CSF-1 signals directly to renal tubular epithelial cells to mediate repair in mice

Journal of Clinical Investigation

Volumn 119, Issue 8, 2009, Pages 2330-2342

  Menke, Julia ^a   Iwata, Yasunori ^a   Rabacal, Whitney A ^a   Basu, Ranu ^b   Yeung, Yee G ^b   Humphreys, Benjamin D ^a   Wada, Takashi ^c   Schwarting, Andreas ^d   Stanley, E Richard ^b   Kelley, Vicki Rubin ^a,e  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c KANAZAWA UNIVERSITY   (Japan)

^d JOHANNES GUTENBERG UNIVERSITY   (Germany)

^e HARVARD INSTITUTES OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLONY STIMULATING FACTOR 1;

ACUTE KIDNEY TUBULE NECROSIS; ALBUMINURIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; EPITHELIUM CELL; HISTOPATHOLOGY; HUMAN; HUMAN CELL; KIDNEY CORTEX; KIDNEY FIBROSIS; KIDNEY FUNCTION; KIDNEY ISCHEMIA; KIDNEY MEDULLA; KIDNEY TUBULE DISORDER; KIDNEY TUBULE EPITHELIUM; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY;

ANIMALS; APOPTOSIS; CELL PROLIFERATION; EPITHELIAL CELLS; FIBROSIS; HUMANS; KIDNEY TUBULES; MACROPHAGE COLONY-STIMULATING FACTOR; MACROPHAGES; MICE; MICE, INBRED C3H; RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR; REGENERATION; REPERFUSION INJURY;

EID: 68849096531     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI39087     Document Type: Article

References (57)

1. Humphreys, B.D., et al. 2008. Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell. 2:284-291.
2. Goligorsky, M.S. 2008. Immune system in renal injury and repair: burning the candle from both ends? Pharmacol. Res. 58:122-128.
3. Witzgall, R., Brown, D., Schwarz, C., and Bonventre, J.V. 1994. Localization of proliferating cell nuclear antigen, vimentin, c-Fos, and clusterin in the postischemic kidney. Evidence for a heterogenous genetic response among nephron segments, and a large pool of mitotically active and dedifferentiated cells. J. Clin. Invest. 93:2175-2188.
4. Thadhani, R., Pascual, M., and Bonventre, J.V. 1996. Acute renal failure. N. Engl. J. Med. 334:1448-1460.
5. Bonventre, J.V., and Weinberg, J.M. 2003. Recent advances in the pathophysiology of ischemic acute renal failure. J. Am. Soc. Nephrol. 14:2199-2210.
6. Bonventre, J.V., and Zuk, A. 2004. Ischemic acute renal failure: an inflammatory disease? Kidney Int. 66:480-485.
7. Duffield, J.S., and Bonventre, J.V. 2005. Kidney tubular epithelium is restored without replacement with bone marrow-derived cells during repair after ischemic injury. Kidney Int. 68:1956-1961.
8. Pixley, F.J., and Stanley, E.R. 2004. CSF-1 regulation of the wandering macrophage: complexity in action. Trends Cell Biol. 14:628-638.
9. Chitu, V., and Stanley, E.R. 2006. Colony-stimulating factor-1 in immunity and inflammation. Curr. Opin. Immunol. 18:39-48.
10. Lenda, D.M., Kikawada, E., Stanley, E.R., and Kelley, V.R. 2003. Reduced macrophage recruitment, proliferation, and activation in colony-stimulating factor-1-deficient mice results in decreased tubular apoptosis during renal inflammation. J. Immunol. 170:3254-3262.
11. Lenda, D.M., Stanley, E.R., and Kelley, V.R. 2004. Negative role of colony-stimulating factor-1 in macrophage, T cell, and B cell mediated autoimmune disease in MRL-Fas(lpr) mice. J. Immunol. 173:4744- 4754.
12. Aharinejad, S., et al. 2008. Colony-stimulating factor-1 transfection of myoblasts improves the repair of failing myocardium following autologous myoblast transplantation. Cardiovasc. Res. 79:395-404.
13. Ricardo, S.D., van Goor, H., and Eddy, A.A. 2008. Macrophage diversity in renal injury and repair. J. Clin. Invest. 118:3522-3530.
14. Gratchev, A., et al. 2006. Mphi1 and Mphi2 can be repolarized by Th2 or Th1 cytokines, respectively, and respond to exogenous danger signals. Immunobiology. 211:473-486.
15. Sapi, E. 2004. The role of CSF-1 in normal physiology of mammary gland and breast cancer: an update. Exp. Biol. Med. (Maywood). 229:1-11.
16. Borycki, A.G., Smadja, F., Stanley, R., and Leibovitch, S.A. 1995. Colony-stimulating factor 1 (CSF-1) is involved in an autocrine growth control of rat myogenic cells. Exp. Cell. Res. 218:213-222.
17. Sapi, E., Flick, M.B., Rodov, S., Carter, D., and Kacinski, B.M. 1998. Expression of CSF-I and CSF-I receptor by normal lactating mammary epithelial cells. J. Soc. Gynecol. Investig. 5:94-101.
18. Yui, M.A., Brissette, W.H., Brennan, D.C., Wuthrich, R.P., and Rubin-Kelley, V.E. 1991. Increased macrophage colony-stimulating factor in neonatal and adult autoimmune MRL-lpr mice. Am. J. Pathol. 139:255-261.
19. Bloom, R.D., Florquin, S., Singer, G.G., Brennan, D.C., and Kelley, V.R. 1993. Colony stimulating factor-1 in the induction of lupus nephritis. Kidney Int. 43:1000-1009.
20. Naito, T., et al. 1996. Macrophage growth factors introduced into the kidney initiate renal injury. Mol. Med. 2:297-312.
21. Ichimura, T., et al. 1998. Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury. J. Biol. Chem. 273:4135-4142.
22. Bonventre, J.V. 2003. Dedifferentiation and proliferation of surviving epithelial cells in acute renal failure. J. Am. Soc. Nephrol. 14(Suppl. 1):S55-S61.
23. Hume, D.A. 2008. Differentiation and heterogeneity in the mononuclear phagocyte system. Mucosal Immunol. 1:432-441.
24. Duffield, J.S., et al. 2005. Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J. Clin. Invest. 115:56-65.
25. Sasmono, R.T., et al. 2003. A macrophage colonystimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse. Blood. 101:1155-1163.
26. Jang, M.H., et al. 2006. Distinct in vivo roles of colony-stimulating factor-1 isoforms in renal inflammation. J. Immunol. 177:4055- 4063.
27. Ryan, G.R., et al. 2001. Rescue of the colony-stimulating factor 1 (CSF-1)-nullizygous mouse (Csf1(op)/Csf1(op)) phenotype with a CSF-1 transgene and identification of sites of local CSF-1 synthesis. Blood. 98:74-84.
28. Liu, K.D., and Brakeman, P.R. 2008. Renal repair and recovery. Crit. Care Med. 36:S187-S192.
29. van Amerongen, M.J., et al. 2007. Macrophage depletion impairs wound healing and increases left ventricular remodeling after myocardial injury in mice. Am. J. Pathol. 170:818-829.
30. Arnold, L., et al. 2007. Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis. J. Exp. Med. 204:1057-1069.
31. Nahrendorf, M., et al. 2007. The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J. Exp. Med. 204:3037-3047.
32. Jang, H.S., Kim, J., Park, Y.K., and Park, K.M. 2008. Infiltrated macrophages contribute to recovery after ischemic injury but not to ischemic preconditioning in kidneys. Transplantation 85:447-455.
33. Ide, H., et al. 2002. Expression of colony-stimulating factor 1 receptor during prostate development and prostate cancer progression. Proc. Natl. Acad. Sci. U. S. A. 99:14404-14409.
34. Kacinski, B.M. 1997. CSF-1 and its receptor in breast carcinomas and neoplasms of the female reproductive tract. Mol. Reprod. Dev. 46:71-74.
35. Sakai, M., et al. 1997. Production of heparin binding epidermal growth factor-like growth factor in the early phase of regeneration after acute renal injury. Isolation and localization of bioactive molecules. J. Clin. Invest. 99:2128-2138.
36. Homma, T., et al. 1995. Induction of heparin-binding epidermal growth factor-like growth factor mRNA in rat kidney after acute injury. J. Clin. Invest. 96:1018-1025.
37. Cantaluppi, V., et al. 2008. Macrophage stimulating protein may promote tubular regeneration after acute injury. J. Am. Soc. Nephrol. 19:1904-1918.
38. Christensen, E.I., and Verroust, P.J. 2008. Interstitial fibrosis: tubular hypothesis versus glomerular hypothesis. Kidney Int. 74:1233-1236.
39. Iwano, M., and Neilson, E.G. 2004. Mechanisms of tubulointerstitial fibrosis. Curr. Opin. Nephrol. Hypertens. 13:279-284.
40. Dai, X.M., Zong, X.H., Akhter, M.P., and Stanley, E.R. 2004. Osteoclast deficiency results in disorganized matrix, reduced mineralization, and abnormal osteoblast behavior in developing bone. J. Bone Miner. Res. 19:1441-1451.
41. Sudo, T., et al. 1995. Functional hierarchy of c-kit and c-fms in intramarrow production of CFU-M. Oncogene. 11:2469-2476.
42. Menke, J., et al. 2007. Programmed death 1 ligand (PD-L) 1 and PD-L2 limit autoimmune kidney disease: distinct roles. J. Immunol. 179:7466-7477.
43. Faust, J., et al. 2002. Correlation of renal tubular epithelial cell-derived interleukin-18 up- regulation with disease activity in MRL-Faslpr mice with autoimmune lupus nephritis. Arthritis Rheum. 46:3083-3095.
44. Wuthrich, R.P., et al. 1990. MHC class II, antigen presentation and tumor necrosis factor in renal tubular epithelial cells. Kidney Int. 37:783-792.
45. Huang, J., Tatsumi, T., Pizzoferrato, E., Vujanovic, N., and Storkus, W.J. 2005. Nitric oxide sensitizes tumor cells to dendritic cell-mediated apoptosis, uptake, and cross-presentation. Cancer Res. 65:8461-8470.
46. Ramamoorthy, L., and Tizard, I.R. 1998. Induction of apoptosis in a macrophage cell line RAW 264.7 by acemannan, a beta-(1,4)-acetylated mannan. Mol. Pharmacol. 53:415-421.
47. Lee, H.T., and Emala, C.W. 2002. Adenosine attenuates oxidant injury in human proximal tubular cells via A1 and A2a adenosine receptors10.1152/ajprenal. 00195.2001. Am. J. Physiol. Renal Physiol. 282:F844-F852.
48. Strefford, J.C., et al. 2001. The characterisation of the lymphoma cell line U937, using comparative genomic hybridisation and multi-plex FISH. Cytogenet. Cell Genet. 94:9-14.
49. Fordis, C.M., Anagnou, N.P., Dean, A., Nienhuis, A.W., and Schechter, A.N. 1984. A {beta} -globin gene, inactive in the K562 leukemic cell, functions normally in a heterologous expression system. Proc. Natl. Acad. Sci. U. S. A. 81:4485-4489.
50. Bar-Shavit, Z., et al. 1985. Differentiation of a human leukemia cell line and expression of collagenase inhibitor. Proc. Natl. Acad. Sci. U. S. A. 82:5380-5384.
51. Myrick, D., et al. 1999. Paclitaxel-induced apoptosis in Jurkat, a leukemic T cell line, is enhanced by ceramide. Leuk. Res. 23:569-578.
52. Kikawada, E., Lenda, D.M., and Kelley, V.R. 2003. IL-12 Deficiency in MRL-Fas(lpr) mice delays nephritis and intrarenal IFN-gamma expression, and diminishes systemic pathology. J. Immunol. 170:3915-3925.
53. -/- macrophages: regulation of proliferation, differentiation, and morphology. J. Leukoc. Biol. 84:852-863.
54. Yeung, Y.G., Wang, Y., Einstein, D.B., Lee, P.S., and Stanley, E.R. 1998. Colony-stimulating factor-1 stimulates the formation of multimeric cytosolic complexes of signaling proteins and cytoskeletal components in macrophages. J. Biol. Chem. 273:17128-17137.
55. Stanley, E.R. 1985. The macrophage colony-stimulating factor, CSF-1. Methods Enzymol. 116:564-587.
56. Moore, K.J., Yeh, K., Naito, T., and Kelley, V.R. 1996. TNF-alpha enhances colony-stimulating factor-1-induced macrophage accumulation in autoimmune renal disease. J. Immunol. 157:427-432.
57. Menke, J., et al. 2008. Sunlight triggers cutaneous lupus through a CSF-1-dependent mechanism in MRL-Fas(lpr) mice. J. Immunol. 181:7367-7379.