Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 37, 2016, Pages E5399-E5407

  Sasaki, Nobuo ^a,b,d   Sachs, Norman ^a,b   Wiebrands, Kay ^a,b   Ellenbroek, Saskia I J ^a,b   Fumagalli, Arianna ^a,b   Lyubimova, Anna ^a,b   Begthel, Harry ^a,b   Van Born, Maaike Den ^a,b   Van Es, Johan H ^a,b   Karthaus, Wouter R ^a,b,e   Li, Vivian S W ^a,b,f   López Iglesias, Carmen ^c   Peters, Peter J ^c   Van Rheenen, Jacco ^a,b   Van Oudenaarden, Alexander ^a,b   Clevers, Hans ^a,b  

^a HUBRECHT INSTITUTE   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c MAASTRICHT UNIVERSITY   (Netherlands)

^d KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^f NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

Deep crypt secretory cells; Intestinal stem cell; Lgr5; Niche; Reg4

Indexed keywords

NOTCH RECEPTOR; PROTEIN; REGENERATING ISLETLED DERIVED FAMILY MEMBER 4; UNCLASSIFIED DRUG; WNT PROTEIN; G PROTEIN COUPLED RECEPTOR; LGR5 PROTEIN, MOUSE; REG4 PROTEIN, MOUSE; TUMOR PROTEIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CONTROLLED STUDY; DEEP CRYPT SECRETORY CELL; GENE LOCUS; HOMEOSTASIS; IN VITRO STUDY; INTESTINAL STEM CELL; MOUSE; NONHUMAN; PANETH CELL; PRIORITY JOURNAL; RECEPTOR GENE; SECRETORY CELL; STEM CELL NICHE; ANIMAL; COLON; COLON TUMOR; CYTOLOGY; EPITHELIUM CELL; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; ORGANOID; PATHOLOGY; SMALL INTESTINE; STEM CELL; WNT SIGNALING;

ANIMALS; COLON; COLONIC NEOPLASMS; EPITHELIAL CELLS; INTESTINE, SMALL; MICE; NEOPLASM PROTEINS; ORGANOIDS; PANETH CELLS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NOTCH; STEM CELL NICHE; STEM CELLS; WNT SIGNALING PATHWAY;

EID: 85047289665     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1607327113     Document Type: Article

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