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Volumn 46, Issue , 2018, Pages 268-277

Metagenomics analysis of gut microbiota modulatory effect of green tea polyphenols by high fat diet-induced obesity mice model

Author keywords

Green tea polyphenols; Intestinal microbiota; Metagenomics; Modulatory effect; Obesity

Indexed keywords


EID: 85046650260     PISSN: 17564646     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jff.2018.05.003     Document Type: Article
Times cited : (78)

References (51)
  • 2
    • 48249125862 scopus 로고    scopus 로고
    • Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
    • Cani, P.D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A.M., Delzenne, N.M., Burcelin, R., Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 57 (2008), 1470–1481.
    • (2008) Diabetes , vol.57 , pp. 1470-1481
    • Cani, P.D.1    Bibiloni, R.2    Knauf, C.3    Waget, A.4    Neyrinck, A.M.5    Delzenne, N.M.6    Burcelin, R.7
  • 5
    • 84898052961 scopus 로고    scopus 로고
    • Biotransformation of tea polyphenols by gut microbiota
    • Chen, H., Sang, S., Biotransformation of tea polyphenols by gut microbiota. Journal of Functional Foods 7 (2014), 26–42.
    • (2014) Journal of Functional Foods , vol.7 , pp. 26-42
    • Chen, H.1    Sang, S.2
  • 6
    • 85007090189 scopus 로고    scopus 로고
    • The modulatory effect of (-)-epigallocatechin 3-O-(3-O-methyl) gallate (EGCG3’’Me) on intestinal microbiota of high fat diet-induced obesity mice model
    • Cheng, M., Zhang, X., Miao, Y.J., Cao, J.X., Wu, Z.F., Weng, P.F., The modulatory effect of (-)-epigallocatechin 3-O-(3-O-methyl) gallate (EGCG3’’Me) on intestinal microbiota of high fat diet-induced obesity mice model. Food Research International 92 (2017), 9–16.
    • (2017) Food Research International , vol.92 , pp. 9-16
    • Cheng, M.1    Zhang, X.2    Miao, Y.J.3    Cao, J.X.4    Wu, Z.F.5    Weng, P.F.6
  • 10
    • 0036793753 scopus 로고    scopus 로고
    • Acetate utilization and butyryl coenzyme a (CoA): Acetate-CoA transferase in butyrate-producing bacteria from the human large intestine
    • Duncan, S.H., Barcenilla, A., Stewart, C.S., Pryde, S.E., Flint, H.J., Acetate utilization and butyryl coenzyme a (CoA): Acetate-CoA transferase in butyrate-producing bacteria from the human large intestine. Applied & Environmental Microbiology 68 (2002), 5186–5190.
    • (2002) Applied & Environmental Microbiology , vol.68 , pp. 5186-5190
    • Duncan, S.H.1    Barcenilla, A.2    Stewart, C.S.3    Pryde, S.E.4    Flint, H.J.5
  • 11
    • 84907486192 scopus 로고    scopus 로고
    • Effects of Oolong tea polyphenols, EGCG, and EGCG3’’Me on pancreatic α-amylase activity in vitro
    • Fei, Q.Q., Gao, Y., Zhang, X., Sun, Y., Hu, B., Zhou, L., Zeng, X.X., Effects of Oolong tea polyphenols, EGCG, and EGCG3’’Me on pancreatic α-amylase activity in vitro. Journal of Agricultural and Food Chemistry 62 (2014), 9507–9514.
    • (2014) Journal of Agricultural and Food Chemistry , vol.62 , pp. 9507-9514
    • Fei, Q.Q.1    Gao, Y.2    Zhang, X.3    Sun, Y.4    Hu, B.5    Zhou, L.6    Zeng, X.X.7
  • 12
    • 84990957256 scopus 로고    scopus 로고
    • Exposing the exposures responsible for type 2 diabetes and obesity
    • Franks, P.W., McCarthy, M.I., Exposing the exposures responsible for type 2 diabetes and obesity. Science 354 (2016), 69–73.
    • (2016) Science , vol.354 , pp. 69-73
    • Franks, P.W.1    McCarthy, M.I.2
  • 14
    • 85019184272 scopus 로고    scopus 로고
    • Green tea polyphenols reduces obesity in high fat-diet induced mice by modulating intestinal microbiota composition
    • Guo, X.J., Cheng, M., Zhang, X., Cao, J.X., Wu, Z.F., Weng, P.F., Green tea polyphenols reduces obesity in high fat-diet induced mice by modulating intestinal microbiota composition. International Journal of Food Science and Technology 52 (2017), 1723–1730.
    • (2017) International Journal of Food Science and Technology , vol.52 , pp. 1723-1730
    • Guo, X.J.1    Cheng, M.2    Zhang, X.3    Cao, J.X.4    Wu, Z.F.5    Weng, P.F.6
  • 15
    • 79951817432 scopus 로고    scopus 로고
    • Dietary polyphenols and human gut microbiota: A review
    • Hervert-Hernandez, D., Goñi, I., Dietary polyphenols and human gut microbiota: A review. Food Reviews International 27 (2011), 154–169.
    • (2011) Food Reviews International , vol.27 , pp. 154-169
    • Hervert-Hernandez, D.1    Goñi, I.2
  • 16
    • 0037423144 scopus 로고    scopus 로고
    • Obesity and the environment: Where do we go from here?
    • Hill, J.O., Wyatt, H.R., Reed, G.W., Peters, J.C., Obesity and the environment: Where do we go from here?. Science 299 (2003), 853–855.
    • (2003) Science , vol.299 , pp. 853-855
    • Hill, J.O.1    Wyatt, H.R.2    Reed, G.W.3    Peters, J.C.4
  • 17
    • 75449099982 scopus 로고    scopus 로고
    • Proteasome inhibition in human breast cancer cells with high catechol-O-methyltransferase activity by green tea polyphenol EGCG analogs
    • Huo, C.D., Yang, H.J., Cui, Q.Z., Dou, Q.P., Chan, T.H., Proteasome inhibition in human breast cancer cells with high catechol-O-methyltransferase activity by green tea polyphenol EGCG analogs. Bioorganic & Medicine Chemistry 18 (2010), 1252–1258.
    • (2010) Bioorganic & Medicine Chemistry , vol.18 , pp. 1252-1258
    • Huo, C.D.1    Yang, H.J.2    Cui, Q.Z.3    Dou, Q.P.4    Chan, T.H.5
  • 18
    • 85020198990 scopus 로고    scopus 로고
    • Effects of (-)-epigallocatechin 3-O-(3-O-methyl) gallate (EGCG3’’Me)-phospholipids complex on pancreatic α-amylase and lipase activities
    • Jiang, J.S., Cheng, M., Zhang, X., Wu, Z.F., Weng, P.F., Effects of (-)-epigallocatechin 3-O-(3-O-methyl) gallate (EGCG3’’Me)-phospholipids complex on pancreatic α-amylase and lipase activities. Journal of Food Biochemistry, 41, 2017, e12388.
    • (2017) Journal of Food Biochemistry , vol.41 , pp. e12388
    • Jiang, J.S.1    Cheng, M.2    Zhang, X.3    Wu, Z.F.4    Weng, P.F.5
  • 20
    • 78049512483 scopus 로고    scopus 로고
    • Novel approaches for analyzing gut microbes and dietary polyphenols: Challenges and opportunities
    • Kemperman, R.A., Bolca, S., Roger, L.C., Vaughan, E.E., Novel approaches for analyzing gut microbes and dietary polyphenols: Challenges and opportunities. Microbiology 156 (2010), 3224–3231.
    • (2010) Microbiology , vol.156 , pp. 3224-3231
    • Kemperman, R.A.1    Bolca, S.2    Roger, L.C.3    Vaughan, E.E.4
  • 21
    • 85013372266 scopus 로고    scopus 로고
    • D. … Bej, A. K. (2017) Metagenomics approach to the study of the gut microbiome structure and function in zebrafish Danio rerio fed with gluten formulated diet. Journal of Microbiological Methods, 135
    • Koo, H., Hakim, J. A., Powell, M. L., Kumar, R., Eipers, P. G., Morrow, C. D. … Bej, A. K. (2017) Metagenomics approach to the study of the gut microbiome structure and function in zebrafish Danio rerio fed with gluten formulated diet. Journal of Microbiological Methods, 135, pp. 69–76.
    • Koo, H.1    Hakim, J.A.2    Powell, M.L.3    Kumar, R.4    Eipers, P.G.5    Morrow, C.6
  • 22
    • 33749507179 scopus 로고    scopus 로고
    • Effect of tea phenolics and their aromatic fecal bacterial metabolites on intestinal microbiota
    • Lee, H.C., Jenner, A.M., Lowa, C.S., Lee, Y.K., Effect of tea phenolics and their aromatic fecal bacterial metabolites on intestinal microbiota. Research in Microbiology 157 (2006), 876–884.
    • (2006) Research in Microbiology , vol.157 , pp. 876-884
    • Lee, H.C.1    Jenner, A.M.2    Lowa, C.S.3    Lee, Y.K.4
  • 23
    • 85021728102 scopus 로고    scopus 로고
    • Grape seed proanthocyanidin extract ameliorates inflammation and adiposity by modulating gut microbiota in high-fat diet mice
    • Liu, W., Zhao, S., Wang, J., Shi, J., Sun, Y., Wang, W., Liu, R., Grape seed proanthocyanidin extract ameliorates inflammation and adiposity by modulating gut microbiota in high-fat diet mice. Molecular Nutrition & Food Research, 61, 2017, 1601082.
    • (2017) Molecular Nutrition & Food Research , vol.61 , pp. 1601082
    • Liu, W.1    Zhao, S.2    Wang, J.3    Shi, J.4    Sun, Y.5    Wang, W.6    Liu, R.7
  • 24
    • 84862002340 scopus 로고    scopus 로고
    • Green tea polyphenols reduce body weight in rats by modulating obesity-related genes
    • Lu, C., Zhu, W., Shen, C.L., Gao, W., Green tea polyphenols reduce body weight in rats by modulating obesity-related genes. PLoS ONE, 7, 2012, e38332.
    • (2012) PLoS ONE , vol.7 , pp. e38332
    • Lu, C.1    Zhu, W.2    Shen, C.L.3    Gao, W.4
  • 25
    • 72149128905 scopus 로고    scopus 로고
    • Formulation with ascorbic acid and sucrose modulates catechin bioavailability from green tea
    • Peters, C.M., Green, R.J., Janle, E.M., Ferruzzi, M.G., Formulation with ascorbic acid and sucrose modulates catechin bioavailability from green tea. Food Research International 43 (2010), 95–102.
    • (2010) Food Research International , vol.43 , pp. 95-102
    • Peters, C.M.1    Green, R.J.2    Janle, E.M.3    Ferruzzi, M.G.4
  • 26
    • 79251631421 scopus 로고    scopus 로고
    • High polyphenol, low probiotic diet for weight loss because of intestinal microbiota interaction
    • Rastmanesh, R., High polyphenol, low probiotic diet for weight loss because of intestinal microbiota interaction. Chemico-Biological Interactions 189 (2011), 1–8.
    • (2011) Chemico-Biological Interactions , vol.189 , pp. 1-8
    • Rastmanesh, R.1
  • 28
  • 30
    • 77956648224 scopus 로고    scopus 로고
    • Green tea polyphenols mitigate bone loss of female rats in a chronic inflammation-induced bone loss model
    • Shen, C.L., Yeh, J.K., Cao, J.J., Tatum, O.L., Dagda, R.Y., Wang, J.S., Green tea polyphenols mitigate bone loss of female rats in a chronic inflammation-induced bone loss model. Journal of Nutritional Biochemistry 21 (2010), 968–974.
    • (2010) Journal of Nutritional Biochemistry , vol.21 , pp. 968-974
    • Shen, C.L.1    Yeh, J.K.2    Cao, J.J.3    Tatum, O.L.4    Dagda, R.Y.5    Wang, J.S.6
  • 31
    • 78651493061 scopus 로고    scopus 로고
    • Green tea polyphenols attenuate deterioration of bone microarchitecture in female rats with systemic chronic inflammation
    • Shen, C.L., Yeh, J.K., Samathanam, C., Cao, J.J., Stoecker, B.J., Dagda, R.Y., Wang, J.S., Green tea polyphenols attenuate deterioration of bone microarchitecture in female rats with systemic chronic inflammation. Osteoporosis International 22 (2011), 327–337.
    • (2011) Osteoporosis International , vol.22 , pp. 327-337
    • Shen, C.L.1    Yeh, J.K.2    Samathanam, C.3    Cao, J.J.4    Stoecker, B.J.5    Dagda, R.Y.6    Wang, J.S.7
  • 32
    • 80555123045 scopus 로고    scopus 로고
    • Green tea catechin, epigallocatechin-3-gallate (EGCG): Mechanisms, perspectives and clinical applications
    • Singh, B.N., Shankar, S., Srivastava, R.K., Green tea catechin, epigallocatechin-3-gallate (EGCG): Mechanisms, perspectives and clinical applications. Biochemical Pharmacology 82 (2011), 1807–1821.
    • (2011) Biochemical Pharmacology , vol.82 , pp. 1807-1821
    • Singh, B.N.1    Shankar, S.2    Srivastava, R.K.3
  • 33
    • 79955017875 scopus 로고    scopus 로고
    • Molecular binding of black tea theaflavins to biological membranes: Relationship to bioactivities
    • Sirk, T.W., Friedman, M., Brown, E.F., Molecular binding of black tea theaflavins to biological membranes: Relationship to bioactivities. Journal of Agricultural and Food Chemistry 59 (2011), 3780–3787.
    • (2011) Journal of Agricultural and Food Chemistry , vol.59 , pp. 3780-3787
    • Sirk, T.W.1    Friedman, M.2    Brown, E.F.3
  • 34
    • 77954000859 scopus 로고    scopus 로고
    • A comparison of the in vitro biotransformation of (-)-epicatechin and procyanidin B2 by human faecal microbiota
    • Stoupi, S., Williamson, G., Drynan, J.W., Barron, D., Clifford, M.N., A comparison of the in vitro biotransformation of (-)-epicatechin and procyanidin B2 by human faecal microbiota. Molecular Nutrition & Food Research 54 (2010), 747–759.
    • (2010) Molecular Nutrition & Food Research , vol.54 , pp. 747-759
    • Stoupi, S.1    Williamson, G.2    Drynan, J.W.3    Barron, D.4    Clifford, M.N.5
  • 35
    • 85014565444 scopus 로고    scopus 로고
    • Long chain arabinoxylans shift the mucosa-associated microbiota in the proximal colon of the simulator of the human intestinal microbial ecosystem (M-SHIME)
    • Truchado, P., Hernandez-Sanabria, E., Salden, B.N., Abbeele, P.V.D., Vilchez-Vargas, R., Jauregui, R., Wiele, T.V.D., Long chain arabinoxylans shift the mucosa-associated microbiota in the proximal colon of the simulator of the human intestinal microbial ecosystem (M-SHIME). Journal of Functional Foods 32 (2017), 226–237.
    • (2017) Journal of Functional Foods , vol.32 , pp. 226-237
    • Truchado, P.1    Hernandez-Sanabria, E.2    Salden, B.N.3    Abbeele, P.V.D.4    Vilchez-Vargas, R.5    Jauregui, R.6    Wiele, T.V.D.7
  • 36
    • 33845874101 scopus 로고    scopus 로고
    • An obesity-associated gut microbiome with increased capacity for energy harvest
    • Turnbaugh, P.J., Ley, R.E., Mahowald, M.A., Magrini, V., Mardis, E.R., Gordon, J.I., An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444 (2006), 1027–1031.
    • (2006) Nature , vol.444 , pp. 1027-1031
    • Turnbaugh, P.J.1    Ley, R.E.2    Mahowald, M.A.3    Magrini, V.4    Mardis, E.R.5    Gordon, J.I.6
  • 37
    • 77950669604 scopus 로고    scopus 로고
    • The effect of diet on the human gut microbiome: A metagenomic analysis in humanized gnotobiotic mice
    • Turnbaugh, P.J., Ridaura, V.K., Faith, J.J., Rey, F.E., The effect of diet on the human gut microbiome: A metagenomic analysis in humanized gnotobiotic mice. Science Translational Medicine 1 (2009), 6799–6806.
    • (2009) Science Translational Medicine , vol.1 , pp. 6799-6806
    • Turnbaugh, P.J.1    Ridaura, V.K.2    Faith, J.J.3    Rey, F.E.4
  • 38
    • 85019055027 scopus 로고    scopus 로고
    • D. (2017) Metagenomics analysis of gut microbiota and immune modulation in zebrafish (Danio rerio) fed chitosan silver nanocomposites. Fish & Shellfish Immunology, 66
    • Udayangani, R. M. C., Dananjaya, S. H. S., Nikapitiya, C., Heo, G. J., Lee, J., & Zoysa, M. D. (2017) Metagenomics analysis of gut microbiota and immune modulation in zebrafish (Danio rerio) fed chitosan silver nanocomposites. Fish & Shellfish Immunology, 66, pp. 173–184.
    • Udayangani, R.M.C.1    Dananjaya, S.H.S.2    Nikapitiya, C.3    Heo, G.J.4    Lee, J.5    Zoysa, M.6
  • 39
    • 79951759025 scopus 로고    scopus 로고
    • Effects of dietary polyphenol-rich grape products on intestinal microflora and gut morphology in broiler chicks
    • Viveros, A., Chamorro, S., Pizarro, M., Arija, I., Centeno, C., Brenes, A., Effects of dietary polyphenol-rich grape products on intestinal microflora and gut morphology in broiler chicks. Poultry Science 90 (2011), 566–578.
    • (2011) Poultry Science , vol.90 , pp. 566-578
    • Viveros, A.1    Chamorro, S.2    Pizarro, M.3    Arija, I.4    Centeno, C.5    Brenes, A.6
  • 40
    • 84899870181 scopus 로고    scopus 로고
    • Flos Lonicera ameliorates obesity and associated endotoxemia in rats through modulation of gut permeability and intestinal microbiota
    • Wang, J.H., Bose, S., Kim, G.C., Hong, S.U., Kim, J.H., Kim, J.E., Kim, H., Flos Lonicera ameliorates obesity and associated endotoxemia in rats through modulation of gut permeability and intestinal microbiota. PLoS ONE 9 (2014), 1–14.
    • (2014) PLoS ONE , vol.9 , pp. 1-14
    • Wang, J.H.1    Bose, S.2    Kim, G.C.3    Hong, S.U.4    Kim, J.H.5    Kim, J.E.6    Kim, H.7
  • 41
    • 84927694747 scopus 로고    scopus 로고
    • Rocher, … Shen, J. (2015). Modulation of gut microbiota during probiotic-mediated attenuation of metabolic syndrome in high fat diet-fed mice. The ISME Journal, 9
    • Wang, J., Tang, H., Zhang, C., Zhao, Y., Derrien, M., Rocher, … Shen, J. (2015). Modulation of gut microbiota during probiotic-mediated attenuation of metabolic syndrome in high fat diet-fed mice. The ISME Journal, 9, pp. 1-15.
    • Wang, J.1    Tang, H.2    Zhang, C.3    Zhao, Y.4    Derrien, M.5
  • 43
    • 84882843632 scopus 로고    scopus 로고
    • Milk enhances intestinal absorption of green tea catechins in in vitro digestion/Caco-2 cells model
    • Xie, Y.L., Kosińska, A., Xu, H.R., Andlauer, W., Milk enhances intestinal absorption of green tea catechins in in vitro digestion/Caco-2 cells model. Food Research International 53 (2013), 793–800.
    • (2013) Food Research International , vol.53 , pp. 793-800
    • Xie, Y.L.1    Kosińska, A.2    Xu, H.R.3    Andlauer, W.4
  • 44
    • 84930625033 scopus 로고    scopus 로고
    • Effect of methylated tea catechins from Chinese oolong tea on the proliferation and differentiation of 3T3-L1 preadipocyte
    • Yang, Y., Qiao, L.L., Zhang, X., Wu, Z.F., Weng, P.F., Effect of methylated tea catechins from Chinese oolong tea on the proliferation and differentiation of 3T3-L1 preadipocyte. Fitoterapia 104 (2015), 45–49.
    • (2015) Fitoterapia , vol.104 , pp. 45-49
    • Yang, Y.1    Qiao, L.L.2    Zhang, X.3    Wu, Z.F.4    Weng, P.F.5
  • 45
    • 77956338564 scopus 로고    scopus 로고
    • Possible anti-obesity therapeutics from nature - A review
    • Yun, J.W., Possible anti-obesity therapeutics from nature - A review. Phytochemistry 71 (2010), 1625–1641.
    • (2010) Phytochemistry , vol.71 , pp. 1625-1641
    • Yun, J.W.1
  • 46
    • 84908042204 scopus 로고    scopus 로고
    • Antioxidant and hepatoprotective effect of (-)-epigallocatechin 3-O-(3-O-Methyl) gallate (EGCG3’’Me) from Chinese oolong Tea
    • Zhang, X., Wu, Z.F., Weng, P.F., Antioxidant and hepatoprotective effect of (-)-epigallocatechin 3-O-(3-O-Methyl) gallate (EGCG3’’Me) from Chinese oolong Tea. Journal of Agricultural and Food Chemistry 62 (2014), 10046–10054.
    • (2014) Journal of Agricultural and Food Chemistry , vol.62 , pp. 10046-10054
    • Zhang, X.1    Wu, Z.F.2    Weng, P.F.3
  • 47
    • 84963749077 scopus 로고    scopus 로고
    • The modulatory effect of anthocyanins from purple sweet potato on human intestinal microbiota in vitro
    • Zhang, X., Yang, Y., Wu, Z.F., Weng, P.F., The modulatory effect of anthocyanins from purple sweet potato on human intestinal microbiota in vitro. Journal of Agricultural and Food Chemistry 64 (2016), 2582–2590.
    • (2016) Journal of Agricultural and Food Chemistry , vol.64 , pp. 2582-2590
    • Zhang, X.1    Yang, Y.2    Wu, Z.F.3    Weng, P.F.4
  • 48
    • 84887001051 scopus 로고    scopus 로고
    • Fermentation in vitro of EGCG, GCG and EGCG3’’Me isolated from Oolong tea by human intestinal microbiota
    • Zhang, X., Zhu, X.L., Sun, Y.K., Hu, B., Sun, Y., Jabbar, S., Zeng, X.X., Fermentation in vitro of EGCG, GCG and EGCG3’’Me isolated from Oolong tea by human intestinal microbiota. Food Research International 54 (2013), 1589–1595.
    • (2013) Food Research International , vol.54 , pp. 1589-1595
    • Zhang, X.1    Zhu, X.L.2    Sun, Y.K.3    Hu, B.4    Sun, Y.5    Jabbar, S.6    Zeng, X.X.7
  • 49
    • 1342304952 scopus 로고    scopus 로고
    • Anti-obesity effects of three major components of green tea, catechins, caffeine and theanine, in mice
    • Zheng, G., Sayama, K., Okubo, T., Juneja, L.R., Oguni, I., Anti-obesity effects of three major components of green tea, catechins, caffeine and theanine, in mice. In Vivo 18 (2004), 55–62.
    • (2004) In Vivo , vol.18 , pp. 55-62
    • Zheng, G.1    Sayama, K.2    Okubo, T.3    Juneja, L.R.4    Oguni, I.5
  • 50
    • 84942834458 scopus 로고    scopus 로고
    • Modulation of gut microbiota in rats fed high-fat diets by processing whole-grain barley to barley malt
    • Zhong, Y., Nyman, M., Fåk, F., Modulation of gut microbiota in rats fed high-fat diets by processing whole-grain barley to barley malt. Molecular Nutrition & Food Research 59 (2015), 2066–2076.
    • (2015) Molecular Nutrition & Food Research , vol.59 , pp. 2066-2076
    • Zhong, Y.1    Nyman, M.2    Fåk, F.3
  • 51
    • 54349126970 scopus 로고    scopus 로고
    • High-throughput diversity and functionality analysis of the gastrointestinal tract microbiota
    • Zoetendal, E., Rajilic-Stojanovic, M.V.W., High-throughput diversity and functionality analysis of the gastrointestinal tract microbiota. Gut 57 (2008), 1605–1615.
    • (2008) Gut , vol.57 , pp. 1605-1615
    • Zoetendal, E.1    Rajilic-Stojanovic, M.V.W.2


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