Design, synthesis, and study of a mycobactin-artemisinin conjugate that has selective and potent activity against tuberculosis and malaria

Journal of the American Chemical Society

Volumn 133, Issue 7, 2011, Pages 2076-2079

  Miller, Marvin J ^a   Walz, Andrew J ^a   Zhu, Helen ^a   Wu, Chunrui ^a   Moraski, Garrett ^a   Möllmann, Ute ^b   Tristani, Esther M ^c   Crumbliss, Alvin L ^c   Ferdig, Michael T ^a   Checkley, Lisa ^a   Edwards, Rachel L ^d   Boshoff, Helena I ^d  

^a UNIVERSITY OF NOTRE DAME   (United States)

^b HANS KNÖLL INSTITUTE   (Germany)

^c DUKE UNIVERSITY   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC ACTIVITY; ANTIMALARIAL ACTIVITY; ANTIMALARIAL AGENT; ARTEMISININ; DELIVERY VEHICLE; DRUG-RESISTANT STRAINS; IRON CHELATORS; IRON COMPLEX; IRON COMPONENTS; MYCOBACTERIAL; MYCOBACTERIUM TUBERCULOSIS; POTENT ACTIVITY; RADICAL CHEMISTRY; SIDEROPHORES; THERAPEUTIC AGENTS; TROJAN HORSE;

BIOMATERIALS; IRON COMPOUNDS;

IRON;

ARTEMISININ; FERRIC ION; FERROUS ION; IRON COMPLEX; MYCOBACTIN; SIDEROPHORE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; CONJUGATE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; FENTON REACTION; MALARIA; MALARIA FALCIPARUM; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHYSICAL CHEMISTRY; TUBERCULOSIS; WHOLE CELL;

ANTITUBERCULAR AGENTS; ARTEMISININS; DRUG DESIGN; IRON CHELATING AGENTS; MALARIA; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; OXAZOLES; TUBERCULOSIS;

EID: 79951816261     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja109665t     Document Type: Article

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