Signatures of negative selection in the genetic architecture of human complex traits

Nature Genetics

Volumn 50, Issue 5, 2018, Pages 746-753

  Zeng, Jian ^a   De Vlaming, Ronald ^b,c   Wu, Yang ^a   Robinson, Matthew R ^a,d   Lloyd Jones, Luke R ^a   Yengo, Loic ^a   Yap, Chloe X ^a   Xue, Angli ^a   Sidorenko, Julia ^a,e   McRae, Allan F ^a   Powell, Joseph E ^a   Montgomery, Grant W ^a   Metspalu, Andres ^e   Esko, Tonu ^e   Gibson, Greg ^f   Wray, Naomi R ^a   Visscher, Peter M ^a   Yang, Jian ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

^c ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^d UNIVERSITY OF LAUSANNE   (Switzerland)

^e UNIVERSITY OF TARTU   (Estonia)

^f GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHROPOMETRY; ARTICLE; BAYES THEOREM; BIOBANK; BODY HEIGHT; BODY MASS; CARDIOVASCULAR DISEASE; COMPLEX TRAIT; CONTROLLED STUDY; EDUCATIONAL STATUS; EFFECT SIZE; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENETIC ENGINEERING; GENETIC VARIABILITY; GENOME-WIDE ASSOCIATION STUDY; HERITABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; NATURAL SELECTION; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PURIFYING SELECTION; QUANTITATIVE TRAIT; REPRODUCTION; SIMULATION; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL MODEL; BIOLOGICAL MODEL; GENETIC SELECTION; GENETICS; GENOTYPE; MULTIFACTORIAL INHERITANCE; PHENOTYPE; PROCEDURES;

BAYES THEOREM; GENE FREQUENCY; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; LINEAR MODELS; MODELS, GENETIC; MULTIFACTORIAL INHERITANCE; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT, HERITABLE; SELECTION, GENETIC;

EID: 85045429525     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/s41588-018-0101-4     Document Type: Article

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