β2 adrenergic antagonist inhibits cerebral cortical oxygen delivery after severe haemodilution in rats

British Journal of Anaesthesia

Volumn 97, Issue 5, 2006, Pages 617-623

  Hare, G M T ^a,b   Worrall, J M A ^a   Baker, A J ^a   Liu, E ^a   Sikich, N ^a   Mazer, C D ^a,b  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Cerebral blood flow; Cerebral hypoxia; Cerebral tissue oxygen tension; Haemodilution; 2 adrenergic blockade

Indexed keywords

3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; BETA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; HEMOGLOBIN; HETASTARCH; ISOFLURANE; OXYGEN; SODIUM CHLORIDE; BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT;

ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIAL GAS; ARTICLE; BLOOD VOLUME; BRAIN BLOOD FLOW; BRAIN CORTEX; CONTROLLED STUDY; DRUG MECHANISM; GENERAL ANESTHESIA; HEART RATE; HEMODILUTION; HIPPOCAMPUS; HYPOXEMIA; INHIBITION KINETICS; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; OXIMETRY; OXYGEN TISSUE LEVEL; OXYGEN TRANSPORT; PARIETAL LOBE; PRIORITY JOURNAL; RAT; TEMPERATURE; ANIMAL; BLOOD; BLOOD PRESSURE; BRAIN; BRAIN CIRCULATION; DRUG ANTAGONISM; DRUG EFFECT; OXYGEN CONSUMPTION; PHYSIOLOGY; PRESSURE; SPRAGUE DAWLEY RAT; VASODILATATION;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; BLOOD PRESSURE; BRAIN; CEREBROVASCULAR CIRCULATION; HEART RATE; HEMODILUTION; MALE; OXYGEN; OXYGEN CONSUMPTION; PARTIAL PRESSURE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, BETA-2; TEMPERATURE; VASODILATION;

EID: 33750139990     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/ael238     Document Type: Article

References (34)

1. Weiskopf RB, Kramer JH, Viele M, et al. Acute severe isovolemic anemia impairs cognitive function and memory in humans. Anesthesiology 2000; 92: 1646-52
2. Weiskopf RB, Toy P, Hopf HW, et al. Acute isovolemic anemia impairs central processing as determined by P300 latency. Clin Neurophysiol 2005; 116: 1028-32
3. Jonas RA, Wypij D, Roth SJ, et al. The influence of haemodilution on outcome after hypothermic cardiopulmonary bypass: Results of a randomized trial in infants. J Thorac Cardiovasc Surg 2003; 126: 1765-74
4. Habib RH, Zacharias A, Schwann TA, Riordan CJ, Durham SJ, Shah A. Adverse effects of low haematocrit during cardiopulmonary bypass in the adult: Should current practice be changed? J Thorac Cardiovasc Surg 2003; 125: 1438-50
5. Dunne JR, Malone D, Tracy JK, Gannon C, Napolitano LM. Perioperative anemia: An independent risk factor for infection, mortality, and resource utilization in surgery. J Surg Res 2002; 102: 237-44
6. Carson JL, Poses RM, Spence RK, Bonavita G. Severity of anaemia and operative mortality and morbidity. Lancet 1988; 1: 727-9
7. Homi HM, Yang H, Pearlstein RD, Grocott HP. Haemodilution during cardiopulmonary bypass increases cerebral infarct volume after middle cerebral artery occlusion in rats. Anesth Analg 2004; 99: 974-81
8. van Bommel J, Trouwborst A, Schwarte L, Siegemund M, Ince C, Henny C. Intestinal and cerebral oxygenation during severe isovolemic haemodilution and subsequent hyperoxic ventilation in a pig model. Anesthesiology 2002; 97: 660-70
9. Shen H, Greene AS, Stein EA, Hudetz AG. Functional cerebral hyperemia is unaffected by isovolemic haemodilution. Anesthesiology 2002; 96: 142-7
10. Hudetz AG, Wood JD, Kampine JP. 7-Nitroindazole impedes erythrocyte flow response to isovolemic haemodilution in the cerebral capillary circulation. J Cereb Blood Flow Metab 2000; 20: 220-4
11. Rebel A, Lenz C, Krieter H, Waschke KF, Van Ackern K, Kuschinsky W. Oxygen delivery at high blood viscosity and decreased arterial oxygen content to brains of conscious rats. Am J Physiol Heart Circ Physiol 2001; 280: H2591-7
12. Todd MM, Wu B, Maktabi M, Hindman BJ, Warner DS. Cerebral blood flow and oxygen delivery during hypoxemia and haemodilution: Role of arterial oxygen content. Am J Physiol 1994; 267: H2025-31
13. Toda N, Tanaka T, Ayajiki K, Okamura T. Cerebral vasodilatation induced by stimulation of the pterygopalatine ganglion and greater petrosal nerve in anaesthetized monkeys. Neuroscience 2000; 96: 393-8
14. Uchida S, Kawashima K, Lee TJ. Nicotine-induced NO-mediated increase in cortical cerebral blood flow is blocked by beta2-adrenoceptor antagonists in the anaesthetized rats. Auton Neurosci 2002; 96: 126-30
15. Hayashi T, Katsumi Y, Mukai T, et al. Neuronal nitric oxide has a role as a perfusion regulator and a synaptic modulator in cerebellum but not in neocortex during somatosensory stimulation - an animal PET study. Neurosci Res 2002; 44: 155-65
16. Yang G, Zhang Y, Ross ME, Iadecola C. Attenuation of activity-induced increases in cerebellar blood flow in mice lacking neuronal nitric oxide synthase. Am J Physiol 2003; 285: H298-304
17. Lee TJ, Zhang W, Sarwinski S. Presynaptic beta(2)-adrenoceptors mediate nicotine-induced NOergic neurogenic dilation in porcine basilar arteries. Am J Physiol Heart Circ Physiol 2000; 279: H808-16
18. Hare GMT, Qu R, Worrall JMA, et al. Beta2 adrenergic blockade inhibits cerebral hyperemia and reduces cerebral cortical oxygen tension following haemodilution in rats. Anesth Analg 2005; 100: S-60
19. O'Donnell JM. Pharmacological characterization of the discriminative stimulus effects of clenbuterol in rats. Pharmacol Biochem Behav 1997; 58: 813-18
20. Hallberg H, Almgren O. Modulation of oxotremorine-induced tremor by central beta-adrenoceptors. Acta Physiol Scand 1987; 129: 407-13
21. Gaiddon C, Larmet Y, Trinh E, Boutillier AL, Sommer B, Loeffler JP. Brain-derived neurotrophic factor exerts opposing effects on beta2-adrenergic receptor according to depolarization status of cerebellar neurons. J Neurochem 1999; 73: 1467-76
22. McConville P, Spencer RG, Lakatta EG. Temporal dynamics of inotropic, chronotropic, and metabolic responses during beta1-and beta2-AR stimulation in the isolated, perfused rat heart. Am J Physiol 2005; 289: E412-18
23. Clarke TN, Foex P, Roberts IG, Saner CA, Bennett MI. Circulatory responses of the dog to acute isovolumic anaemia in the presence of high-grade adrenergic beta-receptor blockade. Br J Anaesth 1980; 52: 337-41
24. Nozaki J, Kitahata K Tanaka K, Kawahito S, Oshita S. The effects of acute normovolemic haemodilution on left ventricular systolic and diastolic function in the absence or presence of beta-adrenergic blockade in dogs. Anesth Analg 2002; 94: 1120-6
25. Chruscinski A, Brede ME, Meinel L, Lohse MJ, Kobilka BK, Hein L. Differential distribution of beta-adrenergic receptor subtypes in blood vessels of knockout mice lacking beta(1)- or beta(2)-adrenergic receptors. Mol Pharmacol 2001; 60: 955-62
26. Chiba S, Tsukada M. Vascular responses to beta-adrenoceptor subtype-selective agonists with and without endothelium in rat common carotid arteries. J Auton Pharmacol 2001; 21: 7-13
27. Sun D, Huang A, Mital S, et al. Norepinephrine elicits beta2-receptor-mediated dilation of isolated human coronary arterioles. Circulation 2002; 106: 550-5
28. Pottecher J, Cheisson G, Huet O, et al. Beta2-adrenergic agonist protects human endothelial cells from hypoxia/reoxygenation injury in vitro. Crit Care Med 2006; 34: 165-72
29. Hillman KL, Doze VA, Porter JE. Functional characterization of the beta-adrenergic receptor subtypes expressed by CAI pyramidal cells in the rat hippocampus. J Pharmacol Exp Ther 2005; 314: 561-7
30. Junker V, Becker A, Huhne R, et al. Stimulation of beta-adrenoceptors activates astrocytes and provides neuroprotection. Eur J Pharmacol 2002; 446: 25-36
31. Ferro A, Coash M, Yamamoto T, Rob J, Ji Y, Queen L. Nitric oxide-dependent beta2-adrenergic dilatation of rat aorta is mediated through activation of both protein kinase A and Akt. Br J Pharmacol 2004; 143: 397-403
32. Hare GMT, Mazer CD, Mak W, et al. Haemodilutional anemia is associated with increased cerebral neuronal nitric oxide synthase gene expression. J Appl Physiol 2003; 94: 2058-67
33. Dunn JF, Nwaigwe CI, Roche M. Measurement of arterial, venous, and interstitial pO2 during acute hypoxia in rat brain using a time-resolved luminescence-based oxygen sensor. Adv Exp Med Biol 1999; 471: 43-8
34. Piantadosi CA, Zhang J, Demchenko IT. Production of hydroxyl radical in the hippocampus after CO hypoxia or hypoxic hypoxia in the rat. Free Radic Biol Med 1997; 22: 725-32