T cells that target carcinoembryonic antigen eradicate orthotopic pancreatic carcinomas without inducing autoimmune colitis in mice

Gastroenterology

Volumn 143, Issue 4, 2012, Pages

  Chmielewski, Markus ^a   Hahn, Olga ^a   Rappl, Gunter ^a   Nowak, Michael ^b   Schmidt Wolf, Ingo H ^b   Hombach, Andreas A ^a   Abken, Hinrich ^a,c  

^a UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^b UNIVERSITY HOSPITAL BONN   (Germany)

^c UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Adoptive Cell Therapy; CEA; Chimeric Antigen Receptor; Immune Cell Therapy

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; CYCLOHEXIMIDE; CYCLOPHOSPHAMIDE; FLUDARABINE; LUCIFERASE; SCA431; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; BEETLE; BIOLUMINESCENCE; CARCINOMA CELL; CELL ENGINEERING; CELL INFILTRATION; CELL THERAPY; CELLULAR IMMUNITY; CONTROLLED STUDY; DISEASE CONTROL; DISEASE MODEL; FIBROSARCOMA; HUMAN; HUMAN CELL; IMMUNOCOMPETENCE; LIMIT OF DETECTION; LUMINESCENCE; MOUSE; NONHUMAN; PANCREAS CANCER; PANCREAS CARCINOMA; PRIORITY JOURNAL; SARCOMA CELL; SINGLE DRUG DOSE; T LYMPHOCYTE; TRANSGENE;

EID: 84866653054     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2012.06.037     Document Type: Article

References (24)

1. D. Hariharan, A. Saied, H.M. Kocher Analysis of mortality rates for pancreatic cancer across the world HPB (Oxford) 10 2008 58 62
2. M.R. Parkhurst, J.C. Yang, R.C. Langan T cells targeting carcinoembryonic antigen can mediate regression of metastatic colorectal cancer but induce severe transient colitis Mol Ther 19 2011 620 626
3. J.N. Kochenderfer, W.H. Wilson, J.E. Janik Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19 Blood 116 2010 4099 4102
4. A. Hombach, C. Heuser, H. Abken The recombinant T cell receptor strategy: insights into structure and function of recombinant immunoreceptors on the way towards an optimal receptor design for cellular immunotherapy Curr Gene Ther 2 2002 211 226
5. S. Gansauge, F. Gansauge, H.G. Beger Molecular oncology in pancreatic cancer J Mol Med (Berl) 74 1996 313 320
6. J.W. Hodge Carcinoembryonic antigen as a target for cancer vaccines Cancer Immunol Immunother 43 1996 127 134
7. A.A. Hombach, V. Schildgen, C. Heuser T cell activation by antibody-like immunoreceptors: the position of the binding epitope within the target molecule determines the efficiency of activation of redirected T cells J Immunol 178 2007 4650 4657
8. A.M. Eades-Perner, P.H. van der, A. Hirth Mice transgenic for the human carcinoembryonic antigen gene maintain its spatiotemporal expression pattern Cancer Res 54 1994 4169 4176
9. T.H. Corbett, B.J. Roberts, W.R. Leopold Induction and chemotherapeutic response of two transplantable ductal adenocarcinomas of the pancreas in C57BL/6 mice Cancer Res 44 1984 717 726
10. A. Bruynck, G. Seemann, K. Bosslet Characterisation of a humanised bispecific monoclonal antibody for cancer therapy Br J Cancer 67 1993 436 440
11. K. Bosslet, A. Steinstraesser, A. Schwarz Quantitative considerations supporting the irrelevance of circulating serum CEA for the immunoscintigraphic visualization of CEA expressing carcinomas Eur J Nucl Med 14 1988 523
12. K.W. Hance, H.E. Zeytin, J.W. Greiner Mouse models expressing human carcinoembryonic antigen (CEA) as a transgene: evaluation of CEA-based cancer vaccines Mutat Res 576 2005 132 154
13. C.L. Smith, N. Dulphy, M. Salio Immunotherapy of colorectal cancer Br Med Bull 64 2002 181 200
14. P. Clarke, J. Mann, J.F. Simpson Mice transgenic for human carcinoembryonic antigen as a model for immunotherapy Cancer Res 58 1998 1469 1477
15. T. Ojima, M. Iwahashi, M. Nakamura Successful cancer vaccine therapy for carcinoembryonic antigen (CEA)-expressing colon cancer using genetically modified dendritic cells that express CEA and T helper-type 1 cytokines in CEA transgenic mice Int J Cancer 120 2007 585 593
16. R. Bos, S. van Duikeren, H. Morreau Balancing between antitumor efficacy and autoimmune pathology in T-cell-mediated targeting of carcinoembryonic antigen Cancer Res 68 2008 8446 8455
17. M.E. Dudley, J.C. Yang, R. Sherry Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens J Clin Oncol 26 2008 5233 5239
18. M.R. Parkhurst, J. Joo, J.P. Riley Characterization of genetically modified T-cell receptors that recognize the CEA:691-699 peptide in the context of HLA-A2.1 on human colorectal cancer cells Clin Cancer Res 15 2009 169 180
19. R.P. Junghans Is it safer CARs that we need, or safer rules of the road? Mol Ther 18 2010 1742 1743
20. M.E. Dudley, J.R. Wunderlich, P.F. Robbins Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes Science 298 2002 850 854
21. P.F. Robbins, M.E. Dudley, J. Wunderlich Cutting edge: persistence of transferred lymphocyte clonotypes correlates with cancer regression in patients receiving cell transfer therapy J Immunol 173 2004 7125 7130
22. C.M. Paulos, A. Kaiser, C. Wrzesinski Toll-like receptors in tumor immunotherapy Clin Cancer Res 13 2007 5280 5289
23. M. Kalos, B.L. Levine, D.L. Porter T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia Sci Transl Med 3 2011 95ra73
24. M. Chmielewski, G. Rappl, A.A. Hombach, H. Abken T cells redirected by a CD3ζ chimeric antigen receptor can establish self-antigen-specific tumour protection in the long term Gene Ther 2012 [Epub ahead of print]