Priming of hypoxia-inducible factor by neuronal nitric oxide synthase is essential for adaptive responses to severe anemia

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 42, 2011, Pages 17544-17549

  Tsui, Albert K Y ^a,b   Marsden, Philip A ^a   Mazer, C David ^a,b   Adamson, S Lee ^b,c   Henkelman, R Mark ^d   Ho, J J David ^a,d   Wilson, David F ^e   Heximer, Scott P ^b,f   Connelly, Kim A ^a   Bolz, Steffen Sebastian ^b,f   Lidington, Darcy ^b,f   El Beheiry, Mostafa H ^a,b   Dattani, Neil D ^a   Chen, Kevin M ^a   Hare, Gregory M T ^a,b,f  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c MOUNT SINAI HOSPITAL   (Canada)

^d HOSPITAL FOR SICK CHILDREN   (Canada)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

^f UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC PROTEIN; ERYTHROPOIETIN; GLUCOSE TRANSPORTER 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LUCIFERASE; MESSENGER RNA; NEURONAL NITRIC OXIDE SYNTHASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; S NITROSOGLUTATHIONE; VASCULOTROPIN;

ANEMIA; ARTICLE; BRAIN; CARDIOVASCULAR RESPONSE; CONTROLLED STUDY; DISEASE SEVERITY; HEART OUTPUT; HYPOXIA; IN VIVO STUDY; MALE; MORTALITY; MOUSE; NITROSYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; SURVIVAL; SYSTEMIC VASCULAR RESISTANCE; TRANSGENIC ANIMAL; WILD TYPE;

ADAPTATION, PHYSIOLOGICAL; ANEMIA; ANIMALS; BRAIN; CARDIAC OUTPUT; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; NITRIC OXIDE SYNTHASE TYPE I; OXYGEN; RNA, MESSENGER; SIGNAL TRANSDUCTION; VASCULAR RESISTANCE; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

ANIMALIA; MUS;

EID: 80054806718     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1114026108     Document Type: Article

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