Differential HIF and NOS responses to acute anemia: Defining organ-specific hemoglobin thresholds for tissue hypoxia

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 307, Issue 1, 2014, Pages

  Tsui, Albert K Y ^a,b   Marsden, Philip A ^a,b   David Mazer, C ^a,b,c   Sled, John G ^d   Lee, Keith M ^a   Henkelman, R Mark ^d   Cahill, Lindsay S ^d   Zhou, Yu Qing ^d   Chan, Neville ^a   Liu, Elaine ^a,b   Hare, Gregory M T ^a,b,c  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b ST MICHAEL'S HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Anemia; Hemoglobin threshold; Hypoxia inducible factor; Nitric oxide synthase

Indexed keywords

HEMOGLOBIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; NITRIC OXIDE SYNTHASE; RNA;

ANEMIA; ANIMAL EXPERIMENT; ARTICLE; BIOMICROSCOPY; BRAIN; CAROTID ARTERY FLOW; CONTROLLED STUDY; HEMOGLOBIN DETERMINATION; HYPOXEMIA; IN VITRO STUDY; IN VIVO STUDY; KIDNEY; KIDNEY BLOOD FLOW; LIVER; LUCIFERASE ASSAY; MOUSE; NONHUMAN; ORGAN INJURY; PARAMETERS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENIC MOUSE;

ANEMIA; HEMOGLOBIN THRESHOLD; HYPOXIA INDUCIBLE FACTOR; NITRIC OXIDE SYNTHASE;

ACUTE DISEASE; ANEMIA; ANIMALS; ANOXIA; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BIOLOGICAL MARKERS; BRAIN; CEREBROVASCULAR CIRCULATION; DISEASE MODELS, ANIMAL; ERYTHROPOIETIN; HEMODILUTION; HEMODYNAMICS; HEMOGLOBINS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; KIDNEY; LIVER; LUCIFERASES, FIREFLY; MICE; MICE, TRANSGENIC; MONOCARBOXYLIC ACID TRANSPORTERS; MUSCLE PROTEINS; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE III; RECOMBINANT FUSION PROTEINS; RENAL CIRCULATION; SEVERITY OF ILLNESS INDEX;

EID: 84903649734     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00411.2013     Document Type: Article

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