TRAF6-mediated SM22α K21 ubiquitination promotes G6PD activation and NADPH production, contributing to GSH homeostasis and VSMC survival in vitro and in vivo

Circulation Research

Volumn 117, Issue 8, 2015, Pages 684-694

  Dong, Li Hua ^a   Li, Liang ^a   Song, Yu ^a   Duan, Zhi Li ^a   Sun, Shao Guang ^a   Lin, Yan Ling ^a   Miao, Sui Bing ^a   Yin, Ya Juan ^a   Shu, Ya Nan ^a   Li, Huan ^a   Chen, Peng ^a   Zhao, Li Li ^a   Han, Mei ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

Glucose 6 phosphate dehydrogenase; Platelet derived growth factor; Survival; Tumor necrosis factor receptor associated factor 6; Vascular smooth muscle

Indexed keywords

6 PHOSPHOFRUCTOKINASE; ALDOLASE A; ALDOLASE C; CALPONIN; FRUCTOSE BISPHOSPHATE ALDOLASE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUTATHIONE; GLUTATHIONE REDUCTASE; MESSENGER RNA; PHOSPHOGLUCOMUTASE; PLATELET DERIVED GROWTH FACTOR BB; PROTEIN MDM2; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; TRANSGELIN; TRANSKETOLASE; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG; ACTIN BINDING PROTEIN; MUSCLE PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PLATELET DERIVED GROWTH FACTOR B; PLATELET-DERIVED GROWTH FACTOR BB; TAGLN PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATHEROSCLEROTIC PLAQUE; CAROTID ATHEROSCLEROSIS; CELL MEMBRANE; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DISEASE COURSE; DOWN REGULATION; GENE SILENCING; GLUCOSE METABOLISM; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NEOINTIMA; NONHUMAN; PENTOSE PHOSPHATE CYCLE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RAT; UBIQUITINATION; UPREGULATION; VASCULAR DISEASE; VASCULAR SMOOTH MUSCLE CELL; VASCULAR SURGERY; ANIMAL; CAROTID ARTERY INJURY; CELL CULTURE; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; ENZYME ACTIVATION; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; HOMEOSTASIS; KNOCKOUT MOUSE; MALE; METABOLISM; PATHOLOGY; PROTEIN TRANSPORT; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CELL; SMOOTH MUSCLE FIBER; SPRAGUE DAWLEY RAT; TIME; TIME FACTOR; VASCULAR SMOOTH MUSCLE;

ANIMALS; APOPTOSIS; CAROTID ARTERY INJURIES; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; GLUCOSEPHOSPHATE DEHYDROGENASE; GLUTATHIONE; HOMEOSTASIS; MALE; MICE, KNOCKOUT; MICROFILAMENT PROTEINS; MUSCLE PROTEINS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NADP; NEOINTIMA; PENTOSE PHOSPHATE PATHWAY; PLAQUE, ATHEROSCLEROTIC; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-SIS; RATS, SPRAGUE-DAWLEY; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTORS; TNF RECEPTOR-ASSOCIATED FACTOR 6; TRANSFECTION; UBIQUITINATION;

EID: 85047289450     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.115.306233     Document Type: Article

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