Phosphorylation of smooth muscle 22α facilitates angiotensin II-induced ROS production via activation of the PKCδ-P47phox axis through release of PKCδ and actin dynamics and is associated with hypertrophy and hyperplasia of vascular smooth muscle cells in vitro and in vivo

Circulation Research

Volumn 111, Issue 6, 2012, Pages 697-707

  Lv, Pin ^a   Miao, Sui Bing ^a   Shu, Ya Nan ^a   Dong, Li Hua ^a   Liu, George ^b   Xie, Xiao Li ^a   Gao, Min ^a   Wang, Yu Can ^a   Yin, Ya Juan ^a   Wang, Xiao Juan ^a   Han, Mei ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b PEKING UNIVERSITY   (China)

Author keywords

Ang II; angiotensin II; PKC; ROS; SM22 ; VSMC

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN II; CALPONIN; HYDROETHIDINE; MALONALDEHYDE; PHOXIM; PROTEASOME; PROTEIN KINASE C DELTA; PROTEIN P47; REACTIVE OXYGEN METABOLITE; SERINE; SMOOTH MUSCLE 22ALPHA; SMOOTH MUSCLE ACTIN; SUPEROXIDE; UBIQUITIN; UNCLASSIFIED DRUG;

ACTIN FILAMENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOVASCULAR DISEASE; CELL HYPERPLASIA; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYPERTROPHY; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; UBIQUITINATION; VASCULAR SMOOTH MUSCLE;

ACTINS; ANGIOTENSIN II; ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; DOWN-REGULATION; ENZYME ACTIVATION; GREEN FLUORESCENT PROTEINS; HUMANS; HYPERPLASIA; HYPERTROPHY; MALE; MICROFILAMENT PROTEINS; MICROSCOPY, CONFOCAL; MUSCLE PROTEINS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NADPH OXIDASE; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASE C-DELTA; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE;

EID: 84865860904     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.112.272013     Document Type: Article

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