Cutting it close: CRISPR-associated endoribonuclease structure and function

Trends in Biochemical Sciences

Volumn 40, Issue 1, 2015, Pages 58-66

  Hochstrasser, Megan L ^a   Doudna, Jennifer A ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

Cas5; Cas6; CRISPR Cas; crRNA; Endoribonuclease; Structure and function

Indexed keywords

CRISPR ASSOCIATED PROTEIN; RIBONUCLEASE; RNA; CRISPR-ASSOCIATED PROTEINS; ENDORIBONUCLEASES;

AMINO TERMINAL SEQUENCE; BACILLUS HALODURANS; BIOGENESIS; CARBOXY TERMINAL SEQUENCE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME DEGRADATION; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STRUCTURE; ESCHERICHIA COLI; EUKARYOTE; MANNHEIMIA; METHANOCOCCUS MARIPALUDIS; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN METABOLISM; PROTEIN RNA BINDING; PSEUDOMONAS AERUGINOSA; PYROCOCCUS FURIOSUS; PYROCOCCUS HORIKOSHII; REVIEW; SIGNAL TRANSDUCTION; STAPHYLOCOCCUS EPIDERMIDIS; STREPTOCOCCUS PYOGENES; SULFOLOBUS SOLFATARICUS; THERMUS THERMOPHILUS; XANTHOMONAS ORYZAE; BACTERIA; CHEMISTRY; CRISPR-CAS SYSTEMS; GENETICS; IMMUNOLOGY; METABOLISM; PROTEIN CONFORMATION; PROTEIN FOLDING; RNA INTERFERENCE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EUKARYOTA;

BACTERIA; CRISPR-ASSOCIATED PROTEINS; CRISPR-CAS SYSTEMS; ENDORIBONUCLEASES; PROTEIN CONFORMATION; PROTEIN FOLDING; RNA; RNA INTERFERENCE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 84924740446     PISSN: 09680004     EISSN: 13624326     Source Type: Journal    
DOI: 10.1016/j.tibs.2014.10.007     Document Type: Review

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