-
1
-
-
84877625807
-
Disparate individual fates compose robust CD8+ T cell immunity
-
Buchholz VR, Flossdorf M, Hensel I, Kretschmer L, Weissbrich B, Graf P, et al. Disparate individual fates compose robust CD8+ T cell immunity. Science 2013;340:630-5.
-
(2013)
Science
, vol.340
, pp. 630-635
-
-
Buchholz, V.R.1
Flossdorf, M.2
Hensel, I.3
Kretschmer, L.4
Weissbrich, B.5
Graf, P.6
-
2
-
-
84877601429
-
Heterogeneous differentiation patterns of individual CD8+ T cells
-
Gerlach C, Rohr JC, Perie L, van Rooij N, van Heijst JW, Velds A, et al. Heterogeneous differentiation patterns of individual CD8+ T cells. Science 2013;340:635-9.
-
(2013)
Science
, vol.340
, pp. 635-639
-
-
Gerlach, C.1
Rohr, J.C.2
Perie, L.3
Van Rooij, N.4
Van Heijst, J.W.5
Velds, A.6
-
3
-
-
20444499355
-
Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells
-
Gattinoni L, Klebanoff CA, Palmer DC, Wrzesinski C, Kerstann K, Yu Z, et al. Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells. J Clin Invest 2005;115:1616-26.
-
(2005)
J Clin Invest
, vol.115
, pp. 1616-1626
-
-
Gattinoni, L.1
Klebanoff, C.A.2
Palmer, D.C.3
Wrzesinski, C.4
Kerstann, K.5
Yu, Z.6
-
4
-
-
67650465237
-
Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells
-
Gattinoni L, Zhong XS, Palmer DC, Ji Y, Hinrichs CS, Yu Z, et al. Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells. Nat Med 2009;15:808-13.
-
(2009)
Nat Med
, vol.15
, pp. 808-813
-
-
Gattinoni, L.1
Zhong, X.S.2
Palmer, D.C.3
Ji, Y.4
Hinrichs, C.S.5
Yu, Z.6
-
5
-
-
70350458112
-
Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity
-
Hinrichs CS, Borman ZA, Cassard L, Gattinoni L, Spolski R, Yu Z, et al. Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity. Proc Natl Acad Sci U S A 2009;106:17469-74.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 17469-17474
-
-
Hinrichs, C.S.1
Borman, Z.A.2
Cassard, L.3
Gattinoni, L.4
Spolski, R.5
Yu, Z.6
-
6
-
-
78751689288
-
Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy
-
Hinrichs CS, Borman ZA, Gattinoni L, Yu Z, Burns WR, Huang J, et al. Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy. Blood 2011;117:808-14.
-
(2011)
Blood
, vol.117
, pp. 808-814
-
-
Hinrichs, C.S.1
Borman, Z.A.2
Gattinoni, L.3
Yu, Z.4
Burns, W.R.5
Huang, J.6
-
7
-
-
22144437688
-
Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells
-
Klebanoff CA, Gattinoni L, Torabi-Parizi P, Kerstann K, Cardones AR, Finkelstein SE, et al. Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells. Proc Natl Acad Sci U S A 2005;102:9571-6.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 9571-9576
-
-
Klebanoff, C.A.1
Gattinoni, L.2
Torabi-Parizi, P.3
Kerstann, K.4
Cardones, A.R.5
Finkelstein, S.E.6
-
8
-
-
84862682110
-
The three main stumbling blocks for anticancer T cells
-
Baitsch L, Fuertes-Marraco SA, Legat A, Meyer C, Speiser DE. The three main stumbling blocks for anticancer T cells. Trends Immunol 2012;33:364-72.
-
(2012)
Trends Immunol
, vol.33
, pp. 364-372
-
-
Baitsch, L.1
Fuertes-Marraco, S.A.2
Legat, A.3
Meyer, C.4
Speiser, D.E.5
-
9
-
-
84857702419
-
Molecular pathways: Hypoxia response in immune cells fighting or promoting cancer
-
Palazon A, Aragones J, Morales-Kastresana A, de Landazuri MO, Melero I. Molecular pathways: hypoxia response in immune cells fighting or promoting cancer. Clin Cancer Res 2012;18:1207-13.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 1207-1213
-
-
Palazon, A.1
Aragones, J.2
Morales-Kastresana, A.3
De Landazuri, M.O.4
Melero, I.5
-
10
-
-
84856453804
-
Regulation of TOR by small GTPases
-
Duran RV, Hall MN. Regulation of TOR by small GTPases. EMBO Rep 2012;13:121-8.
-
(2012)
EMBO Rep
, vol.13
, pp. 121-128
-
-
Duran, R.V.1
Hall, M.N.2
-
11
-
-
80755190061
-
Proline-rich akt substrate of 40 kDa (PRAS40): A novel downstream target of PI3k/Akt signaling pathway
-
Wang H, Zhang Q, Wen Q, Zheng Y, Lazarovici P, Jiang H, et al. Proline-rich Akt substrate of 40 kDa (PRAS40): a novel downstream target of PI3k/Akt signaling pathway. Cell Signal 2012;24:17-24.
-
(2012)
Cell Signal
, vol.24
, pp. 17-24
-
-
Wang, H.1
Zhang, Q.2
Wen, Q.3
Zheng, Y.4
Lazarovici, P.5
Jiang, H.6
-
12
-
-
80053377123
-
CD3 limits the efficacy of TCR gene therapy in vivo
-
Ahmadi M, King JW, Xue SA, Voisine C, Holler A, Wright GP, et al. CD3 limits the efficacy of TCR gene therapy in vivo. Blood 2011;118:3528-37.
-
(2011)
Blood
, vol.118
, pp. 3528-3537
-
-
Ahmadi, M.1
King, J.W.2
Xue, S.A.3
Voisine, C.4
Holler, A.5
Wright, G.P.6
-
13
-
-
84886721392
-
Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch
-
Gubser PM, Bantug GR, Razik L, Fischer M, Dimeloe S, Hoenger G, et al. Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch. Nat Immunol 2013;14:1064-72.
-
(2013)
Nat Immunol
, vol.14
, pp. 1064-1072
-
-
Gubser, P.M.1
Bantug, G.R.2
Razik, L.3
Fischer, M.4
Dimeloe, S.5
Hoenger, G.6
-
15
-
-
84874271196
-
mTOR, linking metabolism and immunity
-
Xu X, Ye L, Araki K, Ahmed R. mTOR, linking metabolism and immunity. Semin Immunol 2012;24:429-35.
-
(2012)
Semin Immunol
, vol.24
, pp. 429-435
-
-
Xu, X.1
Ye, L.2
Araki, K.3
Ahmed, R.4
-
16
-
-
0037097863
-
Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
-
Fingar DC, Salama S, Tsou C, Harlow E, Blenis J. Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev 2002;16:1472-87.
-
(2002)
Genes Dev
, vol.16
, pp. 1472-1487
-
-
Fingar, D.C.1
Salama, S.2
Tsou, C.3
Harlow, E.4
Blenis, J.5
-
17
-
-
42449110816
-
Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking
-
Sinclair LV, Finlay D, Feijoo C, Cornish GH, Gray A, Ager A, et al. Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking. Nat Immunol 2008;9:513-21.
-
(2008)
Nat Immunol
, vol.9
, pp. 513-521
-
-
Sinclair, L.V.1
Finlay, D.2
Feijoo, C.3
Cornish, G.H.4
Gray, A.5
Ager, A.6
-
18
-
-
74649085700
-
The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and eomesodermin
-
Rao RR, Li Q, Odunsi K, Shrikant PA. The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin. Immunity 2010;32:67-78.
-
(2010)
Immunity
, vol.32
, pp. 67-78
-
-
Rao, R.R.1
Li, Q.2
Odunsi, K.3
Shrikant, P.A.4
-
19
-
-
79951834881
-
Retroviral and transposon-based tet-regulated all-in-one vectors with reduced background expression and improved dynamic range
-
Heinz N, Schambach A, Galla M, Maetzig T, Baum C, Loew R, et al. Retroviral and transposon-based tet-regulated all-in-one vectors with reduced background expression and improved dynamic range. Hum Gene Ther 2011;22:166-76.
-
(2011)
Hum Gene Ther
, vol.22
, pp. 166-176
-
-
Heinz, N.1
Schambach, A.2
Galla, M.3
Maetzig, T.4
Baum, C.5
Loew, R.6
-
20
-
-
84907373133
-
A highly compact epitope-based marker/suicide gene for easier and safer T-cell therapy
-
Philip B, Kokalaki E, Mekkaoui L, Thomas S, Straathof K, Flutter B, et al. A highly compact epitope-based marker/suicide gene for easier and safer T-cell therapy. Blood 2014;124:1277-87.
-
(2014)
Blood
, vol.124
, pp. 1277-1287
-
-
Philip, B.1
Kokalaki, E.2
Mekkaoui, L.3
Thomas, S.4
Straathof, K.5
Flutter, B.6
-
21
-
-
84886672916
-
Hypoxia-inducible factors enhance the effector responses of CD8(+)Tcells to persistent antigen
-
Doedens AL, Phan AT, Stradner MH, Fujimoto JK, Nguyen JV, Yang E, et al. Hypoxia-inducible factors enhance the effector responses of CD8(+)Tcells to persistent antigen. Nat Immunol 2013;14:1173-82.
-
(2013)
Nat Immunol
, vol.14
, pp. 1173-1182
-
-
Doedens, A.L.1
Phan, A.T.2
Stradner, M.H.3
Fujimoto, J.K.4
Nguyen, J.V.5
Yang, E.6
-
22
-
-
84885055994
-
Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function
-
Sukumar M, Liu J, Ji Y, Subramanian M, Crompton JG, Yu Z, et al. Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function. J Clin Invest 2013;123:4479-88.
-
(2013)
J Clin Invest
, vol.123
, pp. 4479-4488
-
-
Sukumar, M.1
Liu, J.2
Ji, Y.3
Subramanian, M.4
Crompton, J.G.5
Yu, Z.6
-
23
-
-
66149118659
-
Tumor-infiltrating regulatory dendritic cells inhibit CD8+ T cell function via L-arginine metabolism
-
Norian LA, Rodriguez PC, O'Mara LA, Zabaleta J, Ochoa AC, Cella M, et al. Tumor-infiltrating regulatory dendritic cells inhibit CD8+ T cell function via L-arginine metabolism. Cancer Res 2009;69:3086-94.
-
(2009)
Cancer Res
, vol.69
, pp. 3086-3094
-
-
Norian, L.A.1
Rodriguez, P.C.2
O'Mara, L.A.3
Zabaleta, J.4
Ochoa, A.C.5
Cella, M.6
-
24
-
-
4143130091
-
Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses
-
Rodriguez PC, Quiceno DG, Zabaleta J, Ortiz B, Zea AH, Piazuelo MB, et al. Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses. Cancer Res 2004;64:5839-49.
-
(2004)
Cancer Res
, vol.64
, pp. 5839-5849
-
-
Rodriguez, P.C.1
Quiceno, D.G.2
Zabaleta, J.3
Ortiz, B.4
Zea, A.H.5
Piazuelo, M.B.6
-
25
-
-
80455179612
-
Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias
-
Brentjens RJ, Riviere I, Park JH, Davila ML, Wang X, Stefanski J, et al. Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias. Blood 2011;118:4817-28.
-
(2011)
Blood
, vol.118
, pp. 4817-4828
-
-
Brentjens, R.J.1
Riviere, I.2
Park, J.H.3
Davila, M.L.4
Wang, X.5
Stefanski, J.6
-
26
-
-
55949125601
-
Adoptive cell therapy for patients with metastatic melanoma: Evaluation of intensive myeloablative chemoradiation preparative regimens
-
Dudley ME, Yang JC, Sherry R, Hughes MS, Royal R, Kammula U, et al. Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens. J Clin Oncol 2008;26:5233-9.
-
(2008)
J Clin Oncol
, vol.26
, pp. 5233-5239
-
-
Dudley, M.E.1
Yang, J.C.2
Sherry, R.3
Hughes, M.S.4
Royal, R.5
Kammula, U.6
-
27
-
-
82955207691
-
Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma
-
Louis CU, Savoldo B, Dotti G, Pule M, Yvon E, Myers GD, et al. Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma. Blood 2011;118:6050-6.
-
(2011)
Blood
, vol.118
, pp. 6050-6056
-
-
Louis, C.U.1
Savoldo, B.2
Dotti, G.3
Pule, M.4
Yvon, E.5
Myers, G.D.6
-
28
-
-
67650074206
-
mTOR regulates memory CD8 T-cell differentiation
-
Araki K, Turner AP, Shaffer VO, Gangappa S, Keller SA, Bachmann MF, et al. mTOR regulates memory CD8 T-cell differentiation. Nature 2009;460: 108-12.
-
(2009)
Nature
, vol.460
, pp. 108-112
-
-
Araki, K.1
Turner, A.P.2
Shaffer, V.O.3
Gangappa, S.4
Keller, S.A.5
Bachmann, M.F.6
-
29
-
-
84892941233
-
Aptamer-targeted inhibition of mTOR in T cells enhances antitumor immunity
-
Berezhnoy A, Castro I, Levay A, Malek TR, Gilboa E. Aptamer-targeted inhibition of mTOR in T cells enhances antitumor immunity. J Clin Invest 2014;124:188-97.
-
(2014)
J Clin Invest
, vol.124
, pp. 188-197
-
-
Berezhnoy, A.1
Castro, I.2
Levay, A.3
Malek, T.R.4
Gilboa, E.5
-
30
-
-
84904264964
-
Immunememory-boosting doseofrapamycin impairs macrophage vesicle acidification and curtails glycolysis in effector CD8 cells, impairing defense against acute infections
-
Goldberg EL, Smithey MJ, Lutes LK, Uhrlaub JL, Nikolich-Zugich J. Immunememory-boosting doseofrapamycin impairs macrophage vesicle acidification and curtails glycolysis in effector CD8 cells, impairing defense against acute infections. J Immunol 2014;193:757-63.
-
(2014)
J Immunol
, vol.193
, pp. 757-763
-
-
Goldberg, E.L.1
Smithey, M.J.2
Lutes, L.K.3
Uhrlaub, J.L.4
Nikolich-Zugich, J.5
-
31
-
-
84859400580
-
Regulating mammalian target of rapamycin to tune vaccination-induced CD8(+)Tcellresponses for tumor immunity
-
Li Q, Rao R, Vazzana J, Goedegebuure P, Odunsi K, Gillanders W, et al. Regulating mammalian target of rapamycin to tune vaccination-induced CD8(+)Tcellresponses for tumor immunity. J Immunol 2012;188:3080-7.
-
(2012)
J Immunol
, vol.188
, pp. 3080-3087
-
-
Li, Q.1
Rao, R.2
Vazzana, J.3
Goedegebuure, P.4
Odunsi, K.5
Gillanders, W.6
-
32
-
-
84899561523
-
Foxp3+ T cells inhibit antitumor immune memory modulated by mTOR inhibition
-
Wang Y, Sparwasser T, Figlin R, Kim HL. Foxp3+ T cells inhibit antitumor immune memory modulated by mTOR inhibition. Cancer Res 2014;74:2217-28.
-
(2014)
Cancer Res
, vol.74
, pp. 2217-2228
-
-
Wang, Y.1
Sparwasser, T.2
Figlin, R.3
Kim, H.L.4
-
33
-
-
84914159677
-
Inhibition of akt signaling promotes the generation of superior tumor-reactive T cells for adoptive immunotherapy
-
van der Waart AB, van de Weem NM, Maas F, Kramer CS, Kester MG, Falkenburg JH, et al. Inhibition of Akt signaling promotes the generation of superior tumor-reactive T cells for adoptive immunotherapy. Blood 2014;124:3490-500.
-
(2014)
Blood
, vol.124
, pp. 3490-3500
-
-
Van Der Waart, A.B.1
Van De Weem, N.M.2
Maas, F.3
Kramer, C.S.4
Kester, M.G.5
Falkenburg, J.H.6
|