PKR inhibition rescues memory deficit and atf4 overexpression in apoe ε4 human replacement mice

Journal of Neuroscience

Volumn 35, Issue 38, 2015, Pages 12986-12993

  Segev, Yifat ^a   Barrera, Iliana ^a   Ounallah Saad, Hadile ^a   Wibrand, Karin ^b   Sporild, Ida ^b   Livne, Adva ^a   Rosenberg, Tali ^a   David, Orit ^a   Mints, Meshi ^a   Bramham, Clive R ^b   Rosenblum, Kobi ^a  

^a UNIVERSITY OF HAIFA   (Israel)

^b UNIVERSITY OF BERGEN   (Norway)

Author keywords

Alzheimer s disease; ATF4; Cognitive enhancer; Memory consolidation; Translation regulation

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; APOLIPOPROTEIN E4; INITIATION FACTOR 2ALPHA; MESSENGER RNA; PROTEIN KINASE INHIBITOR; PROTEIN KINASE R; PROTEIN KINASE R INHIBITOR C 16; UNCLASSIFIED DRUG; APOLIPOPROTEIN E3; ATF4 PROTEIN, MOUSE; ENZYME INHIBITOR; PROTEIN KINASE;

AGED; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CLINICAL ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; ENZYME INHIBITION; FEAR; FEMALE; GENE OVEREXPRESSION; GENETIC RISK; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MEMORY CONSOLIDATION; MEMORY DISORDER; METABOLIC STRESS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; RNA ISOLATION; TRANSCRIPTION REGULATION; TRANSLATION REGULATION; VERY ELDERLY; WESTERN BLOTTING; ANIMAL; CONDITIONING; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; IN VITRO STUDY; MEMORY DISORDERS; METABOLISM; NONPARAMETRIC TEST; PHOSPHORYLATION; PHYSIOLOGY; PSYCHOLOGY; TRANSGENIC MOUSE;

ACTIVATING TRANSCRIPTION FACTOR 4; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANIMALS; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; CONDITIONING (PSYCHOLOGY); ENZYME INHIBITORS; FEAR; FEMALE; GENE EXPRESSION REGULATION; HIPPOCAMPUS; HUMANS; IN VITRO TECHNIQUES; MALE; MEMORY DISORDERS; MICE; MICE, TRANSGENIC; PHOSPHORYLATION; PROTEIN KINASES; RNA, MESSENGER; STATISTICS, NONPARAMETRIC;

EID: 85047288766     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5241-14.2015     Document Type: Article

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