Chronic apoptosis of vascular smooth muscle cells accelerates atherosclerosis and promotes calcification and medial degeneration

Circulation Research

Volumn 102, Issue 12, 2008, Pages 1529-1538

  Clarke, Murray C H ^a   Littlewood, Trevor D ^a   Figg, Nichola ^a   Maguire, Janet J ^a   Davenport, Anthony P ^a   Goddard, Martin ^b   Bennett, Martin R ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b PAPWORTH HOSPITAL   (United Kingdom)

Author keywords

Apoptosis; Atherosclerosis; Calcification; Mouse models; VSMC

Indexed keywords

APOLIPOPROTEIN E; ACTIN; CYTOKINE; DIPHTHERIA TOXIN; DIPHTHERIA TOXIN GMCSF FUSINO PROTEIN, RECOMBINANT; DIPHTHERIA TOXIN-GMCSF FUSINO PROTEIN, RECOMBINANT; DPH2L1 PROTEIN, MOUSE; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; HEPARIN-BINDING EGF-LIKE GROWTH FACTOR; HYBRID PROTEIN; SIGNAL PEPTIDE; TUMOR SUPPRESSOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTERY CALCIFICATION; ARTERY CONSTRICTION; ARTERY MEDIA; ARTERY OCCLUSION; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CONTROLLED STUDY; DEGENERATION; EXPERIMENTAL MODEL; EXTRACELLULAR MATRIX; MOUSE; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER; TISSUE NECROSIS; VASCULAR SMOOTH MUSCLE; AMINO ACID SUBSTITUTION; ANIMAL; AORTA DISEASE; CALCINOSIS; CHEMISTRY; DISEASE COURSE; GENETICS; MOUSE MUTANT; NECROSIS; PATHOLOGY; PHYSIOLOGY; SECRETION; STENOSIS, OCCLUSION AND OBSTRUCTION; THORACIC AORTA; TRANSGENIC MOUSE; TUNICA MEDIA; VASOCONSTRICTION;

ACTINS; AMINO ACID SUBSTITUTION; ANIMALS; AORTA, THORACIC; AORTIC DISEASES; APOLIPOPROTEINS E; APOPTOSIS; ATHEROSCLEROSIS; CALCINOSIS; CONSTRICTION, PATHOLOGIC; CYTOKINES; DIPHTHERIA TOXIN; DISEASE PROGRESSION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MYOCYTES, SMOOTH MUSCLE; NECROSIS; RECOMBINANT FUSION PROTEINS; TUMOR SUPPRESSOR PROTEINS; TUNICA MEDIA; VASOCONSTRICTION;

EID: 48249133229     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.108.175976     Document Type: Article

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