Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes

Nature

Volumn 556, Issue 7699, 2018, Pages 64-69

  Shen, Kuang ^a,b,c   Huang, Rick K ^d   Brignole, Edward J ^b   Condon, Kendall J ^a,b,c   Valenstein, Max L ^a,b,c   Chantranupong, Lynne ^a,b,c,e   Bomaliyamu, Aimaiti ^a   Choe, Abigail ^a   Hong, Chuan ^d   Yu, Zhiheng ^d   Sabatini, David M ^a,b,c  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c KOCH INSTITUTE FOR INTEGRATIVE CANCER RESEARCH   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GATOR1 PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; HETERODIMER; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; RAG GTPASE; RAGA PRIOTEIN; UNCLASSIFIED DRUG; AMINO ACID; DEPDC5 PROTEIN, HUMAN; GUANOSINE TRIPHOSPHATE; MONOMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; MULTIPROTEIN COMPLEX; NPRL2 PROTEIN, HUMAN; NPRL3 PROTEIN, HUMAN; PROTEIN BINDING; REPRESSOR PROTEIN; RRAGA PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

ELECTRON MICROSCOPY; ENZYME; ENZYME ACTIVITY; HOMOLOGY; HYDROLYSIS; INHIBITION; PROTEIN;

ARTICLE; BIOCHEMICAL ANALYSIS; CONTROLLED STUDY; CRYOELECTRON MICROSCOPY; ENZYME REPRESSION; MTOR SIGNALING; NUTRIENT AVAILABILITY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN HYDROLYSIS; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN SUBUNIT; SEQUENCE HOMOLOGY; STARVATION; STRUCTURE ANALYSIS; TRANSCRIPTION REGULATION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DEFICIENCY; HUMAN; HYDROLYSIS; METABOLISM; MOLECULAR MODEL; PROTEIN MULTIMERIZATION; ULTRASTRUCTURE;

AMINO ACIDS; CRYOELECTRON MICROSCOPY; GTPASE-ACTIVATING PROTEINS; GUANOSINE TRIPHOSPHATE; HUMANS; HYDROLYSIS; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MODELS, MOLECULAR; MONOMERIC GTP-BINDING PROTEINS; MULTIPROTEIN COMPLEXES; PROTEIN BINDING; PROTEIN DOMAINS; PROTEIN MULTIMERIZATION; PROTEIN SUBUNITS; REPRESSOR PROTEINS; TUMOR SUPPRESSOR PROTEINS;

EID: 85045144337     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature26158     Document Type: Article

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