Mapping a functional cancer genome atlas of tumor suppressors in mouse liver using AAV-CRISPR-mediated direct in vivo screening

Science Advances

Volumn 4, Issue 2, 2018, Pages

  Wang, Guangchuan ^a   Chow, Ryan D ^a   Ye, Lupeng ^a   Guzman, Christopher D ^a   Dai, Xiaoyun ^a   Dong, Matthew B ^a   Zhang, Feng ^b,c   Sharp, Phillip A ^d   Platt, Randall J ^e,f   Chen, Sidi ^a,g  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c USA   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e ETH ZURICH   (Switzerland)

^f UNIVERSITY OF BASEL   (Switzerland)

^g YALE CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; GENES; MAMMALS; MAPPING; ONCOGENIC VIRUSES; TUMORS;

ADENO-ASSOCIATED VIRUS; CANCER GENOMICS; COMPREHENSIVE ASSESSMENT; HIGH-THROUGHPUT; LIVER CANCERS; MULTIPLE VARIANTS; TUMOR SUPPRESSOR GENES; TUMOR SUPPRESSORS;

DIAGNOSIS;

ANIMAL; CARCINOGENESIS; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; DEPENDOPARVOVIRUS; GENETIC SCREENING; GENETICS; GENOME; LIVER; MOUSE; MUTATION; NEOPLASM; PATHOLOGY; TUMOR SUPPRESSOR GENE;

ANIMALS; CARCINOGENESIS; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; DEPENDOVIRUS; GENES, TUMOR SUPPRESSOR; GENETIC TESTING; GENOME; LIVER; MICE; MUTATION; NEOPLASMS;

EID: 85044786552     PISSN: None     EISSN: 23752548     Source Type: Journal    
DOI: 10.1126/sciadv.aao5508     Document Type: Article

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