Red blood cell antibody-induced anemia causes differential degrees of tissue hypoxia in kidney and brain

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 314, Issue 4, 2018, Pages R611-R622

  Mistry, Nikhil ^a,b   Mazer, C David ^a,b,c   Sled, John G ^b,d   Lazarus, Alan H ^c,e   Cahill, Lindsay S ^d   Solish, Max ^c   Zhou, Yu Qing ^d   Romanova, Nadya ^f   Hare, Alexander G M ^c   Doctor, Allan ^g   Fisher, Joseph A ^b,h   Brunt, Keith R ⁱ   Simpson, Jeremy A ^f   Hare, Gregory M T ^a,b,c  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c ST MICHAEL'S HOSPITAL   (Canada)

^d HOSPITAL FOR SICK CHILDREN   (Canada)

^e CANADIAN BLOOD SERVICES   (Canada)

^f UNIVERSITY OF GUELPH   (Canada)

^g WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h UNIVERSITY OF TORONTO   (Canada)

ⁱ DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Acute kidney injury; Anemia induced tissue hypoxia; Subacute anemia

Indexed keywords

ERYTHROCYTE ANTIBODY; ERYTHROPOIETIN; GLYCOPHORIN A; HEME OXYGENASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LUCIFERASE; MESSENGER RNA; EPO PROTEIN, MOUSE; GLYCOPHORIN; HIF1A PROTEIN, MOUSE; MONOCLONAL ANTIBODY; OXYGEN;

ACUTE KIDNEY FAILURE; ANEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL OXYGEN SATURATION; ARTICLE; BIOMICROSCOPY; BRAIN FUNCTION; BRAIN HYPOXIA; BRAIN TISSUE; CARDIOVASCULAR FUNCTION; CAROTID ARTERY FLOW; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVITY; ERYTHROCYTE METABOLISM; FEMALE; HEMOGLOBIN BLOOD LEVEL; HEMOGLOBIN DETERMINATION; HYPOXEMIA; IN VIVO STUDY; INTRAVASCULAR HEMOLYSIS; KIDNEY BLOOD FLOW; KIDNEY TISSUE; LIVER WEIGHT; MALE; MOUSE; NONHUMAN; OXYGEN TISSUE LEVEL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REPORTER GENE; RNA ISOLATION; RNA TRANSCRIPTION; SPLEEN; ANIMAL; BLOOD; BRAIN; BRAIN CIRCULATION; DISEASE MODEL; ERYTHROCYTE; GENETICS; HEMOLYSIS; IMMUNOLOGY; KIDNEY; KIDNEY CIRCULATION; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; SEVERITY OF ILLNESS INDEX; TRANSGENIC MOUSE; UPREGULATION; VASCULARIZATION;

ACUTE KIDNEY INJURY; ANEMIA; ANIMALS; ANTIBODIES, MONOCLONAL; BRAIN; CEREBROVASCULAR CIRCULATION; DISEASE MODELS, ANIMAL; ERYTHROCYTES; ERYTHROPOIETIN; GLYCOPHORIN; HEMOLYSIS; HYPOXIA, BRAIN; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; KIDNEY; MALE; MICE, TRANSGENIC; OXYGEN; RENAL CIRCULATION; SEVERITY OF ILLNESS INDEX; SPLEEN; UP-REGULATION;

EID: 85046836636     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00182.2017     Document Type: Article

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