeannin, P.2    Gauchat, J.F.3
  • 36
    • 25144453335 scopus 로고    scopus 로고
    • Regulation of mammalian defensin expression by Toll-like receptor-dependent and independent signalling pathways
    • Froy O. Regulation of mammalian defensin expression by Toll-like receptor-dependent and independent signalling pathways. Cell Microbiol. 7(10), 1387-1397 (2005).
    • (2005) Cell Microbiol , vol.7 , Issue.10 , pp. 1387-1397
    • Froy, O.1
  • 37
    • 4644226608 scopus 로고    scopus 로고
    • Stimulus-dependent requirement for granulocyte - macrophage colony-stimulating factor in inflammation
    • Cook AD, Braine EL, Hamilton JA. Stimulus-dependent requirement for granulocyte - macrophage colony-stimulating factor in inflammation. J. Immunol. 173(7), 4643-4651 (2004).
    • (2004) J. Immunol , vol.173 , Issue.7 , pp. 4643-4651
    • Cook, A.D.1    Braine, E.L.2    Hamilton, J.A.3
  • 38
    • 20544474210 scopus 로고    scopus 로고
    • Pathogen recognition with Toll-like receptors
    • Kawai T, Akira S. Pathogen recognition with Toll-like receptors. Curr. Opin. Immunol. 17(4), 338-344 (2005).
    • (2005) Curr. Opin. Immunol , vol.17 , Issue.4 , pp. 338-344
    • Kawai, T.1    Akira, S.2
  • 39
    • 3042717148 scopus 로고    scopus 로고
    • Up-regulation of human β-defensin 2 by interleukin-1β in A549 cells: Involvement of PI3K, PKC, p38 MAPK, JNK, and NF-κB
    • Jang BC, Lim KJ, Paik JH et al. Up-regulation of human β-defensin 2 by interleukin-1β in A549 cells: involvement of PI3K, PKC, p38 MAPK, JNK, and NF-κB. Biochem. Biophys. Res. Commun. 320(3), 1026-1033 (2004).
    • (2004) Biochem. Biophys. Res. Commun , vol.320 , Issue.3 , pp. 1026-1033
    • Jang, B.C.1    Lim, K.J.2    Paik, J.H.3
  • 40
  • 41
    • 7244257312 scopus 로고    scopus 로고
    • NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal α-defensin expression
    • Wehkamp J, Harder J, Weichenthal M et al. NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal α-defensin expression. Gut 53(11), 1658-1664 (2004).
    • (2004) Gut , vol.53 , Issue.11 , pp. 1658-1664
    • Wehkamp, J.1    Harder, J.2    Weichenthal, M.3
  • 42
    • 13244292161 scopus 로고    scopus 로고
    • Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract
    • Kobayashi KS, Chamaillard M, Ogura Y et al. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307(5710), 731-734 (2005).
    • (2005) Science , vol.307 , Issue.5710 , pp. 731-734
    • Kobayashi, K.S.1    Chamaillard, M.2    Ogura, Y.3
  • 44
    • 34247117757 scopus 로고    scopus 로고
    • Cationic host defence peptides: Innate immune regulatory peptides as a novel approach for treating infections
    • Mookherjee N, Hancock RE. Cationic host defence peptides: innate immune regulatory peptides as a novel approach for treating infections. Cell Mol. Life Sci. 64(7-8), 922-933 (2007).
    • (2007) Cell Mol. Life Sci , vol.64 , Issue.7-8 , pp. 922-933
    • Mookherjee, N.1    Hancock, R.E.2
  • 45
    • 33847040438 scopus 로고    scopus 로고
    • Antimicrobial peptides human β-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines
    • Niyonsaba F, Ushio H, Nakano N et al. Antimicrobial peptides human β-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines. J. Invest. Dermatol. 127(3), 594-604 (2007).
    • (2007) J. Invest. Dermatol , vol.127 , Issue.3 , pp. 594-604
    • Niyonsaba, F.1    Ushio, H.2    Nakano, N.3
  • 46
    • 22544457464 scopus 로고    scopus 로고
    • The human β-defensins (-1, -2, -3, -4) and cathelicidin LL-37 induce IL-18 secretion through p38 and ERK MAPK activation in primary human keratinocytes
    • Niyonsaba F, Ushio H, Nagaoka I, Okumura K, Ogawa H. The human β-defensins (-1, -2, -3, -4) and cathelicidin LL-37 induce IL-18 secretion through p38 and ERK MAPK activation in primary human keratinocytes. J. Immunol. 175(3), 1776-1784 (2005).
    • (2005) J. Immunol , vol.175 , Issue.3 , pp. 1776-1784
    • Niyonsaba, F.1    Ushio, H.2    Nagaoka, I.3    Okumura, K.4    Ogawa, H.5
  • 47
    • 0030775610 scopus 로고    scopus 로고
    • Effect of neutrophil serine proteinases and defensins on lung epithelial cells: Modulation of cytotoxicity and IL-8 production
    • Van WS, Mannesse-Lazeroms SP, Dijkman JH, Hiemstra PS. Effect of neutrophil serine proteinases and defensins on lung epithelial cells: modulation of cytotoxicity and IL-8 production. J. Leukoc. Biol. 62(2), 217-226 (1997).
    • (1997) J. Leukoc. Biol , vol.62 , Issue.2 , pp. 217-226
    • Van, W.S.1    Mannesse-Lazeroms, S.P.2    Dijkman, J.H.3    Hiemstra, P.S.4
  • 48
    • 13644250633 scopus 로고    scopus 로고
    • Differential effects of α- and β-defensin on cytokine production by cultured human bronchial epithelial cells
    • Sakamoto N, Mukae H, Fujii T et al. Differential effects of α- and β-defensin on cytokine production by cultured human bronchial epithelial cells. Am. J. Physiol. Lung Cell Mol. Physiol. 288(3), L508-L513 (2005).
    • (2005) Am. J. Physiol. Lung Cell Mol. Physiol , vol.288 , Issue.3
    • Sakamoto, N.1    Mukae, H.2    Fujii, T.3
  • 49
    • 33846194101 scopus 로고    scopus 로고
    • The concentration-dependent chemokine release and pro-apoptotic effects of neutrophil-derivedα-defensin-1 on human bronchial and alveolar epithelial cells
    • Liu CY, Lin HC, Yu CT et al. The concentration-dependent chemokine release and pro-apoptotic effects of neutrophil-derivedα-defensin-1 on human bronchial and alveolar epithelial cells. Life Sci. 80(8), 749-758 (2007).
    • (2007) Life Sci , vol.80 , Issue.8 , pp. 749-758
    • Liu, C.Y.1    Lin, H.C.2    Yu, C.T.3
  • 50
    • 34548810954 scopus 로고    scopus 로고
    • A novel role for defensins in intestinal homeostasis: Regulation of IL-1β secretion
    • Shi J, Aono S, Lu W et al. A novel role for defensins in intestinal homeostasis: regulation of IL-1β secretion. J. Immunol. 179(2), 1245-1253 (2007).
    • (2007) J. Immunol , vol.179 , Issue.2 , pp. 1245-1253
    • Shi, J.1    Aono, S.2    Lu, W.3
  • 51
    • 0030038197 scopus 로고    scopus 로고
    • Identification of defensin-1, defensin-2, and CAP37/azurocidin as T-cell chemoattractant proteins released from interleukin-8-stimulated neutrophils
    • Chertov O, Michiel DF, Xu L et al. Identification of defensin-1, defensin-2, and CAP37/azurocidin as T-cell chemoattractant proteins released from interleukin-8-stimulated neutrophils. J. Biol. Chem. 271(6), 2935-2940 (1996).
    • (1996) J. Biol. Chem , vol.271 , Issue.6 , pp. 2935-2940
    • Chertov, O.1    Michiel, D.F.2    Xu, L.3
  • 52
    • 0033844287 scopus 로고    scopus 로고
    • Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells
    • Yang D, Chen Q, Chertov O, Oppenheim JJ. Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells. J. Leukoc. Biol. 68(1), 9-14 (2000).
    • (2000) J. Leukoc. Biol , vol.68 , Issue.1 , pp. 9-14
    • Yang, D.1    Chen, Q.2    Chertov, O.3    Oppenheim, J.J.4
  • 53
    • 35748968488 scopus 로고    scopus 로고
    • Chemoattraction of macrophages, T lymphocytes, and mast cells is evolutionarily conserved within the human α-defensin family
    • Grigat J, Soruri A, Forssmann U, Riggert J, Zwirner J. Chemoattraction of macrophages, T lymphocytes, and mast cells is evolutionarily conserved within the human α-defensin family. J. Immunol. 179(6), 3958-3965 (2007).
    • (2007) J. Immunol , vol.179 , Issue.6 , pp. 3958-3965
    • Grigat, J.1    Soruri, A.2    Forssmann, U.3    Riggert, J.4    Zwirner, J.5
  • 54
    • 0033569408 scopus 로고    scopus 로고
    • β-defensins: Linking innate and adaptive immunity through dendritic and T cell CCR6
    • Yang D, Chertov O, Bykovskaia SN et al. β-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. Science 286(5439), 525-528 (1999).
    • (1999) Science , vol.286 , Issue.5439 , pp. 525-528
    • Yang, D.1    Chertov, O.2    Bykovskaia, S.N.3
  • 55
    • 34548772992 scopus 로고    scopus 로고
    • β-defensins chemoattract macrophages and mast cells but not lymphocytes and dendritic cells: CCR6 is not involved
    • Soruri A, Grigat J, Forssmann U, Riggert J, Zwirner J. β-defensins chemoattract macrophages and mast cells but not lymphocytes and dendritic cells: CCR6 is not involved. Eur. J. Immunol. 37(9), 2474-2486 (2007).
    • (2007) Eur. J. Immunol , vol.37 , Issue.9 , pp. 2474-2486
    • Soruri, A.1    Grigat, J.2    Forssmann, U.3    Riggert, J.4    Zwirner, J.5
  • 56
    • 0017162027 scopus 로고
    • Inflammatory effects of prostaglandin D2 in rat and human skin
    • Flower RJ, Harvey EA, Kingston WP. Inflammatory effects of prostaglandin D2 in rat and human skin. Br. J. Pharmacol. 56(2), 229-233 (1976).
    • (1976) Br. J. Pharmacol , vol.56 , Issue.2 , pp. 229-233
    • Flower, R.J.1    Harvey, E.A.2    Kingston, W.P.3
  • 57
    • 0035058454 scopus 로고    scopus 로고
    • Evaluation of the effects of peptide antibiotics human β-defensins-1/-2 and LL-37 on histamine release and prostaglandin D2 production from mast cells
    • Niyonsaba F, Someya A, Hirata M, Ogawa H, Nagaoka I. Evaluation of the effects of peptide antibiotics human β-defensins-1/-2 and LL-37 on histamine release and prostaglandin D2 production from mast cells. Eur. J. Immunol. 31(4), 1066-1075 (2001).
    • (2001) Eur. J. Immunol , vol.31 , Issue.4 , pp. 1066-1075
    • Niyonsaba, F.1    Someya, A.2    Hirata, M.3    Ogawa, H.4    Nagaoka, I.5
  • 58
    • 33947728599 scopus 로고    scopus 로고
    • Antimicrobial peptides human β-defensin (hBD)-3 and hBD-4 activate mast cells and increase skin vascular permeability
    • Chen X, Niyonsaba F, Ushio H et al. Antimicrobial peptides human β-defensin (hBD)-3 and hBD-4 activate mast cells and increase skin vascular permeability. Eur. J. Immunol. 37(2), 434-444 (2007).
    • (2007) Eur. J. Immunol , vol.37 , Issue.2 , pp. 434-444
    • Chen, X.1    Niyonsaba, F.2    Ushio, H.3
  • 60
    • 2542467586 scopus 로고    scopus 로고
    • Release of anti-HIV mediators after administration of leukotriene B4 to humans
    • Flamand L, Borgeat P, Lalonde R, Gosrelin J. Release of anti-HIV mediators after administration of leukotriene B4 to humans. J. Infect. Dis. 189(11), 2001-2009 (2004).
    • (2004) J. Infect. Dis , vol.189 , Issue.11 , pp. 2001-2009
    • Flamand, L.1    Borgeat, P.2    Lalonde, R.3    Gosrelin, J.4
  • 61
    • 34250177883 scopus 로고    scopus 로고
    • Leukotriene B4 triggers the in vitro and in vivo release of potent antimicrobial agents
    • Flamand L, Tremblay MJ, Borgeat P. Leukotriene B4 triggers the in vitro and in vivo release of potent antimicrobial agents. J. Immunol. 178(12), 8036-8045 (2007).
    • (2007) J. Immunol , vol.178 , Issue.12 , pp. 8036-8045
    • Flamand, L.1    Tremblay, M.J.2    Borgeat, P.3
  • 62
    • 34250357688 scopus 로고    scopus 로고
    • Resolvin E1 and protecrin D1 activate inflammation-resolution programmes
    • Schwab JM, Chiang N, Arita M, Serhan CN. Resolvin E1 and protecrin D1 activate inflammation-resolution programmes. Nature 447(7146), 869-874 (2007).
    • (2007) Nature , vol.447 , Issue.7146 , pp. 869-874
    • Schwab, J.M.1    Chiang, N.2    Arita, M.3    Serhan, C.N.4
  • 63
    • 38049181031 scopus 로고    scopus 로고
    • Hematopoietic prostaglandin D2 synthase controls the onset and resolution of acute inflammation through PGD2 and 15-deoxyδ12 14 PGJ2
    • Rajakariar R, Hilliard M, Lawrence T et al. Hematopoietic prostaglandin D2 synthase controls the onset and resolution of acute inflammation through PGD2 and 15-deoxyδ12 14 PGJ2. Proc. Natl Acad. Sci. USA 104(52), 20979-20984 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , Issue.52 , pp. 20979-20984
    • Rajakariar, R.1    Hilliard, M.2    Lawrence, T.3
  • 64
    • 33750934617 scopus 로고    scopus 로고
    • Dendritic cells: Translating innate to adaptive immunity
    • Steinman RM, Hemmi H. Dendritic cells: translating innate to adaptive immunity. Curr. Top. Microbiol. Immunol. 311, 17-58 (2006).
    • (2006) Curr. Top. Microbiol. Immunol , vol.311 , pp. 17-58
    • Steinman, R.M.1    Hemmi, H.2
  • 65
    • 33645734929 scopus 로고    scopus 로고
    • Toll-dependent selection of microbial antigens for presentation by dendritic cells
    • Blander JM, Medzhitov R. Toll-dependent selection of microbial antigens for presentation by dendritic cells. Nature 440(7085), 808-812 (2006).
    • (2006) Nature , vol.440 , Issue.7085 , pp. 808-812
    • Blander, J.M.1    Medzhitov, R.2
  • 66
    • 0034201213 scopus 로고    scopus 로고
    • Neutrophil α-defensin human neutrophil peptide modulates cytokine production in human monocytes and adhesion molecule expression in endothelial cells
    • Chaly YV, Paleolog EM, Kolesnikova TS, Tikhonov II, Petratchenko EV, Voitenok NN. Neutrophil α-defensin human neutrophil peptide modulates cytokine production in human monocytes and adhesion molecule expression in endothelial cells. Eur. Cytokine Netw. 11(2), 257-266 (2000).
    • (2000) Eur. Cytokine Netw , vol.11 , Issue.2 , pp. 257-266
    • Chaly, Y.V.1    Paleolog, E.M.2    Kolesnikova, T.S.3    Tikhonov, I.I.4    Petratchenko, E.V.5    Voitenok, N.N.6
  • 67
    • 36749042671 scopus 로고    scopus 로고
    • Human -defensin-3 activates professional antigen-presenting cells via Toll-like receptors 1 and 2
    • Funderburg N, Lederman MM, Feng Z et al. Human -defensin-3 activates professional antigen-presenting cells via Toll-like receptors 1 and 2. Proc. Natl Acad. Sci. USA 104(47), 18631-18635 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , Issue.47 , pp. 18631-18635
    • Funderburg, N.1    Lederman, M.M.2    Feng, Z.3
  • 68
    • 44449154973 scopus 로고    scopus 로고
    • Murine β-defensin 2 promotes TLR-4/MyD88-mediated and NF-κB-dependent atypical death of APCs via activation of TNFR2
    • Biragyn A, Coscia M, Nagashima K, Sanford M, Young HA, Olkhanud P. Murine β-defensin 2 promotes TLR-4/MyD88-mediated and NF-κB-dependent atypical death of APCs via activation of TNFR2. J. Leukoc. Biol. 83(4), 998-1008 (2008).
    • (2008) J. Leukoc. Biol , vol.83 , Issue.4 , pp. 998-1008
    • Biragyn, A.1    Coscia, M.2    Nagashima, K.3    Sanford, M.4    Young, H.A.5    Olkhanud, P.6
  • 70
    • 0037911520 scopus 로고    scopus 로고
    • Defensin-induced adaptive immunity in mice and its potential in preventing periodontal disease
    • Brogden KA, Heidari M, Sacco RE et al. Defensin-induced adaptive immunity in mice and its potential in preventing periodontal disease. Oral Microbiol. Immunol. 18(2), 95-99 (2003).
    • (2003) Oral Microbiol. Immunol , vol.18 , Issue.2 , pp. 95-99
    • Brogden, K.A.1    Heidari, M.2    Sacco, R.E.3
  • 71
    • 36749008499 scopus 로고    scopus 로고
    • A β-defensin mutation causes black coat color in domestic dogs
    • Candille SI, Kaelin CB, Cattanach BM et al. A β-defensin mutation causes black coat color in domestic dogs. Science 318(5855), 1418-1423 (2007).
    • (2007) Science , vol.318 , Issue.5855 , pp. 1418-1423
    • Candille, S.I.1    Kaelin, C.B.2    Cattanach, B.M.3
  • 72
    • 0032533889 scopus 로고    scopus 로고
    • Inhibition of activation of the classical pathway of complement by human neutrophil defensins
    • van den Berg RH, Faber-Krol MC, Van Wetering S, Hiemstra PS, Daha MR. Inhibition of activation of the classical pathway of complement by human neutrophil defensins. Blood 92(10), 3898-3903 (1998).
    • (1998) Blood , vol.92 , Issue.10 , pp. 3898-3903
    • van den Berg, R.H.1    Faber-Krol, M.C.2    Van Wetering, S.3    Hiemstra, P.S.4    Daha, M.R.5
  • 73
    • 34249089844 scopus 로고    scopus 로고
    • Human neutrophil peptide-1 inhibits both the classical and the lectin pathway of complement activation
    • Groeneveld TW, Ramwadhdoebe TH, Trouw LA et al. Human neutrophil peptide-1 inhibits both the classical and the lectin pathway of complement activation. Mol. Immunol. 44(14), 3608-3614 (2007).
    • (2007) Mol. Immunol , vol.44 , Issue.14 , pp. 3608-3614
    • Groeneveld, T.W.1    Ramwadhdoebe, T.H.2    Trouw, L.A.3
  • 74
    • 34250204072 scopus 로고    scopus 로고
    • Human neutrophil defensins increase neutrophil uptake of influenza A virus and bacteria and modify virus-induced respiratory burst responses
    • Tecle T, White MR, Gantz D, Crouch EC, Hartshorn KL. Human neutrophil defensins increase neutrophil uptake of influenza A virus and bacteria and modify virus-induced respiratory burst responses. J. Immunol. 178(12), 8046-8052 (2007).
    • (2007) J. Immunol , vol.178 , Issue.12 , pp. 8046-8052
    • Tecle, T.1    White, M.R.2    Gantz, D.3    Crouch, E.C.4    Hartshorn, K.L.5
  • 75
    • 2942670459 scopus 로고    scopus 로고
    • Can innate immunity be enhanced to treat microbial infections?
    • Finlay BB, Hancock RE. Can innate immunity be enhanced to treat microbial infections? Nat. Rev. Microbiol. 2(6), 497-504 (2004).
    • (2004) Nat. Rev. Microbiol , vol.2 , Issue.6 , pp. 497-504
    • Finlay, B.B.1    Hancock, R.E.2
  • 76
    • 33745463739 scopus 로고    scopus 로고
    • A comprehensive map of the Toll-like receptor signaling network
    • Oda K, Kitano H. A comprehensive map of the Toll-like receptor signaling network. Mol. Syst. Biol. 2, 2006 (2006).
    • (2006) Mol. Syst. Biol , vol.2 , pp. 2006
    • Oda, K.1    Kitano, H.2
  • 77
    • 34249709500 scopus 로고    scopus 로고
    • Complexities of targeting innate immunity to treat infection
    • Brown KL, Cosseau C, Gardy JL, Hancock RE. Complexities of targeting innate immunity to treat infection. Trends Immunol. 28(6), 260-266 (2007).
    • (2007) Trends Immunol , vol.28 , Issue.6 , pp. 260-266
    • Brown, K.L.1    Cosseau, C.2    Gardy, J.L.3    Hancock, R.E.4
  • 78
    • 1342303482 scopus 로고    scopus 로고
    • Of mice and not men: Differences between mouse and human immunology
    • Mestas J, Hughes CC. Of mice and not men: differences between mouse and human immunology. J. Immunol. 172(5), 2731-2738 (2004).
    • (2004) J. Immunol , vol.172 , Issue.5 , pp. 2731-2738
    • Mestas, J.1    Hughes, C.C.2
  • 79
    • 34147147029 scopus 로고    scopus 로고
    • An anti-infective peptide that selectively modulates the innate immune response
    • Scott MG, Dullaghan E, Mookherjee N et al. An anti-infective peptide that selectively modulates the innate immune response. Nat. Biotechnol. 25(4), 465-472 (2007).
    • (2007) Nat. Biotechnol , vol.25 , Issue.4 , pp. 465-472
    • Scott, M.G.1    Dullaghan, E.2    Mookherjee, N.3
  • 80
    • 34249677845 scopus 로고    scopus 로고
    • Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists
    • Kanzler H, Barrat FJ, Hessel EM, Coffman RL. Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists. Nat. Med. 13(5), 552-559 (2007).
    • (2007) Nat. Med , vol.13 , Issue.5 , pp. 552-559
    • Kanzler, H.1    Barrat, F.J.2    Hessel, E.M.3    Coffman, R.L.4
  • 81
    • 33745946911 scopus 로고    scopus 로고
    • Therapeutic potential of Toll-like receptor 9 activation
    • Krieg AM. Therapeutic potential of Toll-like receptor 9 activation. Nat. Rev. Drug Discov. 5(6), 471-484 (2006).
    • (2006) Nat. Rev. Drug Discov , vol.5 , Issue.6 , pp. 471-484
    • Krieg, A.M.1
  • 82
    • 32944478316 scopus 로고    scopus 로고
    • Translating innate immunity into immunological memory: Implications for vaccine development
    • Pulendran B, Ahmed R. Translating innate immunity into immunological memory: implications for vaccine development. Cell 124(4), 849-863 (2006).
    • (2006) Cell , vol.124 , Issue.4 , pp. 849-863
    • Pulendran, B.1    Ahmed, R.2
  • 83
    • 34248160010 scopus 로고    scopus 로고
    • Pandrug-resistant Gram-negative bacteria: The dawn of the post-antibiotic era?
    • Falagas ME, Bliziotis IA. Pandrug-resistant Gram-negative bacteria: the dawn of the post-antibiotic era? Int. J. Antimicrob. Agents 29(6), 630-636 (2007).
    • (2007) Int. J. Antimicrob. Agents , vol.29 , Issue.6 , pp. 630-636
    • Falagas, M.E.1    Bliziotis, I.A.2
  • 84
    • 33845903833 scopus 로고    scopus 로고
    • Drugs for bad bugs: Confronting the challenges of antibacterial discovery
    • Payne DJ, Gwynn MN, Holmes DJ, Pompliano DL. Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nat. Rev. Drug Discov. 6(1), 29-40 (2007).
    • (2007) Nat. Rev. Drug Discov , vol.6 , Issue.1 , pp. 29-40
    • Payne, D.J.1    Gwynn, M.N.2    Holmes, D.J.3    Pompliano, D.L.4


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