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Volumn 9, Issue MAR, 2018, Pages

Advances in glioblastoma multiforme treatment: New models for nanoparticle therapy

Author keywords

Blood brain barrier modeling; Cytoscape; Delphinidin; Glioblastoma; Nanoparticle

Indexed keywords

BEVACIZUMAB; DELPHINIDIN; NANOPARTICLE; TEMOZOLOMIDE;

EID: 85044104001     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2018.00170     Document Type: Review
Times cited : (119)

References (91)
  • 1
    • 84997132543 scopus 로고    scopus 로고
    • Why one-size-fits-all vaso-modulatory interventions fail to control glioma invasion: in silico insights
    • Alfonso, J. C., Köhn-Luque, A., Stylianopoulos, T., Feuerhake, F., Deutsch, A., and Hatzikirou, H. (2016). Why one-size-fits-all vaso-modulatory interventions fail to control glioma invasion: in silico insights. Sci. Rep. 6:37283. doi: 10.1038/srep37283
    • (2016) Sci. Rep , vol.6
    • Alfonso, J.C.1    Köhn-Luque, A.2    Stylianopoulos, T.3    Feuerhake, F.4    Deutsch, A.5    Hatzikirou, H.6
  • 2
    • 84933672366 scopus 로고    scopus 로고
    • Glioblastoma multiforme: pathogenesis and treatment
    • Alifieris, C., and Trafalis, D. T. (2015). Glioblastoma multiforme: pathogenesis and treatment. Pharmacol. Ther. 152, 63-82. doi: 10.1016/j.pharmthera.2015.05.005
    • (2015) Pharmacol. Ther. , vol.152 , pp. 63-82
    • Alifieris, C.1    Trafalis, D.T.2
  • 3
    • 85011884912 scopus 로고    scopus 로고
    • Anthocyanins encapsulated by PLGA PEG nanoparticles potentially improved its free radical scavenging capabilities via p38/JNK pathway against Aß1-42-induced oxidative stress
    • Amin, F. U., Shah, S. A., Badshah, H., Khan, M., and Kim, M. O. (2017). Anthocyanins encapsulated by PLGA PEG nanoparticles potentially improved its free radical scavenging capabilities via p38/JNK pathway against Aß1-42-induced oxidative stress. J. Nanobiotechnol. 15, 12. doi: 10.1186/s12951-016-0227-4
    • (2017) J. Nanobiotechnol. , vol.15 , pp. 12
    • Amin, F.U.1    Shah, S.A.2    Badshah, H.3    Khan, M.4    Kim, M.O.5
  • 5
    • 84901589724 scopus 로고    scopus 로고
    • Ultrasound-mediated blood-brain barrier disruption for targeted drug delivery in the central nervous system
    • Aryal, M., Arvanitis, C. D., Alexander, P. M., and McDannold, N. (2014). Ultrasound-mediated blood-brain barrier disruption for targeted drug delivery in the central nervous system. Adv. Drug Deliv. Rev. 72, 94-109. doi: 10.1016/j.addr.2014.01.008
    • (2014) Adv. Drug Deliv. Rev. , vol.72 , pp. 94-109
    • Aryal, M.1    Arvanitis, C.D.2    Alexander, P.M.3    McDannold, N.4
  • 6
    • 34547816195 scopus 로고    scopus 로고
    • Mathematical model for the transport of Paclitaxel (Taxol) across the blood-brain barrier
    • Bandara, S., Diehl, M., and Fricker, G. (2007). Mathematical model for the transport of Paclitaxel (Taxol) across the blood-brain barrier. Chem. Eng. Res. Des. 85, 1065-1071. doi: 10.1205/cherd06238
    • (2007) Chem. Eng. Res. Des. , vol.85 , pp. 1065-1071
    • Bandara, S.1    Diehl, M.2    Fricker, G.3
  • 7
    • 34548427504 scopus 로고    scopus 로고
    • Active targeting of brain tumors using nanocarriers
    • Béduneau, A., Saulnier, P., and Benoit, J. P. (2007). Active targeting of brain tumors using nanocarriers. Biomaterials 28, 4947-4967. doi: 10.1016/j.biomaterials.2007.06.011
    • (2007) Biomaterials , vol.28 , pp. 4947-4967
    • Béduneau, A.1    Saulnier, P.2    Benoit, J.P.3
  • 8
    • 84904264611 scopus 로고    scopus 로고
    • Blood-brain barrier models and their relevance for a successful development of CNS drug delivery systems: a review
    • Bicker, J., Alves, G., Fortuna, A., and Falcão, A. (2014). Blood-brain barrier models and their relevance for a successful development of CNS drug delivery systems: a review. Eur. J. Pharm. Biopharm. 87, 409-432. doi: 10.1016/j.ejpb.2014.03.012
    • (2014) Eur. J. Pharm. Biopharm. , vol.87 , pp. 409-432
    • Bicker, J.1    Alves, G.2    Fortuna, A.3    Falcão, A.4
  • 9
    • 84856460087 scopus 로고    scopus 로고
    • Investigation of the migration/proliferation dichotomy and its impact on avascular glioma invasion
    • Böttger, K., Hatzikirou, H., Chauviere, A., and Deutsch, A. (2012). Investigation of the migration/proliferation dichotomy and its impact on avascular glioma invasion. Math. Model. Nat. Phenom. 7, 105-135. doi: 10.1051/mmnp/20127106
    • (2012) Math. Model. Nat. Phenom. , vol.7 , pp. 105-135
    • Böttger, K.1    Hatzikirou, H.2    Chauviere, A.3    Deutsch, A.4
  • 10
    • 0035108398 scopus 로고    scopus 로고
    • Multicenter phase II trial of temozolomide in patients with glioblastoma multiforme at first relapse
    • Brada, M., Hoang-Xuan, K., Rampling, R., Dietrich, P. Y., Dirix, L. Y., Macdonald, D., et al. (2001). Multicenter phase II trial of temozolomide in patients with glioblastoma multiforme at first relapse. Ann. Oncol. 12, 259-266. doi: 10.1023/A:1008382516636
    • (2001) Ann. Oncol. , vol.12 , pp. 259-266
    • Brada, M.1    Hoang-Xuan, K.2    Rampling, R.3    Dietrich, P.Y.4    Dirix, L.Y.5    Macdonald, D.6
  • 11
    • 84906482265 scopus 로고    scopus 로고
    • Mathematical modeling of efficient protocols to control glioma growth
    • Branco, J. R., Ferreira, J. A., and de Oliveira, P. (2014). Mathematical modeling of efficient protocols to control glioma growth. Math. Biosci. 255, 83-90. doi: 10.1016/j.mbs.2014.07.002
    • (2014) Math. Biosci. , vol.255 , pp. 83-90
    • Branco, J.R.1    Ferreira, J.A.2    de Oliveira, P.3
  • 12
    • 84941938990 scopus 로고    scopus 로고
    • Direct transfection of miR-137 mimics is more effective than DNA demethylation of miR-137 promoter to augment anti-tumor mechanisms of delphinidin in human glioblastoma U87MG and LN18 cells
    • Chakrabarti, M., and Ray, S. K. (2015). Direct transfection of miR-137 mimics is more effective than DNA demethylation of miR-137 promoter to augment anti-tumor mechanisms of delphinidin in human glioblastoma U87MG and LN18 cells. Gene 573, 141-152. doi: 10.1016/j.gene.2015.07.034
    • (2015) Gene , vol.573 , pp. 141-152
    • Chakrabarti, M.1    Ray, S.K.2
  • 13
    • 84896726167 scopus 로고    scopus 로고
    • Multifunctional nanoparticles for brain tumor imaging and therapy
    • Cheng, Y., Morshed, R. A., Auffinger, B., Tobias, A. L., and Lesniak, M. S. (2014). Multifunctional nanoparticles for brain tumor imaging and therapy. Adv. Drug Deliv. Rev. 66, 42-57. doi: 10.1016/j.addr.2013.09.006
    • (2014) Adv. Drug Deliv. Rev. , vol.66 , pp. 42-57
    • Cheng, Y.1    Morshed, R.A.2    Auffinger, B.3    Tobias, A.L.4    Lesniak, M.S.5
  • 14
    • 33646397592 scopus 로고    scopus 로고
    • Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells
    • Chithrani, B. D., Ghazani, A. A., and Chan, W. C. (2006). Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells. Nano Lett. 6, 662-668. doi: 10.1021/nl052396o
    • (2006) Nano Lett. , vol.6 , pp. 662-668
    • Chithrani, B.D.1    Ghazani, A.A.2    Chan, W.C.3
  • 16
    • 84940864404 scopus 로고    scopus 로고
    • Towards the personalized treatment of glioblastoma: integrating patient-specific clinical data in a continuous mechanical model
    • Colombo, M. C., Giverso, C., Faggiano, E., Boffano, C., Acerbi, F., and Ciarletta, P. (2015). Towards the personalized treatment of glioblastoma: integrating patient-specific clinical data in a continuous mechanical model. PLoS ONE 10:e0132887. doi: 10.1371/journal.pone.0132887
    • (2015) PLoS ONE , vol.10
    • Colombo, M.C.1    Giverso, C.2    Faggiano, E.3    Boffano, C.4    Acerbi, F.5    Ciarletta, P.6
  • 17
    • 43849112187 scopus 로고    scopus 로고
    • The receptor-mediated endocytosis of nonspherical particles
    • Decuzzi, P., and Ferrari, M. (2008). The receptor-mediated endocytosis of nonspherical particles. Biophys. J. 94, 3790-3797. doi: 10.1529/biophysj.107.120238
    • (2008) Biophys. J. , vol.94 , pp. 3790-3797
    • Decuzzi, P.1    Ferrari, M.2
  • 18
    • 0036627484 scopus 로고    scopus 로고
    • Drug transport to the brain: key roles for the efflux pump P-glycoprotein in the blood-brain barrier
    • Demeule, M., Régina, A., Jodoin, J., Laplante, A., Dagenais, C., Berthelet, F., et al. (2002). Drug transport to the brain: key roles for the efflux pump P-glycoprotein in the blood-brain barrier. Vascul. Pharmacol. 38, 339-348. doi: 10.1016/S1537-1891(02)00201-X
    • (2002) Vascul. Pharmacol. , vol.38 , pp. 339-348
    • Demeule, M.1    Régina, A.2    Jodoin, J.3    Laplante, A.4    Dagenais, C.5    Berthelet, F.6
  • 19
    • 84888309273 scopus 로고    scopus 로고
    • Enhanced accumulation of curcumin and temozolomide loaded magnetic nanoparticles executes profound cytotoxic effect in glioblastoma spheroid model
    • Dilnawaz, F., and Sahoo, S. K. (2013). Enhanced accumulation of curcumin and temozolomide loaded magnetic nanoparticles executes profound cytotoxic effect in glioblastoma spheroid model. Eur. J. Pharm. Biopharm. 85, 452-462. doi: 10.1016/j.ejpb.2013.07.013
    • (2013) Eur. J. Pharm. Biopharm. , vol.85 , pp. 452-462
    • Dilnawaz, F.1    Sahoo, S.K.2
  • 20
    • 85013856670 scopus 로고    scopus 로고
    • Numerical Methods in Biomedical Engineering
    • New York, NY: Academic Press; Elsevier.
    • Dunn, S., Constantinides, A., and Moghe, P. V. (2006). Numerical Methods in Biomedical Engineering. New York, NY: Academic Press; Elsevier.
    • (2006)
    • Dunn, S.1    Constantinides, A.2    Moghe, P.V.3
  • 21
    • 67649884820 scopus 로고    scopus 로고
    • Virtual glioblastoma: growth, migration and treatment in a three-dimensional mathematical model
    • Eikenberry, S. E., Sankar, T., Preul, M. C., Kostelich, E. J., Thalhauser, C. J., and Kuang, Y. (2009). Virtual glioblastoma: growth, migration and treatment in a three-dimensional mathematical model. Cell Prolif. 42, 511-528. doi: 10.1111/j.1365-2184.2009.00613.x
    • (2009) Cell Prolif. , vol.42 , pp. 511-528
    • Eikenberry, S.E.1    Sankar, T.2    Preul, M.C.3    Kostelich, E.J.4    Thalhauser, C.J.5    Kuang, Y.6
  • 22
    • 84930959876 scopus 로고    scopus 로고
    • Membrane lipid therapy: Modulation of the cell membrane composition and structure as a molecular base for drug discovery and new disease treatment
    • Escribá, P. V., Busquets, X., Inokuchi, J. I., Balogh, G., Török, Z., Horváth, I., et al. (2015). Membrane lipid therapy: Modulation of the cell membrane composition and structure as a molecular base for drug discovery and new disease treatment. Prog. Lipid Res. 59, 38-53. doi: 10.1016/j.plipres.2015.04.003
    • (2015) Prog. Lipid Res. , vol.59 , pp. 38-53
    • Escribá, P.V.1    Busquets, X.2    Inokuchi, J.I.3    Balogh, G.4    Törö k, Z.5    Horváth, I.6
  • 23
    • 62549085978 scopus 로고    scopus 로고
    • A mathematical model of doxorubicin penetration through multicellular layers
    • Evans, C. J., Phillips, R. M., Jones, P. F., Loadman, P. M., Sleeman, B. D., Twelves, C. J., et al. (2009). A mathematical model of doxorubicin penetration through multicellular layers. J. Theor. Biol. 257, 598. doi: 10.1016/j.jtbi.2008.11.031
    • (2009) J. Theor. Biol. , vol.257 , pp. 598
    • Evans, C.J.1    Phillips, R.M.2    Jones, P.F.3    Loadman, P.M.4    Sleeman, B.D.5    Twelves, C.J.6
  • 24
    • 79251537778 scopus 로고    scopus 로고
    • Controlling ligand surface density optimizes nanoparticle binding to ICAM-1
    • Fakhari, A., Baoum, A., Siahaan, T. J., Le, K. B., and Berkland, C. (2011). Controlling ligand surface density optimizes nanoparticle binding to ICAM-1. J. Pharm. Sci. 100, 1045-1056. doi: 10.1002/jps.22342
    • (2011) J. Pharm. Sci. , vol.100 , pp. 1045-1056
    • Fakhari, A.1    Baoum, A.2    Siahaan, T.J.3    Le, K.B.4    Berkland, C.5
  • 25
    • 84982883515 scopus 로고    scopus 로고
    • Drug delivery approaches for the treatment of glioblastoma multiforme
    • Fakhoury, M. (2015). Drug delivery approaches for the treatment of glioblastoma multiforme. Artif. Cells Nanomed. Biotechnol. 1401, 1-9. doi: 10.3109/21691401.2015.1052467
    • (2015) Artif. Cells Nanomed. Biotechnol. , vol.1401 , pp. 1-9
    • Fakhoury, M.1
  • 26
    • 85014783804 scopus 로고    scopus 로고
    • Nanocarriers for microRNA delivery in cancer medicine
    • Fernandez-Piñeiro, I., Badiola, I., and Sanchez, A. (2017). Nanocarriers for microRNA delivery in cancer medicine. Biotechnol. Adv. 35, 350-360. doi: 10.1016/j.biotechadv.2017.03.002
    • (2017) Biotechnol. Adv. , vol.35 , pp. 350-360
    • Fernandez-Piñeiro, I.1    Badiola, I.2    Sanchez, A.3
  • 27
    • 0027516695 scopus 로고
    • Meta-analysis of radiation therapy with and without adjuvant chemotherapy for malignant gliomas in adults
    • Fine, H. A., Dear, K. B., Loeffler, J. S., Black, P. M., and Canellos, G. P. (1993). Meta-analysis of radiation therapy with and without adjuvant chemotherapy for malignant gliomas in adults. Cancer 71, 2585-2597. doi:10.1002/1097-0142(19930415)71:8<2585::AID-CNCR2820710825>3.0.CO;2-S
    • (1993) Cancer , vol.71 , pp. 2585-2597
    • Fine, H.A.1    Dear, K.B.2    Loeffler, J.S.3    Black, P.M.4    Canellos, G.P.5
  • 28
    • 84863798167 scopus 로고    scopus 로고
    • Glioblastoma-derived tumor cells induce vasculogenic mimicry through Flk-1 protein activation
    • Francescone, R., Scully, S., Bentley, B., Yan, W., Taylor, S. L., Oh, D., et al. (2012). Glioblastoma-derived tumor cells induce vasculogenic mimicry through Flk-1 protein activation. J. Biol. Chem. 287, 24821-24831. doi: 10.1074/jbc.M111.334540
    • (2012) J. Biol. Chem. , vol.287 , pp. 24821-24831
    • Francescone, R.1    Scully, S.2    Bentley, B.3    Yan, W.4    Taylor, S.L.5    Oh, D.6
  • 29
  • 30
    • 84874526323 scopus 로고    scopus 로고
    • A computational model for predicting nanoparticle accumulation in tumor vasculature
    • Frieboes, H. B., Wu, M., Lowengrub, J., Decuzzi, P., and Cristini, V. (2013). A computational model for predicting nanoparticle accumulation in tumor vasculature. PLoS ONE 8:e56876. doi: 10.1371/journal.pone.0056876
    • (2013) PLoS ONE , vol.8
    • Frieboes, H.B.1    Wu, M.2    Lowengrub, J.3    Decuzzi, P.4    Cristini, V.5
  • 31
    • 70350461699 scopus 로고    scopus 로고
    • Bevacizumab alone and in combination with Irinotecan in recurrent glioblastoma
    • Friedman, H. S., Prados, M. D., Wen, P. Y., Mikkelsen, T., Schiff, D., Abrey, L. E., et al. (2009). Bevacizumab alone and in combination with Irinotecan in recurrent glioblastoma. J. Clin. Oncol. 27, 4733-4740. doi: 10.1200/JCO.2008.19.8721
    • (2009) J. Clin. Oncol. , vol.27 , pp. 4733-4740
    • Friedman, H.S.1    Prados, M.D.2    Wen, P.Y.3    Mikkelsen, T.4    Schiff, D.5    Abrey, L.E.6
  • 32
    • 84955178929 scopus 로고    scopus 로고
    • Limited advances in therapy of glioblastoma trigger re-consideration of research policy
    • Frosina, G. (2015). Limited advances in therapy of glioblastoma trigger re-consideration of research policy. Crit. Rev. Oncol. Hematol. 96, 257-261. doi: 10.1016/j.critrevonc.2015.05.013
    • (2015) Crit. Rev. Oncol. Hematol. , vol.96 , pp. 257-261
    • Frosina, G.1
  • 34
    • 79959267314 scopus 로고    scopus 로고
    • Computational modeling of tumor response to vascular-targeting therapies- Part I: validation
    • Gevertz, J. L. (2011). Computational modeling of tumor response to vascular-targeting therapies- Part I: validation. Comput. Math. Methods Med. 2011:830515. doi: 10.1155/2011/830515
    • (2011) Comput. Math. Methods Med , vol.2011 , pp. 830515
    • Gevertz, J.L.1
  • 35
    • 58149163462 scopus 로고    scopus 로고
    • Simulating tumor growth in confined heterogeneous environments
    • Gevertz, J. L., Gillies, G. T., and Torquato, S. (2008). Simulating tumor growth in confined heterogeneous environments. Phys. Biol. 5:036010. doi: 10.1088/1478-3975/5/3/036010
    • (2008) Phys. Biol , vol.5 , pp. 036010
    • Gevertz, J.L.1    Gillies, G.T.2    Torquato, S.3
  • 36
    • 8344282653 scopus 로고    scopus 로고
    • Targeting anti-transferrin receptor antibody (OX26) and OX26-conjugated liposomes to brain capillary endothelial cells using in situ perfusion
    • Gosk, S., Vermehren, C., Storm, G., and Moos, T. (2004). Targeting anti-transferrin receptor antibody (OX26) and OX26-conjugated liposomes to brain capillary endothelial cells using in situ perfusion. J. Cereb. Blood Flow. Metab. 24, 1193-1204. doi: 10.1097/01.WCB.0000135592.28823.47
    • (2004) J. Cereb. Blood Flow. Metab. , vol.24 , pp. 1193-1204
    • Gosk, S.1    Vermehren, C.2    Storm, G.3    Moos, T.4
  • 38
    • 85038361134 scopus 로고    scopus 로고
    • Blood-brain barrier permeation of glutathione-coated nanoparticle
    • Grover, A., Hirani, A., and Sutariya, V. (2014). Blood-brain barrier permeation of glutathione-coated nanoparticle. SOJ Pharm. Pharm. Sci. 4, 2-5. doi: 10.15226/2374-6866/1/1/00103
    • (2014) SOJ Pharm. Pharm. Sci. , vol.4 , pp. 2-5
    • Grover, A.1    Hirani, A.2    Sutariya, V.3
  • 39
    • 84892956242 scopus 로고    scopus 로고
    • Cell-based in vitro blood-brain barrier model can rapidly evaluate nanoparticles' brain permeability in association with particle size and surface modification
    • Hanada, S., Fujioka, K., Inoue, Y., Kanaya, F., Manome, Y., and Yamamoto, K. (2014). Cell-based in vitro blood-brain barrier model can rapidly evaluate nanoparticles' brain permeability in association with particle size and surface modification. Int. J. Mol. Sci. 15, 1812-1825. doi: 10.3390/ijms15021812
    • (2014) Int. J. Mol. Sci. , vol.15 , pp. 1812-1825
    • Hanada, S.1    Fujioka, K.2    Inoue, Y.3    Kanaya, F.4    Manome, Y.5    Yamamoto, K.6
  • 41
    • 84877040295 scopus 로고    scopus 로고
    • Tumor targeting and microenvironment-responsive nanoparticles for gene delivery
    • Huang, S., Shao, K., Kuang, Y., Liu, Y., Li, J., An, S., et al. (2013a). Tumor targeting and microenvironment-responsive nanoparticles for gene delivery. Biomaterials 34, 5294-5302. doi: 10.1016/j.biomaterials.2013.03.043
    • (2013) Biomaterials , vol.34 , pp. 5294-5302
    • Huang, S.1    Shao, K.2    Kuang, Y.3    Liu, Y.4    Li, J.5    An, S.6
  • 42
    • 84875648834 scopus 로고    scopus 로고
    • Tumor-targeting and microenvironment-responsive smart nanoparticles for combination therapy of antiangiogenesis and apoptosis
    • Huang, S., Shao, K., Liu, Y., Kuang, Y., Li, J., An, S., et al. (2013b). Tumor-targeting and microenvironment-responsive smart nanoparticles for combination therapy of antiangiogenesis and apoptosis. ACS Nano 7, 2860-2871. doi: 10.1021/nn400548g
    • (2013) ACS Nano , vol.7 , pp. 2860-2871
    • Huang, S.1    Shao, K.2    Liu, Y.3    Kuang, Y.4    Li, J.5    An, S.6
  • 43
    • 85044109983 scopus 로고    scopus 로고
    • Three-dimensional simulation of paclitaxel delivery to a brain tumor
    • Available online at
    • Huang, Y., Arifin, D. Y., and Wang, C. H. (2009). Three-dimensional simulation of paclitaxel delivery to a brain tumor. Brain 1, 2. Available online at: http://pdfs.semanticscholar.org/ceca/6a347a1342e8a94919c5682519b0bf4e366b.pdf
    • (2009) Brain 1, 2
    • Huang, Y.1    Arifin, D.Y.2    Wang, C.H.3
  • 44
    • 78049452610 scopus 로고    scopus 로고
    • Delivering nanomedicine to solid tumors
    • Jain, R. K., and Stylianopoulos, T. (2010). Delivering nanomedicine to solid tumors. Nat. Rev. Clin. Oncol. 7, 653-664. doi: 10.1038/nrclinonc.2010.139
    • (2010) Nat. Rev. Clin. Oncol. , vol.7 , pp. 653-664
    • Jain, R.K.1    Stylianopoulos, T.2
  • 45
    • 84942108229 scopus 로고    scopus 로고
    • Size, surface charge, and shape determine therapeutic effects of nanoparticles on brain and retinal diseases
    • Jo, D. H., Kim, J. H., Lee, T. G., and Kim, J. H. (2015). Size, surface charge, and shape determine therapeutic effects of nanoparticles on brain and retinal diseases. Nanomedicine 11, 1603-1611. doi: 10.1016/j.nano.2015.04.015
    • (2015) Nanomedicine , vol.11 , pp. 1603-1611
    • Jo, D.H.1    Kim, J.H.2    Lee, T.G.3    Kim, J.H.4
  • 46
    • 79957465397 scopus 로고    scopus 로고
    • Nanobiotechnology: application of nanotechnology in diagnosis, drug discovery and drug development
    • Available online at
    • Kawadkar, J. I., Chauhan, M. K., and Maharana, M. A. (2011). Nanobiotechnology: application of nanotechnology in diagnosis, drug discovery and drug development. Asian J. Pharm. Clin. Res. 4, 23-28. Available online at: http://www.ajpcr.com/Vol4Issue1/218.pdf
    • (2011) Asian J. Pharm. Clin. Res , vol.4 , pp. 23-28
    • Kawadkar, J.I.1    Chauhan, M.K.2    Maharana, M.A.3
  • 47
    • 84891067126 scopus 로고    scopus 로고
    • Current advances in mathematical modeling of anti-cancer drug penetration into tumor tissues
    • Kim, M., Gillies, R. J., and Rejniak, K. A. (2013). Current advances in mathematical modeling of anti-cancer drug penetration into tumor tissues. Front. Oncol. 3:278. doi: 10.3389/fonc.2013.00278
    • (2013) Front. Oncol , vol.3 , pp. 278
    • Kim, M.1    Gillies, R.J.2    Rejniak, K.A.3
  • 48
    • 85028449898 scopus 로고    scopus 로고
    • Enhanced neuroprotection of anthocyanin-loaded PEG-gold nanoparticles against Aß1-42-induced neuroinflammation and neurodegeneration via the NF-KB/ JNK/ GSK3ß signaling pathway
    • Kim, M. J., Rehman, S. U., Amin, F. U., and Kim, M. O. (2017). Enhanced neuroprotection of anthocyanin-loaded PEG-gold nanoparticles against Aß1-42-induced neuroinflammation and neurodegeneration via the NF-KB/ JNK/ GSK3ß signaling pathway. Nanomedicine 13, 2533-2544. doi: 10.1016/j.nano.2017.06.022
    • (2017) Nanomedicine , vol.13 , pp. 2533-2544
    • Kim, M.J.1    Rehman, S.U.2    Amin, F.U.3    Kim, M.O.4
  • 49
    • 84951570439 scopus 로고    scopus 로고
    • Effective treatment of glioblastoma requires crossing the blood-brain barrier and targeting tumors including cancer stem cells: The promise of nanomedicine
    • Kim, S. S., Harford, J. B., Pirollo, K. F., and Chang, E. H. (2015). Effective treatment of glioblastoma requires crossing the blood-brain barrier and targeting tumors including cancer stem cells: The promise of nanomedicine. Biochem. Biophys. Res. Commun. 468, 485-489. doi: 10.1016/j.bbrc.2015.06.137
    • (2015) Biochem. Biophys. Res. Commun. , vol.468 , pp. 485-489
    • Kim, S.S.1    Harford, J.B.2    Pirollo, K.F.3    Chang, E.H.4
  • 50
    • 77954341696 scopus 로고    scopus 로고
    • Survival signalling and apoptosis resistance in glioblastomas: opportunities for targeted therapeutics
    • Krakstad, C., and Chekenya, M. (2010). Survival signalling and apoptosis resistance in glioblastomas: opportunities for targeted therapeutics. Mol. Cancer 9:135. doi: 10.1186/1476-4598-9-135
    • (2010) Mol. Cancer , vol.9 , pp. 135
    • Krakstad, C.1    Chekenya, M.2
  • 51
    • 85007137392 scopus 로고    scopus 로고
    • Tanycytes: a gateway to the metabolic hypothalamus
    • Langlet, F. (2014). Tanycytes: a gateway to the metabolic hypothalamus. J. Neuroendocrinol. 26, 753-760. doi: 10.1111/jne.12191
    • (2014) J. Neuroendocrinol. , vol.26 , pp. 753-760
    • Langlet, F.1
  • 52
    • 84881550022 scopus 로고    scopus 로고
    • Tanycyte-like cells form a blood-cerebrospinal fluid barrier in the circumventricular organs of the mouse brain
    • Langlet, F., Mullier, A., Bouret, S. G., Prevot, V., and Dehouck, B. (2013). Tanycyte-like cells form a blood-cerebrospinal fluid barrier in the circumventricular organs of the mouse brain. J. Comp. Neurol. 521, 3389-3405. doi: 10.1002/cne.23355
    • (2013) J. Comp. Neurol. , vol.521 , pp. 3389-3405
    • Langlet, F.1    Mullier, A.2    Bouret, S.G.3    Prevot, V.4    Dehouck, B.5
  • 53
    • 84947648721 scopus 로고    scopus 로고
    • Nanoparticle-mediated growth factor delivery systems: a new way to treat Alzheimer's disease
    • Lauzon, M. A., Daviau, A., Marcos, B., and Faucheux, N. (2015). Nanoparticle-mediated growth factor delivery systems: a new way to treat Alzheimer's disease. J. Control. Release 206, 187-205. doi: 10.1016/j.jconrel.2015.03.024
    • (2015) J. Control. Release , vol.206 , pp. 187-205
    • Lauzon, M.A.1    Daviau, A.2    Marcos, B.3    Faucheux, N.4
  • 54
    • 84929492799 scopus 로고    scopus 로고
    • Simulation predicts IGFBP2-HIF1a interaction drives glioblastoma growth
    • Lin, K. W., Liao, A., and Qutub, A. A. (2015). Simulation predicts IGFBP2-HIF1a interaction drives glioblastoma growth. PLOS Comput. Biol. 11:e1004169. doi: 10.1371/journal.pcbi.1004169
    • (2015) PLOS Comput. Biol , vol.11
    • Lin, K.W.1    Liao, A.2    Qutub, A.A.3
  • 55
    • 84862090881 scopus 로고    scopus 로고
    • Recent advances in brain tumor-targeted nano-drug delivery systems
    • Liu, Y., and Lu, W. (2012). Recent advances in brain tumor-targeted nano-drug delivery systems. Expert Opin. Drug Deliv. 9, 671-686. doi: 10.1517/17425247.2012.682726
    • (2012) Expert Opin. Drug Deliv. , vol.9 , pp. 671-686
    • Liu, Y.1    Lu, W.2
  • 58
    • 84988598646 scopus 로고    scopus 로고
    • Computational modeling to predict the functions and impact of drug transporters
    • Matsson, P., and Bergström, C. A. (2015). Computational modeling to predict the functions and impact of drug transporters. Silico Pharmacol. 3, 8. doi: 10.1186/s40203-015-0012-3
    • (2015) Silico Pharmacol. , vol.3 , pp. 8
    • Matsson, P.1    Bergström, C.A.2
  • 59
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • McLendon, R., Friedman, A., Bigner, D., Van Meir, E. G., Brat, D. J., Mastrogianakis, G. M., et al. (2008). Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455, 1061-1068.
    • (2008) Nature , vol.455 , pp. 1061-1068
    • McLendon, R.1    Friedman, A.2    Bigner, D.3    Van Meir, E.G.4    Brat, D.J.5    Mastrogianakis, G.M.6
  • 61
    • 84877859124 scopus 로고    scopus 로고
    • Response classification based on a minimal model of glioblastoma growth is prognostic for clinical outcomes and distinguishes progression from pseudoprogression
    • Neal, M. L., Trister, A. D., Ahn, S., Baldock, A., Bridge, C. A., Guyman, L., et al. (2013). Response classification based on a minimal model of glioblastoma growth is prognostic for clinical outcomes and distinguishes progression from pseudoprogression. Cancer Res. 73, 2976-2986. doi: 10.1158/0008-5472.CAN-12-3588
    • (2013) Cancer Res. , vol.73 , pp. 2976-2986
    • Neal, M.L.1    Trister, A.D.2    Ahn, S.3    Baldock, A.4    Bridge, C.A.5    Guyman, L.6
  • 62
    • 84901020087 scopus 로고    scopus 로고
    • Epithelial membrane protein-2 (EMP2) activates Src protein and is a novel therapeutic target for glioblastoma
    • Qin, Y., Fu, M., Takahashi, M., Iwanami, A., Kuga, D., Rao, R. G., et al. (2014). Epithelial membrane protein-2 (EMP2) activates Src protein and is a novel therapeutic target for glioblastoma. J. Biol. Chem. 289, 13974-13985. doi: 10.1074/jbc.M113.543728
    • (2014) J. Biol. Chem. , vol.289 , pp. 13974-13985
    • Qin, Y.1    Fu, M.2    Takahashi, M.3    Iwanami, A.4    Kuga, D.5    Rao, R.G.6
  • 63
    • 0026076377 scopus 로고
    • The relationship between survival and the extent of the resection in patients with supratentorial malignant gliomas
    • Discussion: 388-389
    • Quigley, M. R., and Maroon, J. C. (1991). The relationship between survival and the extent of the resection in patients with supratentorial malignant gliomas. Neurosurgery 29, 385-388. Discussion: 388-389. doi: 10.1227/00006123-199109000-00008
    • (1991) Neurosurgery , vol.29 , pp. 385-388
    • Quigley, M.R.1    Maroon, J.C.2
  • 64
    • 84961566869 scopus 로고    scopus 로고
    • In silico tumor control induced via alternating immunostimulating and immunosuppressive phases
    • Reppas, A. I., Alfonso, J. C., and Hatzikirou, H. (2016). In silico tumor control induced via alternating immunostimulating and immunosuppressive phases. Virulence 7, 174-186. doi: 10.1080/21505594.2015.1076614
    • (2016) Virulence , vol.7 , pp. 174-186
    • Reppas, A.I.1    Alfonso, J.C.2    Hatzikirou, H.3
  • 65
    • 84964698904 scopus 로고    scopus 로고
    • A patient-specific computational model of hypoxia-modulated radiation resistance in glioblastoma using 18F-FMISO-PET
    • Rockne, R. C., Trister, A. D., Jacobs, J., Hawkins-Daarud, A. J., Neal, M. L., Hendrickson, K., et al. (2004). A patient-specific computational model of hypoxia-modulated radiation resistance in glioblastoma using 18F-FMISO-PET. J. R. Soc. Interface 12:20141174. doi: 10.1098/rsif.2014.1174
    • (2004) J. R. Soc. Interface , vol.12
    • Rockne, R.C.1    Trister, A.D.2    Jacobs, J.3    Hawkins-Daarud, A.J.4    Neal, M.L.5    Hendrickson, K.6
  • 67
    • 2942577499 scopus 로고    scopus 로고
    • Applications of nanoparticles in biology and medicine
    • Salata, O. (2004). Applications of nanoparticles in biology and medicine. J. Nanobiotechnol. 2:3. doi: 10.1186/1477-3155-2-3
    • (2004) J. Nanobiotechnol , vol.2 , pp. 3
    • Salata, O.1
  • 68
    • 0018628457 scopus 로고
    • High dose radiation therapy in the treatment of malignant gliomas: final report
    • Salazar, O. M., Rubin, P., Feldstein, M. L., and Pizzutiello, R. (1979). High dose radiation therapy in the treatment of malignant gliomas: final report. Int. J. Radiat. Oncol. Biol. Phys. 5, 1733-1740. doi: 10.1016/0360-3016(79)90554-6
    • (1979) Int. J. Radiat. Oncol. Biol. Phys. , vol.5 , pp. 1733-1740
    • Salazar, O.M.1    Rubin, P.2    Feldstein, M.L.3    Pizzutiello, R.4
  • 69
    • 0024057883 scopus 로고
    • Surgical resection of malignant brain tumors: who benefits?
    • 59-60, 63.
    • Salcman, M. (1988). Surgical resection of malignant brain tumors: who benefits? Oncology 2, 47-56, 59-60, 63.
    • (1988) Oncology , vol.2 , pp. 47-56
    • Salcman, M.1
  • 70
    • 0025771713 scopus 로고
    • Drugs released from polymers: diffusion and elimination in brain tissue
    • Saltzman, W. M., and Radomsky, M. L. (1991). Drugs released from polymers: diffusion and elimination in brain tissue. Chem. Eng. Sci. 46, 2429-2444. doi: 10.1016/0009-2509(91)80036-X
    • (1991) Chem. Eng. Sci. , vol.46 , pp. 2429-2444
    • Saltzman, W.M.1    Radomsky, M.L.2
  • 71
    • 84866509184 scopus 로고    scopus 로고
    • Computational modeling of single-cell migration: the leading role of extracellular matrix fibers
    • Schlüter, D. K., Ramis-Conde, I., and Chaplain, M. A. J. (2012). Computational modeling of single-cell migration: the leading role of extracellular matrix fibers. Biophys. J. 6, 1141-1151. doi: 10.1016/j.bpj.2012.07.048
    • (2012) Biophys. J. , vol.6 , pp. 1141-1151
    • Schlüter, D.K.1    Ramis-Conde, I.2    Chaplain, M.A.J.3
  • 72
    • 84939935260 scopus 로고    scopus 로고
    • Nanomedicine to overcome radioresistance in glioblastoma stem-like cells and surviving clones
    • Séhédic, D., Cikankowitz, A., Hindré, F., Davodeau, F., and Garcion, E. (2015). Nanomedicine to overcome radioresistance in glioblastoma stem-like cells and surviving clones. Trends Pharmacol. Sci. 36, 236-252. doi: 10.1016/j.tips.2015.02.002
    • (2015) Trends Pharmacol. Sci , vol.36 , pp. 236-252
    • Séhédic, D.1    Cikankowitz, A.2    Hindré, F.3    Davodeau, F.4    Garcion, E.5
  • 73
    • 84255170467 scopus 로고    scopus 로고
    • Quantifying the role of angiogenesis in malignant progression of gliomas: in silico modeling integrates imaging and histology
    • Swanson, K. R., Rockne, R. C., Claridge, J., Chaplain, M. A., Alvord, E. C., and Anderson, A. R. (2011). Quantifying the role of angiogenesis in malignant progression of gliomas: in silico modeling integrates imaging and histology. Cancer Res. 71, 7366-7375. doi: 10.1158/0008-5472.CAN-11-1399
    • (2011) Cancer Res. , vol.71 , pp. 7366-7375
    • Swanson, K.R.1    Rockne, R.C.2    Claridge, J.3    Chaplain, M.A.4    Alvord, E.C.5    Anderson, A.R.6
  • 74
    • 16444363225 scopus 로고    scopus 로고
    • Ligand density effect on biorecognition by PEGylated gold nanoparticles: regulated interaction of RCA120 lectin with lactose installed to the distal end of tethered PEG strands on gold surface
    • Takae, S., Akiyama, Y., Otsuka, H., Nakamura, T., Nagasaki, Y., and Kataoka, K. (2005). Ligand density effect on biorecognition by PEGylated gold nanoparticles: regulated interaction of RCA120 lectin with lactose installed to the distal end of tethered PEG strands on gold surface. Biomacromolecules 6, 818-824. doi: 10.1021/bm049427e
    • (2005) Biomacromolecules , vol.6 , pp. 818-824
    • Takae, S.1    Akiyama, Y.2    Otsuka, H.3    Nakamura, T.4    Nagasaki, Y.5    Kataoka, K.6
  • 75
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • TCGA (2008). Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455, 1061-1068. doi: 10.1038/nature07385
    • (2008) Nature , vol.455 , pp. 1061-1068
  • 76
    • 80052566106 scopus 로고    scopus 로고
    • Identification of intrinsic in vitro cellular mechanisms for glioma invasion
    • Tektonidis, M., Hatzikirou, H., Chauvière, A., Simon, M., Schaller, K., and Deutsch, A. (2011). Identification of intrinsic in vitro cellular mechanisms for glioma invasion. J. Theor. Biol. 287, 131-147. doi: 10.1016/j.jtbi.2011.07.012
    • (2011) J. Theor. Biol. , vol.287 , pp. 131-147
    • Tektonidis, M.1    Hatzikirou, H.2    Chauvière, A.3    Simon, M.4    Schaller, K.5    Deutsch, A.6
  • 77
    • 85044104120 scopus 로고
    • Available online at(Accessed May 24, 2017).
    • The New WHO Classification of Tumors Affecting the Central Nervous System [WWW Document] (1993). Available online at: http://neurosurgery.mgh.harvard.edu/newwhobt.htm (Accessed May 24, 2017).
    • (1993)
  • 78
    • 84927178674 scopus 로고    scopus 로고
    • A novel literature-based approach to identify genetic and molecular predictors of survival in glioblastoma multiforme: analysis of 14,678 patients using systematic review and meta-analytical tools
    • Thuy, M. N., Kam, J. K., Lee, G. C., Tao, P. L., Ling, D. Q., Cheng, M., et al. (2015). A novel literature-based approach to identify genetic and molecular predictors of survival in glioblastoma multiforme: analysis of 14,678 patients using systematic review and meta-analytical tools. J. Clin. Neurosci. 22, 785-799. doi: 10.1016/j.jocn.2014.10.029
    • (2015) J. Clin. Neurosci. , vol.22 , pp. 785-799
    • Thuy, M.N.1    Kam, J.K.2    Lee, G.C.3    Tao, P.L.4    Ling, D.Q.5    Cheng, M.6
  • 79
    • 84947485225 scopus 로고    scopus 로고
    • Drug and gene delivery across the blood-brain barrier with focused ultrasound
    • Timbie, K. F., Mead, B. P., and Price, R. J. (2015). Drug and gene delivery across the blood-brain barrier with focused ultrasound. J. Control. Release 219, 61-75. doi: 10.1016/j.jconrel.2015.08.059
    • (2015) J. Control. Release , vol.219 , pp. 61-75
    • Timbie, K.F.1    Mead, B.P.2    Price, R.J.3
  • 80
    • 79953048071 scopus 로고    scopus 로고
    • Tumor delivery of macromolecular drugs based on the EPR effect
    • Torchilin, V. (2011). Tumor delivery of macromolecular drugs based on the EPR effect. Adv. Drug Deliv. Rev. 63, 131-135. doi: 10.1016/j.addr.2010.03.011
    • (2011) Adv. Drug Deliv. Rev. , vol.63 , pp. 131-135
    • Torchilin, V.1
  • 82
    • 0019142613 scopus 로고
    • Randomized comparisons of radiotherapy and nitrosoureas for the treatment of maligant glioma after surgery
    • Walker, M. D., Green, S. B., Byar, D. P., Alexander Jr, E., Batzdorf, U., Brooks, W. H., et al. (1980). Randomized comparisons of radiotherapy and nitrosoureas for the treatment of maligant glioma after surgery. N. Engl. J. Med. 303, 1323-1329. doi: 10.1056/NEJM198012043032303
    • (1980) N. Engl. J. Med. , vol.303 , pp. 1323-1329
    • Walker, M.D.1    Green, S.B.2    Byar, D.P.3    Alexander, E.4    Batzdorf, U.5    Brooks, W.H.6
  • 83
    • 85007607595 scopus 로고    scopus 로고
    • A mathematical model of tumor growth and its response to single irradiation
    • Watanabe, Y., Dahlman, E. L., Leder, K. Z., and Hui, S. K. (2016). A mathematical model of tumor growth and its response to single irradiation. Theor. Biol. Med. Model. 13, 6. doi: 10.1186/s12976-016-0032-7
    • (2016) Theor. Biol. Med. Model. , vol.13 , pp. 6
    • Watanabe, Y.1    Dahlman, E.L.2    Leder, K.Z.3    Hui, S.K.4
  • 84
    • 84925664415 scopus 로고    scopus 로고
    • ATM and ATR as therapeutic targets in cancer
    • Weber, A. M., and Ryan, A. J. (2015). ATM and ATR as therapeutic targets in cancer. Pharmacol. Ther. 149, 124-138. doi: 10.1016/j.pharmthera.2014.12.001
    • (2015) Pharmacol. Ther. , vol.149 , pp. 124-138
    • Weber, A.M.1    Ryan, A.J.2
  • 85
    • 84925301551 scopus 로고    scopus 로고
    • Brain tumor-targeted drug delivery strategies
    • Wei, X., Chen, X., Ying, M., and Lu, W. (2014). Brain tumor-targeted drug delivery strategies. Acta Pharm. Sin. B 4, 193-201. doi: 10.1016/j.apsb.2014.03.001
    • (2014) Acta Pharm. Sin. B , vol.4 , pp. 193-201
    • Wei, X.1    Chen, X.2    Ying, M.3    Lu, W.4
  • 86
    • 48249125791 scopus 로고    scopus 로고
    • Malignant gliomas in adults
    • Wen, P. Y., and Kesari, S. (2008). Malignant gliomas in adults. New Engl. J. Med. 359, 492-507. doi: 10.1056/NEJMra0708126
    • (2008) New Engl. J. Med. , vol.359 , pp. 492-507
    • Wen, P.Y.1    Kesari, S.2
  • 87
    • 84948711443 scopus 로고    scopus 로고
    • First in human nanotechnology doxorubicin delivery system to target epidermal growth factor receptors in recurrent glioblastoma
    • Whittle, J. R., Lickliter, J. D., Gan, H. K., Scott, A. M., Simes, J., Solomon, B. J., et al. (2015). First in human nanotechnology doxorubicin delivery system to target epidermal growth factor receptors in recurrent glioblastoma. J. Clin. Neurosci. 22, 1889-1894. doi: 10.1016/j.jocn.2015.06.005
    • (2015) J. Clin. Neurosci. , vol.22 , pp. 1889-1894
    • Whittle, J.R.1    Lickliter, J.D.2    Gan, H.K.3    Scott, A.M.4    Simes, J.5    Solomon, B.J.6
  • 88
    • 0016904717 scopus 로고
    • Chemotherapy of brain tumors
    • Wilson, C. B. (1976). Chemotherapy of brain tumors. Adv. Neurol. 15, 361-367.
    • (1976) Adv. Neurol , vol.15 , pp. 361-367
    • Wilson, C.B.1
  • 89
    • 0032855728 scopus 로고    scopus 로고
    • Multicenter phase II trial of temozolomide in patients with anaplastic astrocytoma or anaplastic oligoastrocytoma at first relapse
    • Yung, W. K., Prados, M. D., Yaya-Tur, R., Rosenfeld, S. S., Brada, M., Freidman, H. S., et al. (1999). Multicenter phase II trial of temozolomide in patients with anaplastic astrocytoma or anaplastic oligoastrocytoma at first relapse. Temodal. Brain Tumor. Group. J. Clin. Oncol. 17, 2762-2771. doi: 10.1200/JCO.1999.17.9.2762
    • (1999) Temodal. Brain Tumor. Group. J. Clin. Oncol. , vol.17 , pp. 2762-2771
    • Yung, W.K.1    Prados, M.D.2    Yaya-Tur, R.3    Rosenfeld, S.S.4    Brada, M.5    Freidman, H.S.6
  • 90
    • 33750974791 scopus 로고    scopus 로고
    • Development of three-dimensional multiscale agent-based tumor model: simulating gene protein interaction profiles, cell phenotypes and multicellular patterns in brain cancer
    • Zhang, L., Athale, C. A., and Deisboeck, T. S. (2007). Development of three-dimensional multiscale agent-based tumor model: simulating gene protein interaction profiles, cell phenotypes and multicellular patterns in brain cancer. J. Theor. Biol. 244, 96-107. doi: 10.1016/j.jtbi.2006.06.034
    • (2007) J. Theor. Biol. , vol.244 , pp. 96-107
    • Zhang, L.1    Athale, C.A.2    Deisboeck, T.S.3


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