DNA origami as an in vivo drug delivery vehicle for cancer therapy

ACS Nano

Volumn 8, Issue 7, 2014, Pages 6633-6643

  Zhang, Qian ^a,b,d   Jiang, Qiao ^c   Li, Na ^c   Dai, Luru ^c   Liu, Qing ^c   Song, Linlin ^c   Wang, Jinye ^c   Li, Yaqian ^b   Tian, Jie ^a,b,d   Ding, Baoquan ^c   Du, Yang ^b  

^a XIDIAN UNIVERSITY   (China)

^b INSTITUTE OF AUTOMATION   (China)

^c NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY   (China)

^d BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

cancer therapy; DNA origami; doxorubicin; fluorescence imaging; in vivo delivery

Indexed keywords

BIOCOMPATIBILITY; DISEASES; DRUG DELIVERY; FLUORESCENCE; MEDICAL IMAGING; NANOSTRUCTURES; ONCOLOGY; TOXICITY; TUMORS;

CANCER THERAPY; DNA ORIGAMIS; DOXORUBICIN; FLUORESCENCE IMAGING; IN-VIVO;

DNA;

ANTINEOPLASTIC AGENT; DNA; DRUG CARRIER; NANOMATERIAL;

ANIMAL; CHEMISTRY; DRUG RELEASE; DRUG SCREENING; FEMALE; HUMAN; MAMMARY NEOPLASMS, EXPERIMENTAL; METABOLISM; MOUSE; PATHOLOGY; TISSUE DISTRIBUTION; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DNA; DRUG CARRIERS; DRUG LIBERATION; FEMALE; HUMANS; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; NANOSTRUCTURES; TISSUE DISTRIBUTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84904737777     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn502058j     Document Type: Article

References (53)

1. Young, C. W.; Burchenal, J. H. Cancer Chemotherapy Annu. Rev. Pharmacol. 1971, 11, 369-386
2. Carter, S. K.; Slavik, M. Chemotherapy of Cancer Annu. Rev. Pharmacol. 1974, 14, 157-183
3. Chabner, B. A.; Roberts, T. G. Chemotherapy and the War on Cancer Nat. Rev. Cancer 2005, 5, 65-72
4. Petros, R. A.; DeSimone, J. M. Strategies in the Design of Nanoparticles for Therapeutic Applications Nat. Rev. Drug Discovery 2010, 9, 615-627
5. Davis, M. E.; Shin, D. M. Nanoparticle Therapeutics: An Emerging Treatment Modality for Cancer Nat. Rev. Drug Discovery 2008, 7, 771-782
6. Heath, J. R.; Davis, M. E. Nanotechnology and Cancer Annu. Rev. Med. 2008, 59, 251-265
7. Wang, A. Z.; Langer, R.; Farokhzad, O. C. Nanoparticle Delivery of Cancer Drugs Annu. Rev. Med. 2012, 63, 185-198
8. Torchilin, V. Tumor Delivery of Macromolecular Drugs Based on the EPR Effect Adv. Drug Delivery Rev. 2011, 63, 131-135
9. Zhao, F.; Zhao, Y.; Liu, Y.; Chang, X.; Chen, C.; Zhao, Y. Cellular Uptake, Intracellular Trafficking, and Cytotoxicity of Nanomaterials Small 2011, 7, 1322-1337
10. Jain, R. K.; Stylianopoulos, T. Delivering Nanomedicine to Solid Tumors Nat. Rev. Clin. Oncol. 2010, 7, 653-664
11. Rothemund, P. W. Folding DNA To Create Nanoscale Shapes and Patterns Nature 2006, 440, 297-302
12. Pinheiro, A. V.; Han, D.; Shih, W. M.; Yan, H. Challenges and Opportunities for Structural DNA Nanotechnology Nat. Nanotechnol. 2011, 6, 763-772
13. Chhabra, R.; Sharma, J.; Liu, Y.; Rinker, S.; Yan, H. DNA Self-Assembly for Nanomedicine Adv. Drug Delivery Rev. 2010, 62, 617-625
14. Ding, B.; Deng, Z.; Yan, H.; Cabrini, S.; Zuckermann, R. N.; Bokor, J. Gold Nanoparticle Self-Similar Chain Structure Organized by DNA Origami J. Am. Chem. Soc. 2010, 132, 3248-3249
15. Stearns, L. A.; Chhabra, R.; Sharma, J.; Liu, Y.; Petuskey, W. T.; Yan, H.; Chaput, J. C. Template-Directed Nucleation and Growth of Inorganic Nanoparticles on DNA Scaffolds Angew. Chem., Int. Ed. 2009, 48, 8494-8496
16. Pal, S.; Varghese, R.; Deng, Z.; Zhao, Z.; Kumar, A.; Yan, H.; Liu, Y. Site-Specific Synthesis and In Situ Immobilization of Fluorescent Silver Nanoclusters on DNA Nanoscaffolds by Use of the Tollens Reaction Angew. Chem., Int. Ed. 2011, 123, 4262-4265
17. Ding, B.; Wu, H.; Xu, W.; Zhao, Z.; Liu, Y.; Yu, H.; Yan, H. Interconnecting Gold Islands with DNA Origami Nanotubes Nano Lett. 2010, 10, 5065-5069
18. Voigt, N. V.; Tørring, T.; Rotaru, A.; Jacobsen, M. F.; Ravnsbæk, J. B.; Subramani, R.; Mamdouh, W.; Kjems, J.; Mokhir, A.; Besenbacher, F. et al. Single-Molecule Chemical Reactions on DNA Origami Nat. Nanotechnol 2010, 5, 200-203
19. Chang, M.; Yang, C.-S.; Huang, D.-M. Aptamer-Conjugated DNA Icosahedral Nanoparticles as a Carrier of Doxorubicin for Cancer Therapy ACS Nano 2011, 5, 6156-6163
20. Li, J.; Pei, H.; Zhu, B.; Liang, L.; Wei, M.; He, Y.; Chen, N.; Li, D.; Huang, Q.; Fan, C. Self-Assembled Multivalent DNA Nanostructures for Noninvasive Intracellular Delivery of Immunostimulatory CpG Oligonucleotides ACS Nano 2011, 5, 8783-8789
21. Bhatia, D.; Surana, S.; Chakraborty, S.; Koushika, S. P.; Krishnan, Y. A Synthetic Icosahedral DNA-Based Host-Cargo Complex for Functional In Vivo Imaging Nat. Commun. 2011, 2, 339
22. Lee, H.; Lytton-Jean, A. K.; Chen, Y.; Love, K. T.; Park, A. I.; Karagiannis, E. D.; Sehgal, A.; Querbes, W.; Zurenko, C. S.; Jayaraman, M. et al. Molecularly Self-Assembled Nucleic Acid Nanoparticles for Targeted In Vivo SiRNA Delivery Nat. Nanotechnol. 2012, 7, 389-393
23. Liu, X.; Xu, Y.; Yu, T.; Clifford, C.; Liu, Y.; Yan, H.; Chang, Y. A DNA Nanostructure Platform for Directed Assembly of Synthetic Vaccines Nano Lett. 2012, 12, 4254-4259
24. Mei, Q.; Wei, X.; Su, F.; Liu, Y.; Youngbull, C.; Johnson, R.; Lindsay, S.; Yan, H.; Meldrum, D. Stability of DNA Origami Nanoarrays in Cell Lysate Nano Lett. 2011, 11, 1477-1482
25. Shen, X.; Jiang, Q.; Wang, J.; Dai, L.; Zou, G.; Wang, Z. G.; Chen, W. Q.; Jiang, W.; Ding, B. Visualization of the Intracellular Location and Stability of DNA Origami with a Label-Free Fluorescent Probe Chem. Commun. 2012, 48, 11301-11303
26. Douglas, S. M.; Bachelet, I.; Church, G. M. A Logic-Gated Nanorobot for Targeted Transport of Molecular Payloads Science 2012, 335, 831-834
27. Schuller, V. J.; Heidegger, S.; Sandholzer, N.; Nickels, P. C.; Suhartha, N. A.; Endres, S.; Bourquin, C.; Liedl, T. Cellular Immunostimulation by CpG-Sequence-Coated DNA Origami Structures ACS Nano 2011, 5, 9696-9702
28. Jiang, Q.; Song, C.; Nangreave, J.; Liu, X.; Lin, L.; Qiu, D.; Wang, Z.-G.; Zou, G.; Liang, X.; Yan, H. DNA Origami as a Carrier for Circumvention of Drug Resistance J. Am. Chem. Soc. 2012, 134, 13396-13403
29. Zhao, Y. X.; Shaw, A.; Zeng, X.; Benson, E.; Nystrom, A. M.; Hogberg, B. DNA Origami Delivery System for Cancer Therapy with Tunable Release Properties ACS Nano 2012, 6, 8684-8691
30. Rudin, M.; Weissleder, R. Molecular Imaging in Drug Discovery and Development Nat. Rev. Drug Discovery 2003, 2, 123-131
31. Seddon, B. M.; Workman, P. The Role of Functional and Molecular Imaging in Cancer Drug Discovery and Development Br. J. Radiol. 2003, 76, S128-138
32. Zhang, Q.; Du, Y.; Xue, Z.; Chi, C.; Jia, X.; Tian, J. Comprehensive Evaluation of the Anti-angiogenic and Anti-neoplastic Effects of Endostar on Liver Cancer through Optical Molecular Imaging PLoS One 2014, 9, e85559
33. Aryal, S.; Hu, C. M.; Zhang, L. Polymer-Cisplatin Conjugate Nanoparticles for Acid-Responsive Drug Delivery ACS Nano 2010, 4, 251-258
34. Yuan, Q.; Yeudall, W. A.; Yang, H. PEGylated Polyamidoamine Dendrimers with Bis-aryl Hydrazone Linkages for Enhanced Gene Delivery Biomacromolecules 2010, 11, 1940-1947
35. Dimarzio, C. A.; Niedre, M. Pre-clinical Optical Molecular Imaging in the Lung: Technological Challenges and Future Prospects J. Thorac. Dis. 2012, 4, 556-557
36. Chan, L. W.; Wang, Y. N.; Lin, L. Y.; Upton, M. P.; Hwang, J. H.; Pun, S. H. Synthesis and Characterization of Anti-EGFR Fluorescent Nanoparticles for Optical Molecular Imaging Bioconjugate Chem. 2013, 24, 167-175
37. Pigram, W. J.; Fuller, W.; Hamilton, L. D. Stereochemistry of Intercalation: Interaction of Daunomycin with DNA Nat. New Biol. 1972, 235, 17-19
38. Anderson, A. B.; Gergen, J.; Arriaga, E. A. Detection of Doxorubicin and Metabolites in Cell Extracts and in Single Cells by Capillary Electrophoresis with Laser-Induced Fluorescence Detection J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2002, 769, 97-106
39. Santos, R. V.; Batista, M. L., Jr.; Caperuto, E. C.; Costa Rosa, L. F. Chronic Supplementation of Creatine and Vitamins C and E Increases Survival and Improves Biochemical Parameters after Doxorubicin Treatment in Rats Clin. Exp. Pharmacol. Physiol. 2007, 34, 1294-1299
40. Chen, Y. H.; Xu, D. X.; Zhao, L.; Wang, H.; Wang, J. P.; Wei, W. Ascorbic Acid Protects against Lipopolysaccharide-Induced Intra-uterine Fetal Death and Intra-uterine Growth Retardation in Mice Toxicology 2006, 217, 39-45
41. 24 in Doxorubicin-Induced Hepatotoxicity in Rats with Mammary Carcinomas Biomaterials 2008, 29, 3451-3460
42. Meng, H.; Xue, M.; Xia, T.; Ji, Z.; Tarn, D. Y.; Zink, J. I.; Nel, A. E. Use of Size and a Copolymer Design Feature To Improve the Biodistribution and the Enhanced Permeability and Retention Effect of Doxorubicin-Loaded Mesoporous Silica Nanoparticles in a Murine Xenograft Tumor Model ACS Nano 2011, 5, 4131-4144
43. Nomura, R.; Ishizaki, Y.; Suzuki, K.; Kawasaki, S. Development of Hepatic Steatosis after Pancreatoduodenectomy Am. J. Roentgenol. 2007, 189, 1484-1488
44. Klinger, M.; Eipeldauer, S.; Hacker, S.; Herberger, B.; Tamandl, D.; Dorfmeister, M.; Koelblinger, C.; Gruenberger, B.; Gruenberger, T. Bevacizumab Protects against Sinusoidal Obstruction Syndrome and Does Not Increase Response Rate in Neoadjuvant Xelox/Folfox Therapy of Colorectal Cancer Liver Metastases Eur. J. Surg. Oncol. 2009, 35, 515-520
45. Yagmurca, M.; Erdogan, H.; Iraz, M.; Songur, A.; Ucar, M.; Fadillioglu, E. Caffeic Acid Phenethyl Ester as a Protective Agent against Doxorubicin Nephrotoxicity in Rats Clin. Chim. Acta 2004, 348, 27-34
46. Cai, W.; Gambhir, S. S.; Chen, X. Molecular Imaging of Tumor Vasculature. In Methods in Enzymology; Elsevier: Amsterdam, 2008; Vol. 445, pp 141-176, Chapter 7.
47. Chou, L. Y.; Zagorovsky, K.; Chan, W. C. DNA Assembly of Nanoparticle Superstructures for Controlled Biological Delivery and Elimination Nat. Nanotechnol. 2014, 9, 148-155
48. Albanese, A.; Tang, P. S.; Chan, W. C. The Effect of Nanoparticle Size, Shape, and Surface Chemistry on Biological Systems Annu. Rev. Biomed. Eng. 2012, 14, 1-16
49. Farokhzad, O. C.; Langer, R. Impact of Nanotechnology on Drug Delivery ACS Nano 2009, 3, 16-20
50. Mikkila, J.; Eskelinen, A. P.; Niemela, E. H.; Linko, V.; Frilander, M. J.; Torma, P.; Kostiainen, M. A. Virus-Encapsulated DNA Origami Nanostructures for Cellular Delivery Nano Lett. 2014, 14, 2196-2200
51. Allen, T. M.; Mumbengegwi, D. R.; Charrois, G. J. Anti-CD19-Targeted Liposomal Doxorubicin Improves the Therapeutic Efficacy in Murine B-Cell Lymphoma and Ameliorates the Toxicity of Liposomes with Varying Drug Release Rates Clin. Cancer Res. 2005, 11, 3567-3573
52. Bandak, S.; Goren, D.; Horowitz, A.; Tzemach, D.; Gabizon, A. Pharmacological Studies of Cisplatin Encapsulated in Long-Circulating Liposomes in Mouse Tumor Models Anticancer Drugs 1999, 10, 911-920
53. Minelli, C.; Lowe, S. B.; Stevens, M. M. Engineering Nanocomposite Materials for Cancer Therapy Small 2010, 6, 2336-2357