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Volumn 9, Issue 1, 2018, Pages

The role of CSF1R-dependent macrophages in control of the intestinal stem-cell niche

Author keywords

[No Author keywords available]

Indexed keywords

COLONY STIMULATING FACTOR 1; MESSENGER RNA; CSF1R PROTEIN, MOUSE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR; GREEN FLUORESCENT PROTEIN;

EID: 85044539596     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/s41467-018-03638-6     Document Type: Article
Times cited : (153)

References (65)
  • 1
    • 67349123408 scopus 로고    scopus 로고
    • Single Lgr5+ stem cells build crypt-villus structures in vitro without a mesenchymal niche
    • Sato, T. et al. Single Lgr5+ stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 459, 262-265 (2009).
    • (2009) Nature , vol.459 , pp. 262-265
    • Sato, T.1
  • 2
    • 78751644734 scopus 로고    scopus 로고
    • Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
    • Sato, T. et al. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature 469, 415-418 (2011).
    • (2011) Nature , vol.469 , pp. 415-418
    • Sato, T.1
  • 3
    • 84921313153 scopus 로고    scopus 로고
    • Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult
    • Bain, C. C. et al. Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult. Nat. Immunol. 15, 929-937 (2014).
    • (2014) Nat. Immunol. , vol.15 , pp. 929-937
    • Bain, C.C.1
  • 4
    • 84875830139 scopus 로고    scopus 로고
    • Intestinal macrophages: Well educated exceptions from the rule
    • Zigmond, E. &Jung, S. Intestinal macrophages: well educated exceptions from the rule. Trends Immunol. 34, 162-168 (2013).
    • (2013) Trends Immunol. , vol.34 , pp. 162-168
    • Zigmond, E.1    Jung, S.2
  • 5
    • 0036092801 scopus 로고    scopus 로고
    • Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects
    • Dai, X. M. et al. Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects. Blood 99, 111-120 (2002).
    • (2002) Blood , vol.99 , pp. 111-120
    • Dai, X.M.1
  • 6
    • 78149462163 scopus 로고    scopus 로고
    • An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue-and tumourassociated macrophages but does not inhibit inflammation
    • MacDonald, K. P. et al. An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue-and tumourassociated macrophages but does not inhibit inflammation. Blood 116, 3955-3963 (2010).
    • (2010) Blood , vol.116 , pp. 3955-3963
    • MacDonald, K.P.1
  • 7
    • 0023685533 scopus 로고
    • The effect of human recombinant macrophage colony-stimulating factor (CSF-1) on the murine mononuclear phagocyte system in vivo
    • Hume, D. A., Pavli, P., Donahue, R. E. &Fidler, I. J. The effect of human recombinant macrophage colony-stimulating factor (CSF-1) on the murine mononuclear phagocyte system in vivo. J. Immunol. 141, 3405-3409 (1988).
    • (1988) J. Immunol. , vol.141 , pp. 3405-3409
    • Hume, D.A.1    Pavli, P.2    Donahue, R.E.3    Fidler, I.J.4
  • 8
    • 84964316024 scopus 로고    scopus 로고
    • Characterisation of a novel Fc conjugate of Macrophage Colony-Stimulating Factor (CSF1)
    • Gow, D. et al. Characterisation of a novel Fc conjugate of Macrophage Colony-Stimulating Factor (CSF1). Mol. Ther. 22, 1580-1592 (2014).
    • (2014) Mol. Ther. , vol.22 , pp. 1580-1592
    • Gow, D.1
  • 9
    • 84872311693 scopus 로고    scopus 로고
    • The CSF-1 receptor fashions the intestinal stem cell niche
    • Akcora, D. et al. The CSF-1 receptor fashions the intestinal stem cell niche. Stem Cell Res. 10, 203-212 (2013).
    • (2013) Stem Cell Res. , vol.10 , pp. 203-212
    • Akcora, D.1
  • 10
    • 67649183644 scopus 로고    scopus 로고
    • Colony stimulating factor-1 dependence of Paneth cell development in the mouse small intestine
    • Huynh, D. et al. Colony stimulating factor-1 dependence of Paneth cell development in the mouse small intestine. Gastroenterology 137, 136-144 (2009).
    • (2009) Gastroenterology , vol.137 , pp. 136-144
    • Huynh, D.1
  • 11
    • 84874304319 scopus 로고    scopus 로고
    • CSF-1 receptor-dependent colon development, homeostasis and inflammatory stress response
    • Huynh, D. et al. CSF-1 receptor-dependent colon development, homeostasis and inflammatory stress response. PLoS ONE 8, e56951 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e56951
    • Huynh, D.1
  • 12
    • 0037307026 scopus 로고    scopus 로고
    • A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse
    • Sasmono, R. T. et al. A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse. Blood 101, 1155-1163 (2003).
    • (2003) Blood , vol.101 , pp. 1155-1163
    • Sasmono, R.T.1
  • 13
    • 84905049757 scopus 로고    scopus 로고
    • Pleiotropic effects of extended blockade of CSF1R signalling in adult mice
    • Sauter, K. A. et al. Pleiotropic effects of extended blockade of CSF1R signalling in adult mice. J. Leukoc. Biol. 96, 265-274 (2014).
    • (2014) J. Leukoc. Biol. , vol.96 , pp. 265-274
    • Sauter, K.A.1
  • 14
    • 63149088164 scopus 로고    scopus 로고
    • Trophic macrophages in development and disease
    • Pollard, J. W. Trophic macrophages in development and disease. Nat. Rev. Immunol. 9, 259-270 (2009).
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 259-270
    • Pollard, J.W.1
  • 15
    • 84904573974 scopus 로고    scopus 로고
    • Crosstalk between muscularis macrophages and enteric neurones regulates gastrointestinal motility
    • Muller, P. A. et al. Crosstalk between muscularis macrophages and enteric neurones regulates gastrointestinal motility. Cell 158, 300-313 (2014).
    • (2014) Cell , vol.158 , pp. 300-313
    • Muller, P.A.1
  • 16
    • 84955567315 scopus 로고    scopus 로고
    • Neuro-immune interactions drive tissue programming in intestinal macrophages
    • Gabanyi, I. et al. Neuro-immune interactions drive tissue programming in intestinal macrophages. Cell 164, 378-391 (2016).
    • (2016) Cell , vol.164 , pp. 378-391
    • Gabanyi, I.1
  • 17
    • 84866465328 scopus 로고    scopus 로고
    • Peyer's patch M cells derive from Lgr5+ stem cells, require SpiB and are induced by RankL in cultured 'organoids'
    • de Lau, W. et al. Peyer's patch M cells derive from Lgr5+ stem cells, require SpiB and are induced by RankL in cultured 'organoids'. Mol. Cell. Biol. 32, 3639-3647 (2012).
    • (2012) Mol. Cell. Biol. , vol.32 , pp. 3639-3647
    • De Lau, W.1
  • 18
    • 84879336857 scopus 로고    scopus 로고
    • Microfold (M) cells: Important immunosurveillance posts in the intestinal epithelium
    • Mabbott, N. A., Donaldson, D. S., Ohno, H., Williams, I. R. &Mahajan, A. Microfold (M) cells: important immunosurveillance posts in the intestinal epithelium. Mucosal Immunol. 6, 666-677 (2013).
    • (2013) Mucosal Immunol. , vol.6 , pp. 666-677
    • Mabbott, N.A.1    Donaldson, D.S.2    Ohno, H.3    Williams, I.R.4    Mahajan, A.5
  • 19
    • 70449653428 scopus 로고    scopus 로고
    • Uptake through glycoprotein 2 of FimH+ bacteria by M cells initiates mucosal immune responses
    • Hase, K. et al. Uptake through glycoprotein 2 of FimH+ bacteria by M cells initiates mucosal immune responses. Nature 462, 226-231 (2009).
    • (2009) Nature , vol.462 , pp. 226-231
    • Hase, K.1
  • 20
    • 84864147310 scopus 로고    scopus 로고
    • The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells
    • Kanaya, T. et al. The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells. Nat. Immunol. 13, 729-736 (2012).
    • (2012) Nat. Immunol. , vol.13 , pp. 729-736
    • Kanaya, T.1
  • 21
    • 84911446682 scopus 로고    scopus 로고
    • A novel vaccine targeting Peyer's patch M cells induces protective antigen-specific IgA responses
    • Shima, H. et al. A novel vaccine targeting Peyer's patch M cells induces protective antigen-specific IgA responses. Int. Immunol. 26, 619-625 (2014).
    • (2014) Int. Immunol. , vol.26 , pp. 619-625
    • Shima, H.1
  • 22
    • 3442878663 scopus 로고    scopus 로고
    • Insulin cell mass is altered in Csf1op/Csf1op macrophage-deficient mice
    • Banaei-Bouchareb, L. et al. Insulin cell mass is altered in Csf1op/Csf1op macrophage-deficient mice. J. Leukoc. Biol. 76, 359-367 (2004).
    • (2004) J. Leukoc. Biol. , vol.76 , pp. 359-367
    • Banaei-Bouchareb, L.1
  • 23
    • 34347405754 scopus 로고    scopus 로고
    • Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1
    • Sasmono, R. T. et al. Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1. J. Leukoc. Biol. 82, 111-123 (2007).
    • (2007) J. Leukoc. Biol. , vol.82 , pp. 111-123
    • Sasmono, R.T.1
  • 24
    • 73949156838 scopus 로고    scopus 로고
    • Cellular plasticity of inflammatory myeloid cells in the peritoneal foreign body response
    • Mooney, J. E. et al. Cellular plasticity of inflammatory myeloid cells in the peritoneal foreign body response. Am. J. Pathol. 176, 369-380 (2010).
    • (2010) Am. J. Pathol. , vol.176 , pp. 369-380
    • Mooney, J.E.1
  • 25
    • 84897406127 scopus 로고    scopus 로고
    • A promoter-level mammalian expression atlas
    • FANTOM Consortium and the RIKEN PMI and CLST (DGT)
    • FANTOM Consortium and the RIKEN PMI and CLST (DGT), Forrest, A. R. et al. A promoter-level mammalian expression atlas. Nature 507, 462-470 (2014).
    • (2014) Nature , vol.507 , pp. 462-470
    • Forrest, A.R.1
  • 26
    • 84941201582 scopus 로고    scopus 로고
    • Single-cell messenger RNA sequencing reveals rare intestinal cell types
    • Grun, G. et al. Single-cell messenger RNA sequencing reveals rare intestinal cell types. Nature 525, 251-255 (2015).
    • (2015) Nature , vol.525 , pp. 251-255
    • Grun, G.1
  • 27
    • 84899029183 scopus 로고    scopus 로고
    • Adult stem cells in the small intestine are intrinsically programmed with their location-specific function
    • Middendorp, S. et al. Adult stem cells in the small intestine are intrinsically programmed with their location-specific function. Stem Cells 32, 1083-1091 (2014).
    • (2014) Stem Cells , vol.32 , pp. 1083-1091
    • Middendorp, S.1
  • 28
    • 80054041585 scopus 로고    scopus 로고
    • A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable
    • Tian, H. et al. A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable. Nature 478, 255-259 (2011).
    • (2011) Nature , vol.478 , pp. 255-259
    • Tian, H.1
  • 29
    • 84862946094 scopus 로고    scopus 로고
    • The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations
    • Yan, K. S. et al. The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations. Proc. Natl Acad. Sci. USA 109, 466-471 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 466-471
    • Yan, K.S.1
  • 30
    • 46249128798 scopus 로고    scopus 로고
    • Bmi1 is expressed in vivo in intestinal stem cells
    • Sangiorgi, E. &Capecchi, M. R. Bmi1 is expressed in vivo in intestinal stem cells. Nat. Genet. 40, 915-920 (2008).
    • (2008) Nat. Genet. , vol.40 , pp. 915-920
    • Sangiorgi, E.1    Capecchi, M.R.2
  • 31
    • 85047289665 scopus 로고    scopus 로고
    • Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon
    • Sasaki, N. et al. Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon. Proc. Natl Acad. Sci. USA 113, E5399-E5407 (2016).
    • (2016) Proc. Natl Acad. Sci. USA , vol.113 , pp. E5399-E5407
    • Sasaki, N.1
  • 32
    • 84975889728 scopus 로고    scopus 로고
    • The activation of Wnt signaling by a STAT6-dependent macrophage phenotype promotes mucosal repair in murine IBD
    • Cosin-Roger, J. et al. The activation of Wnt signaling by a STAT6-dependent macrophage phenotype promotes mucosal repair in murine IBD. Mucosal Immunol. 9, 986-998 (2015).
    • (2015) Mucosal Immunol. , vol.9 , pp. 986-998
    • Cosin-Roger, J.1
  • 33
    • 84991702569 scopus 로고    scopus 로고
    • Macrophage-derived extracellular vesicle-packaged WNTs rescue intetinal stem cells and enhance survival after radiation injury
    • Saha, S. et al. Macrophage-derived extracellular vesicle-packaged WNTs rescue intetinal stem cells and enhance survival after radiation injury. Nat. Commun. 7, 13096 (2016).
    • (2016) Nat. Commun. , vol.7 , pp. 13096
    • Saha, S.1
  • 34
    • 84879334035 scopus 로고    scopus 로고
    • The functional maturation of M cells is dramatically reduced in the Peyer's patches of aged mice
    • Kobayashi, A. et al. The functional maturation of M cells is dramatically reduced in the Peyer's patches of aged mice. Mucosal Immunol. 6, 1027-1037 (2013).
    • (2013) Mucosal Immunol. , vol.6 , pp. 1027-1037
    • Kobayashi, A.1
  • 35
    • 77950491661 scopus 로고    scopus 로고
    • RANKL is necessary and sufficient to initiate development of antigen-sampling M cells in the intestinal epithelium
    • Knoop, K. A. et al. RANKL is necessary and sufficient to initiate development of antigen-sampling M cells in the intestinal epithelium. J. Immunol. 183, 5738-5747 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 5738-5747
    • Knoop, K.A.1
  • 36
    • 70350279311 scopus 로고    scopus 로고
    • Colonystimulating factor-1 (CSF-1) directly inhibits receptor activator of nuclear factor-kB ligand (RANKL) expression by osteoclasts
    • Wittrant, Y., Gorin, Y., Mohan, S., Wager, B. &Abboud-Werner, S. L. Colonystimulating factor-1 (CSF-1) directly inhibits receptor activator of nuclear factor-kB ligand (RANKL) expression by osteoclasts. Endocrinology 150, 4977-4988 (2009).
    • (2009) Endocrinology , vol.150 , pp. 4977-4988
    • Wittrant, Y.1    Gorin, Y.2    Mohan, S.3    Wager, B.4    Abboud-Werner, S.L.5
  • 37
    • 85018362824 scopus 로고    scopus 로고
    • Identification of subepithelial mesenchymal cells that induce IgA and diversify gut microbiota
    • Nagashima, K. et al. Identification of subepithelial mesenchymal cells that induce IgA and diversify gut microbiota. Nat. Immunol. 18, 675-682 (2017).
    • (2017) Nat. Immunol. , vol.18 , pp. 675-682
    • Nagashima, K.1
  • 38
    • 79953301149 scopus 로고    scopus 로고
    • CCR6hiCD11cint B cells promote M-cell differentiation in Peyer's patch
    • Ebisawa, M. et al. CCR6hiCD11cint B cells promote M-cell differentiation in Peyer's patch. Int. Immunol. 23, 261-269 (2011).
    • (2011) Int. Immunol. , vol.23 , pp. 261-269
    • Ebisawa, M.1
  • 39
    • 84959017482 scopus 로고    scopus 로고
    • Visualization of a short-range Wnt gradient in the intestinal stem-cell niche
    • Farin, H. F. et al. Visualization of a short-range Wnt gradient in the intestinal stem-cell niche. Nature 530, 340-343 (2016).
    • (2016) Nature , vol.530 , pp. 340-343
    • Farin, H.F.1
  • 40
    • 20244364236 scopus 로고    scopus 로고
    • Wnt signalling induces maturation of Paneth cells in intestinal crypts
    • van Es, J. H. et al. Wnt signalling induces maturation of Paneth cells in intestinal crypts. Nat. Cell Biol. 7, 381-386 (2005).
    • (2005) Nat. Cell Biol. , vol.7 , pp. 381-386
    • Van Es, J.H.1
  • 41
    • 84863230213 scopus 로고    scopus 로고
    • Intact functin of Lgr5 receptorexpressing intestinal stem cells in the absence of Paneth cells
    • Kim, T.-H., Escudero, S. &Shivdasani, R. A. Intact functin of Lgr5 receptorexpressing intestinal stem cells in the absence of Paneth cells. Proc. Natl Acad. Sci. USA 109, 3932-3937 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 3932-3937
    • Kim, T.-H.1    Escudero, S.2    Shivdasani, R.A.3
  • 42
    • 84893749715 scopus 로고    scopus 로고
    • Wnt secretion from epithelial cells and subepithelial myofibroblasts is not required in the mouse intestinal stem cell niche in vivo
    • San Roman, A. K., Jayewickreme, C. D., Murtaugh, L. C. &Shivdasani, R. A. Wnt secretion from epithelial cells and subepithelial myofibroblasts is not required in the mouse intestinal stem cell niche in vivo. Stem Cell Rep. 2, 127-134 (2014).
    • (2014) Stem Cell Rep. , vol.2 , pp. 127-134
    • San Roman, A.K.1    Jayewickreme, C.D.2    Murtaugh, L.C.3    Shivdasani, R.A.4
  • 43
    • 84869864069 scopus 로고    scopus 로고
    • Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells
    • Farin, H. F., van Es, J. H. &Clevers, H. Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells. Gastroenterology 143, 1518-1529 (2012).
    • (2012) Gastroenterology , vol.143 , pp. 1518-1529
    • Farin, H.F.1    Van Es, J.H.2    Clevers, H.3
  • 45
    • 85036571700 scopus 로고    scopus 로고
    • R-spondin1 expands Paneth cells and prevents dysbiosis induced by graft-versus-host disease
    • Hayase, E. et al. R-spondin1 expands Paneth cells and prevents dysbiosis induced by graft-versus-host disease. J. Exp. Med. 214, 3507-3518 (2017).
    • (2017) J. Exp. Med. , vol.214 , pp. 3507-3518
    • Hayase, E.1
  • 46
    • 85035139912 scopus 로고    scopus 로고
    • Paneth cell defects induce microbiota dysbiosis in mice and promote visceral hypersensitivity
    • Riba, A. et al. Paneth cell defects induce microbiota dysbiosis in mice and promote visceral hypersensitivity. Gastroenterology 153, 1594-1606 (2017).
    • (2017) Gastroenterology , vol.153 , pp. 1594-1606
    • Riba, A.1
  • 47
    • 79951694373 scopus 로고    scopus 로고
    • Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche
    • Chow, A. et al. Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche. J. Exp. Med. 208, 261-271 (2011).
    • (2011) J. Exp. Med. , vol.208 , pp. 261-271
    • Chow, A.1
  • 48
    • 84878444005 scopus 로고    scopus 로고
    • CD169+ macrophages provide a niche promoting erythropoiesis under homeostasis and stress
    • Chow, A. et al. CD169+ macrophages provide a niche promoting erythropoiesis under homeostasis and stress. Nat. Immunol. 19, 429-436 (2013).
    • (2013) Nat. Immunol. , vol.19 , pp. 429-436
    • Chow, A.1
  • 49
    • 49049098143 scopus 로고    scopus 로고
    • Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivo
    • Chang, M. K. et al. Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivo. J. Immunol. 181, 1232-1244 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 1232-1244
    • Chang, M.K.1
  • 50
    • 85028529755 scopus 로고    scopus 로고
    • Myeloid Wnt ligands are required for normal development of the dermal lymphatic vasculature
    • Mulley, A. et al. Myeloid Wnt ligands are required for normal development of the dermal lymphatic vasculature. PLoS ONE 12, e0181549 (2017).
    • (2017) PLoS ONE , vol.12 , pp. e0181549
    • Mulley, A.1
  • 51
    • 84947207751 scopus 로고    scopus 로고
    • Mini-gut organoids: Reconstitution of the stem cell niche
    • Date, S. &Sato, T. Mini-gut organoids: reconstitution of the stem cell niche. Annu. Rev. Cell. Dev. Biol. 31, 269-289 (2015).
    • (2015) Annu. Rev. Cell. Dev. Biol. , vol.31 , pp. 269-289
    • Date, S.1    Sato, T.2
  • 52
    • 0035412388 scopus 로고    scopus 로고
    • Rescue of the colony-stimulating factor 1 (CSF-1)-nullizygous mouse (Csf1op/Csf1op) phenotype with a CSF-1 transgene and identification of sites of local CSF-1 synthesis
    • Ryan, G. R. et al. Rescue of the colony-stimulating factor 1 (CSF-1)-nullizygous mouse (Csf1op/Csf1op) phenotype with a CSF-1 transgene and identification of sites of local CSF-1 synthesis. Blood 98, 74-84 (2001).
    • (2001) Blood , vol.98 , pp. 74-84
    • Ryan, G.R.1
  • 53
    • 66149134501 scopus 로고    scopus 로고
    • The EGF/CSF-1 paracrine invasion loop can be triggered by heregulin beta1 and CXCL12
    • Hernandez, L. et al. The EGF/CSF-1 paracrine invasion loop can be triggered by heregulin beta1 and CXCL12. Cancer Res. 69, 3221-3227 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 3221-3227
    • Hernandez, L.1
  • 54
    • 80051926611 scopus 로고    scopus 로고
    • Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
    • De Lau, W. et al. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature 476, 293-297 (2011).
    • (2011) Nature , vol.476 , pp. 293-297
    • De Lau, W.1
  • 55
    • 68849096531 scopus 로고    scopus 로고
    • CSF-1 signals directly to renal tubular epithelial cells to mediate repair in mice
    • Menke, J. et al. CSF-1 signals directly to renal tubular epithelial cells to mediate repair in mice. J. Clin. Invest. 119, 2330-2342 (2009).
    • (2009) J. Clin. Invest. , vol.119 , pp. 2330-2342
    • Menke, J.1
  • 56
    • 80052836313 scopus 로고    scopus 로고
    • Colony-stimulating factor-1 promotes kidney growth and repair via alteration of macrophage responses
    • Alikhan, M. A. et al. Colony-stimulating factor-1 promotes kidney growth and repair via alteration of macrophage responses. Am. J. Pathol. 179, 1243-1256 (2011).
    • (2011) Am. J. Pathol. , vol.179 , pp. 1243-1256
    • Alikhan, M.A.1
  • 57
    • 84895803050 scopus 로고    scopus 로고
    • Shp2/MAPK signaling controls goblet/paneth cell fate decision in the intestine
    • Heuberger, J. et al. Shp2/MAPK signaling controls goblet/paneth cell fate decision in the intestine. Proc. Natl Acad. Sci. USA 111, 3472-3477 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 3472-3477
    • Heuberger, J.1
  • 58
    • 84857618521 scopus 로고    scopus 로고
    • Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling
    • Hume, D. A. &MacDonald, K. P. Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling. Blood 119, 1810-1820 (2012).
    • (2012) Blood , vol.119 , pp. 1810-1820
    • Hume, D.A.1    MacDonald, K.P.2
  • 59
    • 84946762352 scopus 로고    scopus 로고
    • Crohn's disease-derived monocytes fail to induce Paneth cell defensins
    • Courth, L. F. et al. Crohn's disease-derived monocytes fail to induce Paneth cell defensins. Proc. Natl Acad. Sci. USA 112, 14000-14005 (2015).
    • (2015) Proc. Natl Acad. Sci. USA , vol.112 , pp. 14000-14005
    • Courth, L.F.1
  • 60
    • 79959508609 scopus 로고    scopus 로고
    • Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibeal injury model
    • Alexander, K. A. et al. Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibeal injury model. J. Bone Miner. Res. 2011, 1517-1532 (2011).
    • (2011) J. Bone Miner. Res. , vol.2011 , pp. 1517-1532
    • Alexander, K.A.1
  • 61
    • 84952928093 scopus 로고    scopus 로고
    • CSF1 restores innate immunity after liver injury in mice and serum levels indicate outcomes of patients with acute liver failure
    • Stutchfield, B. M. et al. CSF1 restores innate immunity after liver injury in mice and serum levels indicate outcomes of patients with acute liver failure. Gastroenterology 149, 1896-1909 (2015).
    • (2015) Gastroenterology , vol.149 , pp. 1896-1909
    • Stutchfield, B.M.1
  • 62
    • 23444446424 scopus 로고    scopus 로고
    • Validation of computer-assisted, pixel-based analysis of multiple-colour immunofluorescence histology
    • Inman, C. F. et al. Validation of computer-assisted, pixel-based analysis of multiple-colour immunofluorescence histology. J. Immunol. Met 302, 156-167 (2005).
    • (2005) J. Immunol. Met , vol.302 , pp. 156-167
    • Inman, C.F.1
  • 63
    • 84870489063 scopus 로고    scopus 로고
    • Primary mouse small intestinal epithelial cell cultures
    • Sato, T. &Clevers, H. Primary mouse small intestinal epithelial cell cultures. Methods Mol. Biol. 945, 319-328 (2013).
    • (2013) Methods Mol. Biol. , vol.945 , pp. 319-328
    • Sato, T.1    Clevers, H.2
  • 64
    • 84975824503 scopus 로고    scopus 로고
    • Antigen sampling by intestinal M cells is the principal pathway initiating mucosal IgA production to commensal enteric bacteria
    • Rios, D. et al. Antigen sampling by intestinal M cells is the principal pathway initiating mucosal IgA production to commensal enteric bacteria. Mucosal Immunol. 9, 907-916 (2016).
    • (2016) Mucosal Immunol. , vol.9 , pp. 907-916
    • Rios, D.1
  • 65
    • 34547591343 scopus 로고    scopus 로고
    • Primer3Plus, an enhanced web interface to Primer3
    • Untergasser, A. et al. Primer3Plus, an enhanced web interface to Primer3. Nucleic Acids Res. 35, W71-W74 (2007).
    • (2007) Nucleic Acids Res. , vol.35 , pp. W71-W74
    • Untergasser, A.1


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