Cas4-Dependent Prespacer Processing Ensures High-Fidelity Programming of CRISPR Arrays

Molecular Cell

Volumn 70, Issue 1, 2018, Pages 48-59.e5

  Lee, Hayun ^a   Zhou, Yi ^b   Taylor, David W ^b   Sashital, Dipali G ^a  

^a IOWA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Cas1 Cas2; Cas4; CRISPR Cas; DNA cleavage; DNA integration; negative stain EM

Indexed keywords

CAS1 INTEGRASE; CAS2 PROTEIN; CAS4 PROTEIN; CRISPR ASSOCIATED PROTEIN; DIMER; INTEGRASE; UNCLASSIFIED DRUG; BACTERIAL DNA; DEOXYRIBONUCLEASE; ESCHERICHIA COLI PROTEIN; MULTIENZYME COMPLEX; YGBT PROTEIN, E COLI;

ARTICLE; BACILLUS HALODURANS; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CONTROLLED STUDY; PROTEIN CLEAVAGE; PROTEIN INTERACTION; CONFORMATION; CRISPR CAS SYSTEM; ENZYME SPECIFICITY; ENZYMOLOGY; ESCHERICHIA COLI; GENE EDITING; GENETICS; IMMUNOLOGY; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR MODEL; PROCEDURES; PROTEIN CONFORMATION; PROTEIN SUBUNIT;

CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; CRISPR-ASSOCIATED PROTEIN 9; CRISPR-ASSOCIATED PROTEINS; CRISPR-CAS SYSTEMS; DNA, BACTERIAL; ENDODEOXYRIBONUCLEASES; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GENE EDITING; MODELS, MOLECULAR; MULTIENZYME COMPLEXES; NUCLEIC ACID CONFORMATION; PROTEIN CONFORMATION; PROTEIN SUBUNITS; SUBSTRATE SPECIFICITY;

EID: 85044055719     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2018.03.003     Document Type: Article

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