Metoprolol reduces cerebral tissue oxygen tension after acute hemodilution in rats

Anesthesiology

Volumn 111, Issue 5, 2009, Pages 988-1000

  Ragoonanan, Tenille E ^a   Beattie, W Scott ^d   Mazer, C David ^a   Tsui, Albert K Y ^a   Leong Poi, Howard ^b   Wilson, David F ^f   Tait, Gordon ^e   Yu, Julie ^g   Liu, Elaine ^c   Noronha, Melissa ^a   Dattani, Neil D ^g   Mitsakakis, Nicholas ^d   Hare, Gregory M T ^a  

^a Departments of Anesthesia and Physiology   (Canada)

^b Department of Medicine

^c ST MICHAEL'S HOSPITAL   (Canada)

^d Department of Anesthesia ^*

^e TORONTO GENERAL HOSPITAL   (Canada)

^f UNIVERSITY OF PENNSYLVANIA   (United States)

^g UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN II; CATECHOLAMINE; ERYTHROPOIETIN; HETASTARCH; HYPOXIA INDUCIBLE FACTOR 1ALPHA; ISOFLURANE; METOPROLOL; OXYGEN; SODIUM CHLORIDE;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; BLEEDING; BLOOD VOLUME; BRAIN BLOOD FLOW; BRAIN LEVEL; BRAIN OXYGEN TENSION; CONTROLLED STUDY; FLUID RESUSCITATION; HEART OUTPUT; HEART RATE; HEART STROKE VOLUME; HEMODILUTION; KIDNEY; MALE; NONHUMAN; OUTCOME ASSESSMENT; OXYGEN BLOOD LEVEL; OXYGEN TISSUE LEVEL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING;

EID: 70449585638     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0b013e3181b87f0e     Document Type: Article

References (65)

1. Poldermans D, Hoeks SE, Feringa HH: Pre-operative risk assessment and risk reduction before surgery. J Am Coll Cardiol 2008; 51:1913-1924
2. Mangano DT, Browner WS, Hollenberg M, London MJ, Tubau JF, Tateo IM: Association of perioperative myocardial ischemia with cardiac morbidity and mortality in men undergoing noncardiac surgery. The Study of Perioperative Ischemia Research Group. N Engl J Med 1990; 323:1781-1788
3. Fleisher LA, Beckman JA, Brown KA, Calkins H, Chaikof E, Fleischmann KE, Freeman WK, Froehlich JB, Kasper EK, Kersten JR, Riegel B, Robb JF, Smith SC Jr, Jacobs AK, Adams CD, Anderson JL, Antman EM, Buller CE, Creager MA, Ettinger SM, Faxon DP, Fuster V, Halperin JL, Hiratzka LF, Hunt SA, Lytle BW, Nishimura R, Ornato JP, Page RL, Tarkington LG, Yancy CW: ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery): Developed in collaboration with the American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Rhythm Society, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, and Society for Vascular Surgery. Circulation 2007; 116:e418-99
4. Poldermans D, Boersma E, Bax JJ, Thomson IR, van de Ven LL, Blankensteijn JD, Baars HF, Yo TI, Trocino G, Vigna C, Roelandt JR, van Urk H: The effect of bisoprolol on perioperative mortality and myocardial infarction in high-risk patients undergoing vascular surgery. Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echocardiography Study Group. N Engl J Med 1999; 341:1789-1794
5. Mangano DT, Layug EL, Wallace A, Tateo I: Effect of atenolol on mortality and cardiovascular morbidity after noncardiac surgery. Multicenter Study of Perioperative Ischemia Research Group. N Engl J Med 1996; 335:1713-1720
6. Brady AR, Gibbs JS, Greenhalgh RM, Powell JT, Sydes MR: Perioperative beta-blockade (POBBLE) for patients undergoing infrarenal vascular surgery: Results of a randomized double-blind controlled trial. J Vasc Surg 2005; 41:602-609
7. Yang H, Raymer K, Butler R, Parlow J, Roberts R: The effects of perioperative beta-blockade: Results of the Metoprolol after Vascular Surgery (MaVS) study: A randomized controlled trial. Am Heart J 2006; 152:983-990
8. Devereaux PJ, Beattie WS, Choi PT, Badner NH, Guyatt GH, Villar JC, Cina CS, Leslie K, Jacka MJ, Montori VM, Bhandari M, Avezum A, Cavalcanti AB, Giles JW, Schricker T, Yang H, Jakobsen CJ, Yusuf S: How strong is the evidence for the use of perioperative beta blockers in non-cardiac surgery? Systematic review and meta-analysis of randomised controlled trials. BMJ 2005; 331:313-321
9. Devereaux PJ, Yang H, Yusuf S, Guyatt G, Leslie K, Villar JC, Xavier D, Chrolavicius S, Greenspan L, Pogue J, Pais P, Liu L, Xu S, Malaga G, Avezum A, Chan M, Montori VM, Jacka M, Choi P: Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): A randomised controlled trial. Lancet 2008; 371:1839-1847
10. Bangalore S, Wetterslev J, Pranesh S, Sawhney S, Gluud C, Messerli FH: Perioperative beta blockers in patients having non-cardiac surgery: A meta-analysis. Lancet 2008; 372:1962-1976
11. Biccard BM, Sear JW, Foex P: Acute peri-operative beta blockade in intermediate-risk patients. Anaesthesia 2006; 61:924-931
12. Lindenauer PK, Pekow P, Wang K, Mamidi DK, Gutierrez B, Benjamin EM: Perioperative beta-blocker therapy and mortality after major noncardiac surgery. N Engl J Med 2005; 353:349-361 (Pubitemid 41132339)
13. London MJ: Quo vadis, perioperative beta blockade? Are you "POISE'd" on the brink? Anesth Analg 2008; 106:1025-1030
14. Fleisher LA, Poldermans D: Perioperative beta blockade: Where do we go from here? Lancet 2008; 371:1813-1814
15. Sear JW, Giles JW, Howard-Alpe G, Foex P: Perioperative beta-blockade, 2008: What does POISE tell us, and was our earlier caution justified? Br J Anaesth 2008; 101:135-138
16. Wu WC, Schifftner TL, Henderson WG, Eaton CB, Poses RM, Uttley G, Sharma SC, Vezeridis M, Khuri SF, Friedmann PD: Preoperative hematocrit levels and postoperative outcomes in older patients undergoing noncardiac surgery. JAMA 2007; 297:2481-2488
17. Dunne JR, Malone D, Tracy JK, Gannon C, Napolitano LM: Perioperative anemia: An independent risk factor for infection, mortality, and resource utilization in surgery. J Surg Res 2002; 102:237-244
18. Carson JL, Poses RM, Spence RK, Bonavita G: Severity of anaemia and operative mortality and morbidity. Lancet 1988; 1:727-729
19. Carson JL, Duff A, Poses RM, Berlin JA, Spence RK, Trout R, Noveck H, Strom BL: Effect of anaemia and cardiovascular disease on surgical mortality and morbidity. Lancet 1996; 348:1055-1060
20. Dunkelgrun M, Hoeks SE, Welten GM, Vidakovic R, Winkel TA, Schouten O, van Domburg RT, Bax JJ, Kuijper R, Chonchol M, Verhagen HJ, Poldermans D: Anemia as an independent predictor of perioperative and long-term cardiovascular outcome in patients scheduled for elective vascular surgery. Am J Cardiol 2008; 101:1196-1200
21. Habib RH, Zacharias A, Schwann TA, Riordan CJ, Durham SJ, Shah A: Adverse effects of low hematocrit during cardiopulmonary bypass in the adult: Should current practice be changed? J Thorac Cardiovasc Surg 2003; 125:1438-1450
22. Karkouti K, Wijeysundera DN, Beattie WS: Risk associated with preoper-ative anemia in cardiac surgery: A multicenter cohort study. Circulation 2008; 117:478-484
23. Kulier A, Levin J, Moser R, Rumpold-Seitlinger G, Tudor IC, Snyder-Ramos SA, Moehnle P, Mangano DT: Impact of preoperative anemia on outcome in patients undergoing coronary artery bypass graft surgery. Circulation 2007; 116:471-479 (Pubitemid 47450255)
24. Beattie WS, Karkouti K, Wijeysundera DN, Tait G: Risk associated with preoperative anemia in noncardiac surgery: A single-center cohort study. ANES-THESIOLOGY 2009; 110:574-581
25. Hebert PC, Wells G, Blajchman MA, Marshall J, Martin C, Pagliarello G, Tweeddale M, Schweitzer I, Yetisir E: A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med 1999; 340:409-417
26. Murphy GJ, Reeves BC, Rogers CA, Rizvi SI, Culliford L, Angelini GD: Increased mortality, postoperative morbidity, and cost after red blood cell transfusion in patients having cardiac surgery. Circulation 2007; 116:2544-2552
27. Hatcher JD, Chiu LK, Jennings DB: Anemia as a stimulus to aortic and carotid chemoreceptors in the cat. J Appl Physiol 1978; 44:696-702
28. Eichelbronner O, D'Almeida M, Sielenkamper A, Sibbald WJ, Chin-Yee IH: Increasing P(50) does not improve DO(2CRIT) or systemic VO(2) in severe anemia. Am J Physiol Heart Circ Physiol 2002; 283:H92-101
29. Ickx BE, Rigolet M, Van Der Linden PJ: Cardiovascular and metabolic response to acute normovolemic anemia. Effects of anesthesia. ANESTHESIOLOGY 2000; 93:1011-1016
30. van Bommel J, Trouwborst A, Schwarte L, Siegemund M, Ince C, Henny C: Intestinal and cerebral oxygenation during severe isovolemic hemodilution and subsequent hyperoxic ventilation in a pig model. ANESTHESIOLOGY 2002; 97:660-670
31. Weiskopf RB, Viele MK, Feiner J, Kelley S, Lieberman J, Noorani M, Leung JM, Fisher DM, Murray WR, Toy P, Moore MA: Human cardiovascular and metabolic response to acute, severe isovolemic anemia. JAMA 1998; 279:217-221
32. Brown MM, Wade JP, Marshall J: Fundamental importance of arterial oxygen content in the regulation of cerebral blood flow in man. Brain 1985; 108:81-93
33. Hare GMT, Mazer CD, Mak W, Gorczynski RM, Hum KM, Kim SY, Wyard L, Barr A, Qu R, Baker AJ: Hemodilutional anemia is associated with increased cerebral neuronal nitric oxide synthase gene expression. J Appl Physiol 2003; 94:2058-2067
34. Beattie WS, Wijeysundera DN, Karkouti K, McCluskey S, Tait G: Does tight heart rate control improve beta-blocker efficacy? An updated analysis of the noncardiac surgical randomized trials. Anesth Analg 2008; 106:1039-1048
35. Cucherat M: Quantitative relationship between resting heart rate reduction and magnitude of clinical benefits in post-myocardial infarction: A meta-regression of randomized clinical trials. Eur Heart J 2007; 28:3012-3019
36. McLaren AT, Marsden PA, Mazer CD, Baker AJ, Stewart DJ, Tsui AK, Li X, Yucel Y, Robb M, Boyd SR, Liu E, Yu J, Hare GM: Increased expression of HIF-1{alpha}, nNOS, and VEGF in the cerebral cortex of anemic rats. Am J Physiol Regul Integr Comp Physiol 2007; 292:R403-14
37. Hocht C, Di VC, Opezzo JA, Taira CA: Pharmacokinetic-pharmacodynamic properties of metoprolol in chronic aortic coarctated rats. Naunyn Schmiede-bergs Arch Pharmacol 2004; 370:1-8
38. Roberts JS, Bratton SL: Colloid volume expanders. Problems, pitfalls and possibilities. Drugs 1998; 55:621-630
39. Hare GM, Mazer CD, Hutchison JS, McLaren AT, Liu E, Rassouli A, Ai J, Shaye RE, Lockwood JA, Hawkins CE, Sikich N, To K, Baker AJ: Severe hemodi-lutional anemia increases cerebral tissue injury following acute neurotrauma. J Appl Physiol 2007; 103:1021-1029
40. Rietveld IB, Kim E, Vinogradov SA: Dendrimers with tetrabenzoporphyrin cores: Near infrared phosphors for in vivo oxygen imaging. Tetrahedron 2003; 59:3821-3831
41. Vinogradov SA, Lo LW, Wilson DF: Dendritic polyglutamic porphoryns: Probing porphyrin protection by oxygen-dependent quenching of phosphores-ence. Chem Eur J 1999; 5:1338-1347
42. Briet F, Keith M, Leong-Poi H, Kadakia A, ba-Alkhail K, Giliberto JP, Stewart D, Errett L, David MC: Triple nutrient supplementation improves survival, infarct size and cardiac function following myocardial infarction in rats. Nutr Metab Cardiovasc Dis 2008; 18:691-699
43. Musso NR, Vergassola C, Pende A, Lotti G: Reversed-phase HPLC separation of plasma norepinephrine, epinephrine, and dopamine, with three-electrode coulometric detection. Clin Chem 1989; 35:1975-1977
44. Hare GM, Worrall JM, Baker AJ, Liu E, Sikich N, Mazer CD: Beta2 adren-ergic antagonist inhibits cerebral cortical oxygen delivery after severe haemodi-lution in rats. Br J Anaesth 2006; 97:617-623
45. Johannes T, Mik EG, Nohe B, Unertl KE, Ince C: Acute decrease in renal microvascular PO2 during acute normovolemic hemodilution. Am J Physiol Renal Physiol 2007; 292:F796-803
46. van Bommel J, Siegemund M, Henny C, Ince C: Heart, kidney, and intestine have different tolerances for anemia. Transl Res 2008; 151:110-117
47. Karkouti K, Beattie WS, Wijeysundera DN, Rao V, Chan C, Dattilo KM, Djaiani G, Ivanov J, Karski J, David TE: Hemodilution during cardiopulmonary bypass is an independent risk factor for acute renal failure in adult cardiac surgery. J Thorac Cardiovasc Surg 2005; 129:391-400 (Pubitemid 40169564)
48. Sharan M, Vovenko EP, Vadapalli A, Popel AS, Pittman RN: Experimental and theoretical studies of oxygen gradients in rat pial microvessels. J Cereb Blood Flow Metab 2008; 28:1597-1604
49. Vovenko EP, Chuikin AE: Oxygen tension in rat cerebral cortex microves-sels in acute anemia. Neurosci Behav Physiol 2008; 38:493-500
50. Rumsey WL, Abbott B, Lo LW, Vinogradov SA, Wilson DF: Imaging of oxygen distribution in the surface and deep areas of the kidney. Adv Exp Med Biol 1997; 411:591-595
51. Piilgaard H, Lauritzen M: Persistent increase in oxygen consumption and impaired neurovascular coupling after spreading depression in rat neocortex (published online June 10, 2009). J Cereb Blood Flow Metab 2009
52. Lauzier MC, Page EL, Michaud MD, Richard DE: Differential regulation of hypoxia-inducible factor-1 through receptor tyrosine kinase transactivation in vascular smooth muscle cells. Endocrinology 2007; 148:4023-4031
53. Karkouti K, Djaiani G, Borger MA, Beattie WS, Fedorko L, Wijeysundera D, Ivanov J, Karski J: Low hematocrit during cardiopulmonary bypass is associated with increased risk of perioperative stroke in cardiac surgery. Ann Thorac Surg 2005; 80:1381-1387
54. Baker JG: The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors. Br J Pharmacol 2005; 144:317-322
55. Chi OZ, Liu X, Weiss HR: The effects of propranolol on heterogeneity of rat cerebral small vein oxygen saturation. Anesth Analg 1999; 89:690-695
56. Bunemann L, Jensen KA, Riisager S, Thomsen LJ: Cerebral blood flow and metabolism during hypotension induced with sodium nitroprusside and meto-prolol. Eur J Anaesthesiol 1991; 8:197-201
57. Summors AC, Gupta AK, Matta BF: Dynamic cerebral autoregulation during sevoflurane anesthesia: A comparison with isoflurane. Anesth Analg 1999; 88:341-345
58. Randomised trial of intravenous atenolol among 16 027 cases of suspected acute myocardial infarction: ISIS-1. First International Study of Infarct Survival Collaborative Group. Lancet 1986; 2:57-66
59. Rinfret S, Abrahamowicz M, Tu J, Humphries K, Eisenberg MJ, Richard H, Austin PC, Pilote L: A population-based analysis of the class effect of beta-blockers after myocardial infarction. Am Heart J 2007; 153:224-230
60. Torp-Pedersen C, Poole-Wilson PA, Swedberg K, Cleland JG, Di LA, Hanrath P, Komajda M, Lutiger B, Metra M, Remme WJ, Scherhag A, Skene A: Effects of metoprolol and carvedilol on cause-specific mortality and morbidity in patients with chronic heart failure-COMET. Am Heart J 2005; 149:370-376
61. Cruickshank JM, Neil-Dwyer G: Beta-blocker brain concentrations in man. Eur J Clin Pharmacol 1985; 28 Suppl:21-23
62. Bangalore S, Messerli FH, Kostis JB, Pepine CJ: Cardiovascular protection using beta-blockers: A critical review of the evidence. J Am Coll Cardiol 2007; 50:563-572
63. Chen ZM, Pan HC, Chen YP, Peto R, Collins R, Jiang LX, Xie JX, Liu LS: Early intravenous then oral metoprolol in 45,852 patients with acute myocardial infarction: Randomised placebo-controlled trial. Lancet 2005; 366: 1622-1632
64. Han SH, Bahk JH, Kim JH, Lim YJ, Park CD, Do SH, Park YS: The effect of esmolol-induced controlled hypotension in combination with acute normovol-emic hemodilution on cerebral oxygenation. Acta Anaesthesiol Scand 2006; 50:863-868
65. Kaila T, Iisalo E: Selectivity of acebutolol, atenolol, and metoprolol in healthy volunteers estimated by the extent the drugs occupy beta 2-receptors in the circulating plasma. J Clin Pharmacol 1993; 33:959-966