A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo

Nature Biotechnology

Volumn 36, Issue 3, 2018, Pages 258-264

  Li, Suping ^a,b   Jiang, Qiao ^a   Liu, Shaoli ^a,b   Zhang, Yinlong ^a,c   Tian, Yanhua ^a,d   Song, Chen ^a   Wang, Jing ^a   Zou, Yiguo ^a   Anderson, Gregory J ^e   Han, Jing Yan ^f   Chang, Yung ^g   Liu, Yan ^g   Zhang, Chen ^h   Chen, Liang ⁱ   Zhou, Guangbiao ^h   Nie, Guangjun ^a,b   Yan, Hao ^g   Ding, Baoquan ^a,b   Zhao, Yuliang ^a,b  

^a NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^d PEKING UNIVERSITY   (China)

^e QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^f PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^g ARIZONA STATE UNIVERSITY   (United States)

^h INSTITUTE OF ZOOLOGY   (China)

ⁱ JINAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD VESSELS; COAGULATION; CONTROLLED DRUG DELIVERY; DISEASES; DNA; ENDOTHELIAL CELLS; ENZYMES; INTELLIGENT ROBOTS; MAMMALS; NANOROBOTS; TARGETED DRUG DELIVERY; TUMORS;

AUTONOMOUS DNA; BLOOD COAGULATION; CANCER THERAPY; DRUG DELIVERY SYSTEM; FUNCTIONALIZED; INHIBITION OF TUMOR GROWTH; INNER CAVITIES; TUMOR NECROSIS;

NANOROBOTICS;

DNA; NANOMATERIAL; NUCLEOLIN; THROMBIN; APTAMER; PHOSPHOPROTEIN; PROTEIN BINDING; RNA BINDING PROTEIN;

ANIMAL CELL; ARTICLE; ATOMIC FORCE MICROSCOPY; CANCER THERAPY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; FEMALE; GENE TARGETING; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; UMBILICAL VEIN ENDOTHELIAL CELL; ANIMAL; BLOOD VESSEL; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECT; DRUG SCREENING; ENDOTHELIUM CELL; GENETICS; GROWTH, DEVELOPMENT AND AGING; NEOPLASM; PATHOLOGY; PIG;

ANIMALS; APTAMERS, NUCLEOTIDE; BLOOD VESSELS; CELL PROLIFERATION; DNA; DRUG DELIVERY SYSTEMS; ENDOTHELIAL CELLS; HUMANS; MICE; NEOPLASMS; PHOSPHOPROTEINS; PROTEIN BINDING; RNA-BINDING PROTEINS; SWINE; THROMBIN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 85042935014     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.4071     Document Type: Article

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