Foreign DNA capture during CRISPR-Cas adaptive immunity

Nature

Volumn 527, Issue 7579, 2015, Pages 535-538

  Nuñez, James K ^a   Harrington, Lucas B ^a   Kranzusch, Philip J ^a   Engelman, Alan N ^b,c   Doudna, Jennifer A ^a,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; FOREIGN DNA; INTEGRASE; NUCLEOTIDE; PROTEIN CAS1; PROTEIN CAS2; SINGLE STRANDED DNA; UNCLASSIFIED DRUG; CRISPR ASSOCIATED PROTEIN; VIRUS DNA;

BACTERIUM; CRYSTAL STRUCTURE; DNA; IMMUNITY; PLASMID; PROTEIN;

ADAPTIVE IMMUNITY; AMINO ACID SEQUENCE; ARTICLE; BASE PAIRING; CONTROLLED STUDY; CRISPR CAS SYSTEM; CRYSTAL STRUCTURE; DNA INTEGRATION; DNA STRAND; ENZYME ACTIVE SITE; ESCHERICHIA COLI; GENE LOCUS; IN VIVO STUDY; NONHUMAN; NUCLEOPHILICITY; PRIORITY JOURNAL; PROTEIN FUNCTION; SEQUENCE ALIGNMENT; CHEMICAL STRUCTURE; CHEMISTRY; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; ENTEROBACTERIA PHAGE M13; ENZYMOLOGY; GENETICS; IMMUNOLOGY; METABOLISM; NUCLEOTIDE SEQUENCE; VIROLOGY; VIRUS DNA CELL DNA INTERACTION; X RAY CRYSTALLOGRAPHY;

ESCHERICHIA COLI;

ADAPTIVE IMMUNITY; BACTERIOPHAGE M13; BASE SEQUENCE; CATALYTIC DOMAIN; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; CRISPR-ASSOCIATED PROTEINS; CRYSTALLOGRAPHY, X-RAY; DNA, VIRAL; ESCHERICHIA COLI; INTEGRASES; MODELS, MOLECULAR; VIRUS INTEGRATION;

EID: 84947495037     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature15760     Document Type: Article

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